CN100477993C - 用于治疗癌症的海鞘素743的组合物和用途 - Google Patents

用于治疗癌症的海鞘素743的组合物和用途 Download PDF

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Publication number
CN100477993C
CN100477993C CNB2005100091622A CN200510009162A CN100477993C CN 100477993 C CN100477993 C CN 100477993C CN B2005100091622 A CNB2005100091622 A CN B2005100091622A CN 200510009162 A CN200510009162 A CN 200510009162A CN 100477993 C CN100477993 C CN 100477993C
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China
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patient
purposes
cancer
treatment
people
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Expired - Lifetime
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CNB2005100091622A
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English (en)
Chinese (zh)
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CN1679631A (zh
Inventor
E·维科维克
G·D·德梅特里
C·古兹曼
J·吉门奥
L·罗佩兹拉扎罗
J·L·米斯瑟特
C·特威维斯
D·D·冯霍夫
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Pharmamar SA
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Pharmamar SA
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Priority claimed from GBGB9911183.3A external-priority patent/GB9911183D0/en
Priority claimed from GBGB9911346.6A external-priority patent/GB9911346D0/en
Priority claimed from GBGB9918534.0A external-priority patent/GB9918534D0/en
Priority claimed from GBGB9927005.0A external-priority patent/GB9927005D0/en
Priority claimed from GBGB9927106.6A external-priority patent/GB9927106D0/en
Priority claimed from GB0007637A external-priority patent/GB0007637D0/en
Application filed by Pharmamar SA filed Critical Pharmamar SA
Publication of CN1679631A publication Critical patent/CN1679631A/zh
Application granted granted Critical
Publication of CN100477993C publication Critical patent/CN100477993C/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CNB2005100091622A 1999-05-13 2000-05-15 用于治疗癌症的海鞘素743的组合物和用途 Expired - Lifetime CN100477993C (zh)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
GB9911183.3 1999-05-13
GBGB9911183.3A GB9911183D0 (en) 1999-05-13 1999-05-13 Treatment of cancers
GB9911346.6 1999-05-14
GBGB9911346.6A GB9911346D0 (en) 1999-05-14 1999-05-14 Treatment of cancers
GB9918534.0 1999-08-05
GBGB9918534.0A GB9918534D0 (en) 1999-08-05 1999-08-05 Treatment of cancers
GB9927005.0 1999-11-15
GBGB9927005.0A GB9927005D0 (en) 1999-11-15 1999-11-15 Treatment of cancers
GBGB9927106.6A GB9927106D0 (en) 1999-11-16 1999-11-16 Cancer treatment
GB9927106.6 1999-11-16
GB0007637A GB0007637D0 (en) 2000-03-29 2000-03-29 Antitumour compound
GB0007637.2 2000-03-29

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN00809976A Division CN1360503A (zh) 1999-05-13 2000-05-15 用于治疗癌症的海鞘素743的组合物和用途

Publications (2)

Publication Number Publication Date
CN1679631A CN1679631A (zh) 2005-10-12
CN100477993C true CN100477993C (zh) 2009-04-15

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CNB2005100091622A Expired - Lifetime CN100477993C (zh) 1999-05-13 2000-05-15 用于治疗癌症的海鞘素743的组合物和用途
CN00809976A Pending CN1360503A (zh) 1999-05-13 2000-05-15 用于治疗癌症的海鞘素743的组合物和用途

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CN00809976A Pending CN1360503A (zh) 1999-05-13 2000-05-15 用于治疗癌症的海鞘素743的组合物和用途

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US (1) US8119638B2 (https=)
EP (3) EP1702618B1 (https=)
JP (2) JP2002544231A (https=)
KR (1) KR20020019914A (https=)
CN (2) CN100477993C (https=)
AR (1) AR028476A1 (https=)
AT (3) ATE375795T1 (https=)
AU (2) AU777417B2 (https=)
BG (1) BG65680B1 (https=)
BR (1) BR0010531A (https=)
CA (1) CA2373794C (https=)
CY (4) CY1105818T1 (https=)
CZ (1) CZ301482B6 (https=)
DE (4) DE60045720D1 (https=)
DK (3) DK1702618T3 (https=)
ES (2) ES2294756T3 (https=)
FR (1) FR08C0013I2 (https=)
HU (2) HU229866B1 (https=)
IL (2) IL146434A0 (https=)
LU (1) LU91418I2 (https=)
MX (1) MXPA01011562A (https=)
MY (1) MY164077A (https=)
NL (1) NL300337I2 (https=)
NO (2) NO324564B1 (https=)
NZ (1) NZ515423A (https=)
PL (1) PL198185B1 (https=)
PT (3) PT1702618E (https=)
SI (3) SI1176964T1 (https=)
SK (1) SK287580B6 (https=)
TR (1) TR200103819T2 (https=)
UA (1) UA74782C2 (https=)
WO (1) WO2000069441A1 (https=)

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MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
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GB0117402D0 (en) * 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
PL368458A1 (en) * 2001-10-19 2005-03-21 Pharmamar S.A. Improved use of antitumoral compound in cancer therapy
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
GB0312407D0 (en) * 2003-05-29 2003-07-02 Pharma Mar Sau Treatment
GB0324201D0 (en) * 2003-10-15 2003-11-19 Pharma Mar Sau Improved antitumoral combinations
HRP20080598T3 (en) * 2003-11-13 2009-01-31 Pharma Mar Combination of et-743 with 5-fluorouracil pro-drugs for the treatment of cancer
AU2004291037A1 (en) * 2003-11-14 2005-06-02 Pharma Mar, S.A. Combination therapy comprising the use of ET-743 and paclitaxel for treating cancer
GB0326486D0 (en) * 2003-11-14 2003-12-17 Pharma Mar Sau Combination treatment
WO2006005602A2 (en) * 2004-07-09 2006-01-19 Pharma Mar, S.A. Use of ecteinascidin in the treatment of cancer in patients with low level of brca1
EP1827500B1 (en) * 2004-10-26 2009-05-06 Pharma Mar S.A., Sociedad Unipersonal Pegylated liposomal doxorubicin in combination with ecteinescidin 743
ATE368461T1 (de) * 2004-10-29 2007-08-15 Pharma Mar Sa Zusammensetzungen enthaltend ecteinascidin und einen disaccharide
GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
CA2652035A1 (en) * 2006-05-12 2007-11-22 Pharma Mar, S.A. Anticancer treatments
US20100267732A1 (en) * 2007-10-19 2010-10-21 Pharma Mar, S.A. Prognostic Molecular Markers for ET-743 Treatment
CA3011527A1 (en) * 2016-02-04 2017-08-10 Jiangsu Hengrui Medicine Co., Ltd. Trabectedin-inclusive injectable pharmaceutical composition for gastrointestinal external use and method for manufacturing the same
KR102491180B1 (ko) 2017-04-27 2023-01-20 파르마 마르 에스.에이. 항종양 화합물
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
CN112574234B (zh) * 2019-09-27 2022-05-24 江苏恒瑞医药股份有限公司 一种海鞘素衍生物的制备方法
EP4353232A3 (en) 2020-04-15 2024-06-26 EVER Valinject GmbH Composition comprising trabectedin and an amino acid
EP3960177A1 (en) * 2020-08-26 2022-03-02 Anturec Pharmaceuticals GmbH Composition comprising ttf-ngr for use in treating soft-tissue sarcoma
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Publication number Publication date
KR20020019914A (ko) 2002-03-13
LU91418I2 (fr) 2008-05-13
EP1702618A3 (en) 2006-12-27
HU229866B1 (en) 2014-10-28
TR200103819T2 (tr) 2002-04-22
ES2294756T3 (es) 2008-04-01
EP1716853A2 (en) 2006-11-02
DE60030554T2 (de) 2007-09-13
AU2005200180B2 (en) 2007-12-13
CY1107143T1 (el) 2010-07-28
DK1716853T3 (da) 2011-06-27
EP1716853B9 (en) 2011-09-28
CN1679631A (zh) 2005-10-12
NO20015516D0 (no) 2001-11-12
WO2000069441A1 (en) 2000-11-23
FR08C0013I2 (fr) 2009-10-30
EP1716853B1 (en) 2011-03-09
EP1176964B1 (en) 2006-09-06
EP1176964A1 (en) 2002-02-06
AR028476A1 (es) 2003-05-14
AU2005200180B9 (en) 2008-05-29
BR0010531A (pt) 2002-06-04
EP1176964B8 (en) 2007-10-10
US8119638B2 (en) 2012-02-21
CY2008007I2 (el) 2009-11-04
DK1702618T3 (da) 2008-02-25
SI1176964T1 (sl) 2007-02-28
PT1176964E (pt) 2007-01-31
NZ515423A (en) 2004-04-30
IL146434A0 (en) 2002-07-25
SI1716853T1 (sl) 2011-10-28
CY1105818T1 (el) 2011-02-02
JP2002544231A (ja) 2002-12-24
JP5777562B2 (ja) 2015-09-09
FR08C0013I1 (https=) 2008-05-30
EP1716853A3 (en) 2006-11-15
CA2373794C (en) 2005-10-11
NL300337I2 (nl) 2008-09-01
JP2012149095A (ja) 2012-08-09
PL352931A1 (en) 2003-09-22
DE60045720D1 (de) 2011-04-21
NO324564B1 (no) 2007-11-19
AU777417B2 (en) 2004-10-14
MY164077A (en) 2017-11-30
NL300337I1 (nl) 2008-05-01
AU2005200180A1 (en) 2005-02-10
DE60030554D1 (de) 2006-10-19
UA74782C2 (uk) 2006-02-15
NO2008005I2 (https=) 2010-09-27
IL146434A (en) 2008-03-20
CZ301482B6 (cs) 2010-03-17
DK1176964T3 (da) 2007-01-15
DE60036826T2 (de) 2008-08-28
SI1702618T1 (sl) 2008-02-29
PT1702618E (pt) 2008-01-11
CN1360503A (zh) 2002-07-24
CZ20014081A3 (cs) 2002-11-13
NO20015516L (no) 2002-01-11
ATE500830T1 (de) 2011-03-15
PT1716853E (pt) 2011-05-12
NO2008005I1 (no) 2008-06-09
EP1702618B1 (en) 2007-10-17
MXPA01011562A (es) 2002-07-30
SK287580B6 (sk) 2011-03-04
EP1702618A2 (en) 2006-09-20
DE122008000013I1 (de) 2008-08-07
DE60030554T8 (de) 2008-01-10
HUP0201187A2 (en) 2002-09-28
DE60036826D1 (de) 2007-11-29
CY2008007I1 (el) 2009-11-04
CA2373794A1 (en) 2000-11-23
BG106171A (en) 2002-06-28
US20070275942A1 (en) 2007-11-29
SK16442001A3 (sk) 2002-03-05
HUS1500001I1 (hu) 2016-08-29
CY1112753T1 (el) 2016-02-10
ATE375795T1 (de) 2007-11-15
ATE338552T1 (de) 2006-09-15
PL198185B1 (pl) 2008-06-30
BG65680B1 (bg) 2009-06-30
AU4597500A (en) 2000-12-05
HUP0201187A3 (en) 2002-11-28
LU91418I9 (https=) 2019-01-02
ES2272279T3 (es) 2007-05-01

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Granted publication date: 20090415