CN101113157A - 异戊烯基黄酮衍生物、制备方法及其用途 - Google Patents

异戊烯基黄酮衍生物、制备方法及其用途 Download PDF

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Publication number
CN101113157A
CN101113157A CNA200610029522XA CN200610029522A CN101113157A CN 101113157 A CN101113157 A CN 101113157A CN A200610029522X A CNA200610029522X A CN A200610029522XA CN 200610029522 A CN200610029522 A CN 200610029522A CN 101113157 A CN101113157 A CN 101113157A
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CN
China
Prior art keywords
preparation
compound
glc
ring
independently
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Pending
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CNA200610029522XA
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English (en)
Chinese (zh)
Inventor
沈敬山
张树军
郭洪利
陈新建
棘玉荣
赵树军
年亦丰
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Shanghai Institute of Materia Medica of CAS
Topharman Shanghai Co Ltd
Qiqihar University
Original Assignee
Shanghai Institute of Materia Medica of CAS
Topharman Shanghai Co Ltd
Qiqihar University
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Application filed by Shanghai Institute of Materia Medica of CAS, Topharman Shanghai Co Ltd, Qiqihar University filed Critical Shanghai Institute of Materia Medica of CAS
Priority to CNA200610029522XA priority Critical patent/CN101113157A/zh
Priority to PCT/CN2007/070375 priority patent/WO2008014722A1/fr
Publication of CN101113157A publication Critical patent/CN101113157A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/06—Benzopyran radicals
    • C07H17/065—Benzo[b]pyrans
    • C07H17/07—Benzo[b]pyran-4-ones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNA200610029522XA 2006-07-28 2006-07-28 异戊烯基黄酮衍生物、制备方法及其用途 Pending CN101113157A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CNA200610029522XA CN101113157A (zh) 2006-07-28 2006-07-28 异戊烯基黄酮衍生物、制备方法及其用途
PCT/CN2007/070375 WO2008014722A1 (fr) 2006-07-28 2007-07-27 Flavonoïdes prényle, préparation et utilisation de ces composés

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CNA200610029522XA CN101113157A (zh) 2006-07-28 2006-07-28 异戊烯基黄酮衍生物、制备方法及其用途

Publications (1)

Publication Number Publication Date
CN101113157A true CN101113157A (zh) 2008-01-30

Family

ID=38996895

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA200610029522XA Pending CN101113157A (zh) 2006-07-28 2006-07-28 异戊烯基黄酮衍生物、制备方法及其用途

Country Status (2)

Country Link
CN (1) CN101113157A (fr)
WO (1) WO2008014722A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102093450A (zh) * 2010-12-24 2011-06-15 台州市黄岩源宏医化科技有限公司 脱水淫羊藿糖苷化合成淫羊藿单甙的方法
CN103622947A (zh) * 2012-08-26 2014-03-12 鲁南制药集团股份有限公司 淫羊藿苷元在制备治疗哮喘药物中的用途
CN104387358A (zh) * 2014-10-27 2015-03-04 广东东阳光药业有限公司 淫羊藿苷类化合物及其应用
CN104447913A (zh) * 2014-11-06 2015-03-25 四川大学 功能化淫羊藿苷衍生物及其制备方法与应用
CN104825479A (zh) * 2015-05-20 2015-08-12 佛山市金骏康健康科技有限公司 淫羊藿次苷类化合物、其制备方法,及其在促进人细胞产生γ-干扰素作用和在疾病治疗中的应用
CN109265502A (zh) * 2018-10-29 2019-01-25 广东金骏康生物技术有限公司 异戊二烯基黄酮化合物、衍生物、药物组合物及其应用
CN109320570A (zh) * 2018-10-29 2019-02-12 广东金骏康生物技术有限公司 一种淫羊藿次苷ⅰ类化合物、衍生物、可药用盐及应用
CN109369748A (zh) * 2018-10-29 2019-02-22 广东金骏康生物技术有限公司 一种淫羊藿次苷ⅰ类化合物、衍生物、药物组合物及其应用
CN109369747A (zh) * 2018-10-29 2019-02-22 广东金骏康生物技术有限公司 淫羊藿次苷ⅰ化合物及其衍生物、药物组合物及其制备方法和应用
CN110317208A (zh) * 2019-05-15 2019-10-11 苏州广奥医药开发有限公司 一种淫羊藿素衍生物的制备方法和医药用途
CN114605483A (zh) * 2022-04-06 2022-06-10 贵州汇腾科技有限公司 一种淫羊藿次苷ⅰ的制备工艺
CN115073409A (zh) * 2021-03-12 2022-09-20 中国海洋大学 一种新型淫羊霍素衍生物及其制备方法和应用

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11377466B2 (en) 2018-08-10 2022-07-05 Whitehead Institute For Biomedical Research Analogs of the natural product icariin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1093086A (zh) * 1993-04-03 1994-10-05 华西医科大学药物研究所 异黄酮脂环烃醚及其肟衍生物
US6399579B1 (en) * 2000-08-15 2002-06-04 Hauser, Inc. Compositions comprising icariside I and anhydroicaritin and methods for making the same
ES2298578T3 (es) * 2002-07-23 2008-05-16 Dsm Ip Assets B.V. Fabricacion de isoflavonas.
CN1268759C (zh) * 2003-08-01 2006-08-09 金凤燮 酶法水解淫羊藿甙糖基制备低糖淫羊藿甙或甙元的方法

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102093450B (zh) * 2010-12-24 2013-09-04 台州市黄岩源宏医化科技有限公司 脱水淫羊藿糖苷化合成淫羊藿单甙的方法
CN102093450A (zh) * 2010-12-24 2011-06-15 台州市黄岩源宏医化科技有限公司 脱水淫羊藿糖苷化合成淫羊藿单甙的方法
CN103622947A (zh) * 2012-08-26 2014-03-12 鲁南制药集团股份有限公司 淫羊藿苷元在制备治疗哮喘药物中的用途
CN104387358B (zh) * 2014-10-27 2016-08-24 广东东阳光药业有限公司 淫羊藿苷类化合物及其应用
CN104387358A (zh) * 2014-10-27 2015-03-04 广东东阳光药业有限公司 淫羊藿苷类化合物及其应用
CN104447913A (zh) * 2014-11-06 2015-03-25 四川大学 功能化淫羊藿苷衍生物及其制备方法与应用
GB2557741B (en) * 2015-05-20 2020-03-04 Golden Health Guangdong Biotechnology Co Ltd Icariside compound, preperation method thereof, and application thereof
CN104825479A (zh) * 2015-05-20 2015-08-12 佛山市金骏康健康科技有限公司 淫羊藿次苷类化合物、其制备方法,及其在促进人细胞产生γ-干扰素作用和在疾病治疗中的应用
GB2557741A (en) * 2015-05-20 2018-06-27 Foshan Golden Health Tech Co Ltd Icarisid compound, preperation method therefor, and application thereof
CN108299530A (zh) * 2015-05-20 2018-07-20 佛山市金骏康健康科技有限公司 一种淫羊藿次苷类化合物及其制备方法和用途
WO2016183905A1 (fr) * 2015-05-20 2016-11-24 佛山市金骏康健康科技有限公司 Composé d'icarisid, procédé de préparation de celui-ci, et application de celui-ci
CN108299530B (zh) * 2015-05-20 2020-07-28 广东金骏康生物技术有限公司 一种淫羊藿次苷类化合物及其制备方法和用途
CN109265502A (zh) * 2018-10-29 2019-01-25 广东金骏康生物技术有限公司 异戊二烯基黄酮化合物、衍生物、药物组合物及其应用
CN109369747A (zh) * 2018-10-29 2019-02-22 广东金骏康生物技术有限公司 淫羊藿次苷ⅰ化合物及其衍生物、药物组合物及其制备方法和应用
CN109369748A (zh) * 2018-10-29 2019-02-22 广东金骏康生物技术有限公司 一种淫羊藿次苷ⅰ类化合物、衍生物、药物组合物及其应用
CN109320570A (zh) * 2018-10-29 2019-02-12 广东金骏康生物技术有限公司 一种淫羊藿次苷ⅰ类化合物、衍生物、可药用盐及应用
CN110317208A (zh) * 2019-05-15 2019-10-11 苏州广奥医药开发有限公司 一种淫羊藿素衍生物的制备方法和医药用途
CN110317208B (zh) * 2019-05-15 2023-02-17 北京东方百奥医药开发有限公司 一种淫羊藿素衍生物的制备方法和医药用途
CN115073409A (zh) * 2021-03-12 2022-09-20 中国海洋大学 一种新型淫羊霍素衍生物及其制备方法和应用
CN114605483A (zh) * 2022-04-06 2022-06-10 贵州汇腾科技有限公司 一种淫羊藿次苷ⅰ的制备工艺
CN114605483B (zh) * 2022-04-06 2024-01-30 贵州汇腾科技有限公司 一种淫羊藿次苷ⅰ的制备工艺

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Application publication date: 20080130