AR048185A1 - Sistema de entrega de farmacos constituido por uno o mas compartimentos, que comprende un compuesto progestagenico disuelto en un copolimero de polietileno acetato de vinilo termoplastico - Google Patents

Sistema de entrega de farmacos constituido por uno o mas compartimentos, que comprende un compuesto progestagenico disuelto en un copolimero de polietileno acetato de vinilo termoplastico

Info

Publication number
AR048185A1
AR048185A1 ARP050101144A ARP050101144A AR048185A1 AR 048185 A1 AR048185 A1 AR 048185A1 AR P050101144 A ARP050101144 A AR P050101144A AR P050101144 A ARP050101144 A AR P050101144A AR 048185 A1 AR048185 A1 AR 048185A1
Authority
AR
Argentina
Prior art keywords
vinyl acetate
polyethylene copolymer
delivery system
progestagenic
thermoplastic vinyl
Prior art date
Application number
ARP050101144A
Other languages
English (en)
Inventor
Graaff Wouter De
Janneke Sophie Groen
Marc Anton Kruft
Laarhoven Johannes Antoniu Van
Raymond Zeeman
Herman Vromans
Original Assignee
Akzo Nobel Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Akzo Nobel Nv filed Critical Akzo Nobel Nv
Publication of AR048185A1 publication Critical patent/AR048185A1/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/34Gestagens

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Un sistema de entrega de fármacos constituido por uno o más compartimentos y que comprende un compuesto progestagénico disuelto en un copolímero de polietileno acetato de vinilo termoplástico, donde si el sistema de entrega está constituido por un compartimento, el compartimento comprende: i) un nucleo de un copolímero de polietileno acetato de vinilo termoplástico que comprende el compuesto progestagénico, esta disuelto en el copolímero de polietileno acetato de vinilo hasta una concentracion inferior al nivel de saturacion a 25 degree C, y un compuesto estrogénico; y ii) un forro de un copolímero de polietileno acetato de vinilo termoplástico que cubre el nucleo, siendo dicho forro permeable para ambos compuestos; si el sistema de entrega está constituido por más de un compartimento, solo un compartimento comprende: iii) el compuesto progestagénico, cuyo compuesto progestagénico está disuelto en un nucleo de un copolímero de polietileno acetato de vinilo termoplástico hasta una concentracion inferior al nivel de saturacion a 25 degree C, y un compuesto estrogénico; y iv) un forro de un copolímero de polietileno acetato de vinilo termoplástico que cubre el nucleo, siendo dicho forro permeable para ambos compuestos. Reivindicacion 15: Uso del sistema de entrega de fármacos de las reivindicaciones 1-12, caracterizado porque sirve para la fabricacion de un kit anticonceptivo o un kit para terapia de reemplazo hormonal.
ARP050101144A 2004-03-24 2005-03-23 Sistema de entrega de farmacos constituido por uno o mas compartimentos, que comprende un compuesto progestagenico disuelto en un copolimero de polietileno acetato de vinilo termoplastico AR048185A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04101215 2004-03-24

Publications (1)

Publication Number Publication Date
AR048185A1 true AR048185A1 (es) 2006-04-05

Family

ID=34928924

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050101144A AR048185A1 (es) 2004-03-24 2005-03-23 Sistema de entrega de farmacos constituido por uno o mas compartimentos, que comprende un compuesto progestagenico disuelto en un copolimero de polietileno acetato de vinilo termoplastico

Country Status (17)

Country Link
US (3) US8481079B2 (es)
EP (1) EP1732520B1 (es)
JP (1) JP2007530500A (es)
CN (1) CN100531800C (es)
AR (1) AR048185A1 (es)
AT (1) ATE434433T1 (es)
AU (1) AU2005224056B2 (es)
BR (1) BRPI0509146B8 (es)
CA (1) CA2559224C (es)
DE (1) DE602005015090D1 (es)
ES (1) ES2327247T3 (es)
IL (1) IL178018A (es)
MX (1) MXPA06010905A (es)
MY (1) MY142824A (es)
PE (1) PE20060127A1 (es)
TW (1) TWI290837B (es)
WO (1) WO2005089723A1 (es)

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ES2293193T5 (es) 2004-07-13 2012-06-13 Bayer Schering Pharma Oy Sistema de suministro retardado con descarga inicial controlada
EP2097063B1 (en) * 2006-11-20 2013-08-07 Intervet International B.V. Helically-shaped drug delivery system
CA2670454A1 (en) * 2006-11-22 2008-05-29 N.V. Organon Delivery system for a non-steroidal non-ionized hydrophilic drug
US8741329B2 (en) * 2007-09-21 2014-06-03 Merck Sharp & Dohme B.V. Drug delivery system
EP2062568A1 (en) * 2007-11-22 2009-05-27 Bayer Schering Pharma Oy Vaginal delivery system
TW200927141A (en) * 2007-11-22 2009-07-01 Bayer Schering Pharma Oy Vaginal delivery system
DK2062569T3 (da) * 2007-11-22 2011-08-29 Bayer Oy Vaginalt afgivelsessystem
UY32492A (es) 2009-03-17 2010-10-29 Organon Nv Dispositivo de suministro de droga zootécnica.
JP2012520847A (ja) * 2009-03-17 2012-09-10 インターベツト・インターナシヨナル・ベー・ベー 大環状ラクトン薬物送達システム
CN103025320A (zh) * 2010-03-28 2013-04-03 伊万斯彻有限公司 阴道内药物递送装置
US8580294B2 (en) 2010-10-19 2013-11-12 International Partnership For Microbicides Platinum-catalyzed intravaginal rings
WO2013029194A1 (es) 2011-08-26 2013-03-07 Universidad De Santiago De Chile Uso de los anti-inflamatorios no esteroidales meloxicam y piroxicam, por via intravaginal, para la interrupción del proceso ovulatorio en la mujer
TW201332585A (zh) 2012-02-14 2013-08-16 Chemo Res S L 核鞘藥物遞送裝置
WO2014032199A1 (es) 2012-09-03 2014-03-06 Ecosea Farming S.A. Sistema de hundimiento de balsa-jaula destinadas al cultivo y/o confinamiento de especies hidrobiologicas
US10137031B2 (en) 2013-11-14 2018-11-27 International Partnership For Microbicides, Inc. Combination therapy intravaginal rings
US10413504B2 (en) * 2013-12-11 2019-09-17 Merck Sharp & Dohme Corp. Intravaginal ring drug delivery system
EP3079659B1 (en) 2013-12-11 2020-10-28 Merck Sharp & Dohme B.V. Drug delivery system for delivery of anti-virals
CN104306380A (zh) * 2014-09-18 2015-01-28 新疆特丰药业股份有限公司 结合雌激素和醋酸甲羟孕酮双层片及其制备方法
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
US10406336B2 (en) 2016-08-03 2019-09-10 Neil S. Davey Adjustable rate drug delivery implantable device
EP3395335A1 (en) * 2017-04-24 2018-10-31 Kern Pharma, S.L. Vaginal ring for the simultaneous release of two active ingredients
AU2019275409A1 (en) 2018-05-24 2020-07-16 Celanese Eva Performance Polymers Llc Implantable device for sustained release of a macromolecular drug compound
SG11202005947RA (en) 2018-05-24 2020-07-29 Celanese Eva Performance Polymers Corp Implantable device for sustained release of a macromolecular drug compound
CN113365634A (zh) * 2018-12-11 2021-09-07 卢品公司 超低剂量雌激素组合的药物递送系统及其方法和用途
WO2021068239A1 (zh) * 2019-10-12 2021-04-15 国家卫生健康委科学技术研究所 用于黄体支持的阴道缓释给药系统及其制备方法与应用
KR102159904B1 (ko) 2020-04-24 2020-09-24 강경원 약물 방출 고리를 구비한 월경컵
WO2023200974A1 (en) * 2022-04-14 2023-10-19 Yale University Nanoparticles and nanoparticle-releasing vaginal rings
WO2024030116A1 (en) * 2022-08-01 2024-02-08 Lupin Inc. Drug delivery system for ultra-low dose estrogen combinations and methods and uses thereof

Family Cites Families (9)

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Publication number Priority date Publication date Assignee Title
US3995634A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal cavity dispensing means and method
US3995633A (en) 1975-12-02 1976-12-07 The Procter & Gamble Company Vaginal Medicament dispensing device
US4237885A (en) 1978-10-23 1980-12-09 Alza Corporation Delivery system with mated members for storing and releasing a plurality of beneficial agents
US4292965A (en) 1978-12-29 1981-10-06 The Population Council, Inc. Intravaginal ring
DE3040978A1 (de) 1980-10-28 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Vaginalring
EP0180264A1 (en) 1984-10-12 1986-05-07 Akzo N.V. Release system for two or more active substances
US6544546B1 (en) * 1995-07-04 2003-04-08 Akzo Nobel, N.V. Ring-shaped devices
IL123813A0 (en) * 1997-04-11 1998-10-30 Akzo Nobel Nv Drug delivery system for two or more active substances
IL136307A (en) 1997-12-12 2004-03-28 Akzo Nobel Nv Packing for holster ring

Also Published As

Publication number Publication date
TW200536572A (en) 2005-11-16
BRPI0509146B8 (pt) 2021-05-25
MXPA06010905A (es) 2007-03-08
AU2005224056B2 (en) 2010-03-18
CN1933820A (zh) 2007-03-21
ES2327247T3 (es) 2009-10-27
IL178018A0 (en) 2006-12-31
CA2559224C (en) 2011-12-13
AU2005224056A1 (en) 2005-09-29
US20130266632A1 (en) 2013-10-10
BRPI0509146A (pt) 2007-09-04
US20070141102A1 (en) 2007-06-21
EP1732520A1 (en) 2006-12-20
US8481079B2 (en) 2013-07-09
TWI290837B (en) 2007-12-11
WO2005089723A1 (en) 2005-09-29
US8808744B2 (en) 2014-08-19
MY142824A (en) 2011-01-14
BRPI0509146B1 (pt) 2018-03-20
DE602005015090D1 (de) 2009-08-06
JP2007530500A (ja) 2007-11-01
CA2559224A1 (en) 2005-09-29
ATE434433T1 (de) 2009-07-15
EP1732520B1 (en) 2009-06-24
IL178018A (en) 2010-05-17
PE20060127A1 (es) 2006-03-15
US20140302115A1 (en) 2014-10-09
CN100531800C (zh) 2009-08-26

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