CN100412073C - 新颖的噻吩脒、其组合物和治疗补体-介导疾病与病症的方法 - Google Patents
新颖的噻吩脒、其组合物和治疗补体-介导疾病与病症的方法 Download PDFInfo
- Publication number
- CN100412073C CN100412073C CNB038161168A CN03816116A CN100412073C CN 100412073 C CN100412073 C CN 100412073C CN B038161168 A CNB038161168 A CN B038161168A CN 03816116 A CN03816116 A CN 03816116A CN 100412073 C CN100412073 C CN 100412073C
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- methyl
- alkyl
- thiophene
- phenyl
- compound
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
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- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
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- C07F7/0803—Compounds with Si-C or Si-Si linkages
- C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Surgery (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38313002P | 2002-05-28 | 2002-05-28 | |
| US60/383,130 | 2002-05-28 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1665800A CN1665800A (zh) | 2005-09-07 |
| CN100412073C true CN100412073C (zh) | 2008-08-20 |
Family
ID=29584510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB038161168A Expired - Fee Related CN100412073C (zh) | 2002-05-28 | 2003-05-28 | 新颖的噻吩脒、其组合物和治疗补体-介导疾病与病症的方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US7138530B2 (enExample) |
| EP (1) | EP1549632A4 (enExample) |
| JP (1) | JP2005538953A (enExample) |
| KR (1) | KR20050009720A (enExample) |
| CN (1) | CN100412073C (enExample) |
| AR (1) | AR039891A1 (enExample) |
| AU (1) | AU2003251384B2 (enExample) |
| BR (1) | BR0311419A (enExample) |
| CA (1) | CA2484822A1 (enExample) |
| CO (1) | CO5640081A2 (enExample) |
| HR (1) | HRP20041220A2 (enExample) |
| IL (1) | IL164890A0 (enExample) |
| MX (1) | MX249034B (enExample) |
| MY (1) | MY137509A (enExample) |
| NO (1) | NO20045403L (enExample) |
| NZ (1) | NZ537346A (enExample) |
| PL (1) | PL372246A1 (enExample) |
| RU (1) | RU2359967C2 (enExample) |
| TW (1) | TW200406395A (enExample) |
| UA (1) | UA80131C2 (enExample) |
| WO (1) | WO2003099805A1 (enExample) |
| ZA (1) | ZA200408711B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2363396A1 (en) * | 2001-06-11 | 2011-09-07 | Virochem Pharma Inc. | Thiophene derivatives as antiviral agents for flavivirus infection |
| DE10162114A1 (de) * | 2001-12-12 | 2003-06-26 | Schering Ag | Neue Amidin-Derivate und deren Verwendung in Arzneimitteln |
| UA80131C2 (en) | 2002-05-28 | 2007-08-27 | Dimensional Pharm Inc | Thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions |
| DE60332482D1 (de) | 2002-12-10 | 2010-06-17 | Virochem Pharma Inc | Verbindungen und methoden zum behandeln oder vorbeugen von flavivirus infektionen |
| GB0305575D0 (en) * | 2003-03-11 | 2003-04-16 | Glaxo Group Ltd | Novel compounds |
| US7482376B2 (en) * | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
| ES2542228T3 (es) | 2004-07-08 | 2015-08-03 | Novo Nordisk A/S | Marcas de prolongación polipeptídica que comprenden un resto de tetrazol |
| WO2006045119A2 (en) * | 2004-10-20 | 2006-04-27 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
| DK1879573T3 (da) | 2005-05-10 | 2013-02-25 | Incyte Corp | Modulatorer af indolamin 2,3-dioxygenase og fremgangsmåder til anvendelse deraf |
| JP5030947B2 (ja) * | 2005-05-13 | 2012-09-19 | ヴァイロケム・ファーマ・インコーポレーテッド | フラビウイルス感染の治療及び予防のための化合物及び方法 |
| ES2540561T3 (es) | 2005-12-20 | 2015-07-10 | Incyte Corporation | N-hidroxiamidinoheterociclos como moduladores de indolamina 2,3-dioxigenasa |
| MX335993B (es) * | 2005-12-30 | 2016-01-07 | Anacor Pharmaceuticals Inc | Moleculas pequeñas que contienen boro. |
| RU2642628C2 (ru) * | 2006-02-16 | 2018-01-25 | Анакор Фармасьютикалз, Инк. | Бор-содержащие малые молекулы в качестве противовоспалительных средств |
| CL2007002650A1 (es) | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| CA2663057C (en) | 2006-09-19 | 2015-12-08 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| US20080146624A1 (en) * | 2006-09-19 | 2008-06-19 | Incyte Corporation | Amidines as modulators of indoleamine 2,3-dioxygenase |
| SG176488A1 (en) * | 2006-11-15 | 2011-12-29 | Virochem Pharma Inc | Thiophene analogues for the treatment or prevention of flavivirus infections |
| EP2148691B1 (en) | 2007-02-05 | 2015-05-20 | Apellis Pharmaceuticals, Inc. | Compstatin analogues for use in the treatment of inflammatory conditions of the respiratory system |
| JO3396B1 (ar) * | 2007-06-20 | 2019-10-20 | Anacor Pharmaceuticals Inc | جزيئات صغيرة تحتوي على البورون |
| WO2009081970A1 (ja) * | 2007-12-26 | 2009-07-02 | Eisai R & D Management Co., Ltd. | ヘテロ環置換ピリジン誘導体の製造方法 |
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| UA80131C2 (en) | 2007-08-27 |
| US7138530B2 (en) | 2006-11-21 |
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| US20040009995A1 (en) | 2004-01-15 |
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| JP2005538953A (ja) | 2005-12-22 |
| BR0311419A (pt) | 2005-04-05 |
| EP1549632A1 (en) | 2005-07-06 |
| MXPA04011671A (es) | 2005-03-07 |
| RU2359967C2 (ru) | 2009-06-27 |
| TW200406395A (en) | 2004-05-01 |
| HK1081187A1 (zh) | 2006-05-12 |
| KR20050009720A (ko) | 2005-01-25 |
| CN1665800A (zh) | 2005-09-07 |
| AU2003251384A1 (en) | 2003-12-12 |
| US7109354B2 (en) | 2006-09-19 |
| US20050234081A1 (en) | 2005-10-20 |
| WO2003099805A1 (en) | 2003-12-04 |
| CO5640081A2 (es) | 2006-05-31 |
| MY137509A (en) | 2009-02-27 |
| CA2484822A1 (en) | 2003-12-04 |
| AU2003251384B2 (en) | 2009-01-29 |
| HRP20041220A2 (hr) | 2006-04-30 |
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