CN101031296A - 毒蕈碱受体调节剂 - Google Patents

毒蕈碱受体调节剂 Download PDF

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Publication number
CN101031296A
CN101031296A CNA2005800325784A CN200580032578A CN101031296A CN 101031296 A CN101031296 A CN 101031296A CN A2005800325784 A CNA2005800325784 A CN A2005800325784A CN 200580032578 A CN200580032578 A CN 200580032578A CN 101031296 A CN101031296 A CN 101031296A
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aliphatic
carbonyl
group
alkyl
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Chinese (zh)
Inventor
L·R·马金斯
M·加西亚-古斯曼布兰科
D·J·哈尔利
I·德鲁图
G·拉费
D·M·伯格伦
中谷彰子
A·P·特尔明
A·西利纳
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of CN101031296A publication Critical patent/CN101031296A/zh
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    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
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    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

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  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Child & Adolescent Psychology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CNA2005800325784A 2004-08-19 2005-08-19 毒蕈碱受体调节剂 Pending CN101031296A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60273104P 2004-08-19 2004-08-19
US60/602,731 2004-08-19

Publications (1)

Publication Number Publication Date
CN101031296A true CN101031296A (zh) 2007-09-05

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CNA2005800325784A Pending CN101031296A (zh) 2004-08-19 2005-08-19 毒蕈碱受体调节剂

Country Status (15)

Country Link
US (4) US7879834B2 (https=)
EP (3) EP2364705A3 (https=)
JP (3) JP2008510728A (https=)
KR (1) KR20070046929A (https=)
CN (1) CN101031296A (https=)
AU (1) AU2005277126A1 (https=)
CA (1) CA2577677A1 (https=)
IL (1) IL181388A0 (https=)
MX (1) MX2007002033A (https=)
NO (1) NO20071272L (https=)
NZ (1) NZ553202A (https=)
RU (1) RU2007109794A (https=)
TW (1) TW200621244A (https=)
WO (1) WO2006023852A2 (https=)
ZA (1) ZA200701397B (https=)

Cited By (1)

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WO2018121770A1 (zh) * 2016-12-30 2018-07-05 中国科学院上海药物研究所 一种抗抑郁化合物及其制备方法和应用

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TW200621244A (en) * 2004-08-19 2006-07-01 Vertex Pharma Modulators of muscarinic receptors
US7655670B2 (en) * 2005-06-02 2010-02-02 Janssen Pharmaceutica N.V. 3-spirocyclic indolyl derivatives useful as ORL-1 receptor modulators
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US7858635B2 (en) * 2005-12-22 2010-12-28 Vertex Pharmaceuticals Incorporated Spiro compounds as modulators of muscarinic receptors
NZ570497A (en) * 2006-02-22 2011-09-30 Vertex Pharma Spiro condensed 4,4'-quinilino-piperidines derivatives as modulators of muscarinic receptors
CN101426499A (zh) * 2006-02-22 2009-05-06 弗特克斯药品有限公司 毒蕈碱受体调节剂
GB0608452D0 (en) * 2006-04-27 2006-06-07 Glaxo Group Ltd Novel compounds
CN101500565A (zh) * 2006-06-29 2009-08-05 弗特克斯药品有限公司 毒蕈碱性受体的调节剂
WO2008021545A2 (en) * 2006-08-18 2008-02-21 Vertex Pharmaceuticals Incorporated Modulators of muscarinic receptors
US8927715B2 (en) 2006-08-25 2015-01-06 Vitae Pharmaceuticals, Inc. Inhibitors of 11β-hydroxysteroid dehydrogenase type 1
CN103202840B (zh) * 2006-11-28 2015-02-11 詹森药业有限公司 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
WO2008121066A1 (en) * 2007-03-30 2008-10-09 Astrazeneca Ab Novel tricyclic spiropiperidines or spiropyrrolidines and their use as modulators of chemokine receptors
JP5490677B2 (ja) 2007-04-09 2014-05-14 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 不安及び鬱病の処置のためのｏｒｌ−１受容体リガンドとしての１，３，８−三置換−１，３，８−トリアザ−スピロ［４．５］デカン−４−オン誘導体
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