CN100356913C - 左旋(r)班布特罗及其药物用途 - Google Patents

左旋(r)班布特罗及其药物用途 Download PDF

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Publication number
CN100356913C
CN100356913C CNB028293975A CN02829397A CN100356913C CN 100356913 C CN100356913 C CN 100356913C CN B028293975 A CNB028293975 A CN B028293975A CN 02829397 A CN02829397 A CN 02829397A CN 100356913 C CN100356913 C CN 100356913C
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CN
China
Prior art keywords
bambuterol
gram
medicine
racemic
milliliters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CNB028293975A
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English (en)
Chinese (zh)
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CN1638756A (zh
Inventor
陈俭龙
谭文
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Individual
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Publication of CN1638756A publication Critical patent/CN1638756A/zh
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Publication of CN100356913C publication Critical patent/CN100356913C/zh
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Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
CNB028293975A 2002-08-08 2002-08-08 左旋(r)班布特罗及其药物用途 Expired - Lifetime CN100356913C (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2002/025225 WO2004014290A2 (en) 2002-08-08 2002-08-08 R-bambuterol, its preparation and therapeutic uses

Publications (2)

Publication Number Publication Date
CN1638756A CN1638756A (zh) 2005-07-13
CN100356913C true CN100356913C (zh) 2007-12-26

Family

ID=31713793

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028293975A Expired - Lifetime CN100356913C (zh) 2002-08-08 2002-08-08 左旋(r)班布特罗及其药物用途

Country Status (8)

Country Link
EP (2) EP1542672B1 (https=)
JP (1) JP4979889B2 (https=)
CN (1) CN100356913C (https=)
AT (1) ATE406887T1 (https=)
AU (1) AU2002332488A1 (https=)
DE (1) DE60228764D1 (https=)
ES (1) ES2312669T3 (https=)
WO (1) WO2004014290A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100803291B1 (ko) 2006-09-08 2008-02-13 (주)팜스웰 밤부테롤 염산염의 개선된 제조방법
JP2012530134A (ja) * 2009-06-16 2012-11-29 タン，ウェン 呼吸器疾患治療における併用療法及び吸入薬剤としてのｒ型バンブテロールの使用
CN102617404A (zh) * 2012-04-06 2012-08-01 张长利 盐酸班布特罗及其中间体的制备工艺
CN103288670B (zh) * 2013-05-16 2014-11-05 南京医科大学第一附属医院 多羟基二苯甲酮衍生物及其应用
CN104478740B (zh) * 2014-11-19 2017-01-25 上海化工研究院 一种稳定同位素标记β受体激动剂类化合物的合成方法
CN104557614B (zh) * 2014-12-15 2017-01-04 广东东阳光药业有限公司 一种胺的还原方法
CN105254512B (zh) * 2015-11-10 2017-03-22 山东达因海洋生物制药股份有限公司 一种硫酸特布他林的制备方法
CN106831452A (zh) * 2017-02-15 2017-06-13 杭州百诚医药科技股份有限公司 一种硫酸特布他林的制备方法
CN107445866A (zh) * 2017-07-13 2017-12-08 上海昕盛医药科技有限公司 一种盐酸班布特罗杂质d的合成方法
CN107445867A (zh) * 2017-07-13 2017-12-08 上海昕盛医药科技有限公司 一种盐酸班布特罗杂质b的合成方法
US20210290580A1 (en) * 2018-07-31 2021-09-23 Wen Tan New use of carbamate ß phenylethanolamine analogues for enhancing intracellular clearance of LDL cholesterol and for combining therapy with statins to enhance the efficacy and reduce adverse effects
CN109942462B (zh) * 2019-03-06 2022-01-14 宏冠生物药业有限公司 一种盐酸班布特罗的合成工艺
JP2022531602A (ja) * 2019-05-07 2022-07-07 ウェン タン 肺の炎症および炎症性リモデリングの予防および治療用Ｒ－エナンチオマーβ２アゴニストの、有害作用を軽減するための使用
CN115531368A (zh) * 2021-06-14 2022-12-30 谭文 R-氨基甲酸酯-β-苯乙醇胺类化合物治疗学习和记忆缺陷以及神经退行性疾病的应用
CN117586152B (zh) * 2023-11-23 2026-04-03 黑龙江乌苏里江制药有限公司 一种盐酸班布特罗的制备方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419364A (en) * 1980-07-09 1983-12-06 Aktiebolaget Draco Bronchospasmolytic carbamate derivatives
US5837727A (en) * 1990-03-16 1998-11-17 Astra Aktiebolag Method for altering blood lipid levels

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9107196D0 (en) * 1991-04-05 1991-05-22 Sandoz Ag Improvements in or relating to organic compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4419364A (en) * 1980-07-09 1983-12-06 Aktiebolaget Draco Bronchospasmolytic carbamate derivatives
US5837727A (en) * 1990-03-16 1998-11-17 Astra Aktiebolag Method for altering blood lipid levels

Also Published As

Publication number Publication date
ES2312669T3 (es) 2009-03-01
JP4979889B2 (ja) 2012-07-18
EP1542672A2 (en) 2005-06-22
JP2006503816A (ja) 2006-02-02
CN1638756A (zh) 2005-07-13
AU2002332488A1 (en) 2004-02-25
EP1542672A4 (en) 2006-06-07
WO2004014290A3 (en) 2004-08-05
EP2002831A1 (en) 2008-12-17
DE60228764D1 (de) 2008-10-16
EP1542672B1 (en) 2008-09-03
ATE406887T1 (de) 2008-09-15
AU2002332488A8 (en) 2004-02-25
WO2004014290A2 (en) 2004-02-19

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