DE60141074D1 - Derivate von kettenverzweigten lipophilen molekülen und deren verwendung - Google Patents
Derivate von kettenverzweigten lipophilen molekülen und deren verwendungInfo
- Publication number
- DE60141074D1 DE60141074D1 DE60141074T DE60141074T DE60141074D1 DE 60141074 D1 DE60141074 D1 DE 60141074D1 DE 60141074 T DE60141074 T DE 60141074T DE 60141074 T DE60141074 T DE 60141074T DE 60141074 D1 DE60141074 D1 DE 60141074D1
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- chain
- lipophiles
- molecules
- derived
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000002634 lipophilic molecules Chemical class 0.000 abstract 2
- 230000004888 barrier function Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000004614 tumor growth Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/11—Esters of phosphoric acids with hydroxyalkyl compounds without further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Virology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
- Fats And Perfumes (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL13767200A IL137672A0 (en) | 2000-08-03 | 2000-08-03 | Derivatives of branched-chain lipophilic molecules and uses thereof |
PCT/IL2001/000713 WO2002011666A2 (en) | 2000-08-03 | 2001-08-01 | Derivatives of branched-chain lipophilic molecules and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60141074D1 true DE60141074D1 (de) | 2010-03-04 |
Family
ID=11074480
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60141074T Expired - Lifetime DE60141074D1 (de) | 2000-08-03 | 2001-08-01 | Derivate von kettenverzweigten lipophilen molekülen und deren verwendung |
Country Status (16)
Country | Link |
---|---|
US (2) | US7186703B2 (de) |
EP (1) | EP1305322B1 (de) |
JP (1) | JP2004505898A (de) |
KR (1) | KR100801207B1 (de) |
CN (1) | CN100467476C (de) |
AT (1) | ATE455120T1 (de) |
AU (2) | AU2001280043B2 (de) |
BR (1) | BR0112835A (de) |
CA (1) | CA2416808C (de) |
CZ (1) | CZ2003208A3 (de) |
DE (1) | DE60141074D1 (de) |
ES (1) | ES2338987T3 (de) |
HU (1) | HUP0301711A3 (de) |
IL (1) | IL137672A0 (de) |
NZ (1) | NZ523664A (de) |
WO (1) | WO2002011666A2 (de) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7582678B2 (en) | 1997-07-09 | 2009-09-01 | D-Pharm Limited | Use of branched-chain fatty acids and derivatives thereof for the treatment of pain |
US6518311B2 (en) * | 1997-07-09 | 2003-02-11 | D-Pharm Ltd. | Use of branched-chain fatty acids and derivatives thereof for the treatment of pain |
DK1379235T3 (da) | 2000-10-10 | 2007-01-29 | Univ North Carolina | Sammensætninger og fremgangsmåder til forbedring af paracellulær permeabilitet over epithel- og endothelbarrierer |
WO2003068242A1 (en) | 2002-02-11 | 2003-08-21 | Vertex Pharmaceuticals Incorporated | Phospholipids as caspase inhibitor prodrugs |
JP5578388B2 (ja) | 2002-04-18 | 2014-08-27 | オプコ ファーマシューティカルズ、エルエルシー | 中枢神経システム及び/若しくは眼の細胞及び組織中の遺伝子の特異的阻害のための手段と方法 |
US7148342B2 (en) | 2002-07-24 | 2006-12-12 | The Trustees Of The University Of Pennyslvania | Compositions and methods for sirna inhibition of angiogenesis |
EP2428516A1 (de) | 2003-11-19 | 2012-03-14 | Metabasis Therapeutics, Inc. | Neue Phosphor enthaltende Thyromimetika |
US8153435B1 (en) | 2005-03-30 | 2012-04-10 | Tracer Detection Technology Corp. | Methods and articles for identifying objects using encapsulated perfluorocarbon tracers |
CN101189248A (zh) * | 2005-05-26 | 2008-05-28 | 症变治疗公司 | 新型含磷拟甲状腺素药 |
CA2606499C (en) | 2005-05-26 | 2017-06-13 | Metabasis Therapeutics, Inc. | Thyromimetics for the treatment of fatty liver diseases |
US8703179B2 (en) * | 2006-05-11 | 2014-04-22 | Kimberly-Clark Worldwide, Inc. | Mucosal formulation |
ES2618482T3 (es) * | 2007-08-10 | 2017-06-21 | Basil Rigas | Compuestos antiinflamatorios y usos de los mismos |
US20110158969A1 (en) * | 2008-02-28 | 2011-06-30 | Henry Ford Health System | Compositions and methods for using stromal cells to enhance treatment of central nervous system injuries |
US20100240883A1 (en) * | 2009-03-18 | 2010-09-23 | Nian Wu | Lipid-drug conjugates for drug delivery |
JP5853869B2 (ja) * | 2012-06-07 | 2016-02-09 | 日油株式会社 | ホスホリルコリン基含有化合物及びその製造法 |
WO2018094265A2 (en) | 2016-11-21 | 2018-05-24 | Viking Therapeutics, Inc. | Method of treating glycogen storage disease |
EP3634426A4 (de) | 2017-06-05 | 2021-04-07 | Viking Therapeutics, Inc. | Zusammensetzungen zur behandlung von fibrose |
JP2021518403A (ja) | 2018-03-22 | 2021-08-02 | バイキング・セラピューティクス・インコーポレイテッド | 化合物の結晶形態及び化合物の結晶形態を生成する方法 |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3006946A (en) | 1953-03-04 | 1961-10-31 | Union Carbide Corp | Production of heterocyclic phosphoruscontaining compounds and products |
US3260688A (en) | 1962-08-10 | 1966-07-12 | Toyo Koatsu Ind Inc | Resin compositions for producing cellular masses and process for producing a cellular product |
US3260668A (en) | 1964-11-04 | 1966-07-12 | Dow Chemical Co | Alkaline scale control in saline water conversion equipment |
DE2038829C3 (de) * | 1970-08-05 | 1975-11-13 | Chemische Werke Huels Ag, 4370 Marl | Zusatzmittel zu Mörtel oder Beton auf Zementbasis |
LU65735A1 (de) | 1972-07-17 | 1974-01-28 | ||
DE2930756A1 (de) | 1979-07-28 | 1981-02-26 | Cassella Ag | Klotzhilfsmittel und verfahren zum faerben von cellulosefasern bzw. gemischen von cellulosefasern zusammen mit synthesefasern mit schwefel-, schwefelkuepen-, kuepen- und reaktivfarbstoffen |
JPS6038363B2 (ja) | 1979-11-27 | 1985-08-31 | ライオン株式会社 | ヘアリンス剤 |
JPS5716064A (en) * | 1980-07-04 | 1982-01-27 | Dai Ichi Kogyo Seiyaku Co Ltd | Dye dispersion |
JPS57112317A (en) * | 1980-12-29 | 1982-07-13 | Lion Corp | Hairdressing agent composition |
JPS5984824A (ja) * | 1982-11-08 | 1984-05-16 | Takeda Chem Ind Ltd | 抗腫瘍剤 |
JPS6072829A (ja) | 1983-09-29 | 1985-04-24 | Kao Corp | ベシクル用組成物 |
JPS60184092A (ja) | 1984-03-01 | 1985-09-19 | Kao Corp | リン酸エステルおよびその製法 |
JPH0832832B2 (ja) | 1984-03-09 | 1996-03-29 | 花王株式会社 | 加熱瀝青質用添加剤 |
US4670575A (en) * | 1984-06-05 | 1987-06-02 | Kao Corporation | Process for purification of phosphoric mono esters |
JPS61129189A (ja) | 1984-11-28 | 1986-06-17 | Kao Corp | リン酸エステルまたはその塩の精製方法 |
US4736051A (en) | 1985-03-20 | 1988-04-05 | Kao Corporation | Process for the preparation of an alkali metal salt of a diester phosphoric acid |
US4751320A (en) | 1985-11-27 | 1988-06-14 | Kao Corporation | Phosphoric ester and process for producing same |
IE59777B1 (en) | 1985-12-04 | 1994-04-06 | Max Planck Gesellschaft | Medicaments |
US5916884A (en) * | 1985-12-04 | 1999-06-29 | Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften | Compositions containing a mixture of phosphorus compounds and alkylglycerols |
JPS62177008A (ja) | 1986-01-29 | 1987-08-03 | Kao Corp | 共重合体の製造法 |
JPS63122775A (ja) | 1986-11-12 | 1988-05-26 | Kao Corp | 油ゲル化剤 |
WO1989011299A1 (en) | 1988-05-18 | 1989-11-30 | State Of Oregon Acting By And Through The State Bo | Method for delivery of therapeutic agents to target brain tissue using monoclonal antibody conjugates |
JPH01290604A (ja) * | 1988-05-18 | 1989-11-22 | Dai Ichi Kogyo Seiyaku Co Ltd | 水中崩壊性良好な農薬粒剤 |
US5059415A (en) | 1989-02-21 | 1991-10-22 | The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon Health | Method for diagnostically imaging lesions in the brain inside a blood-brain barrier |
FR2677360B1 (fr) | 1991-06-05 | 1995-04-14 | Atta | Composes amphiphiles perfluoroalkyles du phosphore, leurs preparations et leurs applications notamment dans le domaine biomedical. |
US5846516A (en) | 1992-06-03 | 1998-12-08 | Alliance Pharmaceutial Corp. | Perfluoroalkylated amphiphilic phosphorus compounds: preparation and biomedical applications |
JP2710900B2 (ja) * | 1992-09-02 | 1998-02-10 | 株式会社ディ・ディ・エス研究所 | 酸性官能基を有する脂質誘導体及び同誘導体によって被覆された微粒子キャリヤー |
US5491004A (en) * | 1994-05-26 | 1996-02-13 | Henkel Corporation | Process for applying a low soiling fiber finish |
DE69623214T2 (de) * | 1995-09-29 | 2003-04-30 | Dainippon Ink & Chemicals | Verfahren zur Herstellung von Polyestermischungen auf Basis von Polylactiden |
JP3747091B2 (ja) * | 1996-03-22 | 2006-02-22 | 株式会社クラブコスメチックス | アポトーシス誘導剤 |
US6030961A (en) * | 1997-03-11 | 2000-02-29 | Bar-Ilan Research & Development Co., Ltd. | Oxyalkylene phosphate compounds and uses thereof |
WO1998055533A1 (en) * | 1997-06-04 | 1998-12-10 | Biocompatibles Limited | Zwitterionic compounds and their use to cross-link collagenous materials |
ZA984837B (en) * | 1997-06-04 | 1999-06-04 | Biocompatibles Ltd | Phosphate compounds |
IL121268A0 (en) * | 1997-07-09 | 1998-01-04 | Dpharm Ltd | Branched chain fatty acids their derivatives and use in the treatment of central nervous system disorders |
IL121269A0 (en) | 1997-07-09 | 1998-01-04 | Dpharm Ltd | Compositions and methods for reversibly increasing permeability of biomembranes |
JP2000053897A (ja) * | 1998-08-07 | 2000-02-22 | Kao Corp | インクジェット記録用水系インク |
-
2000
- 2000-08-03 IL IL13767200A patent/IL137672A0/xx unknown
-
2001
- 2001-08-01 CZ CZ2003208A patent/CZ2003208A3/cs unknown
- 2001-08-01 JP JP2002517004A patent/JP2004505898A/ja active Pending
- 2001-08-01 HU HU0301711A patent/HUP0301711A3/hu unknown
- 2001-08-01 DE DE60141074T patent/DE60141074D1/de not_active Expired - Lifetime
- 2001-08-01 EP EP01958325A patent/EP1305322B1/de not_active Expired - Lifetime
- 2001-08-01 CN CNB01816806XA patent/CN100467476C/zh not_active Expired - Fee Related
- 2001-08-01 AU AU2001280043A patent/AU2001280043B2/en not_active Ceased
- 2001-08-01 AT AT01958325T patent/ATE455120T1/de not_active IP Right Cessation
- 2001-08-01 KR KR1020037001485A patent/KR100801207B1/ko not_active IP Right Cessation
- 2001-08-01 CA CA2416808A patent/CA2416808C/en not_active Expired - Fee Related
- 2001-08-01 BR BR0112835-3A patent/BR0112835A/pt not_active IP Right Cessation
- 2001-08-01 NZ NZ523664A patent/NZ523664A/en not_active IP Right Cessation
- 2001-08-01 ES ES01958325T patent/ES2338987T3/es not_active Expired - Lifetime
- 2001-08-01 US US10/343,105 patent/US7186703B2/en not_active Expired - Lifetime
- 2001-08-01 WO PCT/IL2001/000713 patent/WO2002011666A2/en active IP Right Grant
- 2001-08-01 AU AU8004301A patent/AU8004301A/xx active Pending
-
2007
- 2007-01-11 US US11/652,309 patent/US7687483B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1305322A4 (de) | 2005-04-13 |
KR20030024823A (ko) | 2003-03-26 |
ATE455120T1 (de) | 2010-01-15 |
CN100467476C (zh) | 2009-03-11 |
CZ2003208A3 (cs) | 2003-10-15 |
WO2002011666A3 (en) | 2002-07-11 |
AU2001280043B2 (en) | 2007-05-24 |
CA2416808C (en) | 2011-11-22 |
ES2338987T3 (es) | 2010-05-14 |
KR100801207B1 (ko) | 2008-02-05 |
AU2001280043B8 (en) | 2002-02-18 |
BR0112835A (pt) | 2003-10-21 |
US7687483B2 (en) | 2010-03-30 |
JP2004505898A (ja) | 2004-02-26 |
US20070135381A1 (en) | 2007-06-14 |
EP1305322B1 (de) | 2010-01-13 |
IL137672A0 (en) | 2001-10-31 |
HUP0301711A2 (hu) | 2003-09-29 |
AU8004301A (en) | 2002-02-18 |
CA2416808A1 (en) | 2002-02-14 |
US7186703B2 (en) | 2007-03-06 |
HUP0301711A3 (en) | 2007-05-29 |
WO2002011666A2 (en) | 2002-02-14 |
EP1305322A2 (de) | 2003-05-02 |
NZ523664A (en) | 2004-07-30 |
CN1633440A (zh) | 2005-06-29 |
US20030186897A1 (en) | 2003-10-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |