CN100584859C - 制备棘白菌素衍生物的方法 - Google Patents

制备棘白菌素衍生物的方法 Download PDF

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Publication number
CN100584859C
CN100584859C CN02824928A CN02824928A CN100584859C CN 100584859 C CN100584859 C CN 100584859C CN 02824928 A CN02824928 A CN 02824928A CN 02824928 A CN02824928 A CN 02824928A CN 100584859 C CN100584859 C CN 100584859C
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CN
China
Prior art keywords
formula
compound
acid
reaction
iii
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN02824928A
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English (en)
Chinese (zh)
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CN1604908A (zh
Inventor
P·博费利
A·布鲁亚尔
C·科拉当
S·德鲁
M·埃尔特
D·费鲁
G·勒迈特
J·帕拉迪诺
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Aventis Pharma SA
Novexel SA
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Publication of CN1604908A publication Critical patent/CN1604908A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN02824928A 2001-12-14 2002-12-12 制备棘白菌素衍生物的方法 Expired - Fee Related CN100584859C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0116230A FR2833596B1 (fr) 2001-12-14 2001-12-14 Procede de preparation de derives d'echinocandine
FR01/16230 2001-12-14

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB2005101156130A Division CN1326872C (zh) 2001-12-14 2002-12-12 制备棘白菌素衍生物的方法

Publications (2)

Publication Number Publication Date
CN1604908A CN1604908A (zh) 2005-04-06
CN100584859C true CN100584859C (zh) 2010-01-27

Family

ID=8870520

Family Applications (2)

Application Number Title Priority Date Filing Date
CN02824928A Expired - Fee Related CN100584859C (zh) 2001-12-14 2002-12-12 制备棘白菌素衍生物的方法
CNB2005101156130A Expired - Fee Related CN1326872C (zh) 2001-12-14 2002-12-12 制备棘白菌素衍生物的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB2005101156130A Expired - Fee Related CN1326872C (zh) 2001-12-14 2002-12-12 制备棘白菌素衍生物的方法

Country Status (28)

Country Link
US (3) US20070105760A1 (enExample)
EP (1) EP1456229B1 (enExample)
JP (1) JP4510461B2 (enExample)
KR (1) KR20040066167A (enExample)
CN (2) CN100584859C (enExample)
AR (1) AR037827A1 (enExample)
AT (1) ATE441662T1 (enExample)
AU (1) AU2002364991B9 (enExample)
BR (1) BR0214937A (enExample)
CA (1) CA2469918A1 (enExample)
CO (1) CO5590934A2 (enExample)
CY (1) CY1110694T1 (enExample)
DE (1) DE60233589D1 (enExample)
DK (1) DK1456229T3 (enExample)
EA (1) EA007964B1 (enExample)
ES (1) ES2333784T3 (enExample)
FR (1) FR2833596B1 (enExample)
HU (1) HUP0402602A3 (enExample)
IL (1) IL162385A0 (enExample)
MX (1) MXPA04005484A (enExample)
NO (1) NO20042640L (enExample)
NZ (1) NZ533864A (enExample)
PL (1) PL371763A1 (enExample)
PT (1) PT1456229E (enExample)
SI (1) SI1456229T1 (enExample)
TW (1) TWI322820B (enExample)
WO (1) WO2003054001A2 (enExample)
ZA (1) ZA200404631B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
FR2921060B1 (fr) * 2007-09-14 2012-06-15 Novexel Nouveau procede de preparation d'une piperidine disubsituee et nouveaux intermediaires
FR2936798B1 (fr) * 2008-10-03 2012-09-28 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens.
FR2936951B1 (fr) * 2008-10-10 2010-12-03 Novexel Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments
FR2937034B1 (fr) * 2008-10-10 2012-11-23 Novexel Nouveaux composes heterocycliques azotes, leur preparation et leur utilisation comme medicaments antibacteriens
CN101928670B (zh) 2009-09-24 2012-02-22 上海天伟生物制药有限公司 一种抗生素的高产菌株及其制备方法和用途
CN102627689B (zh) * 2012-03-30 2014-08-06 上海天伟生物制药有限公司 一种环肽类化合物的水合物及其制备方法和用途
CN102627688B (zh) * 2012-03-30 2014-12-31 上海天伟生物制药有限公司 一种高纯度环肽化合物及其制备方法和用途
CN102659930B (zh) * 2012-03-30 2014-04-23 上海天伟生物制药有限公司 一种高纯度环肽类物质的晶体及其制备方法和用途
WO2016056022A2 (en) * 2014-10-07 2016-04-14 Alaparthi Lakshmi Prasad Intermediates and processes to prepare anidulafungin
CN112646854B (zh) * 2020-12-11 2022-10-11 浙江工业大学 一种棘白菌素b合成培养基及应用
CN115785226A (zh) * 2021-09-09 2023-03-14 上海天伟生物制药有限公司 一种棘白菌素药物杂质及其制备、纯化方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001007468A2 (en) * 1999-07-27 2001-02-01 Aventis Pharma Deutschland Gmbh Novel cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical

Family Cites Families (16)

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Publication number Priority date Publication date Assignee Title
US4293484A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912H nucleus
US5207710A (en) * 1988-09-29 1993-05-04 Collagen Corporation Method for improving implant fixation
US5696270A (en) * 1989-05-23 1997-12-09 Abbott Laboratories Intermediate for making retroviral protease inhibiting compounds
US5386009A (en) * 1990-03-19 1995-01-31 Merck & Co. Inc. Lipopeptide derivatives
CZ288974B6 (cs) * 1992-03-19 2001-10-17 Eli Lilly And Company Acylový derivát echinocandinu, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a jeho pouľití
SG75092A1 (en) * 1993-08-09 2000-09-19 Biomeasure Inc Therapeutic peptide derivatives
JP3107691B2 (ja) * 1993-12-03 2000-11-13 株式会社東芝 半導体記憶装置及びその製造方法
EP0781141B1 (en) * 1994-09-16 2002-09-04 Merck & Co. Inc. Aza cyclohexapeptide compounds
US5646111A (en) * 1995-04-07 1997-07-08 Eli Lilly And Company Cyclic peptide antifungal Agents
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
US5852213A (en) * 1996-07-10 1998-12-22 American Cyanamid Company Mercaptoketones and mercaptoalcohols and a process for their preparation
US6207710B1 (en) * 1996-11-22 2001-03-27 Elan Pharmaceuticals, Inc. Compounds for inhibiting β-amyloid peptide release and/or its synthesis
UA72200C2 (uk) * 1997-12-10 2005-02-15 Авентіс Фарма С.А. Похідні ехінокандину, спосіб їх одержання, їх застосування, проміжні сполуки та фармацевтична композиція
FR2794746B1 (fr) * 1999-06-09 2002-12-06 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
FR2794747B1 (fr) * 1999-06-09 2004-04-16 Hoechst Marion Roussel Inc Nouveaux derives de l'echinocandine, leur procede de preparation et leur application comme anti-fongiques
FR2833596B1 (fr) * 2001-12-14 2005-02-18 Aventis Pharma Sa Procede de preparation de derives d'echinocandine

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001007468A2 (en) * 1999-07-27 2001-02-01 Aventis Pharma Deutschland Gmbh Novel cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical

Also Published As

Publication number Publication date
IL162385A0 (en) 2005-11-20
DE60233589D1 (de) 2009-10-15
EP1456229A2 (fr) 2004-09-15
CO5590934A2 (es) 2005-12-30
HK1087720A1 (en) 2006-10-20
PT1456229E (pt) 2009-12-10
TW200301133A (en) 2003-07-01
NZ533864A (en) 2006-03-31
ZA200404631B (en) 2005-01-10
NO20042640L (no) 2004-06-23
EA200400806A1 (ru) 2004-12-30
EA007964B1 (ru) 2007-02-27
US20100273977A1 (en) 2010-10-28
AR037827A1 (es) 2004-12-09
CA2469918A1 (fr) 2003-07-03
WO2003054001A3 (fr) 2004-01-22
HUP0402602A3 (en) 2012-06-28
TWI322820B (en) 2010-04-01
US20070105760A1 (en) 2007-05-10
FR2833596B1 (fr) 2005-02-18
AU2002364991B2 (en) 2008-05-15
HK1071900A1 (zh) 2005-08-05
BR0214937A (pt) 2004-12-14
CN1604908A (zh) 2005-04-06
CN1326872C (zh) 2007-07-18
WO2003054001A2 (fr) 2003-07-03
EP1456229B1 (fr) 2009-09-02
CY1110694T1 (el) 2015-06-10
JP4510461B2 (ja) 2010-07-21
US20050032679A1 (en) 2005-02-10
US7148322B2 (en) 2006-12-12
AU2002364991A1 (en) 2003-07-09
AU2002364991B9 (en) 2008-10-09
SI1456229T1 (sl) 2010-02-26
CN1781938A (zh) 2006-06-07
HUP0402602A2 (hu) 2005-04-28
PL371763A1 (en) 2005-06-27
MXPA04005484A (es) 2004-12-06
JP2005523245A (ja) 2005-08-04
ES2333784T3 (es) 2010-03-01
ATE441662T1 (de) 2009-09-15
KR20040066167A (ko) 2004-07-23
FR2833596A1 (fr) 2003-06-20
DK1456229T3 (da) 2010-01-04

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