BRPI0509146B8 - sistema de liberação de droga, método de fabricação do mesmo, e, uso do sistema de liberação de droga - Google Patents

sistema de liberação de droga, método de fabricação do mesmo, e, uso do sistema de liberação de droga

Info

Publication number
BRPI0509146B8
BRPI0509146B8 BRPI0509146A BRPI0509146A BRPI0509146B8 BR PI0509146 B8 BRPI0509146 B8 BR PI0509146B8 BR PI0509146 A BRPI0509146 A BR PI0509146A BR PI0509146 A BRPI0509146 A BR PI0509146A BR PI0509146 B8 BRPI0509146 B8 BR PI0509146B8
Authority
BR
Brazil
Prior art keywords
delivery system
drug delivery
ethylene
vinyl acetate
copolymer
Prior art date
Application number
BRPI0509146A
Other languages
English (en)
Portuguese (pt)
Inventor
Vromans Herman
Sophie Groen Janneke
Antonius Hendrikus Van Laarhoven Johannes
Antonius Bernardus Kruft Marcus
Zeeman Raymond
De Graaff Wouter
Original Assignee
Merck Sharp & Dohme
Msd Oss Bv
N V Organon
Organon Biosciences Nederland B V
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme, Msd Oss Bv, N V Organon, Organon Biosciences Nederland B V filed Critical Merck Sharp & Dohme
Publication of BRPI0509146A publication Critical patent/BRPI0509146A/pt
Publication of BRPI0509146B1 publication Critical patent/BRPI0509146B1/pt
Publication of BRPI0509146B8 publication Critical patent/BRPI0509146B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036—Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34—Gestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
BRPI0509146A 2004-03-24 2005-03-16 sistema de liberação de droga, método de fabricação do mesmo, e, uso do sistema de liberação de droga BRPI0509146B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP04101215.4 2004-03-24
EP04101215 2004-03-24
PCT/EP2005/051189 WO2005089723A1 (en) 2004-03-24 2005-03-16 Drug delivery system based on polyethylene vinylacetate copolymers

Publications (3)

Publication Number Publication Date
BRPI0509146A BRPI0509146A (pt) 2007-09-04
BRPI0509146B1 BRPI0509146B1 (pt) 2018-03-20
BRPI0509146B8 true BRPI0509146B8 (pt) 2021-05-25

Family

ID=34928924

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0509146A BRPI0509146B8 (pt) 2004-03-24 2005-03-16 sistema de liberação de droga, método de fabricação do mesmo, e, uso do sistema de liberação de droga

Country Status (17)

Country Link
US (3) US8481079B2 (https=)
EP (1) EP1732520B1 (https=)
JP (1) JP2007530500A (https=)
CN (1) CN100531800C (https=)
AR (1) AR048185A1 (https=)
AT (1) ATE434433T1 (https=)
AU (1) AU2005224056B2 (https=)
BR (1) BRPI0509146B8 (https=)
CA (1) CA2559224C (https=)
DE (1) DE602005015090D1 (https=)
ES (1) ES2327247T3 (https=)
IL (1) IL178018A (https=)
MX (1) MXPA06010905A (https=)
MY (1) MY142824A (https=)
PE (1) PE20060127A1 (https=)
TW (1) TWI290837B (https=)
WO (1) WO2005089723A1 (https=)

Families Citing this family (31)

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SI1629844T1 (sl) † 2004-07-13 2007-12-31 Bayer Schering Pharma Oy Sistem podaljšanega oddajanja s kontrolirano začetno dozo
MX2009005364A (es) * 2006-11-20 2009-06-05 Organon Nv Sistema de suministro de farmaco con forma helicoidal.
MX2009005444A (es) * 2006-11-22 2009-06-02 Organon Nv Sistema de suministro para un farmaco hidrofilico no esteroide no ionizado.
US8741329B2 (en) * 2007-09-21 2014-06-03 Merck Sharp & Dohme B.V. Drug delivery system
TW200927141A (en) * 2007-11-22 2009-07-01 Bayer Schering Pharma Oy Vaginal delivery system
EP2062568A1 (en) * 2007-11-22 2009-05-27 Bayer Schering Pharma Oy Vaginal delivery system
PL2062569T3 (pl) * 2007-11-22 2011-10-31 Bayer Oy Dopochwowy układ dostarczania leku
CA2755828A1 (en) 2009-03-17 2010-09-23 Intervet International B.V. Zoo-technical drug delivery device
CA2755753A1 (en) * 2009-03-17 2010-09-23 Intervet International B.V. Macrocyclic lactone drug delivery system
RU2648827C2 (ru) * 2010-03-28 2018-03-28 Эвестра, Инк. Внутривлагалищное устройство для доставки лекарственного средства
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
EP2749286B1 (en) 2011-08-26 2017-03-01 Universidad De Santiago De Chile Use of non-steroidal anti-inflammatory drugs meloxicam and piroxicam, administered intravaginally, for interruption of a woman's ovulation process
TW201332585A (zh) 2012-02-14 2013-08-16 Chemo Res S L 核鞘藥物遞送裝置
TR201808748T4 (tr) 2012-09-03 2018-07-23 Ecosea Farming S A Hidrobiyolojik türlerin kültürü ve/veya korunmasına yönelik rezervuar-kafes daldırma sistemi.
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
US10596103B2 (en) 2013-12-11 2020-03-24 Merek Sharp & Dohme B.V. Drug delivery system for delivery of anti-virals
US10413504B2 (en) * 2013-12-11 2019-09-17 Merck Sharp & Dohme Corp. Intravaginal ring drug delivery system
CN104306380A (zh) * 2014-09-18 2015-01-28 新疆特丰药业股份有限公司 结合雌激素和醋酸甲羟孕酮双层片及其制备方法
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
US10406336B2 (en) 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
EP3395335A1 (en) * 2017-04-24 2018-10-31 Kern Pharma, S.L. Vaginal ring for the simultaneous release of two active ingredients
US11689849B2 (en) 2018-05-24 2023-06-27 Nureva, Inc. Method, apparatus and computer-readable media to manage semi-constant (persistent) sound sources in microphone pickup/focus zones
US11690806B2 (en) 2018-05-24 2023-07-04 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
KR20260007295A (ko) 2018-05-24 2026-01-13 셀라니즈 이브이에이 퍼포먼스 폴리머스 엘엘씨 거대 분자 약물 화합물의 지속적인 방출을 위한 이식가능 장치
CN113365634A (zh) * 2018-12-11 2021-09-07 卢品公司 超低剂量雌激素组合的药物递送系统及其方法和用途
WO2021068239A1 (zh) * 2019-10-12 2021-04-15 国家卫生健康委科学技术研究所 用于黄体支持的阴道缓释给药系统及其制备方法与应用
KR102159904B1 (ko) 2020-04-24 2020-09-24 강경원 약물 방출 고리를 구비한 월경컵
BR112023022439A2 (pt) 2021-04-26 2023-12-26 Celanese Eva Performance Polymers Llc Dispositivo implantável para liberação sustentada de um composto de fármaco macromolecular
EP4507675A1 (en) * 2022-04-14 2025-02-19 Yale University Nanoparticles and nanoparticle-releasing vaginal rings
CA3259928A1 (en) * 2022-08-01 2024-02-08 Lupin Inc. DRUG DELIVERY SYSTEM FOR ULTRA-LOW DOSE ESTROGEN COMBINATIONS AND METHODS AND USES THEREOF

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3995633A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal Medicament dispensing device
US3995634A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal cavity dispensing means and method
US4237885A (en) 1978-10-23 1980-12-09 Alza Corporation Delivery system with mated members for storing and releasing a plurality of beneficial agents
US4292965A (en) 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
DE3040978A1 (de) 1980-10-28 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Vaginalring
US4596576A (en) 1984-10-12 1986-06-24 Akzo N.V. Release system for two or more active substances
WO1997002015A1 (en) 1995-07-04 1997-01-23 Akzo Nobel N.V. Ring-shaped devices
IL123813A0 (en) * 1997-04-11 1998-10-30 Akzo Nobel Nv Drug delivery system for two or more active substances
DK1037812T3 (da) 1997-12-12 2003-11-24 Akzo Nobel Nv Emballage til vaginalring

Also Published As

Publication number Publication date
TWI290837B (en) 2007-12-11
EP1732520A1 (en) 2006-12-20
CN1933820A (zh) 2007-03-21
WO2005089723A1 (en) 2005-09-29
CA2559224A1 (en) 2005-09-29
EP1732520B1 (en) 2009-06-24
US20140302115A1 (en) 2014-10-09
AR048185A1 (es) 2006-04-05
IL178018A (en) 2010-05-17
JP2007530500A (ja) 2007-11-01
TW200536572A (en) 2005-11-16
AU2005224056A1 (en) 2005-09-29
CA2559224C (en) 2011-12-13
US8808744B2 (en) 2014-08-19
US8481079B2 (en) 2013-07-09
BRPI0509146A (pt) 2007-09-04
DE602005015090D1 (de) 2009-08-06
US20070141102A1 (en) 2007-06-21
BRPI0509146B1 (pt) 2018-03-20
ATE434433T1 (de) 2009-07-15
MXPA06010905A (es) 2007-03-08
IL178018A0 (en) 2006-12-31
MY142824A (en) 2011-01-14
ES2327247T3 (es) 2009-10-27
PE20060127A1 (es) 2006-03-15
AU2005224056B2 (en) 2010-03-18
CN100531800C (zh) 2009-08-26
US20130266632A1 (en) 2013-10-10

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: MSD OSS B.V. (NL)

B25A Requested transfer of rights approved

Owner name: ORGANON BIOSCIENCES NEDERLAND B.V. (NL)

B25A Requested transfer of rights approved

Owner name: MERCK SHARP AND DOHME B.V. (NL)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 20/03/2018, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 16/03/2005 OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 19A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2766 DE 09-01-2024 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.