JP4695595B2 - 抗癌剤としての６−アリール−７−ハロ−イミダゾ［１，２−ａ］ピリミジン類 - Google Patents

抗癌剤としての６−アリール−７−ハロ−イミダゾ［１，２−ａ］ピリミジン類 Download PDF

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Publication number
JP4695595B2
JP4695595B2 JP2006528080A JP2006528080A JP4695595B2 JP 4695595 B2 JP4695595 B2 JP 4695595B2 JP 2006528080 A JP2006528080 A JP 2006528080A JP 2006528080 A JP2006528080 A JP 2006528080A JP 4695595 B2 JP4695595 B2 JP 4695595B2
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JP
Japan
Prior art keywords
formula
compound
alkyl
pharmaceutically acceptable
acceptable salt
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Expired - Fee Related
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JP2006528080A
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English (en)
Japanese (ja)
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JP2007506745A (ja
JP2007506745A5 (enExample
Inventor
チャン・ナン
セミラミス・エイラル−カルースティアン
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Wyeth Holdings LLC
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Wyeth Holdings LLC
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2006528080A 2003-09-24 2004-09-17 抗癌剤としての６−アリール−７−ハロ−イミダゾ［１，２−ａ］ピリミジン類 Expired - Fee Related JP4695595B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US50548603P 2003-09-24 2003-09-24
US60/505,486 2003-09-24
PCT/US2004/030595 WO2005030218A1 (en) 2003-09-24 2004-09-17 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agent

Publications (3)

Publication Number Publication Date
JP2007506745A JP2007506745A (ja) 2007-03-22
JP2007506745A5 JP2007506745A5 (enExample) 2007-10-25
JP4695595B2 true JP4695595B2 (ja) 2011-06-08

Family

ID=34393021

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006528080A Expired - Fee Related JP4695595B2 (ja) 2003-09-24 2004-09-17 抗癌剤としての６−アリール−７−ハロ−イミダゾ［１，２−ａ］ピリミジン類

Country Status (14)

Country Link
US (2) US7285555B2 (enExample)
EP (1) EP1684763B1 (enExample)
JP (1) JP4695595B2 (enExample)
CN (1) CN100486580C (enExample)
AT (1) ATE398452T1 (enExample)
AU (1) AU2004275728A1 (enExample)
BR (1) BRPI0414778A (enExample)
CA (1) CA2537520A1 (enExample)
DE (1) DE602004014525D1 (enExample)
DK (1) DK1684763T3 (enExample)
ES (1) ES2308256T3 (enExample)
MX (1) MXPA06002939A (enExample)
PL (1) PL1684763T3 (enExample)
WO (1) WO2005030218A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2353593A1 (en) * 1998-12-18 2000-06-22 Hadasit Medical Research Services & Development Ltd. Method of administering a compound to multi-drug resistant cells
EP1973545B1 (en) 2005-12-23 2013-01-30 Ariad Pharmaceuticals, Inc. Bicyclic heteroaryl compounds
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
TW224044B (enExample) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
IL108731A (en) 1993-03-04 1997-03-18 Shell Int Research 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
AU6558498A (en) 1997-03-18 1998-10-12 American Cyanamid Company Process for the preparation of arylmalonates
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6255309B1 (en) 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6117876A (en) 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US5994360A (en) 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
AU750489B2 (en) 1998-02-11 2002-07-18 Wyeth Holdings Corporation Fungicidal 7-alkyl-triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US6124301A (en) 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
WO1999048893A1 (en) 1998-03-23 1999-09-30 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6284762B1 (en) 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
US6268371B1 (en) 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
US6117865A (en) 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
SI0988790T1 (en) 1998-09-25 2003-10-31 Basf Aktiengesellschaft Fungicidal mixtures
US6156925A (en) 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
DE69914364T2 (de) 1998-09-25 2004-07-22 Basf Ag Nicht-wässriges suspensionskonzentrat
US6277856B1 (en) 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
JP4025468B2 (ja) 1999-07-29 2007-12-19 三井化学株式会社 有機電界発光素子
WO2001035738A2 (en) 1999-11-18 2001-05-25 Basf Corporation Non-aqueous concentrated spreading oil composition
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
JP2004502691A (ja) * 2000-06-30 2004-01-29 ワイス 抗癌薬としての置換トリアゾロピリミジン
MXPA03001263A (es) 2000-08-25 2003-06-24 Basf Ag Formulacion fungicida.
TR200402494T4 (tr) 2000-12-06 2004-12-21 Wyeth Mantar öldürücü 6-(2-triflorometil-fenil)-triazolopirimidinler.
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
ES2236509T3 (es) 2001-04-11 2005-07-16 Basf Aktiengesellschaft 5-halogen-6-fenil-7-fluoroalquilamino-triazolopirimidinas utiles como fungicidas.
EP1431299B1 (en) 2001-09-04 2007-05-23 Sumitomo Chemical Company, Limited IMIDAZO(1,2-a)PYRIMIDINES AND FUNGICIDE COMPOSITIONS CONTAINING THE SAME
AU2003211651A1 (en) * 2002-04-19 2003-11-03 Sumitomo Chemical Company, Limited 5,6-DIPHENYLIMIDAZO(1,2-a)PYRIMIDINE AND BACTERICIDAL COMPOSITION CONTAINING THE SAME

Also Published As

Publication number Publication date
CN100486580C (zh) 2009-05-13
CN1856311A (zh) 2006-11-01
DE602004014525D1 (de) 2008-07-31
EP1684763B1 (en) 2008-06-18
US20050065167A1 (en) 2005-03-24
CA2537520A1 (en) 2005-04-07
US7915266B2 (en) 2011-03-29
AU2004275728A1 (en) 2005-04-07
WO2005030218A1 (en) 2005-04-07
DK1684763T3 (da) 2008-09-01
ES2308256T3 (es) 2008-12-01
PL1684763T3 (pl) 2008-11-28
US20080255157A1 (en) 2008-10-16
JP2007506745A (ja) 2007-03-22
MXPA06002939A (es) 2006-05-31
BRPI0414778A (pt) 2006-11-21
ATE398452T1 (de) 2008-07-15
US7285555B2 (en) 2007-10-23
EP1684763A1 (en) 2006-08-02

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