CN100486580C - 作为抗癌剂的6-芳基-7-卤基-咪唑并[1,2-a]嘧啶 - Google Patents

作为抗癌剂的6-芳基-7-卤基-咪唑并[1,2-a]嘧啶 Download PDF

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Publication number
CN100486580C
CN100486580C CNB2004800273126A CN200480027312A CN100486580C CN 100486580 C CN100486580 C CN 100486580C CN B2004800273126 A CNB2004800273126 A CN B2004800273126A CN 200480027312 A CN200480027312 A CN 200480027312A CN 100486580 C CN100486580 C CN 100486580C
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CN
China
Prior art keywords
alkyl
pharmaceutically acceptable
formula
chemical compound
acceptable salt
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Expired - Fee Related
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CNB2004800273126A
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English (en)
Chinese (zh)
Other versions
CN1856311A (zh
Inventor
张楠
塞米拉米斯·艾拉尔-卡劳斯蒂安
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Wyeth Holdings LLC
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Wyeth Holdings LLC
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Publication of CN1856311A publication Critical patent/CN1856311A/zh
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Publication of CN100486580C publication Critical patent/CN100486580C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB2004800273126A 2003-09-24 2004-09-17 作为抗癌剂的6-芳基-7-卤基-咪唑并[1,2-a]嘧啶 Expired - Fee Related CN100486580C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50548603P 2003-09-24 2003-09-24
US60/505,486 2003-09-24

Publications (2)

Publication Number Publication Date
CN1856311A CN1856311A (zh) 2006-11-01
CN100486580C true CN100486580C (zh) 2009-05-13

Family

ID=34393021

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800273126A Expired - Fee Related CN100486580C (zh) 2003-09-24 2004-09-17 作为抗癌剂的6-芳基-7-卤基-咪唑并[1,2-a]嘧啶

Country Status (14)

Country Link
US (2) US7285555B2 (enExample)
EP (1) EP1684763B1 (enExample)
JP (1) JP4695595B2 (enExample)
CN (1) CN100486580C (enExample)
AT (1) ATE398452T1 (enExample)
AU (1) AU2004275728A1 (enExample)
BR (1) BRPI0414778A (enExample)
CA (1) CA2537520A1 (enExample)
DE (1) DE602004014525D1 (enExample)
DK (1) DK1684763T3 (enExample)
ES (1) ES2308256T3 (enExample)
MX (1) MXPA06002939A (enExample)
PL (1) PL1684763T3 (enExample)
WO (1) WO2005030218A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

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CA2353593A1 (en) * 1998-12-18 2000-06-22 Hadasit Medical Research Services & Development Ltd. Method of administering a compound to multi-drug resistant cells
EP1973545B1 (en) 2005-12-23 2013-01-30 Ariad Pharmaceuticals, Inc. Bicyclic heteroaryl compounds
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途

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TW224044B (enExample) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
IL108731A (en) 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
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US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6255309B1 (en) 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6117876A (en) 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US5994360A (en) 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
AU750489B2 (en) 1998-02-11 2002-07-18 Wyeth Holdings Corporation Fungicidal 7-alkyl-triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US6124301A (en) 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
WO1999048893A1 (en) 1998-03-23 1999-09-30 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6284762B1 (en) 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
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US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
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US6156925A (en) 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
DE69914364T2 (de) 1998-09-25 2004-07-22 Basf Ag Nicht-wässriges suspensionskonzentrat
US6277856B1 (en) 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
JP4025468B2 (ja) 1999-07-29 2007-12-19 三井化学株式会社 有機電界発光素子
WO2001035738A2 (en) 1999-11-18 2001-05-25 Basf Corporation Non-aqueous concentrated spreading oil composition
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
JP2004502691A (ja) * 2000-06-30 2004-01-29 ワイス 抗癌薬としての置換トリアゾロピリミジン
MXPA03001263A (es) 2000-08-25 2003-06-24 Basf Ag Formulacion fungicida.
TR200402494T4 (tr) 2000-12-06 2004-12-21 Wyeth Mantar öldürücü 6-(2-triflorometil-fenil)-triazolopirimidinler.
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
ES2236509T3 (es) 2001-04-11 2005-07-16 Basf Aktiengesellschaft 5-halogen-6-fenil-7-fluoroalquilamino-triazolopirimidinas utiles como fungicidas.
EP1431299B1 (en) 2001-09-04 2007-05-23 Sumitomo Chemical Company, Limited IMIDAZO(1,2-a)PYRIMIDINES AND FUNGICIDE COMPOSITIONS CONTAINING THE SAME
AU2003211651A1 (en) * 2002-04-19 2003-11-03 Sumitomo Chemical Company, Limited 5,6-DIPHENYLIMIDAZO(1,2-a)PYRIMIDINE AND BACTERICIDAL COMPOSITION CONTAINING THE SAME

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

Also Published As

Publication number Publication date
CN1856311A (zh) 2006-11-01
DE602004014525D1 (de) 2008-07-31
EP1684763B1 (en) 2008-06-18
US20050065167A1 (en) 2005-03-24
CA2537520A1 (en) 2005-04-07
US7915266B2 (en) 2011-03-29
AU2004275728A1 (en) 2005-04-07
WO2005030218A1 (en) 2005-04-07
DK1684763T3 (da) 2008-09-01
ES2308256T3 (es) 2008-12-01
PL1684763T3 (pl) 2008-11-28
US20080255157A1 (en) 2008-10-16
JP2007506745A (ja) 2007-03-22
JP4695595B2 (ja) 2011-06-08
MXPA06002939A (es) 2006-05-31
BRPI0414778A (pt) 2006-11-21
ATE398452T1 (de) 2008-07-15
US7285555B2 (en) 2007-10-23
EP1684763A1 (en) 2006-08-02

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