CN101039677A - 利用a2b腺苷受体拮抗剂预防和治疗气道重建及肺部炎症的方法 - Google Patents

利用a2b腺苷受体拮抗剂预防和治疗气道重建及肺部炎症的方法 Download PDF

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Publication number
CN101039677A
CN101039677A CNA200580034824XA CN200580034824A CN101039677A CN 101039677 A CN101039677 A CN 101039677A CN A200580034824X A CNA200580034824X A CN A200580034824XA CN 200580034824 A CN200580034824 A CN 200580034824A CN 101039677 A CN101039677 A CN 101039677A
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CN
China
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optionally substituted
propyl
methyl
dione
ethyl
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Pending
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CNA200580034824XA
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English (en)
Chinese (zh)
Inventor
曾德婉
迈克尔·R·布莱克本
路易斯·贝拉尔迪内利
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Gilead Palo Alto Inc
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CV Therapeutics Inc
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Publication of CN101039677A publication Critical patent/CN101039677A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
CNA200580034824XA 2004-10-15 2005-10-14 利用a2b腺苷受体拮抗剂预防和治疗气道重建及肺部炎症的方法 Pending CN101039677A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61943904P 2004-10-15 2004-10-15
US60/619,439 2004-10-15

Publications (1)

Publication Number Publication Date
CN101039677A true CN101039677A (zh) 2007-09-19

Family

ID=35677798

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA200580034824XA Pending CN101039677A (zh) 2004-10-15 2005-10-14 利用a2b腺苷受体拮抗剂预防和治疗气道重建及肺部炎症的方法

Country Status (13)

Country Link
US (2) US20060159627A1 (https=)
EP (2) EP1799221A1 (https=)
JP (2) JP2008516969A (https=)
KR (1) KR20070063548A (https=)
CN (1) CN101039677A (https=)
AU (1) AU2005295654B2 (https=)
CA (1) CA2583986A1 (https=)
IL (1) IL182493A0 (https=)
MX (1) MX2007004373A (https=)
NO (1) NO20072466L (https=)
NZ (2) NZ554485A (https=)
RU (1) RU2391103C2 (https=)
WO (1) WO2006044610A1 (https=)

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Publication number Priority date Publication date Assignee Title
CN103237548A (zh) * 2010-06-30 2013-08-07 吉利德科学股份有限公司 A2b腺苷受体拮抗剂用于治疗肺高血压的应用
CN116322698A (zh) * 2020-09-04 2023-06-23 泰昂治疗公司 腺苷a2b受体拮抗剂的共晶

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US7598379B2 (en) 2005-02-25 2009-10-06 Pgx Health, Llc Methods for the synthesis of unsymmetrical cycloalkyl substituted xanthines
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WO2007084485A2 (en) * 2006-01-13 2007-07-26 Battelle Memorial Institute Markers for assessing copd-related diseases
WO2007092372A1 (en) 2006-02-03 2007-08-16 Cv Therapeutics, Inc. Process for preparing an a2a-adenosine receptor agonist and its polymorphs
US7884100B2 (en) * 2006-06-16 2011-02-08 Pgxhealth, Llc Substituted 8-[6-amino-3-pyridyl]xanthines
US7767685B2 (en) * 2006-06-29 2010-08-03 King Pharmaceuticals Research And Development, Inc. Adenosine A2B receptor antagonists
US20090081120A1 (en) * 2006-09-01 2009-03-26 Cv Therapeutics, Inc. Methods and Compositions for Increasing Patient Tolerability During Myocardial Imaging Methods
WO2008028140A1 (en) * 2006-09-01 2008-03-06 Cv Therapeutics, Inc. Methods and compositions for increasing patient tolerability during myocardial imaging methods
US20080170990A1 (en) * 2006-09-29 2008-07-17 Cv Therapeutics, Inc. Methods for Myocardial Imaging in Patients Having a History of Pulmonary Disease
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EP2268641B1 (en) * 2008-03-26 2014-09-03 Advinus Therapeutics Pvt. Ltd. Heterocyclic compounds as adenosine receptor antagonist
MX2011003168A (es) * 2008-09-29 2011-05-19 Gilead Sciences Inc Combinaciones de un agente de control de cantidad y un antagonista del receptor a-2-alfa para utilizarse en metodos de tomografia computarizada de detectores multiples.
JP5765239B2 (ja) * 2009-03-13 2015-08-19 アドヴィナス・セラピューティックス・リミテッド 置換縮合ピリミジン化合物
AR085942A1 (es) 2011-04-07 2013-11-06 Gilead Sciences Inc Uso de receptor de aadenosina para tratar la insuficiencia cardiaca y la arritmia en pacientes posinfarto de miocardio
WO2016083304A1 (en) * 2014-11-24 2016-06-02 INSERM (Institut National de la Santé et de la Recherche Médicale) Treatment of acute exacerbations of chronic obstructive pulmonary disease by antagonism of the il-20r.
ES2580702B1 (es) 2015-02-25 2017-06-08 Palobiofarma, S.L. Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina
ES2975753T3 (es) 2018-03-05 2024-07-12 Teon Therapeutics Inc Antagonistas del receptor de adenosina y usos de los mismos

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103237548A (zh) * 2010-06-30 2013-08-07 吉利德科学股份有限公司 A2b腺苷受体拮抗剂用于治疗肺高血压的应用
CN116322698A (zh) * 2020-09-04 2023-06-23 泰昂治疗公司 腺苷a2b受体拮抗剂的共晶

Also Published As

Publication number Publication date
RU2007117907A (ru) 2008-11-20
JP2008516969A (ja) 2008-05-22
US20100105706A1 (en) 2010-04-29
AU2005295654B2 (en) 2011-04-14
WO2006044610A1 (en) 2006-04-27
KR20070063548A (ko) 2007-06-19
IL182493A0 (en) 2007-09-20
US8466129B2 (en) 2013-06-18
CA2583986A1 (en) 2006-04-27
EP2311462A1 (en) 2011-04-20
US20060159627A1 (en) 2006-07-20
JP2012056965A (ja) 2012-03-22
NZ589657A (en) 2012-06-29
NO20072466L (no) 2007-05-14
NZ554485A (en) 2010-12-24
AU2005295654A1 (en) 2006-04-27
RU2391103C2 (ru) 2010-06-10
EP1799221A1 (en) 2007-06-27
MX2007004373A (es) 2007-08-08

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Open date: 20070919