BRPI0414778A - 6-aril-7-halo-imidazo[1,2-a]pirimidinas como agentes anticáncer - Google Patents
6-aril-7-halo-imidazo[1,2-a]pirimidinas como agentes anticáncerInfo
- Publication number
- BRPI0414778A BRPI0414778A BRPI0414778-2A BRPI0414778A BRPI0414778A BR PI0414778 A BRPI0414778 A BR PI0414778A BR PI0414778 A BRPI0414778 A BR PI0414778A BR PI0414778 A BRPI0414778 A BR PI0414778A
- Authority
- BR
- Brazil
- Prior art keywords
- imidazo
- halo
- aryl
- pyrimidines
- anticancer agents
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US50548603P | 2003-09-24 | 2003-09-24 | |
| PCT/US2004/030595 WO2005030218A1 (en) | 2003-09-24 | 2004-09-17 | 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0414778A true BRPI0414778A (pt) | 2006-11-21 |
Family
ID=34393021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0414778-2A BRPI0414778A (pt) | 2003-09-24 | 2004-09-17 | 6-aril-7-halo-imidazo[1,2-a]pirimidinas como agentes anticáncer |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US7285555B2 (enExample) |
| EP (1) | EP1684763B1 (enExample) |
| JP (1) | JP4695595B2 (enExample) |
| CN (1) | CN100486580C (enExample) |
| AT (1) | ATE398452T1 (enExample) |
| AU (1) | AU2004275728A1 (enExample) |
| BR (1) | BRPI0414778A (enExample) |
| CA (1) | CA2537520A1 (enExample) |
| DE (1) | DE602004014525D1 (enExample) |
| DK (1) | DK1684763T3 (enExample) |
| ES (1) | ES2308256T3 (enExample) |
| MX (1) | MXPA06002939A (enExample) |
| PL (1) | PL1684763T3 (enExample) |
| WO (1) | WO2005030218A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU769569B2 (en) * | 1998-12-18 | 2004-01-29 | Alza Corporation | Method of administering a compound to multi-drug resistant cells |
| KR101436303B1 (ko) | 2005-12-23 | 2014-09-02 | 어리어드 파마슈티칼스, 인코포레이티드 | 비시클릭 헤테로아릴 화합물 |
| US20100056371A1 (en) * | 2007-01-08 | 2010-03-04 | Basf Se | Use of Azolopyrimidines for Controlling Phytopathogenic Harmful Fungi |
| CN107935870A (zh) * | 2017-11-09 | 2018-04-20 | 华中药业股份有限公司 | 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593996A (en) * | 1991-12-30 | 1997-01-14 | American Cyanamid Company | Triazolopyrimidine derivatives |
| TW224044B (enExample) | 1991-12-30 | 1994-05-21 | Shell Internat Res Schappej B V | |
| JP2794510B2 (ja) | 1992-03-27 | 1998-09-10 | 富士写真フイルム株式会社 | ハロゲン化銀写真感光材料 |
| IL108747A (en) | 1993-03-04 | 1999-03-12 | Shell Int Research | Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation |
| IL108731A (en) | 1993-03-04 | 1997-03-18 | Shell Int Research | 6, N-DISUBSTITUTED-£1, 2, 4| TRIAZOLO-£1, 5-a| PYRIMIDINE- 7-AMINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS FUNGICIDES |
| RU2147584C1 (ru) | 1995-10-27 | 2000-04-20 | Американ Цианамид Компани | Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов |
| US5817663A (en) | 1996-10-07 | 1998-10-06 | American Cyanamid Company | Pentafluorophenylazolopyrimidines |
| ATE231485T1 (de) | 1997-03-18 | 2003-02-15 | Basf Ag | Verfahren zur herstellung von arylmalonaten |
| US5750766A (en) | 1997-03-18 | 1998-05-12 | American Cyanamid Company | Process for the preparation of arylmalonates |
| US6117876A (en) | 1997-04-14 | 2000-09-12 | American Cyanamid Company | Fungicidal trifluorophenyl-triazolopyrimidines |
| TW460476B (en) | 1997-04-14 | 2001-10-21 | American Cyanamid Co | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
| US5948783A (en) | 1997-04-14 | 1999-09-07 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
| TWI252231B (en) | 1997-04-14 | 2006-04-01 | American Cyanamid Co | Fungicidal trifluorophenyl-triazolopyrimidines |
| US6255309B1 (en) | 1999-03-19 | 2001-07-03 | American Cyanomid Co. | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
| US5994360A (en) | 1997-07-14 | 1999-11-30 | American Cyanamid Company | Fungicidal 5-alkyl-triazolopyrimidines |
| US6020338A (en) | 1998-02-11 | 2000-02-01 | American Cyanamid Company | Fungicidal 7-alkyl-triazolopyrimidines |
| CN1114606C (zh) | 1998-02-11 | 2003-07-16 | 美国氰胺公司 | 具有杀真菌活性的7－烷基－三唑并嘧啶化合物 |
| US6124301A (en) | 1998-03-17 | 2000-09-26 | American Cyanamid Company | Enhancement of the efficacy of triazolopyrimidines |
| JPH11322517A (ja) | 1998-03-17 | 1999-11-24 | American Cyanamid Co | トリアゾロピリミジン類の効力の増進 |
| US6284762B1 (en) | 1998-03-23 | 2001-09-04 | American Cyanamid Company | Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines |
| EA003281B1 (ru) | 1998-03-23 | 2003-04-24 | Америкэн Цианамид Компани | 6-(2-гало-4-алкоксифенил)триазолпиримидины с фунгицидным действием |
| US5981534A (en) | 1998-09-25 | 1999-11-09 | American Cyanamid Company | Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines |
| US6117865A (en) | 1998-09-10 | 2000-09-12 | American Cyanamid Company | Fungicidal trifluorophenyl-triazolopyrimidines |
| US6268371B1 (en) | 1998-09-10 | 2001-07-31 | American Cyanamid Co. | Fungicidal mixtures |
| JP2002525291A (ja) | 1998-09-25 | 2002-08-13 | アメリカン サイアナミツド コンパニー | 非水性懸濁液濃縮物 |
| US5985883A (en) | 1998-09-25 | 1999-11-16 | American Cyanamid Company | Fungicidal trichlorophenyl-triazolopyrimidines |
| JP2000103790A (ja) | 1998-09-25 | 2000-04-11 | American Cyanamid Co | 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類 |
| US5986135A (en) | 1998-09-25 | 1999-11-16 | American Cyanamid Company | Fungicidal trifluoromethylalkylamino-triazolopyrimidines |
| EP0988790B1 (en) | 1998-09-25 | 2003-05-21 | Basf Aktiengesellschaft | Fungicidal mixtures |
| US6156925A (en) | 1998-09-25 | 2000-12-05 | American Cyanamid Company | Process for the preparation of halogenated phenylmaloates |
| US6242451B1 (en) | 1998-09-25 | 2001-06-05 | Klaus-Juergen Pees | Fungicidal trihalophenyl-triazolopyrimidines |
| US6277856B1 (en) | 1998-09-25 | 2001-08-21 | American Cynamid Co. | Fungicidal mixtures |
| JP4025468B2 (ja) | 1999-07-29 | 2007-12-19 | 三井化学株式会社 | 有機電界発光素子 |
| WO2001035738A2 (en) | 1999-11-18 | 2001-05-25 | Basf Corporation | Non-aqueous concentrated spreading oil composition |
| US6559151B2 (en) | 2000-05-08 | 2003-05-06 | Basf Aktiengesellschaft | 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines |
| HK1052646A1 (zh) * | 2000-06-30 | 2003-09-26 | Wyeth | 替代三氮苯(triazolopyrimidines)作为抗癌剂 |
| PT1313370E (pt) | 2000-08-25 | 2004-10-29 | Basf Ag | Formulacao fungicida |
| DE60013188T2 (de) | 2000-12-06 | 2004-12-30 | Basf Ag | Fungiizide 6-(trifluormethyl-phenyl)-triazolpyrimidine |
| WO2002067679A1 (en) | 2001-02-19 | 2002-09-06 | Basf Aktiengesellschaft | Fungicidal mixtures |
| BR0208756A (pt) | 2001-04-11 | 2004-05-11 | Basf Ag | Compostos, processo para a preparação dos mesmos, composição adequada para o controle de fungos fitopatogênicos, e, método para controlar fungos fitopatogênicos |
| EP1431299B1 (en) | 2001-09-04 | 2007-05-23 | Sumitomo Chemical Company, Limited | IMIDAZO(1,2-a)PYRIMIDINES AND FUNGICIDE COMPOSITIONS CONTAINING THE SAME |
| WO2003089433A1 (en) * | 2002-04-19 | 2003-10-30 | Sumitomo Chemical Company, Limited | 5,6-DIPHENYLIMIDAZO[1,2-a]PYRIMIDINE AND BACTERICIDAL COMPOSITION CONTAINING THE SAME |
-
2004
- 2004-09-17 EP EP04784454A patent/EP1684763B1/en not_active Expired - Lifetime
- 2004-09-17 DK DK04784454T patent/DK1684763T3/da active
- 2004-09-17 ES ES04784454T patent/ES2308256T3/es not_active Expired - Lifetime
- 2004-09-17 JP JP2006528080A patent/JP4695595B2/ja not_active Expired - Fee Related
- 2004-09-17 CA CA002537520A patent/CA2537520A1/en not_active Abandoned
- 2004-09-17 CN CNB2004800273126A patent/CN100486580C/zh not_active Expired - Fee Related
- 2004-09-17 BR BRPI0414778-2A patent/BRPI0414778A/pt not_active IP Right Cessation
- 2004-09-17 AT AT04784454T patent/ATE398452T1/de not_active IP Right Cessation
- 2004-09-17 WO PCT/US2004/030595 patent/WO2005030218A1/en not_active Ceased
- 2004-09-17 PL PL04784454T patent/PL1684763T3/pl unknown
- 2004-09-17 AU AU2004275728A patent/AU2004275728A1/en not_active Withdrawn
- 2004-09-17 MX MXPA06002939A patent/MXPA06002939A/es active IP Right Grant
- 2004-09-17 DE DE602004014525T patent/DE602004014525D1/de not_active Expired - Lifetime
- 2004-09-24 US US10/950,542 patent/US7285555B2/en not_active Expired - Fee Related
-
2007
- 2007-09-19 US US11/903,100 patent/US7915266B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN100486580C (zh) | 2009-05-13 |
| US7285555B2 (en) | 2007-10-23 |
| ATE398452T1 (de) | 2008-07-15 |
| JP4695595B2 (ja) | 2011-06-08 |
| JP2007506745A (ja) | 2007-03-22 |
| DE602004014525D1 (de) | 2008-07-31 |
| AU2004275728A1 (en) | 2005-04-07 |
| US20080255157A1 (en) | 2008-10-16 |
| EP1684763A1 (en) | 2006-08-02 |
| DK1684763T3 (da) | 2008-09-01 |
| MXPA06002939A (es) | 2006-05-31 |
| WO2005030218A1 (en) | 2005-04-07 |
| US20050065167A1 (en) | 2005-03-24 |
| PL1684763T3 (pl) | 2008-11-28 |
| EP1684763B1 (en) | 2008-06-18 |
| US7915266B2 (en) | 2011-03-29 |
| ES2308256T3 (es) | 2008-12-01 |
| CA2537520A1 (en) | 2005-04-07 |
| CN1856311A (zh) | 2006-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA200900152A1 (ru) | Ингибиторы пирролотриазинкиназы | |
| TW200740815A (en) | P38 MAP kinase inhibitors and methods for using the same | |
| ATE437872T1 (de) | Proteinkinaseinhibitoren | |
| CY1113538T1 (el) | Παραγωγα της 5-αμινο-2,4,7-τριοξο-3,4,7,8-τετραϋδρο-2η-πυριδο[2,3-d] πυριμιδινης και παρομοιες ενωσεις για την αγωγη του καρκινου | |
| BRPI0412347A (pt) | 2-aminofenil-4-fenilpiridinas como inibidores de quinase | |
| GEP20115174B (en) | Triazolopyrazine derivatives useful as anti-cancer agents | |
| DK1646389T3 (da) | Pyrimidin-2,4-dionderivater som gonadotropinfrigörende hormonreceptorantagonister | |
| ATE440603T1 (de) | 8-hydroxychinolinderivate | |
| TW200833686A (en) | Fused bicyclic derivatives of 2,4-diaminopyrimidine as ALK and c-Met inhibitors | |
| IS8503A (is) | Azatvíhringja heteróhringir sem kannabínóníð-viðtakastillar | |
| TW200728307A (en) | Novel spirochromanone derivatives | |
| BRPI0510560A (pt) | pirido[2,3-d] pirimidin-7-onas pirrolil substituìdas e seus derivados como agentes terapêuticos | |
| TW200612958A (en) | Substituted imidazole derivatives | |
| MX2010013682A (es) | Derivados de 2,4-diamino-l,3,5-triazina triciclicos utiles para el tratamiento del cancer y trastornos mieloproliferativos. | |
| EA200970936A1 (ru) | СОЕДИНЕНИЯ ПИРИДО[2,3-d]ПИРИМИДИН-7-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ PI3K-АЛЬФА ДЛЯ ЛЕЧЕНИЯ РАКА | |
| MX2007013624A (es) | Inhibidores de proteina cinasa. | |
| IL191751A0 (en) | Pyrrolo[2,3-c]pyridine derivatives | |
| MXPA06009475A (es) | Derivados de quinazolina y usos terapeuticos de los mismos. | |
| WO2007120333A3 (en) | Tetracyclic kinase inhibitors | |
| MX2007007027A (es) | Derivados piperazinilpiridina como agentes anti-obesidad. | |
| MX2010001303A (es) | Compuestos terapeuticos. | |
| ATE489399T1 (de) | Antitumor wirksame 2-substituierte estra-1,3, 5(10)-trien-3-yl sulfamate | |
| BRPI0414778A (pt) | 6-aril-7-halo-imidazo[1,2-a]pirimidinas como agentes anticáncer | |
| MX2009005242A (es) | Derivados de 3-(hetero)arilisoquinolinamida sustituida en posición 5, 6 o 7 y uso terapeutico del mismo. | |
| UA86873C2 (en) | SUBSTITUTED ARYL 1,4-PYRAZlNE DERIVATIVES |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE AS 6A E 7A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |