CN100467476C - 支化链亲脂性分子衍生物及其用途 - Google Patents

支化链亲脂性分子衍生物及其用途 Download PDF

Info

Publication number
CN100467476C
CN100467476C CNB01816806XA CN01816806A CN100467476C CN 100467476 C CN100467476 C CN 100467476C CN B01816806X A CNB01816806X A CN B01816806XA CN 01816806 A CN01816806 A CN 01816806A CN 100467476 C CN100467476 C CN 100467476C
Authority
CN
China
Prior art keywords
compound
oxygen base
purposes
phosphoric acid
ethyl ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB01816806XA
Other languages
English (en)
Chinese (zh)
Other versions
CN1633440A (zh
Inventor
A·科扎克
M·温尼科瓦
M·珀雅克
E·贝特-延奈
D·雷滋尼斯基-科亨
A·森德里克欣
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
D Pharm Ltd
Original Assignee
D Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by D Pharm Ltd filed Critical D Pharm Ltd
Publication of CN1633440A publication Critical patent/CN1633440A/zh
Application granted granted Critical
Publication of CN100467476C publication Critical patent/CN100467476C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/11—Esters of phosphoric acids with hydroxyalkyl compounds without further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Fats And Perfumes (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
CNB01816806XA 2000-08-03 2001-08-01 支化链亲脂性分子衍生物及其用途 Expired - Fee Related CN100467476C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL137672 2000-08-03
IL13767200A IL137672A0 (en) 2000-08-03 2000-08-03 Derivatives of branched-chain lipophilic molecules and uses thereof

Publications (2)

Publication Number Publication Date
CN1633440A CN1633440A (zh) 2005-06-29
CN100467476C true CN100467476C (zh) 2009-03-11

Family

ID=11074480

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB01816806XA Expired - Fee Related CN100467476C (zh) 2000-08-03 2001-08-01 支化链亲脂性分子衍生物及其用途

Country Status (16)

Country Link
US (2) US7186703B2 (https=)
EP (1) EP1305322B1 (https=)
JP (1) JP2004505898A (https=)
KR (1) KR100801207B1 (https=)
CN (1) CN100467476C (https=)
AT (1) ATE455120T1 (https=)
AU (2) AU2001280043B2 (https=)
BR (1) BR0112835A (https=)
CA (1) CA2416808C (https=)
CZ (1) CZ2003208A3 (https=)
DE (1) DE60141074D1 (https=)
ES (1) ES2338987T3 (https=)
HU (1) HUP0301711A3 (https=)
IL (1) IL137672A0 (https=)
NZ (1) NZ523664A (https=)
WO (1) WO2002011666A2 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6518311B2 (en) * 1997-07-09 2003-02-11 D-Pharm Ltd. Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
US7582678B2 (en) 1997-07-09 2009-09-01 D-Pharm Limited Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
MXPA03002934A (es) 2000-10-10 2004-05-04 Univ North Carolina Composiciones y metodos para aumentar la permeabilidad paracelular a traves de las barreras epiteliales y endoteliales.
US7410956B2 (en) 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
CA2482904A1 (en) 2002-04-18 2003-10-23 Lynkeus Biotech Gmbh Means and methods for the specific modulation of target genes in the cns and the eye and methods for their identification
US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
CN1882327A (zh) 2003-11-19 2006-12-20 症变治疗公司 含磷的新的拟甲状腺素药
WO2006128058A2 (en) 2005-05-26 2006-11-30 Metabasis Therapeutics, Inc. Thyromimetics for the treatment of fatty liver diseases
US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
AU2006249347A1 (en) * 2005-05-26 2006-11-30 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
US8703179B2 (en) * 2006-05-11 2014-04-22 Kimberly-Clark Worldwide, Inc. Mucosal formulation
US8236820B2 (en) * 2007-08-10 2012-08-07 Basil Rigas Anti-inflammatory compounds and uses thereof
JP2011513318A (ja) * 2008-02-28 2011-04-28 ヘンリ フオルド ヘルス システム 中枢神経系損傷の治療を強化するために間質細胞を使用する組成物及び方法
WO2010107487A2 (en) * 2009-03-18 2010-09-23 Wu Nian Lipid-drug conjugates for drug delivery
JP5853869B2 (ja) * 2012-06-07 2016-02-09 日油株式会社 ホスホリルコリン基含有化合物及びその製造法
CA3044059A1 (en) 2016-11-21 2018-05-24 Viking Therapeutics, Inc. Method of treating glycogen storage disease
US11707472B2 (en) 2017-06-05 2023-07-25 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis
ES3053674T3 (en) 2018-03-22 2026-01-23 Viking Therapeutics Inc Crystalline forms and methods of producing crystalline forms of a compound
WO2020117962A1 (en) 2018-12-05 2020-06-11 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837023A (en) * 1985-12-04 1989-06-06 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften Compositions containing hexadecylophosphocholine and alkylglycerols and uses thereof
US6030961A (en) * 1997-03-11 2000-02-29 Bar-Ilan Research & Development Co., Ltd. Oxyalkylene phosphate compounds and uses thereof

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3006946A (en) * 1953-03-04 1961-10-31 Union Carbide Corp Production of heterocyclic phosphoruscontaining compounds and products
US3260688A (en) * 1962-08-10 1966-07-12 Toyo Koatsu Ind Inc Resin compositions for producing cellular masses and process for producing a cellular product
US3260668A (en) * 1964-11-04 1966-07-12 Dow Chemical Co Alkaline scale control in saline water conversion equipment
DE2038829C3 (de) * 1970-08-05 1975-11-13 Chemische Werke Huels Ag, 4370 Marl Zusatzmittel zu Mörtel oder Beton auf Zementbasis
LU65735A1 (https=) 1972-07-17 1974-01-28
DE2930756A1 (de) 1979-07-28 1981-02-26 Cassella Ag Klotzhilfsmittel und verfahren zum faerben von cellulosefasern bzw. gemischen von cellulosefasern zusammen mit synthesefasern mit schwefel-, schwefelkuepen-, kuepen- und reaktivfarbstoffen
JPS6038363B2 (ja) 1979-11-27 1985-08-31 ライオン株式会社 ヘアリンス剤
JPS5716064A (en) * 1980-07-04 1982-01-27 Dai Ichi Kogyo Seiyaku Co Ltd Dye dispersion
JPS57112317A (en) * 1980-12-29 1982-07-13 Lion Corp Hairdressing agent composition
JPS5984824A (ja) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd 抗腫瘍剤
JPS6072829A (ja) 1983-09-29 1985-04-24 Kao Corp ベシクル用組成物
JPS60184092A (ja) 1984-03-01 1985-09-19 Kao Corp リン酸エステルおよびその製法
JPH0832832B2 (ja) 1984-03-09 1996-03-29 花王株式会社 加熱瀝青質用添加剤
US4670575A (en) * 1984-06-05 1987-06-02 Kao Corporation Process for purification of phosphoric mono esters
JPS61129189A (ja) 1984-11-28 1986-06-17 Kao Corp リン酸エステルまたはその塩の精製方法
US4736051A (en) 1985-03-20 1988-04-05 Kao Corporation Process for the preparation of an alkali metal salt of a diester phosphoric acid
US4751320A (en) 1985-11-27 1988-06-14 Kao Corporation Phosphoric ester and process for producing same
US5916884A (en) * 1985-12-04 1999-06-29 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften Compositions containing a mixture of phosphorus compounds and alkylglycerols
JPS62177008A (ja) 1986-01-29 1987-08-03 Kao Corp 共重合体の製造法
JPS63122775A (ja) 1986-11-12 1988-05-26 Kao Corp 油ゲル化剤
JPH01290604A (ja) * 1988-05-18 1989-11-22 Dai Ichi Kogyo Seiyaku Co Ltd 水中崩壊性良好な農薬粒剤
WO1989011299A1 (en) 1988-05-18 1989-11-30 State Of Oregon Acting By And Through The State Bo Method for delivery of therapeutic agents to target brain tissue using monoclonal antibody conjugates
US5059415A (en) 1989-02-21 1991-10-22 The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon Health Method for diagnostically imaging lesions in the brain inside a blood-brain barrier
FR2677360B1 (fr) 1991-06-05 1995-04-14 Atta Composes amphiphiles perfluoroalkyles du phosphore, leurs preparations et leurs applications notamment dans le domaine biomedical.
US5846516A (en) * 1992-06-03 1998-12-08 Alliance Pharmaceutial Corp. Perfluoroalkylated amphiphilic phosphorus compounds: preparation and biomedical applications
JP2710900B2 (ja) * 1992-09-02 1998-02-10 株式会社ディ・ディ・エス研究所 酸性官能基を有する脂質誘導体及び同誘導体によって被覆された微粒子キャリヤー
US5491004A (en) * 1994-05-26 1996-02-13 Henkel Corporation Process for applying a low soiling fiber finish
US5686540A (en) * 1995-09-29 1997-11-11 Dainippon Ink And Chemicals, Inc. Process for the preparation of lactic acid-based polyester
JP3747091B2 (ja) * 1996-03-22 2006-02-22 株式会社クラブコスメチックス アポトーシス誘導剤
WO1998055487A1 (en) * 1997-06-04 1998-12-10 Biocompatibles Limited Phosphate compounds
AU7781498A (en) * 1997-06-04 1998-12-21 Biocompatibles Limited Zwitterionic compounds and their use to cross-link collagenous materials
IL121268A0 (en) * 1997-07-09 1998-01-04 Dpharm Ltd Branched chain fatty acids their derivatives and use in the treatment of central nervous system disorders
IL121269A0 (en) 1997-07-09 1998-01-04 Dpharm Ltd Compositions and methods for reversibly increasing permeability of biomembranes
JP2000053897A (ja) * 1998-08-07 2000-02-22 Kao Corp インクジェット記録用水系インク

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4837023A (en) * 1985-12-04 1989-06-06 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften Compositions containing hexadecylophosphocholine and alkylglycerols and uses thereof
US6030961A (en) * 1997-03-11 2000-02-29 Bar-Ilan Research & Development Co., Ltd. Oxyalkylene phosphate compounds and uses thereof

Also Published As

Publication number Publication date
CN1633440A (zh) 2005-06-29
KR100801207B1 (ko) 2008-02-05
JP2004505898A (ja) 2004-02-26
US20070135381A1 (en) 2007-06-14
EP1305322A2 (en) 2003-05-02
CZ2003208A3 (cs) 2003-10-15
ATE455120T1 (de) 2010-01-15
AU2001280043B8 (en) 2002-02-18
WO2002011666A3 (en) 2002-07-11
AU8004301A (en) 2002-02-18
DE60141074D1 (de) 2010-03-04
HUP0301711A3 (en) 2007-05-29
ES2338987T3 (es) 2010-05-14
CA2416808C (en) 2011-11-22
WO2002011666A2 (en) 2002-02-14
IL137672A0 (en) 2001-10-31
CA2416808A1 (en) 2002-02-14
US7687483B2 (en) 2010-03-30
KR20030024823A (ko) 2003-03-26
EP1305322A4 (en) 2005-04-13
HUP0301711A2 (hu) 2003-09-29
EP1305322B1 (en) 2010-01-13
AU2001280043B2 (en) 2007-05-24
NZ523664A (en) 2004-07-30
BR0112835A (pt) 2003-10-21
US7186703B2 (en) 2007-03-06
US20030186897A1 (en) 2003-10-02

Similar Documents

Publication Publication Date Title
CN100467476C (zh) 支化链亲脂性分子衍生物及其用途
Feng et al. A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine
DE60214134T2 (de) Modifizierte psma-liganden und deren verwendung
RU2235727C2 (ru) Растворимые в воде фосфонооксиметиловые эфиры затрудненных спиртов или фенолов, фармацевтические композиции на их основе, способ анестезии и способ лечения опухолевых заболеваний
TW319763B (https=)
Shi et al. PET/NIR-II fluorescence imaging and image-guided surgery of glioblastoma using a folate receptor α-targeted dual-modal nanoprobe
Elliott et al. Intravenous RMP-7 selectively increases uptake of carboplatin into rat brain tumors
ES2963120T3 (es) Molécula fluorescente en el infrarrojo cercano de reconocimiento activo para el reconocimiento del receptor de folato y procedimiento de preparación de la misma
KR20110018897A (ko) 수용성 아세트아미노펜 유사체
WO2007112100A2 (en) Highly fluorinated oils and surfactants and methods of making and using same
CN108430520A (zh) 长效钆基肿瘤靶向成像与治疗剂
AU2001280043A1 (en) Derivatives of branched-chain lipophilic molecules and uses thereof
KR20070028312A (ko) 교란된 막에 결합하는 화합물 및 그 이용 방법
CN104800828A (zh) 用于治疗癌症的有机砷化合物和方法
WO2013085422A2 (ru) Противотуберкулезная композиция и способ ее получения
Gumpel Deaths associated with gold treatment: a reassessment
DE19824653A1 (de) Nekrose-affine Verbindungen und ihre Verwendung zur Herstellung von Präparaten zur Pharmakotherapie
KR20130097121A (ko) 암 전이를 치료하기 위한 방법 및 조성물
JP5956533B2 (ja) 放射ターゲット薬物調製用キット及び放射ターゲット薬物の調製方法及び用途
WO2019216477A1 (ko) 엽산 수용체 타겟팅 종양 진단 방사성 프로브의 개발 및 응용
ES2254130T3 (es) Sales del acido 2-metil-3-butenil-1-pirofosforico y agentes para tratar linfocitos.
CN118146291A (zh) 一种蛋白降解靶向嵌合体化合物及其组合物和应用
US9119874B2 (en) Cell-penetrating markers of apoptosis
Ehrlichova et al. 937 Reversal of paclitaxel resistance: the potency of third-generation stony brook taxanes in ovarian cancer
Basler et al. Coccidioidomycosis: clinical review and treatment update.

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C17 Cessation of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20090311

Termination date: 20120801