CN100486580C - 作为抗癌剂的6-芳基-7-卤基-咪唑并[1,2-a]嘧啶 - Google Patents

作为抗癌剂的6-芳基-7-卤基-咪唑并[1,2-a]嘧啶 Download PDF

Info

Publication number
CN100486580C
CN100486580C CNB2004800273126A CN200480027312A CN100486580C CN 100486580 C CN100486580 C CN 100486580C CN B2004800273126 A CNB2004800273126 A CN B2004800273126A CN 200480027312 A CN200480027312 A CN 200480027312A CN 100486580 C CN100486580 C CN 100486580C
Authority
CN
China
Prior art keywords
alkyl
pharmaceutically acceptable
formula
chemical compound
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB2004800273126A
Other languages
English (en)
Chinese (zh)
Other versions
CN1856311A (zh
Inventor
张楠
塞米拉米斯·艾拉尔-卡劳斯蒂安
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
Wyeth Holdings LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Holdings LLC filed Critical Wyeth Holdings LLC
Publication of CN1856311A publication Critical patent/CN1856311A/zh
Application granted granted Critical
Publication of CN100486580C publication Critical patent/CN100486580C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB2004800273126A 2003-09-24 2004-09-17 作为抗癌剂的6-芳基-7-卤基-咪唑并[1,2-a]嘧啶 Expired - Fee Related CN100486580C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50548603P 2003-09-24 2003-09-24
US60/505,486 2003-09-24

Publications (2)

Publication Number Publication Date
CN1856311A CN1856311A (zh) 2006-11-01
CN100486580C true CN100486580C (zh) 2009-05-13

Family

ID=34393021

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2004800273126A Expired - Fee Related CN100486580C (zh) 2003-09-24 2004-09-17 作为抗癌剂的6-芳基-7-卤基-咪唑并[1,2-a]嘧啶

Country Status (14)

Country Link
US (2) US7285555B2 (cg-RX-API-DMAC7.html)
EP (1) EP1684763B1 (cg-RX-API-DMAC7.html)
JP (1) JP4695595B2 (cg-RX-API-DMAC7.html)
CN (1) CN100486580C (cg-RX-API-DMAC7.html)
AT (1) ATE398452T1 (cg-RX-API-DMAC7.html)
AU (1) AU2004275728A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0414778A (cg-RX-API-DMAC7.html)
CA (1) CA2537520A1 (cg-RX-API-DMAC7.html)
DE (1) DE602004014525D1 (cg-RX-API-DMAC7.html)
DK (1) DK1684763T3 (cg-RX-API-DMAC7.html)
ES (1) ES2308256T3 (cg-RX-API-DMAC7.html)
MX (1) MXPA06002939A (cg-RX-API-DMAC7.html)
PL (1) PL1684763T3 (cg-RX-API-DMAC7.html)
WO (1) WO2005030218A1 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2302391T3 (es) * 1998-12-18 2008-07-01 HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT COMPANY, LTD. Procedimiento de administracion de un compuesto a celulas resistentes a multi-farmacos.
DK2495016T3 (da) 2005-12-23 2019-12-16 Ariad Pharma Inc Bicykliske heteroarylforbindelser
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
TW224044B (cg-RX-API-DMAC7.html) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
TW258648B (cg-RX-API-DMAC7.html) 1993-03-04 1995-10-01 Shell Internat Res Schappej Bv
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
DK0984919T3 (da) 1997-03-18 2003-05-12 Basf Ag Fremgangsmåde til fremstilling af arylmalonater
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6117876A (en) 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6255309B1 (en) 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
CZ292964B6 (cs) 1998-02-11 2004-01-14 Wyeth Holdings Corporation Triazolopyrimidiny, způsob jejich přípravy, fungicidní kompozice s jejich obsahem, způsob potírání hub a použití
US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US6124301A (en) 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
US6284762B1 (en) 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
ATE299505T1 (de) 1998-03-23 2005-07-15 Basf Ag Fungizide 6-(2-halo-4-alkoxyphenyl)- triazolopyrimidine
US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6117865A (en) 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6268371B1 (en) 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6156925A (en) 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
HUP0103741A3 (en) 1998-09-25 2004-09-28 Basf Ag Non-aqueous suspension concentrate
US6277856B1 (en) 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
SI0988790T1 (en) 1998-09-25 2003-10-31 Basf Aktiengesellschaft Fungicidal mixtures
US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
JP4025468B2 (ja) 1999-07-29 2007-12-19 三井化学株式会社 有機電界発光素子
WO2001035738A2 (en) 1999-11-18 2001-05-25 Basf Corporation Non-aqueous concentrated spreading oil composition
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
NZ523807A (en) * 2000-06-30 2004-09-24 Wyeth Corp Substituted-triazolopyrimidines as anticancer agents
AR031396A1 (es) 2000-08-25 2003-09-24 Basf Ag Una formulacion fungicida acuosa concentrada para aplicar a las plantas, un metodo de aplicacion de dicha composicion y un kit para la preparacion de una mezcla de aspersion que contiene dicha formulacion
ES2226968T3 (es) 2000-12-06 2005-04-01 Wyeth 6-(2-trifluorometilfenil)-triazolopirimidinas fungicidas.
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
NZ528745A (en) 2001-04-11 2005-03-24 Basf Ag 5-halogen-6-phenyl-7-fluoralkylamino-triazolopyrimidines as fungicides and their preparation process
WO2003022850A1 (en) * 2001-09-04 2003-03-20 Sumitomo Chemical Company, Limited IMIDAZO[1,2-a]PYRIMIDINES AND FUNGICIDE COMPOSITIONS CONTAINING THE SAME
AU2003211651A1 (en) * 2002-04-19 2003-11-03 Sumitomo Chemical Company, Limited 5,6-DIPHENYLIMIDAZO(1,2-a)PYRIMIDINE AND BACTERICIDAL COMPOSITION CONTAINING THE SAME

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

Also Published As

Publication number Publication date
DE602004014525D1 (de) 2008-07-31
DK1684763T3 (da) 2008-09-01
JP2007506745A (ja) 2007-03-22
BRPI0414778A (pt) 2006-11-21
AU2004275728A1 (en) 2005-04-07
CA2537520A1 (en) 2005-04-07
EP1684763A1 (en) 2006-08-02
WO2005030218A1 (en) 2005-04-07
US7915266B2 (en) 2011-03-29
ES2308256T3 (es) 2008-12-01
ATE398452T1 (de) 2008-07-15
US7285555B2 (en) 2007-10-23
MXPA06002939A (es) 2006-05-31
JP4695595B2 (ja) 2011-06-08
CN1856311A (zh) 2006-11-01
PL1684763T3 (pl) 2008-11-28
US20050065167A1 (en) 2005-03-24
US20080255157A1 (en) 2008-10-16
EP1684763B1 (en) 2008-06-18

Similar Documents

Publication Publication Date Title
TWI290919B (en) Nitrogen-containing five-membered ring compound, a pharmacologically permissible salt thereof and the method for producing the same
TW201219394A (en) Inhibitors of PI3K-delta and methods of their use and manufacture
CN100519559C (zh) 作为抗癌剂的6-[(经取代的)苯基]三唑并嘧啶
EP1663241B1 (en) 5-arylpyrimidines as anticancer agents
WO2008067756A1 (fr) Dérivés de 3-pyrrolo-cyclohexylène-2-dihydro-indolinone et utilisations de ceux-ci
EP1515965A1 (de) Phenylaminopyrimidine und ihre verwendung als rho-kinase inhibitoren
MXPA06002347A (es) Compuestos y composiciones como inhibidores de quinasa de proteina.
US7915266B2 (en) 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agents
CN101370813A (zh) 用作抗癌药物的6-[(取代的)苯基]三唑并嘧啶类的二聚体和加合物
HK1090374B (en) 6- [(substituted)phenyl] triazolopyrimidines as anticancer agents

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1096615

Country of ref document: HK

C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090513

Termination date: 20091019

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1096615

Country of ref document: HK