ATE552007T1 - Dezellularisierung und rezellularisierung von organen und geweben - Google Patents

Dezellularisierung und rezellularisierung von organen und geweben

Info

Publication number
ATE552007T1
ATE552007T1 AT06790024T AT06790024T ATE552007T1 AT E552007 T1 ATE552007 T1 AT E552007T1 AT 06790024 T AT06790024 T AT 06790024T AT 06790024 T AT06790024 T AT 06790024T AT E552007 T1 ATE552007 T1 AT E552007T1
Authority
AT
Austria
Prior art keywords
recellularization
decellularization
organs
tissues
organ
Prior art date
Application number
AT06790024T
Other languages
English (en)
Inventor
Harald Ott
Doris Taylor
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota filed Critical Univ Minnesota
Application granted granted Critical
Publication of ATE552007T1 publication Critical patent/ATE552007T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/14—Bioreactors or fermenters specially adapted for specific uses for producing enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Sustainable Development (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Vascular Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Materials For Medical Uses (AREA)
AT06790024T 2005-08-26 2006-08-28 Dezellularisierung und rezellularisierung von organen und geweben ATE552007T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71150105P 2005-08-26 2005-08-26
US81524206P 2006-06-19 2006-06-19
PCT/US2006/033415 WO2007025233A1 (en) 2005-08-26 2006-08-28 Decellularization and recellularization of organs and tissues

Publications (1)

Publication Number Publication Date
ATE552007T1 true ATE552007T1 (de) 2012-04-15

Family

ID=37771950

Family Applications (1)

Application Number Title Priority Date Filing Date
AT06790024T ATE552007T1 (de) 2005-08-26 2006-08-28 Dezellularisierung und rezellularisierung von organen und geweben

Country Status (15)

Country Link
US (5) US8470520B2 (de)
EP (3) EP2431063B1 (de)
JP (6) JP2009505752A (de)
KR (3) KR101376013B1 (de)
CN (2) CN102861359B (de)
AT (1) ATE552007T1 (de)
AU (1) AU2006282783B2 (de)
CA (1) CA2618731C (de)
ES (2) ES2547139T3 (de)
IL (2) IL189418A (de)
MX (3) MX350338B (de)
PL (2) PL2431063T3 (de)
RU (2) RU2463081C2 (de)
SG (1) SG170731A1 (de)
WO (1) WO2007025233A1 (de)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100093066A1 (en) * 2005-08-26 2010-04-15 Regents Of The University Of Minnesota Decellularization and recellularization apparatuses and systems containing the same
ATE552007T1 (de) 2005-08-26 2012-04-15 Univ Minnesota Dezellularisierung und rezellularisierung von organen und geweben
PT2164993T (pt) 2007-05-29 2017-01-12 Reid Christopher B Métodos para produção e usos de populações de células multipotentes, populações de células pluripotentes, populações de célula diferenciadas e populações de células resistentes a vih
WO2009089110A2 (en) * 2008-01-04 2009-07-16 Boston Scientific Scimed, Inc. Methods for repair and regeneration of bone marrow
CA2729765A1 (en) 2008-07-02 2010-01-07 Otsuka Pharmaceutical Factory, Inc. Artificial kidney precursor and process for production thereof
KR20110045067A (ko) * 2008-08-20 2011-05-03 가부시키가이샤 오간 테크놀로지즈 치아 결손부의 수복 방법 및 수복 재료의 제조 방법
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
WO2010091188A1 (en) * 2009-02-04 2010-08-12 Yale University Tissue engineering of lung
US8628572B2 (en) * 2009-02-26 2014-01-14 Wake Forest University Health Sciences Corneal endothelial scaffolds and methods of use
KR101029887B1 (ko) * 2009-03-04 2011-04-18 서울대학교산학협력단 탈세포화를 위한 돼지 각막의 가공방법
AU2010236855C1 (en) * 2009-03-31 2015-04-02 Miromatrix Medical Inc. Decellularization and recellularization of organs and tissues
ES2599828T3 (es) 2009-06-04 2017-02-03 The General Hospital Corporation Pulmón bioartificial
WO2011002926A2 (en) 2009-07-01 2011-01-06 The General Hospital Corporation Isolated adult cells, artificial organs,rehabilitated organs, research rools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
WO2011005306A2 (en) * 2009-07-07 2011-01-13 The Board Of Regents Of The University Of Texas System Production of and uses for decellularized lung tissue
RU2407459C1 (ru) * 2009-07-27 2010-12-27 Учреждение Российской академии медицинских наук Научно-исследовательский институт кардиологии Сибирского отделения РАМН Способ получения соединительно-тканного каркаса магистрального сосуда млекопитающих животных и человека
CA2770490C (en) * 2009-08-11 2024-04-16 The Johns Hopkins University Compositions and methods for implantation of processed adipose tissue and processed adipose tissue products
WO2011038023A1 (en) * 2009-09-22 2011-03-31 Colorado State University Research Foundation Methods for processing biological tissues
JP2013510590A (ja) * 2009-11-17 2013-03-28 ハーバード バイオサイエンス インコーポレーテッド 臓器を形成および／または分析するためのバイオリアクタ、システムおよび方法
WO2011068778A1 (en) * 2009-12-03 2011-06-09 Lifecell Corporation Nerve treatment devices and methods
KR20120111733A (ko) * 2009-12-17 2012-10-10 퀸즈 유니버시티 엣 킹스턴 탈세포화된 지방 조직
WO2011088365A1 (en) * 2010-01-14 2011-07-21 Organogenesis, Inc. Bioengineered tissue constructs and methods for producing and using thereof
US10575515B2 (en) 2010-05-04 2020-03-03 The General Hospital Corporation Methods and compositions for preserving tissues and organs
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
CN101850136B (zh) * 2010-06-11 2013-01-23 四川大学华西医院 一种植入式生物人工肝脏
PL2588592T3 (pl) * 2010-06-30 2018-07-31 Miromatrix Medical Inc. Zastosowanie decelularyzowanych poprzez perfuzję narządów do dopasowanej recelularyzacji
US10233420B2 (en) 2010-09-01 2019-03-19 Regents Of The University Of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
KR101108983B1 (ko) * 2010-09-17 2012-01-31 강원대학교산학협력단 다장기 바이오스캐폴드의 제조방법
KR101273489B1 (ko) * 2011-04-08 2013-06-21 강원대학교산학협력단 심폐 동시 이식용 바이오스캐폴드의 제조방법
KR102109309B1 (ko) 2011-04-28 2020-05-12 라이프셀 코포레이션 조직 생성물의 효소처리방법
US9238793B2 (en) 2011-04-28 2016-01-19 Lifecell Corporation Method for enzymatic treatment of tissue products
US10207025B2 (en) 2011-04-28 2019-02-19 Lifecell Corporation Method for enzymatic treatment of tissue products
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
US20120301958A1 (en) * 2011-05-27 2012-11-29 Advanced Technologies And Regenerative Medicine, Llc Bioartificial proximal tubule systems and methods of use
US20130143323A1 (en) * 2011-06-01 2013-06-06 Geoffrey S. FROST Apparatus and method for decellularizing, recellularizing or treating organs
WO2012170490A2 (en) * 2011-06-06 2012-12-13 Invivosciences, Llc Engineered cardiac tissues and methods of using them
WO2013028968A1 (en) * 2011-08-25 2013-02-28 Wisconsin Alumni Research Foundation 3-dimensional cardiac fibroblast derived extracellular matrix
WO2013052138A2 (en) * 2011-10-03 2013-04-11 Fabrico. Inc. System and method for electrophoretic decellularization
KR101360226B1 (ko) * 2011-11-04 2014-02-12 강원대학교산학협력단 심폐 일체형 탈세포화기법
US20140302480A1 (en) 2011-11-09 2014-10-09 The General Hospital Corporation Composite tissue graft and materials and methods for its production and use
ES2833280T3 (es) * 2012-01-13 2021-06-14 Massachusetts Gen Hospital Células progenitoras pulmonares humanas aisladas y usos de las mismas
EP2809152B1 (de) 2012-02-01 2019-11-20 Nayacure Therapeutics Ltd Verfahren zur induktion von immuntoleranz bei organtransplantationen
PT2782995T (pt) * 2012-03-16 2017-02-14 Novahep Ab Vaso sanguíneo alogénico obtido mediante bioengenharia
US20150093812A1 (en) * 2012-04-18 2015-04-02 The General Hospital Corporation Bioartificial filtration organ
US9877822B2 (en) 2012-04-24 2018-01-30 Biostage, Inc. Engineered tissue scaffolds and supports therefor
US20130344490A1 (en) * 2012-04-27 2013-12-26 Min Peter Kim Neoplastic cells grown on decellularized biomatrix
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
GB201212771D0 (en) 2012-07-18 2012-08-29 Northwick Park Inst For Medcal Res Ltd Implant and method for producing an implant
US9297806B2 (en) * 2012-08-01 2016-03-29 The Johns Hopkins University 5-hydroxymethylcytosine in human cancer
US10111740B2 (en) 2012-08-21 2018-10-30 Regents Of The University Of Minnesota Decellularized biologically-engineered tubular grafts
WO2014058175A1 (ko) * 2012-10-11 2014-04-17 강원대학교산학협력단 미산성 전해수를 유효성분으로 포함하는 바이오 스캐폴드 살균용 조성물 및 이를 이용한 바이오 스캐폴드의 살균 방법
MX2015005795A (es) * 2012-11-07 2016-10-19 Bennie Gandy James Afectación de trasplante de tejidos y tejidos modificados por descelularización y recelularización de tejidos de donadores para reacciones de rechazo evitadas o minimizadas.
US11284987B2 (en) 2013-01-09 2022-03-29 Biostage, Inc. Synthetic scaffolds
US10035980B2 (en) 2013-01-14 2018-07-31 Florida State University Research Foundation, Inc. Extracellular matrix derived from stem cells and methods for production
CN103127550A (zh) * 2013-02-26 2013-06-05 中国人民解放军第二军医大学 骨骼肌全器官脱细胞基质、制备方法及其衍生出的医疗产品
KR20150126841A (ko) 2013-03-07 2015-11-13 알로소스 일관된 칼슘 함량 골 동종이식편 시스템 및 방법
KR20240104179A (ko) 2013-03-15 2024-07-04 미로매트릭스 메디칼 인크. 섬 세포 재세포화를 위한 관류 탈세포화된 간의 용도
US9888680B2 (en) * 2013-04-04 2018-02-13 The Trustees Of Columbia University In The City Of New York Functional recovery of human lungs for transplantation
EP2983718A4 (de) * 2013-04-11 2016-12-07 Univ Of Vermont And State Agricultural College Dezellularisierung und rezellularisierung vollständiger organe
PL2983680T3 (pl) * 2013-04-12 2021-03-08 Houston Methodist Hospital Ulepszanie narządów do przeszczepu
GB201310773D0 (en) * 2013-06-17 2013-07-31 Northwick Park Inst For Medcal Res Ltd Implant and method of producing an implant
AU2014296259B2 (en) 2013-07-30 2017-04-27 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
CA2925332C (en) 2013-11-04 2022-07-12 Lifecell Corporation Methods of removing alpha-galactose
KR101636954B1 (ko) 2013-11-04 2016-07-08 대한민국 재세포화된 바이오 스캐폴드 및 이의 제조방법
US10183097B2 (en) * 2013-11-27 2019-01-22 The Johns Hopkins University Engineered cardiac derived compositions and methods of use
CN103736150B (zh) * 2013-12-31 2015-11-18 中山大学 褪黑素协同细胞外基质生物材料在制备促进间充质干细胞成骨分化药物中的应用
CN103750905B (zh) * 2014-01-20 2015-08-12 辽宁中医药大学 大动物离体工作心双通道灌流实验方法及设备
US11648335B2 (en) 2014-01-31 2023-05-16 Wake Forest University Health Sciences Organ/tissue decellularization, framework maintenance and recellularization
JP6271298B2 (ja) * 2014-02-28 2018-01-31 国立大学法人 東京医科歯科大学 脱細胞組織の製造方法
JP6271299B2 (ja) * 2014-02-28 2018-01-31 株式会社Adeka 脱細胞組織の製造方法
US10918102B2 (en) 2014-03-13 2021-02-16 The General Hospital Corporation Devices and methods to improve and assess viability of human livers
CA2942714C (en) * 2014-03-14 2023-09-05 The General Hospital Corporation Lung bioreactor
CN104940997A (zh) * 2014-03-27 2015-09-30 复旦大学 一种组织工程化人类心肌组织
JP6580329B2 (ja) 2014-03-31 2019-09-25 シスメックス株式会社 未分化細胞から分化細胞および／または分化細胞の産生物を取得する方法
WO2015168528A1 (en) * 2014-05-02 2015-11-05 University Of Houston System Two stage cellularization strategy for the fabrication of bioartificial hearts
WO2015181245A1 (en) * 2014-05-27 2015-12-03 Novahep Ab Bioengineered allogeneic valve
GB201409858D0 (en) * 2014-06-03 2014-07-16 Ucl Business Plc Human liver scaffolds
CN104208751A (zh) * 2014-08-19 2014-12-17 温州医科大学 一种新型肾脏去细胞生物支架的制备方法
ES2957211T3 (es) 2014-09-02 2024-01-15 United Therapeutics Corp Sistema de biorreactor automatizado para la descelularización de un órgano
KR101693831B1 (ko) * 2014-09-03 2017-01-17 서울대학교산학협력단 스페이스 필러를 이용한 이종이식조직의 제조방법
EP3006557A1 (de) 2014-10-07 2016-04-13 Heinrich-Heine-Universität Düsseldorf Gallensäuren zur Induzierung hepatischer Differenzierung
WO2016070162A1 (en) 2014-10-31 2016-05-06 The Administrators Of The Tulane Educational Fund Surgical grafts for replacing the nipple and areola or damaged epidermis
CN104740684A (zh) * 2015-03-03 2015-07-01 上海市闸北区中心医院 一种犬子宫全器官脱细胞基质及其制备方法和应用
JP2018512172A (ja) 2015-03-26 2018-05-17 ミロマトリックス メディカル インコーポレイテッド ガス充填された脱細胞化細胞外マトリックス
JP2016185115A (ja) 2015-03-27 2016-10-27 シスメックス株式会社 臓器灌流方法および臓器灌流装置
CA2986702C (en) 2015-05-21 2023-04-04 David Wang Modified demineralized cortical bone fibers
RU2586952C1 (ru) * 2015-07-20 2016-06-10 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ лечения печеночной недостаточности
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
CN105013014A (zh) * 2015-07-31 2015-11-04 武汉蓝普医品有限公司 一种无细胞基质生物材料的制备方法和用途
CN105031731B (zh) * 2015-08-18 2018-04-17 温州医科大学 一种快速去细胞单叶肝脏生物支架的制备方法
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
WO2017044810A1 (en) 2015-09-11 2017-03-16 The General Hospital Corporation Regeneration of a functional pulmonary vascular bed
AU2016334242B2 (en) 2015-10-09 2020-09-24 Deka Products Limited Partnership Fluid pumping and bioreactor system
EP3184128B1 (de) 2015-12-21 2019-12-11 Heinrich-Heine-Universität Düsseldorf Verfahren zur herstellung einer trägervorrichtung
KR101860798B1 (ko) * 2015-12-29 2018-05-25 포항공과대학교 산학협력단 뇌 조직 탈세포 방법 및 뇌 조직 배양 방법
KR20180133253A (ko) 2016-04-05 2018-12-13 리젠츠 오브 더 유니버시티 오브 미네소타 조직에 매립되어 있는 구조적 구성요소를 갖는 공학처리된 조직, 및 제조 및 사용하는 방법
AU2017268078B2 (en) * 2016-05-16 2023-03-02 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
US10624992B2 (en) 2016-05-16 2020-04-21 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
CA3027505A1 (en) 2016-06-15 2017-12-21 The General Hospital Corporation Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions
CN106075583B (zh) * 2016-07-07 2020-07-14 中国人民解放军第二军医大学 一种采用灌注-压差法制备脱细胞基质生物材料的方法
JP2019521769A (ja) 2016-07-14 2019-08-08 キドニ ラボズ, インク.Qidni Labs, Inc. 生体適合性且つ血液適合性の材料及びフィルタ
RU2639404C1 (ru) * 2016-08-24 2017-12-21 Государственное автономное учреждение здравоохранения Свердловской области "Центр специализированных видов медицинской помощи "Институт медицинских клеточных технологий" Способ восстановления лимфоидной ткани селезенки лабораторных животных
WO2018048899A1 (en) 2016-09-06 2018-03-15 Micromatrix Medical Inc. Use of resected liver serum for whole liver engineering
FR3055805B1 (fr) 2016-09-09 2020-05-15 Assistance Publique - Hopitaux De Paris (Ap-Hp) Biomateriau a usage therapeutique
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
EP3573675A1 (de) 2017-01-30 2019-12-04 LifeCell Corporation Gewebematrixmaterialien und enzymatische klebstoffe
WO2018140853A1 (en) 2017-01-30 2018-08-02 Lifecell Corporation Transglutaminase treated products
CN107096070B (zh) * 2017-03-09 2020-08-21 中国医学科学院阜外医院 一种脱细胞肺支架及其制备方法
RU2665962C1 (ru) 2017-03-17 2018-09-05 Общество с ограниченной ответственностью "Матрифлекс" Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
CN107137769A (zh) * 2017-06-06 2017-09-08 中国人民解放军军事医学科学院基础医学研究所 一种心脏全器官脱细胞基质的制备方法
EP3638019A4 (de) 2017-06-14 2020-08-26 The General Hospital Corporation Kryokonservierung mit temperaturen weit unter dem nullpunkt
WO2019059158A1 (ja) * 2017-09-19 2019-03-28 学校法人明治大学 特定の機能細胞を欠損する臓器を発達させる方法
US12070530B2 (en) 2017-11-09 2024-08-27 University of Pittsburgh—of the Commonwealth System of Higher Education Decellularization and functionalization of extracellular matrix biomaterials
JP7174984B2 (ja) * 2018-02-15 2022-11-18 学校法人自治医科大学 脱細胞化担体製造方法、脱細胞化担体保存方法、細胞充填方法、細胞シート作製方法、及び脱細胞化溶液キット
GB201807788D0 (en) 2018-05-14 2018-06-27 Ucl Business Plc Method
WO2019232268A1 (en) 2018-05-30 2019-12-05 Mustafa Korkut Uygun Cryopreservation of tissues and organs
WO2019241499A1 (en) 2018-06-13 2019-12-19 Miromatrix Medical Inc. Fistula filler and deployment system
TWI712687B (zh) * 2018-09-11 2020-12-11 亞果生醫股份有限公司 去細胞器官及其製備方法
AU2020241583A1 (en) * 2019-03-21 2021-10-14 Miromatrix Medical Inc. Improved decellularization of isolated organs
WO2020243298A1 (en) 2019-05-28 2020-12-03 Regents Of The University Of Minnesota An engineered valve and method of making
CN110694113B (zh) * 2019-10-15 2022-02-01 南通大学附属医院 一种脑脱细胞支架的制备方法
US20230015009A1 (en) * 2019-12-04 2023-01-19 Miromatrix Medical Inc. Methods of Decellularization and Recellularization of Organs and Portions of Organs
KR102748928B1 (ko) * 2020-02-14 2025-01-02 주식회사 세라트젠 심장 오가노이드 배양 및 이식을 위한 탈세포 심장 조직 유래 지지체 및 이의 제조방법
WO2021162533A1 (ko) * 2020-02-14 2021-08-19 연세대학교 산학협력단 장기 오가노이드 배양 및 이식을 위한 탈세포 장기 조직 유래 지지체 및 이의 제조방법
CN111494718B (zh) * 2020-04-24 2021-05-14 四川大学华西医院 一种动物去细胞化肺生物支架材料的制备方法
KR102473682B1 (ko) * 2020-06-30 2022-12-02 서울대학교 산학협력단 개인 맞춤형 경피적 심장 반월판 스텐트 판막의 제조 방법
CN112354014A (zh) * 2020-10-20 2021-02-12 上海亚朋生物技术有限公司 一种清洗脱细胞试剂sds的方法
CN112274697A (zh) * 2020-11-04 2021-01-29 王寅 一种组织工程心肌补片制备方法
US11998662B1 (en) 2021-06-09 2024-06-04 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods
US12383657B1 (en) 2021-06-09 2025-08-12 Reprise Biomedical, Inc. Biologic matrix for a wound site and related methods
DE102021211875B3 (de) * 2021-10-21 2023-01-19 Friedrich-Alexander-Universität Erlangen-Nürnberg, Körperschaft des öffentlichen Rechts Bioreaktor und Verfahren zum Betrieb eines solchen
WO2024006673A1 (en) * 2022-06-30 2024-01-04 Regenmedix Llc Stem cell and organ maturation system and method
CN115554472B (zh) * 2022-09-22 2023-08-18 舩本诚一 一种用于移植的生物组织处理方法
CN120548201A (zh) 2022-11-18 2025-08-26 万益特健康有限责任公司 用于器官支持的体外血液处理

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3545221A (en) * 1967-05-22 1970-12-08 Swenko Research & Dev Inc Apparatus for maintaining organs in vitro in a completely viable state
US3639084A (en) * 1970-04-06 1972-02-01 Baxter Laboratories Inc Mechanism for control pulsatile fluid flow
DE2453363B2 (de) 1974-11-11 1976-08-26 Solco Basel AG, Birsfelden (Schweiz) Verfahren zur herstellung heterologer arterientransplantate
JPS5516016A (en) 1978-07-18 1980-02-04 Dai Ichi Kogyo Seiyaku Co Ltd Improved salt-resistant water-absorbing material
US4801299A (en) * 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
EP0781116A4 (de) 1994-09-12 1999-08-25 Advanced Tissue Sciences Inc Dreidimensionale kulturen von menschlichen zellen auf herzklappengerüst und ihreverwendung
WO1998046165A1 (en) * 1997-04-11 1998-10-22 Cryolife, Inc. Tissue decellularization
JPH1176400A (ja) 1997-09-09 1999-03-23 Masahito Nagaki 人工臓器
JP4222658B2 (ja) 1998-06-23 2009-02-12 テルモ株式会社 細胞支持基材、培養装置および液体処理装置
US6734018B2 (en) * 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
US6448076B2 (en) * 1998-09-15 2002-09-10 The Regents Of The University Of Michigan Method for chemically acellularizing a biological tissue sample
US6432712B1 (en) * 1999-11-22 2002-08-13 Bioscience Consultants, Llc Transplantable recellularized and reendothelialized vascular tissue graft
US20050249816A1 (en) * 1999-12-29 2005-11-10 Wake Forest University Health Services Tissue engineered liver constructs
US6376244B1 (en) 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
US6479064B1 (en) 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
AU5574101A (en) * 2000-04-28 2001-11-12 Univ Emory Decellularized vascular prostheses
DE10021627B4 (de) * 2000-05-04 2009-11-19 Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich Verfahren zur Herstellung eines vaskularisierten bioartifiziellen Gewebes und zugehöriger Versuchsreaktor
EP1315796B1 (de) * 2000-08-16 2006-07-12 Duke University Mittels gewebetechnologie hergestellte dezellularisierte gegenstände und gewebe
US6749064B1 (en) 2000-08-25 2004-06-15 Sanita L. Alrey Bag with article display aperture and support surface
EP1333870A2 (de) 2000-09-20 2003-08-13 Regeneration Technologies, Inc. Verfahren zur herstellung und verarbeitung von transplantatgewebe
IL139708A0 (en) 2000-11-15 2002-02-10 Amiel Gilad Process of decellularizing biological matrices and acellular biological matrices useful in tissue engineering
DE10064948C1 (de) 2000-12-20 2002-07-11 Auto Tissue Gmbh Verfahren zur Dezellularisierung von Fremdmaterial zur Herstellung von Bioprothesen und Vorrichtung zur Durchführung des Verfahrens
MX348185B (es) * 2001-02-14 2017-06-02 Anthrogenesis Corp Placenta de mamíferos postparto, su uso y células madres placentales extraídas de ella.
WO2002088331A1 (en) * 2001-05-01 2002-11-07 Universite Du Quebec A Montreal Tridimensional biocompatible support structure for bioartificial organs and uses thereof
GB2375771A (en) * 2001-05-24 2002-11-27 Univ Leeds Decellularisation of tissue implant material
EP1317934A1 (de) * 2001-11-08 2003-06-11 Artiss GmbH Verfahren zur Herstellung einer azellularisierten Gewebematrix und damit erhältliche Gewebematrix
US7049057B2 (en) * 2001-11-16 2006-05-23 Children's Medical Center Corporation Tissue engineered uterus
AU2002340463A1 (en) * 2001-11-16 2003-06-10 Children's Medical Center Corporation Augmentation of organ function
US20030180268A1 (en) * 2002-02-05 2003-09-25 Anthony Atala Tissue engineered construct for supplementing or replacing a damaged organ
US6790475B2 (en) 2002-04-09 2004-09-14 Wafermasters Inc. Source gas delivery
JP4149897B2 (ja) 2002-11-07 2008-09-17 学校法人 聖マリアンナ医科大学 気管移植片の調製方法および気管移植片
US20040187877A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
US20060147527A1 (en) 2002-12-13 2006-07-06 Cilag Ag Controlled release preparations comprising tramadol and topiramate
US20040176855A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
JP2006223101A (ja) * 2003-05-15 2006-08-31 Univ Waseda 生体組織の保持装置及びこれを用いた生体組織処理装置
WO2005118014A2 (en) * 2004-06-01 2005-12-15 Medtronic, Inc. Decellurisation processes for making bioprotheses
JP3773943B2 (ja) 2004-09-24 2006-05-10 国立大学法人 東京大学 把持状態判定システム及び方法
DE102005023599A1 (de) 2005-05-18 2006-11-23 Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich Bioartifizielles Herzgewebetransplantat und Verfahren zu seiner Herstellung
WO2006126219A1 (en) 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
US7824912B2 (en) 2005-06-23 2010-11-02 Massachusetts Institute Of Technology Methods for ex vivo propagation of adult hepatic stem cells
ATE552007T1 (de) 2005-08-26 2012-04-15 Univ Minnesota Dezellularisierung und rezellularisierung von organen und geweben
US20100093066A1 (en) 2005-08-26 2010-04-15 Regents Of The University Of Minnesota Decellularization and recellularization apparatuses and systems containing the same
AU2013224686B2 (en) 2005-08-26 2015-06-11 Miromatrix Medical Inc. Decellularization and recellularization of organs and tissues
JP4599315B2 (ja) 2006-02-23 2010-12-15 クラレメディカル株式会社 バイオ人工臓器
CN101066477B (zh) 2007-05-17 2010-10-06 中国人民解放军第三军医大学 能在体捕获内皮祖细胞的生物人工血管
EP2225362A1 (de) 2007-11-30 2010-09-08 New York Medical College Verfahren zur verminderung von transplantatabstossung und herz-allotransplantat-vaskulopathie mittels implantieren autologer stammzellen
AU2010236855C1 (en) 2009-03-31 2015-04-02 Miromatrix Medical Inc. Decellularization and recellularization of organs and tissues
PL2588592T3 (pl) 2010-06-30 2018-07-31 Miromatrix Medical Inc. Zastosowanie decelularyzowanych poprzez perfuzję narządów do dopasowanej recelularyzacji
US10233420B2 (en) 2010-09-01 2019-03-19 Regents Of The University Of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
KR20240104179A (ko) 2013-03-15 2024-07-04 미로매트릭스 메디칼 인크. 섬 세포 재세포화를 위한 관류 탈세포화된 간의 용도
SG11201507673WA (en) 2013-03-15 2015-10-29 Miromatrix Medical Inc Use of microparticles and endothelial cells with decellularized organs and tissues
JP6340772B2 (ja) 2013-11-08 2018-06-13 東ソー株式会社 パラメータ変更履歴を管理可能な分析装置
JP2018512172A (ja) 2015-03-26 2018-05-17 ミロマトリックス メディカル インコーポレイテッド ガス充填された脱細胞化細胞外マトリックス
WO2018048899A1 (en) 2016-09-06 2018-03-15 Micromatrix Medical Inc. Use of resected liver serum for whole liver engineering

Also Published As

Publication number Publication date
AU2006282783A1 (en) 2007-03-01
MX369594B (es) 2019-11-13
KR101376013B1 (ko) 2014-03-19
MX2008002589A (es) 2008-03-14
RU2012122055A (ru) 2013-12-10
PL2431063T3 (pl) 2015-11-30
US10220056B2 (en) 2019-03-05
JP2009505752A (ja) 2009-02-12
KR101420585B1 (ko) 2014-07-17
IL189418A0 (en) 2008-06-05
SG170731A1 (en) 2011-05-30
US8470520B2 (en) 2013-06-25
WO2007025233A1 (en) 2007-03-01
EP2431063B1 (de) 2015-06-17
EP2431063A3 (de) 2012-07-11
KR20080065970A (ko) 2008-07-15
KR20130122701A (ko) 2013-11-07
CN101272815B (zh) 2012-09-26
EP2965769A1 (de) 2016-01-13
KR20140040293A (ko) 2014-04-02
US20190343877A1 (en) 2019-11-14
US10441609B2 (en) 2019-10-15
US20200222456A1 (en) 2020-07-16
CN101272815A (zh) 2008-09-24
IL189418A (en) 2014-08-31
CN102861359A (zh) 2013-01-09
US20130344599A1 (en) 2013-12-26
JP6089062B2 (ja) 2017-03-01
CN102861359B (zh) 2015-04-01
RU2008111503A (ru) 2009-10-10
HK1220646A1 (en) 2017-05-12
EP1928519A1 (de) 2008-06-11
RU2635478C9 (ru) 2018-06-05
EP1928519B1 (de) 2012-04-04
HK1168565A1 (en) 2013-01-04
CA2618731A1 (en) 2007-03-01
EP2965769B1 (de) 2018-12-26
JP7286708B2 (ja) 2023-06-05
JP2021120012A (ja) 2021-08-19
AU2006282783B2 (en) 2013-06-06
ES2384721T3 (es) 2012-07-11
US20090202977A1 (en) 2009-08-13
IL233821A (en) 2016-08-31
JP2017038948A (ja) 2017-02-23
PL1928519T3 (pl) 2012-08-31
IL233821A0 (en) 2014-09-30
JP2015164549A (ja) 2015-09-17
JP2019088910A (ja) 2019-06-13
RU2463081C2 (ru) 2012-10-10
CA2618731C (en) 2021-12-28
RU2635478C2 (ru) 2017-11-13
US20130109088A1 (en) 2013-05-02
JP2013056183A (ja) 2013-03-28
ES2547139T3 (es) 2015-10-02
MX350338B (es) 2017-09-04
EP1928519A4 (de) 2009-07-08
EP2431063A2 (de) 2012-03-21

Similar Documents

Publication Publication Date Title
ATE552007T1 (de) Dezellularisierung und rezellularisierung von organen und geweben
MX2011010197A (es) Descelularizacion y recelularizacion de organos y tejidos.
ATE550031T1 (de) Zusammensetzungen und verfahren für die lipomodellierung
ATE554727T1 (de) Operationsinstrument zur ablage einer prothese
ATE320276T1 (de) Zusammensetzungen zur kontrolle von unangenehmen gerüchen mit geruchskontrollmitteln und einen wirkstoff enthaltende mikrokapseln
AU2016204344A1 (en) Improved methods and compositions for wound healing
CY1110026T1 (el) Ενωσεις πιπεραζινης βενζισοξαζολης και μεθοδοι χρησης εξ αυτων
EP1996013A4 (de) Verfahren und zusammensetzungen für die organ- und gewebefunktionalität
EP1948087A4 (de) Herzklappenimplantat
DE602006007429D1 (de) Chirurgische Prothese zum Stützen eines Organs
ATE533518T1 (de) Resorbierbare polyetherester zur herstellung von medizinischen implantaten
CL2007002384A1 (es) Uso de compuestos derivados de 2,5-dihidroxibenceno para el tratamiento de la psoriasis.
DE602005026984D1 (de) Chinolin-derivate zur behandlung von latenter tuberkulose
DE602005026866D1 (de) Vewendung von dreidimensionalem kultiviertem gewebe zur behandlung von kongestivem herzversagen
WO2006081435A3 (en) Method of providing readily available cellular material derived from cord blood, and a composition thereof
WO2006093857A3 (en) Method of providing readily available cellular material derived from peripheral blood and a composition thereof
DE602006017980D1 (de) 3,4-substituierte pyrrolidin-derivate zur behandlung von hypertonie
EA200701306A1 (ru) Лиофилизация виросом
DE602006003922D1 (de) Chirurgisches Implantat
TW200716088A (en) Formulations and methods for treating amyloidosis
ATE517642T1 (de) Kombination zum verkleben von biologischen geweben
MX2007010484A (es) Moleculas y metodos para usarlas para tratar enfermedades asociadas con mcp-1/ccr2.
DE602006003094D1 (de) 4-phenyl-5-oxo-1,4,5,6,7,8-hexahydrochinolin-derivate zur behandlung von unfruchtbarkeit
IL165425A0 (en) Methods of treating disease by transplantation of developing allogeneic or xenogeneic organs or tissues
ZA200708372B (en) KIM-1 antibodies for treatment of Th2-mediated conditions