CN100549175C - 一种具有抑癌作用的重组蛋白及其编码基因与应用 - Google Patents

一种具有抑癌作用的重组蛋白及其编码基因与应用 Download PDF

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Publication number
CN100549175C
CN100549175C CNB2003801106041A CN200380110604A CN100549175C CN 100549175 C CN100549175 C CN 100549175C CN B2003801106041 A CNB2003801106041 A CN B2003801106041A CN 200380110604 A CN200380110604 A CN 200380110604A CN 100549175 C CN100549175 C CN 100549175C
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seq
cancer
protein
acid residue
amino acid
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Expired - Lifetime
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CNB2003801106041A
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Chinese (zh)
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CN1860229A (zh
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朱冰
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Beijing Sunbio Biotech Co Ltd
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Shadong Biological Pharmaceutical (tianjin) Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CNB2003801106041A 2003-11-03 2003-11-03 一种具有抑癌作用的重组蛋白及其编码基因与应用 Expired - Lifetime CN100549175C (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2003/000928 WO2005042744A1 (en) 2003-11-03 2003-11-03 A recombinant protein with cancer suppression action, its encoding gene and use

Publications (2)

Publication Number Publication Date
CN1860229A CN1860229A (zh) 2006-11-08
CN100549175C true CN100549175C (zh) 2009-10-14

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CNB2003801106041A Expired - Lifetime CN100549175C (zh) 2003-11-03 2003-11-03 一种具有抑癌作用的重组蛋白及其编码基因与应用

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Country Link
US (1) US7666989B2 (enExample)
EP (1) EP1688498B1 (enExample)
JP (1) JP4688678B2 (enExample)
CN (1) CN100549175C (enExample)
AT (1) ATE501256T1 (enExample)
AU (1) AU2003280921B2 (enExample)
BR (1) BRPI0318594B8 (enExample)
CA (1) CA2544473C (enExample)
DE (1) DE60336353D1 (enExample)
NZ (1) NZ547274A (enExample)
WO (1) WO2005042744A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003292696A1 (en) 2002-12-26 2004-08-10 Takeda Pharmaceutical Company Limited Metastin derivative and use thereof
CN101845091A (zh) 2004-06-25 2010-09-29 武田药品工业株式会社 转移素衍生物及其用途
TWI386417B (zh) 2005-12-22 2013-02-21 Takeda Pharmaceutical 轉移抑素衍生物及其用途
US8404643B2 (en) 2005-12-22 2013-03-26 Takeda Pharmaceutical Company Limited Metastin derivatives and use thereof
JO3048B1 (ar) 2006-10-25 2016-09-05 Takeda Pharmaceuticals Co مشتقات متاستين واستخدامها
WO2009131191A1 (ja) * 2008-04-24 2009-10-29 武田薬品工業株式会社 メタスチン誘導体およびその用途
RS54057B1 (sr) 2010-12-03 2015-10-30 Adamed Sp. Zo.O. Antikancerski fuzioni protein
PL219845B1 (pl) 2011-01-05 2015-07-31 Adamed Spółka Z Ograniczoną Odpowiedzialnością Przeciwnowotworowe białko fuzyjne
PL394618A1 (pl) 2011-04-19 2012-10-22 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Przeciwnowotworowe bialko fuzyjne
EP2752429B1 (en) 2011-09-16 2017-03-01 Beijing Sunbio Biotech Co. Ltd. Fusion protein comprising circularly permuted form of trail/apo2l, coding gene and use thereof
PL397167A1 (pl) 2011-11-28 2013-06-10 Adamed Spólka Z Ograniczona Odpowiedzialnoscia Przeciwnowotworowe bialko fuzyjne
PL223487B1 (pl) 2011-12-28 2016-10-31 Adamed Spółka Z Ograniczoną Odpowiedzialnością Przeciwnowotworowe białko fuzyjne

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001633A1 (en) * 1995-06-29 1997-01-16 Immunex Corporation Cytokine that induces apoptosis
US6284236B1 (en) * 1995-06-29 2001-09-04 Immunex Corporation Cytokine that induces apoptosis
CN1354183A (zh) * 2001-11-30 2002-06-19 中国人民解放军第二军医大学 肿瘤凋亡诱导配体基因、基因表达蛋白及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010019100A (ko) * 1999-08-25 2001-03-15 황규언 인간 유래 세포소멸인자 ｔｒａｉｌ의 결정화에 의한 3차원 구조
US6900185B1 (en) * 2000-04-12 2005-05-31 University Of Iowa Research Foundation Method of inducing tumor cell apoptosis using trail/Apo-2 ligand gene transfer
KR100436089B1 (ko) * 2000-07-06 2004-06-14 설대우 분비성 재조합 트라이머형의 트레일 단백질 생산을 위한 디엔에이 카세트, 테트라사이클린/독시사이클린-유도성아데노-관련 바이러스 벡터, 이 둘의 조합, 및 이들을이용한 유전자 치료

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997001633A1 (en) * 1995-06-29 1997-01-16 Immunex Corporation Cytokine that induces apoptosis
US6284236B1 (en) * 1995-06-29 2001-09-04 Immunex Corporation Cytokine that induces apoptosis
CN1354183A (zh) * 2001-11-30 2002-06-19 中国人民解放军第二军医大学 肿瘤凋亡诱导配体基因、基因表达蛋白及其制备方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Expression and anti-tumor effects of Trail inhumancholangiocarcinoma. Tanala S et al.Hepatollogy,Vol.32 No.3. 2002 *
TRA IL 与肿瘤治疗研究进展. 段永亮综述，邹声泉审校.国外医学（外科学分册），第30卷第1期. 2003 *
重组人可溶性TRAIL分子诱导细胞凋亡机理探讨. 李宁丽等.上海第二医科大学学报，第23卷第1期. 2003 *

Also Published As

Publication number Publication date
CA2544473A1 (en) 2005-05-12
DE60336353D1 (de) 2011-04-21
HK1089788A1 (zh) 2006-12-08
JP2007536891A (ja) 2007-12-20
CN1860229A (zh) 2006-11-08
BR0318594A (pt) 2006-10-17
US7666989B2 (en) 2010-02-23
NZ547274A (en) 2009-02-28
ATE501256T1 (de) 2011-03-15
BRPI0318594B1 (pt) 2017-12-26
AU2003280921B2 (en) 2007-09-13
US20080280821A1 (en) 2008-11-13
EP1688498A1 (en) 2006-08-09
JP4688678B2 (ja) 2011-05-25
CA2544473C (en) 2013-08-13
EP1688498B1 (en) 2011-03-09
BRPI0318594B8 (pt) 2021-05-25
AU2003280921A1 (en) 2005-05-19
EP1688498A4 (en) 2007-06-20
WO2005042744A1 (en) 2005-05-12

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