DK1684763T3 - 6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel - Google Patents

6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel

Info

Publication number
DK1684763T3
DK1684763T3 DK04784454T DK04784454T DK1684763T3 DK 1684763 T3 DK1684763 T3 DK 1684763T3 DK 04784454 T DK04784454 T DK 04784454T DK 04784454 T DK04784454 T DK 04784454T DK 1684763 T3 DK1684763 T3 DK 1684763T3
Authority
DK
Denmark
Prior art keywords
imidazo
halo
aryl
pyrimidines
anticancer agent
Prior art date
Application number
DK04784454T
Other languages
Danish (da)
English (en)
Inventor
Nan Zhang
Semiramis Ayral-Kaloustian
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Application granted granted Critical
Publication of DK1684763T3 publication Critical patent/DK1684763T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DK04784454T 2003-09-24 2004-09-17 6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel DK1684763T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50548603P 2003-09-24 2003-09-24
PCT/US2004/030595 WO2005030218A1 (en) 2003-09-24 2004-09-17 6-aryl-7-halo-imidazo[1,2-a]pyrimidines as anticancer agent

Publications (1)

Publication Number Publication Date
DK1684763T3 true DK1684763T3 (da) 2008-09-01

Family

ID=34393021

Family Applications (1)

Application Number Title Priority Date Filing Date
DK04784454T DK1684763T3 (da) 2003-09-24 2004-09-17 6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel

Country Status (14)

Country Link
US (2) US7285555B2 (cg-RX-API-DMAC7.html)
EP (1) EP1684763B1 (cg-RX-API-DMAC7.html)
JP (1) JP4695595B2 (cg-RX-API-DMAC7.html)
CN (1) CN100486580C (cg-RX-API-DMAC7.html)
AT (1) ATE398452T1 (cg-RX-API-DMAC7.html)
AU (1) AU2004275728A1 (cg-RX-API-DMAC7.html)
BR (1) BRPI0414778A (cg-RX-API-DMAC7.html)
CA (1) CA2537520A1 (cg-RX-API-DMAC7.html)
DE (1) DE602004014525D1 (cg-RX-API-DMAC7.html)
DK (1) DK1684763T3 (cg-RX-API-DMAC7.html)
ES (1) ES2308256T3 (cg-RX-API-DMAC7.html)
MX (1) MXPA06002939A (cg-RX-API-DMAC7.html)
PL (1) PL1684763T3 (cg-RX-API-DMAC7.html)
WO (1) WO2005030218A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2302391T3 (es) * 1998-12-18 2008-07-01 HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT COMPANY, LTD. Procedimiento de administracion de un compuesto a celulas resistentes a multi-farmacos.
DK2495016T3 (da) 2005-12-23 2019-12-16 Ariad Pharma Inc Bicykliske heteroarylforbindelser
CN101600350A (zh) * 2007-01-08 2009-12-09 巴斯夫欧洲公司 唑并嘧啶在防治植物病原性有害真菌中的用途
CN107935870A (zh) * 2017-11-09 2018-04-20 华中药业股份有限公司 一种2‑甲氨基‑5‑氯二苯甲酮的合成方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5593996A (en) * 1991-12-30 1997-01-14 American Cyanamid Company Triazolopyrimidine derivatives
TW224044B (cg-RX-API-DMAC7.html) 1991-12-30 1994-05-21 Shell Internat Res Schappej B V
JP2794510B2 (ja) 1992-03-27 1998-09-10 富士写真フイルム株式会社 ハロゲン化銀写真感光材料
IL108747A (en) 1993-03-04 1999-03-12 Shell Int Research Mushroom-killing preparations containing a history of 6 metamorphoses of 5 - 7 Dihalo - 1, 2 - 4 Triazlo [A-1,5] Pyrimidine Certain such new compounds and their preparation
TW258648B (cg-RX-API-DMAC7.html) 1993-03-04 1995-10-01 Shell Internat Res Schappej Bv
RU2147584C1 (ru) 1995-10-27 2000-04-20 Американ Цианамид Компани Способ получения дигалоидазолопиримидинов и способ получения дигидроксиазолопиримидинов
US5817663A (en) 1996-10-07 1998-10-06 American Cyanamid Company Pentafluorophenylazolopyrimidines
DK0984919T3 (da) 1997-03-18 2003-05-12 Basf Ag Fremgangsmåde til fremstilling af arylmalonater
US5750766A (en) 1997-03-18 1998-05-12 American Cyanamid Company Process for the preparation of arylmalonates
US5948783A (en) 1997-04-14 1999-09-07 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6117876A (en) 1997-04-14 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6255309B1 (en) 1999-03-19 2001-07-03 American Cyanomid Co. Fungicidal trifluoromethylalkylamino-triazolopyrimidines
TWI252231B (en) 1997-04-14 2006-04-01 American Cyanamid Co Fungicidal trifluorophenyl-triazolopyrimidines
TW460476B (en) 1997-04-14 2001-10-21 American Cyanamid Co Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US5994360A (en) 1997-07-14 1999-11-30 American Cyanamid Company Fungicidal 5-alkyl-triazolopyrimidines
CZ292964B6 (cs) 1998-02-11 2004-01-14 Wyeth Holdings Corporation Triazolopyrimidiny, způsob jejich přípravy, fungicidní kompozice s jejich obsahem, způsob potírání hub a použití
US6020338A (en) 1998-02-11 2000-02-01 American Cyanamid Company Fungicidal 7-alkyl-triazolopyrimidines
JPH11322517A (ja) 1998-03-17 1999-11-24 American Cyanamid Co トリアゾロピリミジン類の効力の増進
US6124301A (en) 1998-03-17 2000-09-26 American Cyanamid Company Enhancement of the efficacy of triazolopyrimidines
US6284762B1 (en) 1998-03-23 2001-09-04 American Cyanamid Company Fungicidal 6-(2-halo-4-alkoxyphenyl)-triazolopyrimidines
ATE299505T1 (de) 1998-03-23 2005-07-15 Basf Ag Fungizide 6-(2-halo-4-alkoxyphenyl)- triazolopyrimidine
US5981534A (en) 1998-09-25 1999-11-09 American Cyanamid Company Fungicidal 6-(2,6-difluoro-4-alkoxyphenyl)-triazolopyrimidines
US6117865A (en) 1998-09-10 2000-09-12 American Cyanamid Company Fungicidal trifluorophenyl-triazolopyrimidines
US6268371B1 (en) 1998-09-10 2001-07-31 American Cyanamid Co. Fungicidal mixtures
US5986135A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trifluoromethylalkylamino-triazolopyrimidines
US6156925A (en) 1998-09-25 2000-12-05 American Cyanamid Company Process for the preparation of halogenated phenylmaloates
HUP0103741A3 (en) 1998-09-25 2004-09-28 Basf Ag Non-aqueous suspension concentrate
US6277856B1 (en) 1998-09-25 2001-08-21 American Cynamid Co. Fungicidal mixtures
JP2000103790A (ja) 1998-09-25 2000-04-11 American Cyanamid Co 殺菌・殺カビ性のトリハロフェニル―トリアゾロピリミジン類
US6242451B1 (en) 1998-09-25 2001-06-05 Klaus-Juergen Pees Fungicidal trihalophenyl-triazolopyrimidines
SI0988790T1 (en) 1998-09-25 2003-10-31 Basf Aktiengesellschaft Fungicidal mixtures
US5985883A (en) 1998-09-25 1999-11-16 American Cyanamid Company Fungicidal trichlorophenyl-triazolopyrimidines
JP4025468B2 (ja) 1999-07-29 2007-12-19 三井化学株式会社 有機電界発光素子
WO2001035738A2 (en) 1999-11-18 2001-05-25 Basf Corporation Non-aqueous concentrated spreading oil composition
US6559151B2 (en) 2000-05-08 2003-05-06 Basf Aktiengesellschaft 6-(2-trifluoromethyl-phenyl)-triazolopyrimidines
NZ523807A (en) * 2000-06-30 2004-09-24 Wyeth Corp Substituted-triazolopyrimidines as anticancer agents
AR031396A1 (es) 2000-08-25 2003-09-24 Basf Ag Una formulacion fungicida acuosa concentrada para aplicar a las plantas, un metodo de aplicacion de dicha composicion y un kit para la preparacion de una mezcla de aspersion que contiene dicha formulacion
ES2226968T3 (es) 2000-12-06 2005-04-01 Wyeth 6-(2-trifluorometilfenil)-triazolopirimidinas fungicidas.
WO2002067679A1 (en) 2001-02-19 2002-09-06 Basf Aktiengesellschaft Fungicidal mixtures
NZ528745A (en) 2001-04-11 2005-03-24 Basf Ag 5-halogen-6-phenyl-7-fluoralkylamino-triazolopyrimidines as fungicides and their preparation process
WO2003022850A1 (en) * 2001-09-04 2003-03-20 Sumitomo Chemical Company, Limited IMIDAZO[1,2-a]PYRIMIDINES AND FUNGICIDE COMPOSITIONS CONTAINING THE SAME
AU2003211651A1 (en) * 2002-04-19 2003-11-03 Sumitomo Chemical Company, Limited 5,6-DIPHENYLIMIDAZO(1,2-a)PYRIMIDINE AND BACTERICIDAL COMPOSITION CONTAINING THE SAME

Also Published As

Publication number Publication date
DE602004014525D1 (de) 2008-07-31
JP2007506745A (ja) 2007-03-22
CN100486580C (zh) 2009-05-13
BRPI0414778A (pt) 2006-11-21
AU2004275728A1 (en) 2005-04-07
CA2537520A1 (en) 2005-04-07
EP1684763A1 (en) 2006-08-02
WO2005030218A1 (en) 2005-04-07
US7915266B2 (en) 2011-03-29
ES2308256T3 (es) 2008-12-01
ATE398452T1 (de) 2008-07-15
US7285555B2 (en) 2007-10-23
MXPA06002939A (es) 2006-05-31
JP4695595B2 (ja) 2011-06-08
CN1856311A (zh) 2006-11-01
PL1684763T3 (pl) 2008-11-28
US20050065167A1 (en) 2005-03-24
US20080255157A1 (en) 2008-10-16
EP1684763B1 (en) 2008-06-18

Similar Documents

Publication Publication Date Title
TW200728307A (en) Novel spirochromanone derivatives
ATE440603T1 (de) 8-hydroxychinolinderivate
GEP20115174B (en) Triazolopyrazine derivatives useful as anti-cancer agents
UA83091C2 (en) Pyrido[2,3-d]pyrimidine-2,4-diamines as pde 2 inhibitors
DK1761528T3 (da) 5-Amino-2,4,7-trioxo-3,4,7,8-tetrahydro-2H-pyrido[2,3-d]pyrimidin-derivater og beslægtede forbindelser til behandling af cancer
MXPA05011643A (es) 5,7-diaminopirazolo[4,3-d]pirimidinas en el tratamiento de hipertension.
WO2005110410A3 (en) Kinase inhibitors as therapeutic agents
WO2006067614A3 (en) Heteroaromatic derivatives useful as anticancer agents
DK1646389T3 (da) Pyrimidin-2,4-dionderivater som gonadotropinfrigörende hormonreceptorantagonister
ATE437872T1 (de) Proteinkinaseinhibitoren
BG108268A (en) Pyrazolopyrimidines as therapeutic agents
ATE430747T1 (de) 2-pyrimidinyl-pyrazolopyridin-erbb- kinaseinhibitoren
MY145074A (en) Thiazolidin-4-one derivatives
GB0112348D0 (en) Compounds
MX2009005292A (es) Metodo de radiosensibilizacion de tumores usando un agente radiosensibilizante.
IS2517B (is) Notkun á setnum 2-amínótetralínum í fyrirbyggjandi meðferð á Parkinsons-veiki
MX2007013624A (es) Inhibidores de proteina cinasa.
WO2007120333A3 (en) Tetracyclic kinase inhibitors
TR200102514T2 (tr) COPD tedavisi için metod
BR0207102A (pt) Forma cristalina, composição farmacêutica, uso de uma forma cristalina, e, método para a prevenção ou o tratamento de doença
ATE489399T1 (de) Antitumor wirksame 2-substituierte estra-1,3, 5(10)-trien-3-yl sulfamate
DK1684763T3 (da) 6-Aryl-7-halogen-imidazo(1,2-a)pyrimidiner som anticancermiddel
WO2008063548A3 (en) 5, 6, or 7-substituted-s- (hetero)arylisoquinolinamine derivatives as antitumor agents
AU7122501A (en) Aryl sulfonamides as serotonin antagonist for the treatment of obesity
WO2008098077A3 (en) Substituted alkine derivatives as anti-cancer agents