CN100531800C - 基于聚乙烯乙酸乙烯酯共聚物的药物递送系统 - Google Patents

基于聚乙烯乙酸乙烯酯共聚物的药物递送系统 Download PDF

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Publication number
CN100531800C
CN100531800C CNB2005800093236A CN200580009323A CN100531800C CN 100531800 C CN100531800 C CN 100531800C CN B2005800093236 A CNB2005800093236 A CN B2005800093236A CN 200580009323 A CN200580009323 A CN 200580009323A CN 100531800 C CN100531800 C CN 100531800C
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CN
China
Prior art keywords
delivery system
vinyl acetate
drug delivery
core body
compartment
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Expired - Fee Related
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CNB2005800093236A
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English (en)
Chinese (zh)
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CN1933820A (zh
Inventor
W·德赫拉夫
J·S·格罗恩
M·A·克拉夫特
J·A·H·范拉霍维
H·弗勒曼斯
R·齐曼
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Organon NV
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Organon NV
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Publication of CN1933820A publication Critical patent/CN1933820A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CNB2005800093236A 2004-03-24 2005-03-16 基于聚乙烯乙酸乙烯酯共聚物的药物递送系统 Expired - Fee Related CN100531800C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04101215.4 2004-03-24
EP04101215 2004-03-24

Publications (2)

Publication Number Publication Date
CN1933820A CN1933820A (zh) 2007-03-21
CN100531800C true CN100531800C (zh) 2009-08-26

Family

ID=34928924

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2005800093236A Expired - Fee Related CN100531800C (zh) 2004-03-24 2005-03-16 基于聚乙烯乙酸乙烯酯共聚物的药物递送系统

Country Status (17)

Country Link
US (3) US8481079B2 (https=)
EP (1) EP1732520B1 (https=)
JP (1) JP2007530500A (https=)
CN (1) CN100531800C (https=)
AR (1) AR048185A1 (https=)
AT (1) ATE434433T1 (https=)
AU (1) AU2005224056B2 (https=)
BR (1) BRPI0509146B8 (https=)
CA (1) CA2559224C (https=)
DE (1) DE602005015090D1 (https=)
ES (1) ES2327247T3 (https=)
IL (1) IL178018A (https=)
MX (1) MXPA06010905A (https=)
MY (1) MY142824A (https=)
PE (1) PE20060127A1 (https=)
TW (1) TWI290837B (https=)
WO (1) WO2005089723A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105979930A (zh) * 2013-12-11 2016-09-28 默沙东有限责任公司 药物递送系统

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SI1629844T1 (sl) † 2004-07-13 2007-12-31 Bayer Schering Pharma Oy Sistem podaljšanega oddajanja s kontrolirano začetno dozo
MX2009005364A (es) * 2006-11-20 2009-06-05 Organon Nv Sistema de suministro de farmaco con forma helicoidal.
MX2009005444A (es) * 2006-11-22 2009-06-02 Organon Nv Sistema de suministro para un farmaco hidrofilico no esteroide no ionizado.
US8741329B2 (en) * 2007-09-21 2014-06-03 Merck Sharp & Dohme B.V. Drug delivery system
TW200927141A (en) * 2007-11-22 2009-07-01 Bayer Schering Pharma Oy Vaginal delivery system
EP2062568A1 (en) * 2007-11-22 2009-05-27 Bayer Schering Pharma Oy Vaginal delivery system
PL2062569T3 (pl) * 2007-11-22 2011-10-31 Bayer Oy Dopochwowy układ dostarczania leku
CA2755828A1 (en) 2009-03-17 2010-09-23 Intervet International B.V. Zoo-technical drug delivery device
CA2755753A1 (en) * 2009-03-17 2010-09-23 Intervet International B.V. Macrocyclic lactone drug delivery system
RU2648827C2 (ru) * 2010-03-28 2018-03-28 Эвестра, Инк. Внутривлагалищное устройство для доставки лекарственного средства
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
EP2749286B1 (en) 2011-08-26 2017-03-01 Universidad De Santiago De Chile Use of non-steroidal anti-inflammatory drugs meloxicam and piroxicam, administered intravaginally, for interruption of a woman's ovulation process
TW201332585A (zh) 2012-02-14 2013-08-16 Chemo Res S L 核鞘藥物遞送裝置
TR201808748T4 (tr) 2012-09-03 2018-07-23 Ecosea Farming S A Hidrobiyolojik türlerin kültürü ve/veya korunmasına yönelik rezervuar-kafes daldırma sistemi.
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
US10596103B2 (en) 2013-12-11 2020-03-24 Merek Sharp & Dohme B.V. Drug delivery system for delivery of anti-virals
CN104306380A (zh) * 2014-09-18 2015-01-28 新疆特丰药业股份有限公司 结合雌激素和醋酸甲羟孕酮双层片及其制备方法
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
US10406336B2 (en) 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
EP3395335A1 (en) * 2017-04-24 2018-10-31 Kern Pharma, S.L. Vaginal ring for the simultaneous release of two active ingredients
US11689849B2 (en) 2018-05-24 2023-06-27 Nureva, Inc. Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones
US11690806B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
KR20260007295A (ko) 2018-05-24 2026-01-13 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 거대 분자 약물 화합물의 지속적인 방출을 위한 이식가능 장치
CN113365634A (zh) * 2018-12-11 2021-09-07 卢品公司 超低剂量雌激素组合的药物递送系统及其方法和用途
WO2021068239A1 (zh) * 2019-10-12 2021-04-15 国家卫生健康委科学技术研究所 用于黄体支持的阴道缓释给药系统及其制备方法与应用
KR102159904B1 (ko) 2020-04-24 2020-09-24 강경원 약물 방출 고리를 구비한 월경컵
BR112023022439A2 (pt) 2021-04-26 2023-12-26 Celanese Eva Performance Polymers Llc Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular
EP4507675A1 (en) * 2022-04-14 2025-02-19 Yale University Nanoparticles and nanoparticle-releasing vaginal rings
CA3259928A1 (en) * 2022-08-01 2024-02-08 Lupin Inc. DRUG DELIVERY SYSTEM FOR ULTRA-LOW DOSE ESTROGEN COMBINATIONS AND METHODS AND USES THEREOF

Citations (2)

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CN1196930A (zh) * 1997-04-11 1998-10-28 阿克佐诺贝尔公司 用于释放两种或多种活性物质的药物释放体系
US6544546B1 (en) * 1995-07-04 2003-04-08 Akzo Nobel, N.V. Ring-shaped devices

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US3995633A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal Medicament dispensing device
US3995634A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal cavity dispensing means and method
US4237885A (en) 1978-10-23 1980-12-09 Alza Corporation Delivery system with mated members for storing and releasing a plurality of beneficial agents
US4292965A (en) 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
DE3040978A1 (de) 1980-10-28 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Vaginalring
US4596576A (en) 1984-10-12 1986-06-24 Akzo N.V. Release system for two or more active substances
DK1037812T3 (da) 1997-12-12 2003-11-24 Akzo Nobel Nv Emballage til vaginalring

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6544546B1 (en) * 1995-07-04 2003-04-08 Akzo Nobel, N.V. Ring-shaped devices
CN1196930A (zh) * 1997-04-11 1998-10-28 阿克佐诺贝尔公司 用于释放两种或多种活性物质的药物释放体系

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105979930A (zh) * 2013-12-11 2016-09-28 默沙东有限责任公司 药物递送系统
CN105979930B (zh) * 2013-12-11 2019-11-19 默沙东有限责任公司 药物递送系统

Also Published As

Publication number Publication date
TWI290837B (en) 2007-12-11
EP1732520A1 (en) 2006-12-20
CN1933820A (zh) 2007-03-21
WO2005089723A1 (en) 2005-09-29
CA2559224A1 (en) 2005-09-29
EP1732520B1 (en) 2009-06-24
US20140302115A1 (en) 2014-10-09
AR048185A1 (es) 2006-04-05
IL178018A (en) 2010-05-17
JP2007530500A (ja) 2007-11-01
TW200536572A (en) 2005-11-16
AU2005224056A1 (en) 2005-09-29
BRPI0509146B8 (pt) 2021-05-25
CA2559224C (en) 2011-12-13
US8808744B2 (en) 2014-08-19
US8481079B2 (en) 2013-07-09
BRPI0509146A (pt) 2007-09-04
DE602005015090D1 (de) 2009-08-06
US20070141102A1 (en) 2007-06-21
BRPI0509146B1 (pt) 2018-03-20
ATE434433T1 (de) 2009-07-15
MXPA06010905A (es) 2007-03-08
IL178018A0 (en) 2006-12-31
MY142824A (en) 2011-01-14
ES2327247T3 (es) 2009-10-27
PE20060127A1 (es) 2006-03-15
AU2005224056B2 (en) 2010-03-18
US20130266632A1 (en) 2013-10-10

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SE01 Entry into force of request for substantive examination
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Granted publication date: 20090826

Termination date: 20110316