CN101056615B - 具有稳定正ζ电势的眼用水包油型乳剂 - Google Patents
具有稳定正ζ电势的眼用水包油型乳剂 Download PDFInfo
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- CN101056615B CN101056615B CN2005800383296A CN200580038329A CN101056615B CN 101056615 B CN101056615 B CN 101056615B CN 2005800383296 A CN2005800383296 A CN 2005800383296A CN 200580038329 A CN200580038329 A CN 200580038329A CN 101056615 B CN101056615 B CN 101056615B
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- oil
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- emulsion
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Description
组分 | Z01EM042 | Z01EM043 |
CTAB(阳离子剂) | 0.05% | 0.1% |
MCT(油) | 2% | 2% |
α-生育酚(抗氧化剂) | 0.01% | 0.01% |
Lipoid E80TM(阴离子表面活性剂) | 0.32% | 0.32% |
Lutrol F68TM(非离子表面活性剂) | 0.5% | 0.5% |
甘油(张力剂) | 2.25% | 2.25% |
水 | 94.87% | 94.82% |
Z01EM042 | Z01EM043 | |
液滴大小(nm) | 126 | 128 |
ζ电势(mV) | 36.4 | 49.5 |
组分 | Z01EM042 |
BAK(阳离子剂) | 0.02% |
MCT(油) | 1% |
α-生育酚(抗氧化剂) | 0.005% |
泰洛沙泊(非离子表面活性剂) | 0.16% |
Lutrol F68(非离子表面活性剂) | 0.5% |
甘油(张力剂) | 2.25% |
水 | 96.07% |
Z01EM093 | |
ζ电势(mV) | 20.4 |
%w/w | Z01EM165 |
油胺 | 0.05 |
矿物油 | 1 |
Lutrol F68 | 0.1 |
泰洛沙泊 | 0.3 |
甘油(张力剂) | 2.25 |
水 | 至100 |
%(w/w) | Z01EM092 |
CTAB | 0.005 |
MCT | 1 |
维生素E | 0.005 |
泰洛沙泊 | 0.16 |
Lutrol | 0.25 |
甘油(张力剂) | 2.25 |
水 | 至100 |
Claims (34)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04292645.1 | 2004-11-09 | ||
EP04292645A EP1655021B1 (en) | 2004-11-09 | 2004-11-09 | Oil-in-water type emulsion with low concentration of cationic agent and positive zeta potential |
US10/991,346 US8298568B2 (en) | 2004-11-09 | 2004-11-18 | Oil-in-water type emulsion with low concentration of cationic agent and positive zeta potential |
US10/991,346 | 2004-11-18 | ||
PCT/EP2005/011650 WO2006050838A2 (en) | 2004-11-09 | 2005-10-10 | Ophthalmic oil-in-water type emulsion with stable positive zeta potential |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101056615A CN101056615A (zh) | 2007-10-17 |
CN101056615B true CN101056615B (zh) | 2011-05-11 |
Family
ID=34931510
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310241506.7A Active CN103356481B (zh) | 2004-11-09 | 2005-10-10 | 含有免疫抑制剂的眼用乳剂 |
CNA2005800300698A Pending CN101014317A (zh) | 2004-11-09 | 2005-10-10 | 含有免疫抑制剂的眼用乳剂 |
CN2005800383296A Active CN101056615B (zh) | 2004-11-09 | 2005-10-10 | 具有稳定正ζ电势的眼用水包油型乳剂 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201310241506.7A Active CN103356481B (zh) | 2004-11-09 | 2005-10-10 | 含有免疫抑制剂的眼用乳剂 |
CNA2005800300698A Pending CN101014317A (zh) | 2004-11-09 | 2005-10-10 | 含有免疫抑制剂的眼用乳剂 |
Country Status (14)
Country | Link |
---|---|
US (5) | US8298568B2 (zh) |
EP (1) | EP1655021B1 (zh) |
JP (3) | JP5587936B2 (zh) |
CN (3) | CN103356481B (zh) |
AT (5) | ATE412400T1 (zh) |
DE (5) | DE602004017477D1 (zh) |
DK (1) | DK1809237T3 (zh) |
ES (4) | ES2314354T3 (zh) |
HK (2) | HK1107938A1 (zh) |
IL (3) | IL181446A (zh) |
MX (2) | MX2007005545A (zh) |
NZ (1) | NZ554929A (zh) |
PT (2) | PT1809238E (zh) |
ZA (1) | ZA200703751B (zh) |
Families Citing this family (100)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7655252B2 (en) | 1999-04-28 | 2010-02-02 | The Regents Of The University Of Michigan | Antimicrobial nanoemulsion compositions and methods |
US7767216B2 (en) | 1999-04-28 | 2010-08-03 | The Regents Of The University Of Michigan | Antimicrobial compositions and methods of use |
US8232320B2 (en) | 1999-04-28 | 2012-07-31 | The Regents Of The University Of Michigan | Antimicrobial nanoemulsion compositions and methods |
US20050208083A1 (en) | 2003-06-04 | 2005-09-22 | Nanobio Corporation | Compositions for inactivating pathogenic microorganisms, methods of making the compositons, and methods of use thereof |
DE602004017477D1 (de) * | 2004-11-09 | 2008-12-11 | Novagali Pharma Sa | Öl-in-Wasser-Emulsion mit niedriger Konzentration des kationischen Mittels und positivem Zetapotential |
JP2008535918A (ja) * | 2005-04-11 | 2008-09-04 | ナノバイオ コーポレーション | 感染性の症状を処置するための四級アンモニウムハライド |
US7297679B2 (en) * | 2005-07-13 | 2007-11-20 | Allergan, Inc. | Cyclosporin compositions |
EP1951200A2 (en) * | 2005-08-09 | 2008-08-06 | Nanobio Corporation | Nanoemulsion compositions having anti-inflammatory activity |
US7797337B2 (en) * | 2005-09-29 | 2010-09-14 | Scenera Technologies, Llc | Methods, systems, and computer program products for automatically associating data with a resource as metadata based on a characteristic of the resource |
AU2007224006A1 (en) * | 2006-03-07 | 2007-09-13 | Novavax, Inc. | Nanoemulsions of poorly soluble pharmaceutical active ingredients and methods of making the same |
US10137083B2 (en) * | 2006-03-07 | 2018-11-27 | SGN Nanopharma Inc | Ophthalmic preparations |
US11311477B2 (en) | 2006-03-07 | 2022-04-26 | Sgn Nanopharma Inc. | Ophthalmic preparations |
US7666912B2 (en) | 2006-03-23 | 2010-02-23 | Massachusetts Eye And Ear Infirmary | Compositions and methods for reducing body fat |
US20080026013A1 (en) * | 2006-07-28 | 2008-01-31 | Laura Rabinovich-Guilatt | Compositions containing quaternary ammonium compounds |
US9132071B2 (en) * | 2006-07-28 | 2015-09-15 | Santen Sas | Compositions containing quaternary ammonium compounds |
WO2008035246A2 (en) | 2006-07-28 | 2008-03-27 | Novagali Pharma Sa | Compositions containing quaternary ammonium compounds |
AU2014201978B2 (en) * | 2006-07-28 | 2016-03-10 | Santen Sas | Compositions containing quaternary ammonium compounds |
PL1891939T3 (pl) * | 2006-07-28 | 2014-01-31 | Santen Sas | Kompozycje zawierające czwartorzędowe związki amonowe |
EP2444829A1 (en) | 2006-09-14 | 2012-04-25 | Carl Zeiss SMT GmbH | Optical element unit and method of supporting an optical element |
EP1938801A1 (en) | 2006-12-22 | 2008-07-02 | Biofrontera Bioscience GmbH | Nanoemulsion |
EP1985298A1 (en) | 2007-04-24 | 2008-10-29 | Azad Pharma AG | Ophtalmic oil-in-water emulsions containing prostaglandins |
WO2008137747A1 (en) | 2007-05-02 | 2008-11-13 | The Regents Of The University Of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
US8512687B2 (en) * | 2007-07-09 | 2013-08-20 | Novagali Pharma Sa | Oil in water emulsion comprising NSAIDs and quaternary ammonium halides |
US20090018057A1 (en) * | 2007-07-09 | 2009-01-15 | Gregory Lambert | OIL IN WATER EMULSION COMPRISING NSAIDs AND QUATERNARY AMMONIUM HALIDES |
US9125807B2 (en) * | 2007-07-09 | 2015-09-08 | Incept Llc | Adhesive hydrogels for ophthalmic drug delivery |
JP5646331B2 (ja) * | 2007-10-16 | 2014-12-24 | サン、ファーマ、アドバンスト、リサーチ、カンパニー、リミテッドSun Pharma Advancedresearch Company Limited | 新規眼科用組成物 |
US7834172B2 (en) * | 2007-11-14 | 2010-11-16 | Novagali Pharma Sa | Composition comprising at least one nucleosidic moiety as a therapeutic agent, and CKC |
WO2009063081A2 (en) * | 2007-11-14 | 2009-05-22 | Novagali Pharma Sa | Composition comprising at least one nucleosidic moiety as a therapeutic agent, and ckc. |
EP2077104A1 (en) * | 2008-01-02 | 2009-07-08 | Novagali Pharma SA | Micellar compositions with ophtalmic applications |
EP2077105A1 (en) * | 2008-01-02 | 2009-07-08 | Novagali Pharma SA | Ophthalmic Micellar Compositions with Enhanced Stability |
EP2127638A1 (en) * | 2008-05-30 | 2009-12-02 | Santen Pharmaceutical Co., Ltd | Method and composition for treating ocular hypertension and glaucoma |
BRPI0918244A2 (pt) * | 2008-09-04 | 2015-12-15 | Santen Pharmaceutical Co Ltd E Asahi Glass Company Ltd | agente promotor do crescimento de pelos, e método para prevenir ou tratar uma doença associada com os cabelos. |
EP2331128B1 (en) * | 2008-09-05 | 2013-11-06 | CEVA Santé Animale SA | Composition comprising chitosan for ocular administration of vaccine(s) to avians |
WO2010057197A1 (en) | 2008-11-17 | 2010-05-20 | The Regents Of The University Of Michigan | Cancer vaccine compositions and methods of using the same |
EP2396070A4 (en) | 2009-02-12 | 2012-09-19 | Incept Llc | ACTIVE COMPOSITION WITH HYDROGEL PLUGS |
EP2228058A1 (en) | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Anionic oil-in-water emulsion containing prostaglandins and uses thereof |
EP2228057A1 (en) * | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Cationic oil-in-water emulsions containing prostaglandins and uses thereof |
WO2010135731A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
CA2780925A1 (en) * | 2009-11-09 | 2011-05-12 | Allergan, Inc. | Compositions for enhancing hair growth |
EP2389939A1 (en) | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions |
AU2011278924B2 (en) * | 2010-07-15 | 2015-06-18 | Eyenovia, Inc. | Ophthalmic drug delivery |
US10154923B2 (en) | 2010-07-15 | 2018-12-18 | Eyenovia, Inc. | Drop generating device |
SG187770A1 (en) | 2010-08-12 | 2013-03-28 | Univ Nanyang Tech | A liposomal formulation for ocular drug delivery |
US8961501B2 (en) | 2010-09-17 | 2015-02-24 | Incept, Llc | Method for applying flowable hydrogels to a cornea |
US9089579B2 (en) | 2011-01-19 | 2015-07-28 | Topokine Therapeutics, Inc. | Methods and compositions for treating metabolic syndrome |
CN103415292A (zh) | 2011-01-26 | 2013-11-27 | 阿勒根公司 | 用于治疗眼科病症的雄性激素组合物 |
ES2666857T3 (es) | 2011-07-18 | 2018-05-08 | Mor-Research Applications Ltd. | Un dispositivo para ajustar la presión intraocular |
US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
ES2791751T3 (es) * | 2011-11-15 | 2020-11-05 | Allergan Inc | Suspensiones de forma 2 de ciclosporina A |
JP6368244B2 (ja) | 2011-11-15 | 2018-08-01 | アラーガン、インコーポレイテッドAllergan,Incorporated | オートクレーブ可能なシクロスポリンa2型の懸濁剤 |
US9205150B2 (en) | 2011-12-05 | 2015-12-08 | Incept, Llc | Medical organogel processes and compositions |
US8426471B1 (en) | 2011-12-19 | 2013-04-23 | Topokine Therapeutics, Inc. | Methods and compositions for reducing body fat and adipocytes |
WO2013125026A1 (ja) * | 2012-02-24 | 2013-08-29 | ファインバイオメディカル有限会社 | 潤滑性調整液 |
CA3050298A1 (en) * | 2012-08-24 | 2014-02-27 | Sun Pharma Global Fze | Ophthalmic formulation of polyoxyl lipid or polyoxyl fatty acid and polyalkoxylated alcohol for use in the treatment of ocular conditions |
EP2892564A4 (en) * | 2012-09-06 | 2016-04-27 | Univ Nanyang Tech | HYALURONIC ACID MEDICINE DELIVERY SYSTEMS |
CA2869676C (en) | 2012-11-21 | 2015-06-23 | Topokine Therapeutics, Inc. | Uses and compositions comprising a thiazolidinedione and oleic acid for locally increasing subcutaneous fat |
US10172789B2 (en) | 2013-01-24 | 2019-01-08 | Palvella Therapeutics Llc | Compositions for transdermal delivery of mTOR inhibitors |
CA2939952C (en) | 2013-03-05 | 2022-03-22 | Morgan V. Fedorchak | Thermoresponsive hydrogel containing polymer microparticles for noninvasive ocular drug delivery |
KR102285110B1 (ko) * | 2013-03-13 | 2021-08-02 | 산텐 세이야꾸 가부시키가이샤 | 마이봄 기능부전의 치료제 |
US20140275261A1 (en) * | 2013-03-15 | 2014-09-18 | Dr. Reddy's Laboratories, Inc. | Diclofenac parenteral compositions |
RU2513597C1 (ru) * | 2013-04-17 | 2014-04-20 | Федеральное государственное бюджетное учреждение "Научно-исследовательский институт глазных болезней" Российской академии медицинских наук (ФГБУ "НИИГБ" РАМН) | Способ лечения воспалительных состояний переднего отрезка глаза |
NO2753788T3 (zh) | 2013-05-10 | 2018-06-16 | ||
WO2014186504A1 (en) | 2013-05-15 | 2014-11-20 | Topokine Therapeutics, Inc. | Methods and compositions for topical delivery of prostaglandins to subcutaneous fat |
EP3013790A1 (en) | 2013-06-27 | 2016-05-04 | Mylan Laboratories Ltd. | Process for the preparation of nepafenac |
US9956195B2 (en) | 2014-01-07 | 2018-05-01 | Nanyang Technological University | Stable liposomal formulations for ocular drug delivery |
WO2015123272A1 (en) | 2014-02-11 | 2015-08-20 | Dr. Reddy's Laboratories Ltd. | Parenteral compositions of celecoxib |
EP3104841A4 (en) * | 2014-02-14 | 2017-09-06 | Jingjun Huang | Compositions of nanoemulsion delivery systems |
US20170087096A1 (en) * | 2014-06-13 | 2017-03-30 | Sanofi | Nanocapsular formulation of active pharmaceutical ingredients |
US10188661B2 (en) | 2014-06-27 | 2019-01-29 | Topokine Therapeutics, Inc. | Topical dosage regimen |
WO2016100972A2 (en) * | 2014-12-19 | 2016-06-23 | Kemin Industries, Inc. | Intraocular delivery of bioactive molecules using iontophoresis |
US20200237859A1 (en) | 2019-01-25 | 2020-07-30 | Newport Research, Inc. | Aqueous suspensions of cyclosporin |
US11324800B2 (en) | 2015-01-15 | 2022-05-10 | Wellspring Ophthalmics, Inc. | Aqueous suspensions of cyclosporin |
EP3253372B8 (en) * | 2015-02-06 | 2022-06-22 | Woodstock Sterile Solutions, Inc. | Preparation of an oil-in-water emulsion for polymer stabilized pharmaceutical formulations |
CN106176600A (zh) * | 2015-05-07 | 2016-12-07 | 上海现代药物制剂工程研究中心有限公司 | 一种前列地尔冻干微乳剂、原料组合物及其制备方法 |
WO2016182926A1 (en) * | 2015-05-08 | 2016-11-17 | Affinsci Inc. | Preparation of nanoemulsions |
JP7072517B2 (ja) | 2016-02-29 | 2022-05-20 | サン ファーマ グローバル エフゼットイー | 局所用シクロスポリン含有製剤およびその使用 |
JP6906899B2 (ja) * | 2016-03-30 | 2021-07-21 | 小林製薬株式会社 | 乳化組成物 |
JP6774508B2 (ja) | 2016-05-03 | 2020-10-28 | ニューマ・リスパイラトリー・インコーポレイテッド | 流体を肺系に供給するための液滴送達装置、及びその使用方法 |
US11395853B2 (en) | 2016-06-23 | 2022-07-26 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Biomimetic drug delivery of an immunomodulatory agent for the treatment of ocular conditions |
PT3266446T (pt) * | 2016-07-07 | 2019-01-30 | Salvat Lab Sa | Composição oftálmica compreendendo óleo de rícino e triglicérido de cadeia média |
CN106782348A (zh) * | 2017-01-04 | 2017-05-31 | 深圳市华星光电技术有限公司 | 一种led背光驱动电路及液晶显示器 |
EP3565520A4 (en) | 2017-01-06 | 2020-08-19 | Palvella Therapeutics, Inc. | Anhydrous compositions of MTOR inhibitors and method of use |
CA3064005C (en) | 2017-05-19 | 2023-03-07 | Pneuma Respiratory, Inc. | Dry powder delivery device and methods of use |
CN111278401B (zh) * | 2017-05-30 | 2023-08-15 | 艾克思摩尔有限公司 | 递送抗生素大环内酯治疗干眼综合征的组合物和方法 |
JP7227163B2 (ja) | 2017-06-10 | 2023-02-21 | アイノビア,インコーポレイティド | 流体を取扱い、目に流体を送出するための方法および装置 |
WO2019071008A1 (en) | 2017-10-04 | 2019-04-11 | Pneuma Respiratory, Inc. | ELECTRONIC DEVICE FOR DELIVERY OF LINEAR SHAPE ADMINISTRATION OPERATED BY BREATHING AND METHODS OF USE |
EP4344719A2 (en) | 2017-10-17 | 2024-04-03 | Pneuma Respiratory, Inc. | Nasal drug delivery apparatus and methods of use |
US11253480B2 (en) | 2017-10-30 | 2022-02-22 | University of Pittsburgh—of the Commonwealth System of Higher Education | Treatment of ocular conditions utilizing a histone/protein deacetylase inhibitor |
JP2021502178A (ja) | 2017-11-08 | 2021-01-28 | ニューマ・リスパイラトリー・インコーポレイテッド | 小容積アンプルを有して呼吸により電気的に作動するインライン液滴送達装置および使用方法 |
AU2019226051A1 (en) * | 2018-02-26 | 2020-09-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Drug delivery systems |
US11000513B2 (en) | 2018-07-02 | 2021-05-11 | Palvella Therapeutics, Inc. | Anhydrous compositions of mTOR inhibitors and methods of use |
CN109010268B (zh) * | 2018-09-28 | 2020-07-10 | 湖北远大天天明制药有限公司 | 一种提高氯霉素稳定性的眼用组合物及其制备方法 |
SG11202106144VA (en) | 2018-12-11 | 2021-07-29 | Disruption Labs Inc | Compositions for the delivery of therapeutic agents and methods of use and making thereof |
CN110237233B (zh) * | 2019-07-30 | 2021-01-15 | 沈阳兴齐眼药股份有限公司 | 一种含有环孢素的眼用药物组合物、其制备方法及用途 |
EP4069220A4 (en) * | 2019-12-04 | 2024-04-24 | Restore Vision Llc | OPHTHALMIC FORMULATIONS FOR THE TREATMENT OF PRESBYOPIA |
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EP4359046A1 (en) | 2021-06-22 | 2024-05-01 | Pneuma Respiratory, Inc. | Droplet delivery device with push ejection |
CN113577024B (zh) * | 2021-08-20 | 2023-05-05 | 山西利普达医药科技有限公司 | 一种眼用组合物及其制备方法和应用 |
CN116407499A (zh) * | 2021-12-29 | 2023-07-11 | 辅必成(上海)医药科技有限公司 | 一种他克莫司眼用乳剂及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030108626A1 (en) * | 2001-11-01 | 2003-06-12 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Method and composition for dry eye treatment |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4599353A (en) | 1982-05-03 | 1986-07-08 | The Trustees Of Columbia University In The City Of New York | Use of eicosanoids and their derivatives for treatment of ocular hypertension and glaucoma |
JPH0818989B2 (ja) | 1984-01-12 | 1996-02-28 | 株式会社ミドリ十字 | 脂肪乳剤中のプロスタグランジンの安定化方法 |
US4839342A (en) | 1987-09-03 | 1989-06-13 | University Of Georgia Research Foundation, Inc. | Method of increasing tear production by topical administration of cyclosporin |
JP2602964B2 (ja) | 1989-10-16 | 1997-04-23 | 裕 水島 | プロスタグランジン類縁体およびその脂肪乳剤 |
IL101241A (en) * | 1992-03-16 | 1997-11-20 | Yissum Res Dev Co | Pharmaceutical or cosmetic composition comprising stabilized oil-in-water type emulsion as carrier |
IL103907A0 (en) * | 1992-11-27 | 1993-04-04 | Pharmos Corp | Ophthalmic compositions |
AU680813B2 (en) * | 1992-08-28 | 1997-08-14 | Pharmos Corporation | Submicron emulsions as ocular drug delivery vehicles |
US5688819A (en) | 1992-09-21 | 1997-11-18 | Allergan | Cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl derivatives as therapeutic agents |
JP3551977B2 (ja) * | 1993-04-08 | 2004-08-11 | ライオン株式会社 | 安定なビタミンa類及びビタミンe類可溶化点眼剤 |
ATE168553T1 (de) * | 1993-06-25 | 1998-08-15 | Alcon Cusi S A | Neue verwendung von polymeren membranen zum ausgeben von pharmazeutischen lösungen, die quarternäre, als konserviermittel dienende ammoniumverbindungen enthalten und entsprechender dosierbehälter |
US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
RU2119351C1 (ru) * | 1994-06-01 | 1998-09-27 | Юхан Корпорейшн | Иммуносупрессорная композиция, содержащая циклоспорин, и способ ее получения |
ES2094688B1 (es) * | 1994-08-08 | 1997-08-01 | Cusi Lab | Manoemulsion del tipo de aceite en agua, util como vehiculo oftalmico y procedimiento para su preparacion. |
US6011062A (en) | 1994-12-22 | 2000-01-04 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
US5631287A (en) * | 1994-12-22 | 1997-05-20 | Alcon Laboratories, Inc. | Storage-stable prostaglandin compositions |
US5767153A (en) * | 1995-06-07 | 1998-06-16 | Insite Vision Incorporated | Sustained release emulsions |
EP0878197B1 (en) | 1997-05-14 | 2002-08-21 | Senju Pharmaceutical Co., Ltd. | Compositions containing difluprednate |
JP3410364B2 (ja) * | 1997-05-14 | 2003-05-26 | 千寿製薬株式会社 | ジフルプレドナート含有組成物 |
US6066671A (en) * | 1997-12-19 | 2000-05-23 | Alcon Laboratories, Inc. | Treatment of GLC1A glaucoma with 3-benzoyl-phenylacetic acids, esters, or amides |
US6225348B1 (en) * | 1998-08-20 | 2001-05-01 | Alfred W. Paulsen | Method of treating macular degeneration with a prostaglandin derivative |
AU2183900A (en) * | 1998-12-24 | 2000-07-31 | Alcon Laboratories, Inc. | Ep4 receptor agonists for treatment of dry eye |
US20020136771A1 (en) * | 1998-12-31 | 2002-09-26 | Amitee Cosmetics, Inc. | Stabilized ascorbic acid composition |
FR2823441B1 (fr) * | 2001-04-12 | 2004-09-10 | Thea Lab | Composition pharmaceutique a base de macrolides pour application locale en ophtalmologie et son procede de preparation |
WO2002085248A2 (en) * | 2001-04-23 | 2002-10-31 | Board Of Regents The University Of Texas System | Prostanoids augment ocular drug penetration |
EP2545937A1 (en) * | 2001-06-05 | 2013-01-16 | The Regents Of The University Of Michigan | Nanoemulsion vaccines |
US6872705B2 (en) * | 2001-07-13 | 2005-03-29 | Allergan, Inc. | Use of antimicrobial peptides as preservatives in ophthalmic preparations, including solutions, emulsions, and suspensions |
ES2343512T3 (es) * | 2001-11-01 | 2010-08-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Procedimiento y composicion para el tratamiento del ojo seco. |
KR100446960B1 (ko) | 2001-12-04 | 2004-09-01 | 김종국 | 프로스타글란딘 e1을 포함하는 온도감응성 에멀젼 외용제조성물 |
US20030165545A1 (en) * | 2002-01-30 | 2003-09-04 | Allergan, Inc. | Ophthalmic compositions including oil-in-water emulsions, and methods for making and using same |
US20050124699A1 (en) * | 2002-07-02 | 2005-06-09 | Wakamoto Pharmaceutical Co., Ltd. | Drugs for treating or preventing disorders of corneal and/or conjunctival epithelial cells |
PT1532981E (pt) | 2002-08-23 | 2007-12-12 | Santen Pharmaceutical Co Ltd | Colírios estáveis contendo latanoprost como ingrediente activo |
KR101182496B1 (ko) | 2002-09-09 | 2012-09-12 | 산텐 세이야꾸 가부시키가이샤 | 라타노프로스트를 유효 성분으로 하는 투명한 점안액 |
US20040115234A1 (en) * | 2002-09-24 | 2004-06-17 | Gewirtz Joan T. | Cosmetic composition |
US7074827B2 (en) * | 2002-10-24 | 2006-07-11 | Sucampo Ag (Usa) Inc. | Method for treating ocular hypertension and glaucoma |
JP4361294B2 (ja) * | 2003-02-25 | 2009-11-11 | ロート製薬株式会社 | ケトチフェン含有組成物 |
JP4694773B2 (ja) * | 2003-06-06 | 2011-06-08 | ロート製薬株式会社 | 粘膜適用液状組成物 |
US20050059583A1 (en) | 2003-09-15 | 2005-03-17 | Allergan, Inc. | Methods of providing therapeutic effects using cyclosporin components |
JP5382972B2 (ja) * | 2003-12-26 | 2014-01-08 | ロート製薬株式会社 | 粘度低下が防止された組成物 |
US20050175651A1 (en) * | 2004-01-09 | 2005-08-11 | L'oreal | Aqueous dispersion of nanocapsules with an oily core |
ATE439123T1 (de) | 2004-07-02 | 2009-08-15 | Novagali Pharma Sa | Verwendung von emulsionen zur intra- und periocularen injection |
JP4999304B2 (ja) * | 2004-09-27 | 2012-08-15 | ロート製薬株式会社 | ヒアルロン酸又はその塩を含有する粘膜適用組成物 |
DE602004017477D1 (de) * | 2004-11-09 | 2008-12-11 | Novagali Pharma Sa | Öl-in-Wasser-Emulsion mit niedriger Konzentration des kationischen Mittels und positivem Zetapotential |
EP1929996B1 (en) * | 2004-11-09 | 2011-02-16 | Novagali Pharma S.A. | Ophthalmic emulsions containing an immunosuppressive agent |
US20090170944A1 (en) * | 2008-01-02 | 2009-07-02 | Novagali Pharma Sa | Ophthalmic micellar compositions with enhanced stability |
US20090169629A1 (en) * | 2008-01-02 | 2009-07-02 | Novagali Pharma Sa | Micellar compositions with ophthalmic applications |
JP2011521957A (ja) * | 2008-05-28 | 2011-07-28 | アルコン リサーチ, リミテッド | 自己防腐エマルジョン |
EP2228058A1 (en) * | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Anionic oil-in-water emulsion containing prostaglandins and uses thereof |
EP2228057A1 (en) * | 2009-03-04 | 2010-09-15 | Novagali Pharma S.A. | Cationic oil-in-water emulsions containing prostaglandins and uses thereof |
EP2389939A1 (en) * | 2010-05-28 | 2011-11-30 | Novagali Pharma S.A. | Use of prostaglandins F2alpha and analogues for the healing of corneal and conjunctival lesions |
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