JP4695595B2 - 抗癌剤としての６−アリール−７−ハロ−イミダゾ［１，２−ａ］ピリミジン類 - Google Patents

抗癌剤としての６−アリール−７−ハロ−イミダゾ［１，２−ａ］ピリミジン類 Download PDF

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Publication number
JP4695595B2
JP4695595B2 JP2006528080A JP2006528080A JP4695595B2 JP 4695595 B2 JP4695595 B2 JP 4695595B2 JP 2006528080 A JP2006528080 A JP 2006528080A JP 2006528080 A JP2006528080 A JP 2006528080A JP 4695595 B2 JP4695595 B2 JP 4695595B2
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JP
Japan
Prior art keywords
formula
compound
alkyl
pharmaceutically acceptable
acceptable salt
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JP2006528080A
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English (en)
Japanese (ja)
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JP2007506745A (ja
JP2007506745A5 (enExample
Inventor
チャン・ナン
セミラミス・エイラル−カルースティアン
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Wyeth Holdings LLC
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Wyeth Holdings LLC
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Publication of JP2007506745A5 publication Critical patent/JP2007506745A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2006528080A 2003-09-24 2004-09-17 抗癌剤としての６−アリール−７−ハロ−イミダゾ［１，２−ａ］ピリミジン類 Expired - Fee Related JP4695595B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50548603P 2003-09-24 2003-09-24
US60/505,486 2003-09-24
PCT/US2004/030595 WO2005030218A1 (en) 2003-09-24 2004-09-17 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agent

Publications (3)

Publication Number Publication Date
JP2007506745A JP2007506745A (ja) 2007-03-22
JP2007506745A5 JP2007506745A5 (enExample) 2007-10-25
JP4695595B2 true JP4695595B2 (ja) 2011-06-08

Family

ID=34393021

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006528080A Expired - Fee Related JP4695595B2 (ja) 2003-09-24 2004-09-17 抗癌剤としての６−アリール−７−ハロ−イミダゾ［１，２−ａ］ピリミジン類

Country Status (14)

Country Link
US (2) US7285555B2 (enExample)
EP (1) EP1684763B1 (enExample)
JP (1) JP4695595B2 (enExample)
CN (1) CN100486580C (enExample)
AT (1) ATE398452T1 (enExample)
AU (1) AU2004275728A1 (enExample)
BR (1) BRPI0414778A (enExample)
CA (1) CA2537520A1 (enExample)
DE (1) DE602004014525D1 (enExample)
DK (1) DK1684763T3 (enExample)
ES (1) ES2308256T3 (enExample)
MX (1) MXPA06002939A (enExample)
PL (1) PL1684763T3 (enExample)
WO (1) WO2005030218A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU769569B2 (en) * 1998-12-18 2004-01-29 Alza Corporation Method of administering a compound to multi-drug resistant cells
KR101436303B1 (ko) 2005-12-23 2014-09-02 어리어드 파마슈티칼스, 인코포레이티드 비시클릭 헤테로아릴 화합물
US20100056371A1 (en) * 2007-01-08 2010-03-04 Basf Se Use of Azolopyrimidines for Controlling Phytopathogenic Harmful Fungi
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
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US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
TW224044B (enExample) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
IL108731A (en) 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
ATE231485T1 (de) 1997-03-18 2003-02-15 Basf Ag Verfahren zur herstellung von arylmalonaten
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
US6117876A (en) 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US6255309B1 (en) 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
CN1114606C (zh) 1998-02-11 2003-07-16 美国氰胺公司 具有杀真菌活性的7－烷基－三唑并嘧啶化合物
US6124301A (en) 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US6284762B1 (en) 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
EA003281B1 (ru) 1998-03-23 2003-04-24 Америкэн Цианамид Компани 6-(2-гало-4-алкоксифенил)триазолпиримидины с фунгицидным действием
US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6117865A (en) 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6268371B1 (en) 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
JP2002525291A (ja) 1998-09-25 2002-08-13 アメリカン サイアナミツド コンパニー 非水性懸濁液濃縮物
US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
EP0988790B1 (en) 1998-09-25 2003-05-21 Basf Aktiengesellschaft Fungicidal mixtures
US6156925A (en) 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US6277856B1 (en) 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
JP4025468B2 (ja) 1999-07-29 2007-12-19 三井化学株式会社 有機電界発光素子
WO2001035738A2 (en) 1999-11-18 2001-05-25 Basf Corporation Non-aqueous concentrated spreading oil composition
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
HK1052646A1 (zh) * 2000-06-30 2003-09-26 Wyeth 替代三氮苯(triazolopyrimidines)作为抗癌剂
PT1313370E (pt) 2000-08-25 2004-10-29 Basf Ag Formulacao fungicida
DE60013188T2 (de) 2000-12-06 2004-12-30 Basf Ag Fungiizide 6-(trifluormethyl-phenyl)-triazolpyrimidine
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
BR0208756A (pt) 2001-04-11 2004-05-11 Basf Ag Compostos, processo para a preparação dos mesmos, composição adequada para o controle de fungos fitopatogênicos, e, método para controlar fungos fitopatogênicos
EP1431299B1 (en) 2001-09-04 2007-05-23 Sumitomo Chemical Company, Limited IMIDAZO(1,2-a)PYRIMIDINES AND FUNGICIDE COMPOSITIONS CONTAINING THE SAME
WO2003089433A1 (en) * 2002-04-19 2003-10-30 Sumitomo Chemical Company, Limited 5,6-DIPHENYLIMIDAZO[1,2-a]PYRIMIDINE AND BACTERICIDAL COMPOSITION CONTAINING THE SAME

Also Published As

Publication number Publication date
CN100486580C (zh) 2009-05-13
US7285555B2 (en) 2007-10-23
ATE398452T1 (de) 2008-07-15
JP2007506745A (ja) 2007-03-22
DE602004014525D1 (de) 2008-07-31
AU2004275728A1 (en) 2005-04-07
US20080255157A1 (en) 2008-10-16
EP1684763A1 (en) 2006-08-02
BRPI0414778A (pt) 2006-11-21
DK1684763T3 (da) 2008-09-01
MXPA06002939A (es) 2006-05-31
WO2005030218A1 (en) 2005-04-07
US20050065167A1 (en) 2005-03-24
PL1684763T3 (pl) 2008-11-28
EP1684763B1 (en) 2008-06-18
US7915266B2 (en) 2011-03-29
ES2308256T3 (es) 2008-12-01
CA2537520A1 (en) 2005-04-07
CN1856311A (zh) 2006-11-01

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