ES2177084T3 - Uso de derivados de benzohidrilo sulfinilo para tratar la somnolencia de origen medicamentoso. - Google Patents

Uso de derivados de benzohidrilo sulfinilo para tratar la somnolencia de origen medicamentoso.

Info

Publication number
ES2177084T3
ES2177084T3 ES98955701T ES98955701T ES2177084T3 ES 2177084 T3 ES2177084 T3 ES 2177084T3 ES 98955701 T ES98955701 T ES 98955701T ES 98955701 T ES98955701 T ES 98955701T ES 2177084 T3 ES2177084 T3 ES 2177084T3
Authority
ES
Spain
Prior art keywords
derivatives
benzohidrile
somnolence
sulfinyl
treat
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES98955701T
Other languages
English (en)
Inventor
Marc Esteve
Jacques Gertner
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Curie
Original Assignee
Institut Curie
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Curie filed Critical Institut Curie
Application granted granted Critical
Publication of ES2177084T3 publication Critical patent/ES2177084T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Uso, para la fabricación de medicamentos con efecto estimulante en situaciones de alteraciones de la vigilancia relacionadas con un tratamiento morfínico, compuestos de benzohidrilo sulfinilo que responden a la fórmula general (I), CH-SO-(CH2)4-CO-NHR en la que, cada uno de los ciclos puede ser sustituido por uno o más grupos F, Cl, Br, CF3, NO2, NH2, alkilo en C1-C4, alkoxi en C1-C4, metilenodioxi; R representa un grupo hidróxilo, un átomo de hidrógeno, un grupo alkilo en C1-C4, un grupo hidroxialkilo en C1- C4, n es un entero igual a 1, 2 ó 3; y sus sales de adición cuando R incluye un resto básico.
ES98955701T 1997-11-19 1998-11-19 Uso de derivados de benzohidrilo sulfinilo para tratar la somnolencia de origen medicamentoso. Expired - Lifetime ES2177084T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9714519A FR2771004B1 (fr) 1997-11-19 1997-11-19 Utilisation de derives de benzhydryl sulfinyle pour la fabrication de medicaments ayant un effet eveillant dans des situations de troubles de la vigilance d'origine medicamenteuse

Publications (1)

Publication Number Publication Date
ES2177084T3 true ES2177084T3 (es) 2002-12-01

Family

ID=9513542

Family Applications (1)

Application Number Title Priority Date Filing Date
ES98955701T Expired - Lifetime ES2177084T3 (es) 1997-11-19 1998-11-19 Uso de derivados de benzohidrilo sulfinilo para tratar la somnolencia de origen medicamentoso.

Country Status (10)

Country Link
US (1) US6566404B2 (es)
EP (1) EP1032376B1 (es)
AT (1) ATE216879T1 (es)
AU (1) AU743915B2 (es)
CA (1) CA2310141C (es)
DE (1) DE69805202T2 (es)
DK (1) DK1032376T3 (es)
ES (1) ES2177084T3 (es)
FR (1) FR2771004B1 (es)
WO (1) WO1999025329A1 (es)

Families Citing this family (40)

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Publication number Priority date Publication date Assignee Title
US6346548B1 (en) 1999-08-16 2002-02-12 Cephalon, Inc. Compositions including modafinil for treatment of attention deficit hyperactivity disorder and multiple sclerosis fatigue
US6455588B1 (en) 1999-08-20 2002-09-24 Cephalon, Inc. Compositions including modafinil for treatment of eating disorders and for appetite stimulation
FR2804322B1 (fr) * 2000-01-31 2002-04-19 Lafon Labor Utilisation du modafinil pour la fabrication d'un medicament destine a corriger les troubles de la vigilance associes aux myopathies
US6492396B2 (en) * 2000-05-16 2002-12-10 Cephalon, Inc. Substituted thioacetamides
US6670358B2 (en) * 2000-05-16 2003-12-30 Cephalon, Inc. Substituted thioacetamides
EP1309547B1 (en) * 2000-07-27 2007-01-17 Teva Pharmaceutical Industries Ltd. Crystalline and pure modafinil, and process of preparing the same
US6489363B2 (en) * 2000-10-11 2002-12-03 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
PL215226B1 (pl) * 2000-10-11 2013-11-29 Cephalon Kompozycja farmaceutyczna zawierajaca zwiazek modafinilu, sposób jej wytwarzania oraz jej zastosowanie
US6919378B2 (en) 2000-10-11 2005-07-19 Cephalon, Inc. Pharmaceutical solutions of modafinil compounds
WO2002030414A1 (en) * 2000-10-11 2002-04-18 Cephalon, Inc. Compositions comprising modafinil compounds
US6992219B2 (en) 2002-08-09 2006-01-31 Cephalon France Modafinil polymorphic forms
US7550590B2 (en) * 2003-03-25 2009-06-23 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US20040242698A1 (en) * 2003-05-13 2004-12-02 Cephalon Inc. Analeptic and antidepressant combinations
US20040229941A1 (en) * 2003-05-13 2004-11-18 Cephalon, Inc. Analeptic and antidepressant combinations
AR045423A1 (es) * 2003-05-13 2005-10-26 Cephalon Inc Combinaciones de analiticos y antidepresivos
AR045314A1 (es) * 2003-05-13 2005-10-26 Cephalon Inc Composiciones farmaceuticas de analepticos y antidepresivos
US20040229943A1 (en) * 2003-05-16 2004-11-18 Cephalon Inc Analeptic and drug combinations
ZA200602051B (en) * 2003-08-13 2007-10-31 Takeda Pharmaceutical 4-pyrimidone derivatives and their use as peptidyl peptidase inhibitors
WO2005026148A1 (en) * 2003-09-08 2005-03-24 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
JP2007513058A (ja) * 2003-09-08 2007-05-24 武田薬品工業株式会社 ジペプチジルぺプチダーゼ阻害剤
US7368591B2 (en) 2003-09-19 2008-05-06 Cephalon France Process for enantioselective synthesis of single enantiomers of modafinil by asymmetric oxidation
CN102127053A (zh) * 2004-03-15 2011-07-20 武田药品工业株式会社 二肽基肽酶抑制剂
US7119214B2 (en) 2004-04-13 2006-10-10 Cephalon France Thio-substituted tricyclic and bicyclic aromatic methanesulfinyl derivatives
US7314875B2 (en) * 2004-04-13 2008-01-01 Cephalon, Inc. Tricyclic aromatic and bis-phenyl sulfinyl derivatives
US7297817B2 (en) 2004-04-13 2007-11-20 Cephalon France Thio-substituted arylmethanesulfinyl derivatives
US7449481B2 (en) 2004-04-13 2008-11-11 Cephalon, Inc. Thio-substituted biaryl-methanesulfinyl derivatives
EP1586560A1 (en) 2004-04-13 2005-10-19 Cephalon, Inc. Thio-substituted arylmethanesulfinyl derivatives
WO2007033265A1 (en) * 2005-09-14 2007-03-22 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors for treating diabetis
PL1931350T5 (pl) * 2005-09-14 2021-11-15 Takeda Pharmaceutical Company Limited Podanie inhibitorów dipeptydylo-peptydazy
DK1942898T4 (da) 2005-09-14 2014-06-02 Takeda Pharmaceutical Dipeptidylpeptidase-inhibitorer til behandling af diabetes
TW200745080A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
TW200745079A (en) * 2005-09-16 2007-12-16 Takeda Pharmaceuticals Co Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
KR101368988B1 (ko) * 2005-09-16 2014-02-28 다케다 야쿠힌 고교 가부시키가이샤 디펩티딜 펩티다제 억제제
JP2009531456A (ja) * 2006-03-28 2009-09-03 武田薬品工業株式会社 （ｒ）−３−アミノピペリジン二塩酸塩の調製
EP2043623A4 (en) * 2006-07-12 2013-03-20 Elan Pharma Int Ltd NANOPARTICLE FORMULATIONS OF MODAFINIL
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
PE20081150A1 (es) * 2006-09-13 2008-10-03 Takeda Pharmaceutical Inhibidores de dipetidilpeptidasa
TW200838536A (en) * 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
FR2987267B1 (fr) 2012-02-28 2015-01-16 Debregeas Et Associes Pharma Application du modafinil dans le traitement de substitution des cacainomanes

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1584462A (en) * 1977-03-31 1981-02-11 Lafon Labor N-diaryl-malonamide and diarylmethyl-sulphinyl-acetamide derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
FR2771004B1 (fr) 2000-02-18
US6566404B2 (en) 2003-05-20
EP1032376A1 (fr) 2000-09-06
WO1999025329A1 (fr) 1999-05-27
DK1032376T3 (da) 2002-08-26
ATE216879T1 (de) 2002-05-15
CA2310141C (fr) 2010-04-27
DE69805202D1 (de) 2002-06-06
DE69805202T2 (de) 2002-12-05
AU1245199A (en) 1999-06-07
US20030008925A1 (en) 2003-01-09
FR2771004A1 (fr) 1999-05-21
EP1032376B1 (fr) 2002-05-02
AU743915B2 (en) 2002-02-07
CA2310141A1 (fr) 1999-05-27

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