MX369594B - Descelularizacion y recelularizacion de organos y tejidos. - Google Patents

Descelularizacion y recelularizacion de organos y tejidos.

Info

Publication number
MX369594B
MX369594B MX2017011107A MX2017011107A MX369594B MX 369594 B MX369594 B MX 369594B MX 2017011107 A MX2017011107 A MX 2017011107A MX 2017011107 A MX2017011107 A MX 2017011107A MX 369594 B MX369594 B MX 369594B
Authority
MX
Mexico
Prior art keywords
recellularization
decellularization
organs
tissues
organ
Prior art date
Application number
MX2017011107A
Other languages
English (en)
Inventor
Taylor Doris
Ott Harald
Original Assignee
Univ Minnesota
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Minnesota filed Critical Univ Minnesota
Publication of MX369594B publication Critical patent/MX369594B/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/08—Bioreactors or fermenters specially adapted for specific uses for producing artificial tissue or for ex-vivo cultivation of tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M21/00—Bioreactors or fermenters specially adapted for specific uses
    • C12M21/14—Bioreactors or fermenters specially adapted for specific uses for producing enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/14—Scaffolds; Matrices
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/04—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus by injection or suction, e.g. using pipettes, syringes, needles
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/34—Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/90—Substrates of biological origin, e.g. extracellular matrix, decellularised tissue

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Sustainable Development (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Vascular Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mechanical Engineering (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La presente invención se refiere a métodos y materiales para descelularizar un órgano sólido y recelularizar este órgano descelularizado para generar con esto un órgano sólido.
MX2017011107A 2005-08-26 2006-08-28 Descelularizacion y recelularizacion de organos y tejidos. MX369594B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71150105P 2005-08-26 2005-08-26
US81524206P 2006-06-19 2006-06-19
PCT/US2006/033415 WO2007025233A1 (en) 2005-08-26 2006-08-28 Decellularization and recellularization of organs and tissues

Publications (1)

Publication Number Publication Date
MX369594B true MX369594B (es) 2019-11-13

Family

ID=37771950

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2017011107A MX369594B (es) 2005-08-26 2006-08-28 Descelularizacion y recelularizacion de organos y tejidos.
MX2014006778A MX350338B (es) 2005-08-26 2006-08-28 Descelularizacion y recelularizacion de organos y tejidos.
MX2008002589A MX2008002589A (es) 2005-08-26 2006-08-28 Descelularizacion y recelularizacion de organos y tejidos.

Family Applications After (2)

Application Number Title Priority Date Filing Date
MX2014006778A MX350338B (es) 2005-08-26 2006-08-28 Descelularizacion y recelularizacion de organos y tejidos.
MX2008002589A MX2008002589A (es) 2005-08-26 2006-08-28 Descelularizacion y recelularizacion de organos y tejidos.

Country Status (16)

Country Link
US (5) US8470520B2 (es)
EP (3) EP1928519B1 (es)
JP (6) JP2009505752A (es)
KR (3) KR101376013B1 (es)
CN (2) CN102861359B (es)
AT (1) ATE552007T1 (es)
AU (1) AU2006282783B2 (es)
CA (1) CA2618731C (es)
ES (2) ES2547139T3 (es)
HK (2) HK1168565A1 (es)
IL (2) IL189418A (es)
MX (3) MX369594B (es)
PL (2) PL1928519T3 (es)
RU (2) RU2463081C2 (es)
SG (1) SG170731A1 (es)
WO (1) WO2007025233A1 (es)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1928519T3 (pl) 2005-08-26 2012-08-31 Univ Minnesota Decelularyzacja i recelularyzacja narządów i tkanek
US20100093066A1 (en) * 2005-08-26 2010-04-15 Regents Of The University Of Minnesota Decellularization and recellularization apparatuses and systems containing the same
EP3128015A3 (en) 2007-05-29 2017-05-03 Christopher B. Reid A method for providing a desired cell population capable of further differentiation in vivo
WO2009089110A2 (en) * 2008-01-04 2009-07-16 Boston Scientific Scimed, Inc. Methods for repair and regeneration of bone marrow
EP2298866A4 (en) * 2008-07-02 2013-11-20 Otsuka Pharma Co Ltd ARTIFICIAL KIDNEY PRECURSOR AND METHOD FOR PRODUCING THE SAME
AU2009283516B2 (en) * 2008-08-20 2014-02-13 Organ Technologies Inc. Method for restoring missing tooth and method for producing restorative material
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
CN102388127B (zh) * 2009-02-04 2016-10-26 耶鲁大学 肺的组织改造
WO2010099310A1 (en) * 2009-02-26 2010-09-02 Wake Forest University Health Sciences Endothelial scaffolds
KR101029887B1 (ko) * 2009-03-04 2011-04-18 서울대학교산학협력단 탈세포화를 위한 돼지 각막의 가공방법
CN102448476A (zh) * 2009-03-31 2012-05-09 明尼苏达大学董事会 器官和组织的脱细胞化和再细胞化
US9005885B2 (en) 2009-06-04 2015-04-14 The General Hospital Corporation Bioartificial lung
US20130323708A1 (en) 2009-07-01 2013-12-05 Massachusetts Institute Of Technology Isolated adult cells, artificial organs, rehabilitated organs, research tools, organ encasements, organ perfusion systems, and methods for preparing and utilizing the same
US20110045045A1 (en) * 2009-07-07 2011-02-24 Joaquin Cortiella Production of and uses for decellularized lung tissue
CN102575229A (zh) * 2009-08-11 2012-07-11 约翰霍普金斯大学 用于植入经加工的脂肪组织和经加工的脂肪组织产品的组合物和方法
US20110236949A1 (en) * 2009-09-22 2011-09-29 Colorado State University Research Foundation Methods for Processing Biological Tissues
CA2818514A1 (en) * 2009-11-17 2011-05-26 Harvard Bioscience, Inc. Bioreactors, systems, and methods for producing and/or analyzing organs
WO2011068778A1 (en) * 2009-12-03 2011-06-09 Lifecell Corporation Nerve treatment devices and methods
MX2012006759A (es) * 2009-12-17 2012-07-30 Univ Kingston Tejido adiposo descelularizado.
CN102892880A (zh) * 2010-01-14 2013-01-23 奥加诺吉尼西斯公司 生物工程化组织构建物及其制备和使用方法
US10575515B2 (en) 2010-05-04 2020-03-03 The General Hospital Corporation Methods and compositions for preserving tissues and organs
US9352003B1 (en) 2010-05-14 2016-05-31 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US10130736B1 (en) 2010-05-14 2018-11-20 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
US8883210B1 (en) 2010-05-14 2014-11-11 Musculoskeletal Transplant Foundation Tissue-derived tissuegenic implants, and methods of fabricating and using same
CN101850136B (zh) * 2010-06-11 2013-01-23 四川大学华西医院 一种植入式生物人工肝脏
PL2588592T3 (pl) * 2010-06-30 2018-07-31 Miromatrix Medical Inc. Zastosowanie decelularyzowanych poprzez perfuzję narządów do dopasowanej recelularyzacji
AU2011295779B2 (en) 2010-09-01 2015-08-27 Regents Of The University Of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
KR101108983B1 (ko) * 2010-09-17 2012-01-31 강원대학교산학협력단 다장기 바이오스캐폴드의 제조방법
KR101273489B1 (ko) * 2011-04-08 2013-06-21 강원대학교산학협력단 심폐 동시 이식용 바이오스캐폴드의 제조방법
US9238793B2 (en) 2011-04-28 2016-01-19 Lifecell Corporation Method for enzymatic treatment of tissue products
US10207025B2 (en) 2011-04-28 2019-02-19 Lifecell Corporation Method for enzymatic treatment of tissue products
ES2720137T3 (es) 2011-04-28 2019-07-18 Lifecell Corp Método para el tratamiento enzimático de productos tisular
US8834928B1 (en) 2011-05-16 2014-09-16 Musculoskeletal Transplant Foundation Tissue-derived tissugenic implants, and methods of fabricating and using same
SG195125A1 (en) * 2011-05-27 2013-12-30 Atrm Llc Bioartificial proximal tubule systems and methods of use
US20130143323A1 (en) * 2011-06-01 2013-06-06 Geoffrey S. FROST Apparatus and method for decellularizing, recellularizing or treating organs
CA2838707C (en) * 2011-06-06 2020-07-21 Invivosciences, Inc. Engineered cardiac tissues and methods of using them
US8802144B2 (en) * 2011-08-25 2014-08-12 Wisconsin Alumni Research Foundation 3-dimensional cardiac fibroblast derived extracellular matrix
WO2013052138A2 (en) * 2011-10-03 2013-04-11 Fabrico. Inc. System and method for electrophoretic decellularization
KR101360226B1 (ko) * 2011-11-04 2014-02-12 강원대학교산학협력단 심폐 일체형 탈세포화기법
EP2775957A4 (en) * 2011-11-09 2015-07-22 Gen Hospital Corp COMPOUND TISSUE TRANSPLANT, MATERIALS AND METHOD FOR THE PRODUCTION AND USE THEREOF
CA2861068C (en) 2012-01-13 2023-10-24 The General Hospital Corporation Isolated human lung progenitor cells and uses thereof
US9295756B2 (en) 2012-02-01 2016-03-29 Nayacure Therapeutics Ltd. Methods for inducing immune tolerance to organ transplants
EP2782995B1 (en) 2012-03-16 2016-11-09 Novahep AB Bioengineered allogeneic blood vessel
US20150093812A1 (en) * 2012-04-18 2015-04-02 The General Hospital Corporation Bioartificial filtration organ
US9877822B2 (en) 2012-04-24 2018-01-30 Biostage, Inc. Engineered tissue scaffolds and supports therefor
US20130344490A1 (en) * 2012-04-27 2013-12-26 Min Peter Kim Neoplastic cells grown on decellularized biomatrix
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
GB201212771D0 (en) * 2012-07-18 2012-08-29 Northwick Park Inst For Medcal Res Ltd Implant and method for producing an implant
US9297806B2 (en) * 2012-08-01 2016-03-29 The Johns Hopkins University 5-hydroxymethylcytosine in human cancer
US10111740B2 (en) 2012-08-21 2018-10-30 Regents Of The University Of Minnesota Decellularized biologically-engineered tubular grafts
KR20140048801A (ko) * 2012-10-11 2014-04-24 강원대학교산학협력단 미산성 전해수를 유효성분으로 포함하는 바이오 스캐폴드 살균용 조성물 및 이를 이용한 바이오 스캐폴드의 살균 방법
US9439949B2 (en) * 2012-11-07 2016-09-13 Gray Reed & Mcgraw, P.C. Decellularization and recellularization of donor tissues for minimized or obviated rejection reactions
WO2014110300A1 (en) 2013-01-09 2014-07-17 Harvard Apparatus Regenerative Technology Synthetic scaffolds
WO2014110586A1 (en) * 2013-01-14 2014-07-17 Florida State University Research Foundation, Inc. Extracellular matrix derived from stem cells and methods for production
CN103127550A (zh) * 2013-02-26 2013-06-05 中国人民解放军第二军医大学 骨骼肌全器官脱细胞基质、制备方法及其衍生出的医疗产品
AU2014225458A1 (en) 2013-03-07 2015-07-09 Allosource Consistent calcium content bone allograft systems and methods
SG10201906304TA (en) 2013-03-15 2019-08-27 Miromatrix Medical Inc Use of perfusion decellularized liver for islet cell recellularization
US9888680B2 (en) * 2013-04-04 2018-02-13 The Trustees Of Columbia University In The City Of New York Functional recovery of human lungs for transplantation
US10918765B2 (en) 2013-04-11 2021-02-16 University Of Vermont And State Agricultural College Decellularization and recellularization of whole organs
GB201310773D0 (en) * 2013-06-17 2013-07-31 Northwick Park Inst For Medcal Res Ltd Implant and method of producing an implant
MX2016001247A (es) 2013-07-30 2016-08-17 Musculoskeletal Transplant Foundation Matrices derivadas de tejido suave acelular y metodos para preparar las mismas.
KR101636954B1 (ko) 2013-11-04 2016-07-08 대한민국 재세포화된 바이오 스캐폴드 및 이의 제조방법
BR112016009178B1 (pt) 2013-11-04 2020-12-15 Lifecell Corporation Método de preparação de um produto de tecido e uso de um produto de tecido
WO2015081226A1 (en) * 2013-11-27 2015-06-04 The Johns Hopkins University Engineered cardiac derived compositions and methods of use
CN103736150B (zh) * 2013-12-31 2015-11-18 中山大学 褪黑素协同细胞外基质生物材料在制备促进间充质干细胞成骨分化药物中的应用
CN103750905B (zh) * 2014-01-20 2015-08-12 辽宁中医药大学 大动物离体工作心双通道灌流实验方法及设备
US11648335B2 (en) 2014-01-31 2023-05-16 Wake Forest University Health Sciences Organ/tissue decellularization, framework maintenance and recellularization
JP6271299B2 (ja) * 2014-02-28 2018-01-31 株式会社Adeka 脱細胞組織の製造方法
JP6271298B2 (ja) * 2014-02-28 2018-01-31 国立大学法人 東京医科歯科大学 脱細胞組織の製造方法
WO2015138832A1 (en) 2014-03-13 2015-09-17 The General Hospital Corporation Devices and methods to improve and assess viability of human livers
ES2841142T3 (es) * 2014-03-14 2021-07-07 Massachusetts Gen Hospital Biorreactor de pulmón
CN104940997A (zh) * 2014-03-27 2015-09-30 复旦大学 一种组织工程化人类心肌组织
JP6580329B2 (ja) 2014-03-31 2019-09-25 シスメックス株式会社 未分化細胞から分化細胞および／または分化細胞の産生物を取得する方法
WO2015168528A1 (en) * 2014-05-02 2015-11-05 University Of Houston System Two stage cellularization strategy for the fabrication of bioartificial hearts
JP2016524954A (ja) * 2014-05-27 2016-08-22 ノーバヘップ アーベー 生物工学で作製された同種異系弁
GB201409858D0 (en) * 2014-06-03 2014-07-16 Ucl Business Plc Human liver scaffolds
CN104208751A (zh) * 2014-08-19 2014-12-17 温州医科大学 一种新型肾脏去细胞生物支架的制备方法
EP3188595B1 (en) * 2014-09-02 2023-08-23 United Therapeutics Corporation Automated bioreactor system for decellularizing an organ
KR101693831B1 (ko) * 2014-09-03 2017-01-17 서울대학교산학협력단 스페이스 필러를 이용한 이종이식조직의 제조방법
EP3006557A1 (en) 2014-10-07 2016-04-13 Heinrich-Heine-Universität Düsseldorf Bile acids for inducing hepatic differentiation
DK3212247T3 (da) 2014-10-31 2021-06-28 The Administrators Of The Tulane Educational Fund Kirurgiske implantater til erstatning af brystvorte og areola eller beskadiget epidermis
CN104740684A (zh) * 2015-03-03 2015-07-01 上海市闸北区中心医院 一种犬子宫全器官脱细胞基质及其制备方法和应用
AU2016235074A1 (en) 2015-03-26 2017-10-12 Miromatrix Medical Inc. Gas filled decellularized extracellular matrix
JP2016185115A (ja) 2015-03-27 2016-10-27 シスメックス株式会社 臓器灌流方法および臓器灌流装置
EP3297694A1 (en) 2015-05-21 2018-03-28 Musculoskeletal Transplant Foundation Modified demineralized cortical bone fibers
RU2586952C1 (ru) * 2015-07-20 2016-06-10 Федеральное государственное бюджетное учреждение "Федеральный научный центр трансплантологии и искусственных органов имени академика В.И. Шумакова" Министерства здравоохранения Российской Федерации Способ лечения печеночной недостаточности
US10912864B2 (en) 2015-07-24 2021-02-09 Musculoskeletal Transplant Foundation Acellular soft tissue-derived matrices and methods for preparing same
CN105013014A (zh) * 2015-07-31 2015-11-04 武汉蓝普医品有限公司 一种无细胞基质生物材料的制备方法和用途
CN105031731B (zh) * 2015-08-18 2018-04-17 温州医科大学 一种快速去细胞单叶肝脏生物支架的制备方法
US11052175B2 (en) 2015-08-19 2021-07-06 Musculoskeletal Transplant Foundation Cartilage-derived implants and methods of making and using same
CN114672451A (zh) 2015-09-11 2022-06-28 通用医疗公司 功能性肺血管床的再生
NZ776411A (en) 2015-10-09 2023-09-29 Deka Products Lp Fluid pumping and bioreactor system
EP3184128B1 (en) * 2015-12-21 2019-12-11 Heinrich-Heine-Universität Düsseldorf Method for producing a support device
KR101860798B1 (ko) * 2015-12-29 2018-05-25 포항공과대학교 산학협력단 뇌 조직 탈세포 방법 및 뇌 조직 배양 방법
KR20230130755A (ko) 2016-04-05 2023-09-12 리젠츠 오브 더 유니버시티 오브 미네소타 조직에 매립되어 있는 구조적 구성요소를 갖는 공학처리된 조직, 및 제조 및 사용하는 방법
US10624992B2 (en) 2016-05-16 2020-04-21 The General Hospital Corporation Human airway stem cells in lung epithelial engineering
WO2017218796A1 (en) 2016-06-15 2017-12-21 Ott Harald C Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions
CN106075583B (zh) * 2016-07-07 2020-07-14 中国人民解放军第二军医大学 一种采用灌注-压差法制备脱细胞基质生物材料的方法
JP2019521769A (ja) 2016-07-14 2019-08-08 キドニ ラボズ, インク.Qidni Labs, Inc. 生体適合性且つ血液適合性の材料及びフィルタ
RU2639404C1 (ru) * 2016-08-24 2017-12-21 Государственное автономное учреждение здравоохранения Свердловской области "Центр специализированных видов медицинской помощи "Институт медицинских клеточных технологий" Способ восстановления лимфоидной ткани селезенки лабораторных животных
EP3509651B1 (en) 2016-09-06 2022-12-28 Miromatrix Medical Inc. Use of resected liver serum for whole liver engineering
FR3055805B1 (fr) 2016-09-09 2020-05-15 Assistance Publique - Hopitaux De Paris (Ap-Hp) Biomateriau a usage therapeutique
US11299705B2 (en) 2016-11-07 2022-04-12 Deka Products Limited Partnership System and method for creating tissue
CN110290817B (zh) 2017-01-30 2020-07-03 生命细胞公司 转谷氨酰胺酶处理的产品
WO2018140854A1 (en) 2017-01-30 2018-08-02 Lifecell Corporation Tissue matrix materials and enzymatic adhesives
CN107096070B (zh) * 2017-03-09 2020-08-21 中国医学科学院阜外医院 一种脱细胞肺支架及其制备方法
RU2665962C1 (ru) 2017-03-17 2018-09-05 Общество с ограниченной ответственностью "Матрифлекс" Биорезорбируемый биологический матрикс для замещения дефектов костной ткани и способ его получения
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
CN107137769A (zh) * 2017-06-06 2017-09-08 中国人民解放军军事医学科学院基础医学研究所 一种心脏全器官脱细胞基质的制备方法
US11172657B2 (en) * 2017-09-19 2021-11-16 Pormedtec Co., Ltd. Method for developing organ that lacks specific functional cell
JP7174984B2 (ja) * 2018-02-15 2022-11-18 学校法人自治医科大学 脱細胞化担体製造方法、脱細胞化担体保存方法、細胞充填方法、細胞シート作製方法、及び脱細胞化溶液キット
GB201807788D0 (en) * 2018-05-14 2018-06-27 Ucl Business Plc Method
TWI712687B (zh) * 2018-09-11 2020-12-11 亞果生醫股份有限公司 去細胞器官及其製備方法
EP3941497A4 (en) * 2019-03-21 2022-12-21 Miromatrix Medical Inc. ENHANCED DECELLULARIZATION OF ISOLATED ORGANS
CN110694113B (zh) * 2019-10-15 2022-02-01 南通大学附属医院 一种脑脱细胞支架的制备方法
US20230015009A1 (en) * 2019-12-04 2023-01-19 Miromatrix Medical Inc. Methods of Decellularization and Recellularization of Organs and Portions of Organs
JP2023513784A (ja) * 2020-02-14 2023-04-03 セルアートジェン インコーポレイテッド 臓器オルガノイドの培養及び移植のための脱細胞臓器組織由来の支持体及びその製造方法
CN111494718B (zh) * 2020-04-24 2021-05-14 四川大学华西医院 一种动物去细胞化肺生物支架材料的制备方法
KR102473682B1 (ko) * 2020-06-30 2022-12-02 서울대학교 산학협력단 개인 맞춤형 경피적 심장 반월판 스텐트 판막의 제조 방법
CN112354014A (zh) * 2020-10-20 2021-02-12 上海亚朋生物技术有限公司 一种清洗脱细胞试剂sds的方法
DE102021211875B3 (de) * 2021-10-21 2023-01-19 Friedrich-Alexander-Universität Erlangen-Nürnberg, Körperschaft des öffentlichen Rechts Bioreaktor und Verfahren zum Betrieb eines solchen
WO2024006673A1 (en) * 2022-06-30 2024-01-04 Regenmedix Llc Stem cell and organ maturation system and method
CN115554472B (zh) * 2022-09-22 2023-08-18 舩本诚一 一种用于移植的生物组织处理方法
WO2024104780A1 (en) 2022-11-18 2024-05-23 Baxter Healthcare Sa Extracorporeal blood treatment for organ support

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3545221A (en) * 1967-05-22 1970-12-08 Swenko Research & Dev Inc Apparatus for maintaining organs in vitro in a completely viable state
US3639084A (en) * 1970-04-06 1972-02-01 Baxter Laboratories Inc Mechanism for control pulsatile fluid flow
DE2453363B2 (de) 1974-11-11 1976-08-26 Solco Basel AG, Birsfelden (Schweiz) Verfahren zur herstellung heterologer arterientransplantate
JPS5516016A (en) 1978-07-18 1980-02-04 Dai Ichi Kogyo Seiyaku Co Ltd Improved salt-resistant water-absorbing material
US4801299A (en) * 1983-06-10 1989-01-31 University Patents, Inc. Body implants of extracellular matrix and means and methods of making and using such implants
US5336616A (en) 1990-09-12 1994-08-09 Lifecell Corporation Method for processing and preserving collagen-based tissues for transplantation
KR970705951A (ko) 1994-09-12 1997-11-03 가일 케이. 노우톤 심장 판막 구조에서 3차원 사람 세포 배양물과 이의 용도(three-dimensional human cell cultures on cardiac valve franeworks and their uses)
DE69827001T2 (de) * 1997-04-11 2005-09-08 Cryolife, Inc. Gewebedezellularization
JPH1176400A (ja) 1997-09-09 1999-03-23 Masahito Nagaki 人工臓器
JP4222658B2 (ja) 1998-06-23 2009-02-12 テルモ株式会社 細胞支持基材、培養装置および液体処理装置
US6734018B2 (en) * 1999-06-07 2004-05-11 Lifenet Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced
US6448076B2 (en) * 1998-09-15 2002-09-10 The Regents Of The University Of Michigan Method for chemically acellularizing a biological tissue sample
US6432712B1 (en) * 1999-11-22 2002-08-13 Bioscience Consultants, Llc Transplantable recellularized and reendothelialized vascular tissue graft
US6376244B1 (en) * 1999-12-29 2002-04-23 Children's Medical Center Corporation Methods and compositions for organ decellularization
US20050249816A1 (en) * 1999-12-29 2005-11-10 Wake Forest University Health Services Tissue engineered liver constructs
US6479064B1 (en) 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
AU2001255741B2 (en) * 2000-04-28 2005-08-04 Baylor College Of Medicine Decellularized vascular prostheses
DE10021627B4 (de) * 2000-05-04 2009-11-19 Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich Verfahren zur Herstellung eines vaskularisierten bioartifiziellen Gewebes und zugehöriger Versuchsreaktor
WO2002014480A2 (en) * 2000-08-16 2002-02-21 Duke University Decellularized tissue engineered constructs and tissues
US6749064B1 (en) 2000-08-25 2004-06-15 Sanita L. Alrey Bag with article display aperture and support surface
EP1333870A2 (en) 2000-09-20 2003-08-13 Regeneration Technologies, Inc. Method of preparing and processing transplant tissue
IL139708A0 (en) 2000-11-15 2002-02-10 Amiel Gilad Process of decellularizing biological matrices and acellular biological matrices useful in tissue engineering
DE10064948C1 (de) 2000-12-20 2002-07-11 Auto Tissue Gmbh Verfahren zur Dezellularisierung von Fremdmaterial zur Herstellung von Bioprothesen und Vorrichtung zur Durchführung des Verfahrens
KR101012952B1 (ko) 2001-02-14 2011-02-08 안트로제네시스 코포레이션 산후 포유류의 태반, 이의 용도 및 태반 줄기세포
WO2002088331A1 (en) * 2001-05-01 2002-11-07 Universite Du Quebec A Montreal Tridimensional biocompatible support structure for bioartificial organs and uses thereof
GB2375771A (en) * 2001-05-24 2002-11-27 Univ Leeds Decellularisation of tissue implant material
EP1317934A1 (de) * 2001-11-08 2003-06-11 Artiss GmbH Verfahren zur Herstellung einer azellularisierten Gewebematrix und damit erhältliche Gewebematrix
DE60239217D1 (de) * 2001-11-16 2011-03-31 Childrens Medical Center Erzeugung gewebetechnologisch hergestellter weiblicher fortpflanzungsorgane
EP2292278B1 (en) * 2001-11-16 2013-04-24 Children's Medical Center Corporation Augmentation of organ function
US20030180268A1 (en) * 2002-02-05 2003-09-25 Anthony Atala Tissue engineered construct for supplementing or replacing a damaged organ
US6790475B2 (en) 2002-04-09 2004-09-14 Wafermasters Inc. Source gas delivery
JP4149897B2 (ja) 2002-11-07 2008-09-17 学校法人 聖マリアンナ医科大学 気管移植片の調製方法および気管移植片
US20040187877A1 (en) 2002-12-04 2004-09-30 Badylak Stephen F. Method for repair of liver tissue
PL377351A1 (pl) 2002-12-13 2006-01-23 Cilag Ag Preparaty o kontrolowanym uwalnianiu zawierające tramadol i topiramat
US20040176855A1 (en) 2003-03-07 2004-09-09 Acell, Inc. Decellularized liver for repair of tissue and treatment of organ deficiency
JP2006223101A (ja) * 2003-05-15 2006-08-31 Univ Waseda 生体組織の保持装置及びこれを用いた生体組織処理装置
WO2005118014A2 (en) * 2004-06-01 2005-12-15 Medtronic, Inc. Decellurisation processes for making bioprotheses
JP3773943B2 (ja) 2004-09-24 2006-05-10 国立大学法人 東京大学 把持状態判定システム及び方法
DE102005023599A1 (de) 2005-05-18 2006-11-23 Corlife Gbr (Vertretungsberechtigte Gesellschafter: Prof. Dr. Alex Haverich Bioartifizielles Herzgewebetransplantat und Verfahren zu seiner Herstellung
WO2006126219A1 (en) 2005-05-26 2006-11-30 Fresenius Medical Care Deutschland G.M.B.H. Liver progenitor cells
US7824912B2 (en) 2005-06-23 2010-11-02 Massachusetts Institute Of Technology Methods for ex vivo propagation of adult hepatic stem cells
US20100093066A1 (en) 2005-08-26 2010-04-15 Regents Of The University Of Minnesota Decellularization and recellularization apparatuses and systems containing the same
PL1928519T3 (pl) 2005-08-26 2012-08-31 Univ Minnesota Decelularyzacja i recelularyzacja narządów i tkanek
AU2013224686B2 (en) 2005-08-26 2015-06-11 Miromatrix Medical Inc. Decellularization and recellularization of organs and tissues
JP4599315B2 (ja) 2006-02-23 2010-12-15 クラレメディカル株式会社 バイオ人工臓器
CN101066477B (zh) 2007-05-17 2010-10-06 中国人民解放军第三军医大学 能在体捕获内皮祖细胞的生物人工血管
EP2225362A1 (en) 2007-11-30 2010-09-08 New York Medical College Methods of reducing transplant rejection and cardiac allograft vasculopathy by implanting autologous stem cells
CN102448476A (zh) * 2009-03-31 2012-05-09 明尼苏达大学董事会 器官和组织的脱细胞化和再细胞化
PL2588592T3 (pl) 2010-06-30 2018-07-31 Miromatrix Medical Inc. Zastosowanie decelularyzowanych poprzez perfuzję narządów do dopasowanej recelularyzacji
AU2011295779B2 (en) 2010-09-01 2015-08-27 Regents Of The University Of Minnesota Methods of recellularizing a tissue or organ for improved transplantability
US9290738B2 (en) 2012-06-13 2016-03-22 Miromatrix Medical Inc. Methods of decellularizing bone
KR102282769B1 (ko) 2013-03-15 2021-07-29 미로매트릭스 메디칼 인크. 탈세포화된 기관 및 조직에 대한 마이크로입자 및 내피 세포의 용도
SG10201906304TA (en) 2013-03-15 2019-08-27 Miromatrix Medical Inc Use of perfusion decellularized liver for islet cell recellularization
JP6340772B2 (ja) 2013-11-08 2018-06-13 東ソー株式会社 パラメータ変更履歴を管理可能な分析装置
AU2016235074A1 (en) 2015-03-26 2017-10-12 Miromatrix Medical Inc. Gas filled decellularized extracellular matrix
EP3509651B1 (en) 2016-09-06 2022-12-28 Miromatrix Medical Inc. Use of resected liver serum for whole liver engineering

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