NZ523664A - Derivatives of branched-chain lipophilic molecules and uses thereof - Google Patents

Derivatives of branched-chain lipophilic molecules and uses thereof

Info

Publication number
NZ523664A
NZ523664A NZ523664A NZ52366401A NZ523664A NZ 523664 A NZ523664 A NZ 523664A NZ 523664 A NZ523664 A NZ 523664A NZ 52366401 A NZ52366401 A NZ 52366401A NZ 523664 A NZ523664 A NZ 523664A
Authority
NZ
New Zealand
Prior art keywords
phosphate
compound
compound according
tumor
pharmaceutical composition
Prior art date
Application number
NZ523664A
Other languages
English (en)
Inventor
Alexander Kozak
Marina Vinnikova
Michael Polyak
Eliezer Beit-Yannai
Dalia Reznitsky-Cohen
Alexander Senderikhin
Original Assignee
Dpharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dpharm Ltd filed Critical Dpharm Ltd
Publication of NZ523664A publication Critical patent/NZ523664A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/11—Esters of phosphoric acids with hydroxyalkyl compounds without further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cosmetics (AREA)
  • Fats And Perfumes (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Hydrogenated Pyridines (AREA)
NZ523664A 2000-08-03 2001-08-01 Derivatives of branched-chain lipophilic molecules and uses thereof NZ523664A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL13767200A IL137672A0 (en) 2000-08-03 2000-08-03 Derivatives of branched-chain lipophilic molecules and uses thereof
PCT/IL2001/000713 WO2002011666A2 (en) 2000-08-03 2001-08-01 Derivatives of branched-chain lipophilic molecules and uses thereof

Publications (1)

Publication Number Publication Date
NZ523664A true NZ523664A (en) 2004-07-30

Family

ID=11074480

Family Applications (1)

Application Number Title Priority Date Filing Date
NZ523664A NZ523664A (en) 2000-08-03 2001-08-01 Derivatives of branched-chain lipophilic molecules and uses thereof

Country Status (16)

Country Link
US (2) US7186703B2 (https=)
EP (1) EP1305322B1 (https=)
JP (1) JP2004505898A (https=)
KR (1) KR100801207B1 (https=)
CN (1) CN100467476C (https=)
AT (1) ATE455120T1 (https=)
AU (2) AU2001280043B2 (https=)
BR (1) BR0112835A (https=)
CA (1) CA2416808C (https=)
CZ (1) CZ2003208A3 (https=)
DE (1) DE60141074D1 (https=)
ES (1) ES2338987T3 (https=)
HU (1) HUP0301711A3 (https=)
IL (1) IL137672A0 (https=)
NZ (1) NZ523664A (https=)
WO (1) WO2002011666A2 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6518311B2 (en) * 1997-07-09 2003-02-11 D-Pharm Ltd. Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
US7582678B2 (en) 1997-07-09 2009-09-01 D-Pharm Limited Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
EP1379235B1 (en) * 2000-10-10 2006-12-20 University Of North Carolina At Chapel Hill Compositions and methods for enhancing paracellular permeability across epithelial and endothelial barriers
US7410956B2 (en) 2002-02-11 2008-08-12 Vertex Pharmaceuticals Incorporated Caspase inhibitor prodrugs
EP1495120B1 (en) 2002-04-18 2012-10-10 Acuity Pharmaceuticals, Inc Means and methods for the specific modulation of target genes in the eye
US7148342B2 (en) 2002-07-24 2006-12-12 The Trustees Of The University Of Pennyslvania Compositions and methods for sirna inhibition of angiogenesis
CN1882327A (zh) 2003-11-19 2006-12-20 症变治疗公司 含磷的新的拟甲状腺素药
US8153435B1 (en) 2005-03-30 2012-04-10 Tracer Detection Technology Corp. Methods and articles for identifying objects using encapsulated perfluorocarbon tracers
EP1891080A2 (en) * 2005-05-26 2008-02-27 Metabasis Therapeutics, Inc. Novel phosphorus-containing thyromimetics
MX2007014502A (es) 2005-05-26 2008-02-07 Metabasis Therapeutics Inc Tiromimeticos para el tratamiento de enfermedades del higado graso.
US8703179B2 (en) * 2006-05-11 2014-04-22 Kimberly-Clark Worldwide, Inc. Mucosal formulation
EP2180788B1 (en) * 2007-08-10 2016-12-21 Basil Rigas Anti-inflammatory compounds and uses thereof
WO2009108632A1 (en) * 2008-02-28 2009-09-03 Henry Ford Health System Compositions and methods for using stromal cells to enhance treatment of central nervous system injuries
US20100240883A1 (en) * 2009-03-18 2010-09-23 Nian Wu Lipid-drug conjugates for drug delivery
JP5853869B2 (ja) * 2012-06-07 2016-02-09 日油株式会社 ホスホリルコリン基含有化合物及びその製造法
JP2020500199A (ja) 2016-11-21 2020-01-09 バイキング・セラピューティクス・インコーポレイテッド グリコーゲン蓄積症の治療方法
AU2018280118B2 (en) 2017-06-05 2021-07-15 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis
ES3053674T3 (en) 2018-03-22 2026-01-23 Viking Therapeutics Inc Crystalline forms and methods of producing crystalline forms of a compound
WO2020117962A1 (en) 2018-12-05 2020-06-11 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3006946A (en) 1953-03-04 1961-10-31 Union Carbide Corp Production of heterocyclic phosphoruscontaining compounds and products
US3260688A (en) 1962-08-10 1966-07-12 Toyo Koatsu Ind Inc Resin compositions for producing cellular masses and process for producing a cellular product
US3260668A (en) 1964-11-04 1966-07-12 Dow Chemical Co Alkaline scale control in saline water conversion equipment
DE2038829C3 (de) * 1970-08-05 1975-11-13 Chemische Werke Huels Ag, 4370 Marl Zusatzmittel zu Mörtel oder Beton auf Zementbasis
LU65735A1 (https=) 1972-07-17 1974-01-28
DE2930756A1 (de) * 1979-07-28 1981-02-26 Cassella Ag Klotzhilfsmittel und verfahren zum faerben von cellulosefasern bzw. gemischen von cellulosefasern zusammen mit synthesefasern mit schwefel-, schwefelkuepen-, kuepen- und reaktivfarbstoffen
JPS6038363B2 (ja) * 1979-11-27 1985-08-31 ライオン株式会社 ヘアリンス剤
JPS5716064A (en) * 1980-07-04 1982-01-27 Dai Ichi Kogyo Seiyaku Co Ltd Dye dispersion
JPS57112317A (en) * 1980-12-29 1982-07-13 Lion Corp Hairdressing agent composition
JPS5984824A (ja) * 1982-11-08 1984-05-16 Takeda Chem Ind Ltd 抗腫瘍剤
JPS6072829A (ja) * 1983-09-29 1985-04-24 Kao Corp ベシクル用組成物
JPS60184092A (ja) * 1984-03-01 1985-09-19 Kao Corp リン酸エステルおよびその製法
JPH0832832B2 (ja) * 1984-03-09 1996-03-29 花王株式会社 加熱瀝青質用添加剤
US4670575A (en) * 1984-06-05 1987-06-02 Kao Corporation Process for purification of phosphoric mono esters
JPS61129189A (ja) * 1984-11-28 1986-06-17 Kao Corp リン酸エステルまたはその塩の精製方法
US4736051A (en) * 1985-03-20 1988-04-05 Kao Corporation Process for the preparation of an alkali metal salt of a diester phosphoric acid
US4751320A (en) 1985-11-27 1988-06-14 Kao Corporation Phosphoric ester and process for producing same
IE59777B1 (en) * 1985-12-04 1994-04-06 Max Planck Gesellschaft Medicaments
US5916884A (en) * 1985-12-04 1999-06-29 Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften Compositions containing a mixture of phosphorus compounds and alkylglycerols
JPS62177008A (ja) * 1986-01-29 1987-08-03 Kao Corp 共重合体の製造法
JPS63122775A (ja) 1986-11-12 1988-05-26 Kao Corp 油ゲル化剤
WO1989011299A1 (en) 1988-05-18 1989-11-30 State Of Oregon Acting By And Through The State Bo Method for delivery of therapeutic agents to target brain tissue using monoclonal antibody conjugates
JPH01290604A (ja) * 1988-05-18 1989-11-22 Dai Ichi Kogyo Seiyaku Co Ltd 水中崩壊性良好な農薬粒剤
US5059415A (en) 1989-02-21 1991-10-22 The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon Health Method for diagnostically imaging lesions in the brain inside a blood-brain barrier
FR2677360B1 (fr) * 1991-06-05 1995-04-14 Atta Composes amphiphiles perfluoroalkyles du phosphore, leurs preparations et leurs applications notamment dans le domaine biomedical.
US5846516A (en) 1992-06-03 1998-12-08 Alliance Pharmaceutial Corp. Perfluoroalkylated amphiphilic phosphorus compounds: preparation and biomedical applications
JP2710900B2 (ja) * 1992-09-02 1998-02-10 株式会社ディ・ディ・エス研究所 酸性官能基を有する脂質誘導体及び同誘導体によって被覆された微粒子キャリヤー
US5491004A (en) * 1994-05-26 1996-02-13 Henkel Corporation Process for applying a low soiling fiber finish
DE69623214T2 (de) * 1995-09-29 2003-04-30 Dainippon Ink And Chemicals, Inc. Verfahren zur Herstellung von Polyestermischungen auf Basis von Polylactiden
JP3747091B2 (ja) * 1996-03-22 2006-02-22 株式会社クラブコスメチックス アポトーシス誘導剤
US6030961A (en) * 1997-03-11 2000-02-29 Bar-Ilan Research & Development Co., Ltd. Oxyalkylene phosphate compounds and uses thereof
AU7781298A (en) * 1997-06-04 1998-12-21 Biocompatibles Limited Phosphate compounds
AU7781498A (en) * 1997-06-04 1998-12-21 Biocompatibles Limited Zwitterionic compounds and their use to cross-link collagenous materials
IL121268A0 (en) * 1997-07-09 1998-01-04 Dpharm Ltd Branched chain fatty acids their derivatives and use in the treatment of central nervous system disorders
IL121269A0 (en) 1997-07-09 1998-01-04 Dpharm Ltd Compositions and methods for reversibly increasing permeability of biomembranes
JP2000053897A (ja) * 1998-08-07 2000-02-22 Kao Corp インクジェット記録用水系インク

Also Published As

Publication number Publication date
US20030186897A1 (en) 2003-10-02
AU2001280043B8 (en) 2002-02-18
BR0112835A (pt) 2003-10-21
AU2001280043B2 (en) 2007-05-24
AU8004301A (en) 2002-02-18
ATE455120T1 (de) 2010-01-15
EP1305322A4 (en) 2005-04-13
WO2002011666A2 (en) 2002-02-14
DE60141074D1 (de) 2010-03-04
KR20030024823A (ko) 2003-03-26
CA2416808C (en) 2011-11-22
EP1305322A2 (en) 2003-05-02
ES2338987T3 (es) 2010-05-14
HUP0301711A2 (hu) 2003-09-29
US20070135381A1 (en) 2007-06-14
CN100467476C (zh) 2009-03-11
US7186703B2 (en) 2007-03-06
CN1633440A (zh) 2005-06-29
CZ2003208A3 (cs) 2003-10-15
EP1305322B1 (en) 2010-01-13
HUP0301711A3 (en) 2007-05-29
US7687483B2 (en) 2010-03-30
KR100801207B1 (ko) 2008-02-05
JP2004505898A (ja) 2004-02-26
IL137672A0 (en) 2001-10-31
CA2416808A1 (en) 2002-02-14
WO2002011666A3 (en) 2002-07-11

Similar Documents

Publication Publication Date Title
US7687483B2 (en) Derivatives of branch-chain lipophilic molecular and uses thereof
AU2001280043A1 (en) Derivatives of branched-chain lipophilic molecules and uses thereof
JP6800748B2 (ja) 脂質ベース白金化合物およびナノ粒子
EP1999136B1 (en) Peptidomimetic inhibitors of psma,compounds comprising them, and methods of use
HU208143B (en) Process for producing synergetic antitumorous pharmaceutical compositions and phosphate derivatives used as their active ingredient
JP6251744B2 (ja) ＭＲＩ用の両親媒性錯体を含む常磁性固体脂質ナノ粒子（ｐＳＬＮ）
US20140171394A1 (en) Cyclitols and their derivatives and their therapeutic applications
EP0040039B1 (en) Ethylene glycol derivatives of ammonioethyl phosphate, their production and use
EP1311514B1 (en) Compositions with vascular damaging activity
HK1212218A1 (en) Organoarsenic compounds and methods for the treatment of cancer
CA2450946C (en) Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
CA2503058A1 (en) Antiprotozoal ring-substituted phospholipids
AU2002314503A1 (en) Use of branched-chain fatty acids and derivatives thereof for the treatment of pain
DE69907720T2 (de) Phospholipid-derivate von nichtsteroiden entzündungshemmenden medikamenten
KR0153279B1 (ko) 혈소판 활성인자의 길항질인 신규 비스-아릴포스페이트 에스테르 및 그의 제조방법 및 그로써 질병을 치료하는 방법
JPS6411029B2 (https=)
US20060116354A1 (en) Antineoplastic ether lipid compounds with modifications at the sn-3 carbon
EP1421941A1 (en) Phospholipid derivatives having a polyhydroxylated aliphatic carbocycle
Krise A novel prodrug approach for tertiary amines: synthesis and evaluation of N-phosphonooxymethyl derivatives
JP2004530688A (ja) 組織透過を改善するための薬剤

Legal Events

Date Code Title Description
PSEA Patent sealed
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)
RENW Renewal (renewal fees accepted)
LAPS Patent lapsed