CL2019003168A1 - Mejoras farmacocinéticas de quelatos bifuncionales y usos de los mismos. - Google Patents

Mejoras farmacocinéticas de quelatos bifuncionales y usos de los mismos.

Info

Publication number
CL2019003168A1
CL2019003168A1 CL2019003168A CL2019003168A CL2019003168A1 CL 2019003168 A1 CL2019003168 A1 CL 2019003168A1 CL 2019003168 A CL2019003168 A CL 2019003168A CL 2019003168 A CL2019003168 A CL 2019003168A CL 2019003168 A1 CL2019003168 A1 CL 2019003168A1
Authority
CL
Chile
Prior art keywords
bifunctional chelates
pharmacokinetic
pharmacokinetic improvements
remainder
same
Prior art date
Application number
CL2019003168A
Other languages
English (en)
Spanish (es)
Inventor
Eric Steven Burak
Stuart James Mahoney
Ryan Wayne Simms
John Fitzmaurice Valliant
Alla Darwish
Original Assignee
Centre For Probe Dev And Commercialization
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre For Probe Dev And Commercialization filed Critical Centre For Probe Dev And Commercialization
Publication of CL2019003168A1 publication Critical patent/CL2019003168A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CL2019003168A 2017-05-05 2019-11-05 Mejoras farmacocinéticas de quelatos bifuncionales y usos de los mismos. CL2019003168A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762502260P 2017-05-05 2017-05-05

Publications (1)

Publication Number Publication Date
CL2019003168A1 true CL2019003168A1 (es) 2020-08-28

Family

ID=64016761

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019003168A CL2019003168A1 (es) 2017-05-05 2019-11-05 Mejoras farmacocinéticas de quelatos bifuncionales y usos de los mismos.

Country Status (15)

Country Link
US (2) US11191854B2 (enExample)
EP (1) EP3619191A4 (enExample)
JP (2) JP7693317B2 (enExample)
KR (1) KR102612882B1 (enExample)
CN (2) CN117603148A (enExample)
AU (3) AU2018261888B2 (enExample)
BR (1) BR112019023246B1 (enExample)
CA (1) CA3062553C (enExample)
CL (1) CL2019003168A1 (enExample)
EA (1) EA201992595A1 (enExample)
IL (1) IL270453B2 (enExample)
MA (1) MA48861A (enExample)
RU (1) RU2019139432A (enExample)
WO (1) WO2018204869A1 (enExample)
ZA (1) ZA201908071B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3068443B1 (en) * 2013-11-12 2019-04-10 Centre for Probe Development and Commercialization Residualizing linkers and uses thereof
JP7693317B2 (ja) 2017-05-05 2025-06-17 センター・フォー・プローブ・デベロップメント・アンド・コマーシャライゼイション 二官能性キレートの薬物動態増強及びその使用
MA49398A (fr) * 2017-05-05 2020-04-22 Eric Steven Burak Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci
WO2020023092A2 (en) * 2018-04-25 2020-01-30 The Johns Hopkins University Alpha particle formulations for treatment of solid tumors
WO2019240884A2 (en) * 2018-04-27 2019-12-19 University Of Iowa Research Foundation Compositions for chelating metals at low temperatures
US20220088231A1 (en) * 2018-12-03 2022-03-24 Fusion Pharmaceuticals Inc. Radioimmunoconjugates and dna damage and repair inhibitor combination therapy
AU2019435951B2 (en) * 2019-03-20 2025-08-14 Provincial Health Services Authority Chelators and methods of making and using same
CA3167409A1 (en) * 2020-01-10 2021-07-15 Fusion Pharmaceuticals Inc. Macrocyclic chelates and uses thereof
CA3167285A1 (en) * 2020-01-10 2021-07-15 Fusion Pharmaceuticals Inc. Sustained immunotherapy
JP2023518818A (ja) * 2020-03-23 2023-05-08 フュージョン ファーマシューティカルズ インコーポレイテッド Ｆｇｆｒ３に標的化されたラジオイムノコンジュゲートおよびその使用
KR102362962B1 (ko) * 2020-06-12 2022-02-16 (주)미래바이오팜 신규한 화합물 및 이를 함유하는 신경 손상, 신경 질환, 또는 발달 장애에 대한 신경세포의 증식 촉진, 분화, 및/또는 재생을 통한 치료 또는 예방용 약제학적 조성물
CN115917313A (zh) * 2020-07-29 2023-04-04 中外制药株式会社 非放射性物质标记的药剂的药代动力学的测定方法
TW202304532A (zh) * 2021-03-23 2023-02-01 加拿大商融合製藥公司 治療癌症之方法
CA3222172A1 (en) * 2021-06-17 2022-12-22 Mayo Foundation For Medical Education And Research Methods and materials for combining biologics with multiple chelators
WO2023164777A1 (en) * 2022-03-04 2023-09-07 Fusion Pharmaceuticals Inc. Gucy2c-targeted radiopharmaceuticals and use thereof
WO2023240135A2 (en) 2022-06-07 2023-12-14 Actinium Pharmaceuticals, Inc. Bifunctional chelators and conjugates
WO2024138060A2 (en) * 2022-12-21 2024-06-27 Mayo Foundation For Medical Education And Research Methods and materials for combining biologics with multiple chelators

Family Cites Families (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175343A (en) 1985-01-14 1992-12-29 Neorx Corporation Metal radionuclide labeled proteins for diagnosis and therapy
DE3713842A1 (de) * 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US4889931A (en) 1988-09-27 1989-12-26 Salutar, Inc. Manganese (II) chelate manufacture
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JPH03504510A (ja) 1989-02-10 1991-10-03 セルテック　リミテッド アザマクロサイクルおよびその製法
US5053503A (en) 1989-02-17 1991-10-01 Centocor Chelating agents
US6274713B1 (en) 1989-04-07 2001-08-14 Salutar, Inc. Polychelants
US5364613A (en) 1989-04-07 1994-11-15 Sieving Paul F Polychelants containing macrocyclic chelant moieties
US7385041B2 (en) 1990-04-25 2008-06-10 Bracco International B.V. Dual functioning excipient for metal chelate contrast agents
BR9102490A (pt) 1990-06-18 1992-01-21 Dow Chemical Co Metodo para uso diagnostico na formacao de imagens e composicao
US5386011A (en) 1990-12-27 1995-01-31 Abbott Laboratories Hexapeptide anaphylatoxin-receptor ligands
GB9112536D0 (en) * 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
WO1992022324A1 (en) 1991-06-14 1992-12-23 Xoma Corporation Microbially-produced antibody fragments and their conjugates
EP0646019B9 (en) 1992-06-09 2002-12-18 Neorx Corporation Biotin-DOTA conjugates and their use in pretargeting methods
US5358704A (en) 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
GB9504922D0 (en) 1995-03-10 1995-04-26 Nycomed As Process
TR199902553T2 (xx) 1997-04-14 2000-03-21 Micromet Gesellschaft F�R Biomedizinische Forschung Mbh �nsan v�cuduna kar�� antijen resept�rlerinin �retimi i�in yeni metod ve kullan�mlar�.
IT1291624B1 (it) 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
IT1304501B1 (it) 1998-12-23 2001-03-19 Bracco Spa Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza
EP1191948A2 (en) 1999-06-11 2002-04-03 Neorx Corporation High dose radionuclide complexes for bone marrow suppression
US6887842B1 (en) * 1999-11-19 2005-05-03 The Board Of Trustees Of The Leland Stanford Junior University Modulating a pharmacokinetic property of a drug by administering a bifunctional molecule containing the drug
DE10002939C1 (de) 2000-01-13 2001-09-20 Schering Ag Paramagnetische DOTA-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung für die Herstellung von pharmazeutischen Mitteln
US20020052354A1 (en) 2000-01-27 2002-05-02 Schering Ag Paramagnetic DOTA derivatives, pharmaceutical agents that contain the latter, process for their production, and their use for MR imaging of necrosis and infarction
US6264966B1 (en) 2000-02-22 2001-07-24 Concat, Ltd. Compounds with chelation affinity and selectivity for first transition elements and their use in cosmetics and personal care products, inhibition of metalloenzymes, and inhibition of reperfusion injury
EP1289571B1 (en) 2000-05-12 2004-07-21 University Hospital Prochelators of radiometal labeled molecules
AU2002249935A1 (en) 2001-01-08 2002-08-19 Neorx Corporation Radioactively labelled conjugates of phosphonates
DE10135355C1 (de) 2001-07-20 2003-04-17 Schering Ag Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie
DE10135356C1 (de) 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
TWI240632B (en) 2001-07-30 2005-10-01 Epix Medical Inc Purified peptides for peptide-based multimeric targeted contrast agents
EP1542709A2 (en) 2002-08-06 2005-06-22 EPIX Pharmaceuticals, Inc. Peptide aggregates
DE10250870A1 (de) 2002-10-31 2004-05-13 Switch Biotech Ag Zusammensetzung enthaltend Aktivatoren von IK-Kaliumkanälen und Calcineurin-Antagonisten und deren Verwendung
WO2004071535A1 (en) 2003-02-13 2004-08-26 Bracco Imaging S.P.A. Contrast enhanced x-ray phase imaging
DK1603598T3 (da) * 2003-03-19 2009-01-26 Univ Bern Radiomærkede konjugater baseret på substans P og anvendelser heraf
WO2005001415A2 (en) 2003-05-23 2005-01-06 Epix Pharmaceuticals, Inc. Optically pure and enriched isomers of chelating ligands and contrast agents
JP4262545B2 (ja) 2003-07-09 2009-05-13 三菱電機株式会社 カスコード接続回路及びその集積回路
ATE458200T1 (de) 2003-09-12 2010-03-15 Life Technologies Corp Anwendungen des resonanzenergietransfers zwischen terbium und gfp
EP1701699B1 (en) 2003-12-19 2011-07-13 Schering Corporation Pharmaceutical compositions of an A2a receptor antagonist
WO2005079803A1 (en) 2004-02-13 2005-09-01 Pfizer Products, Inc. Compounds for treatment of cardiovascular diseases
WO2006015318A2 (en) 2004-07-30 2006-02-09 Biogen Idec Inc. Antibody conjugated to a drug moiety via a poptidic linker
ES2579805T3 (es) 2004-09-23 2016-08-16 Genentech, Inc. Anticuerpos y conjugados modificados por ingeniería genética con cisteína
US20060222595A1 (en) 2005-03-31 2006-10-05 Priyabrata Mukherjee Nanoparticles for therapeutic and diagnostic applications
WO2007009637A2 (de) 2005-07-15 2007-01-25 Bayer Schering Pharma Aktiengesellschaft Deren verwendung als kontrastmittel zur anwendung in der nmr-, rontgen- und radiodiagnostik sowie in der radiotheraphie
US7618957B2 (en) 2005-07-15 2009-11-17 Bayer Schering Pharma Aktiengesellschaft Perfluoroalkyl-containing complexes, process for their production as well as their use
US20100226884A1 (en) * 2009-01-20 2010-09-09 Immunomedics, Inc. Novel Class of Monospecific and Bispecific Humanized Antibodies that Target the Insulin-like Growth Factor Type I Receptor (IGF-1R)
US20080058636A1 (en) 2005-12-29 2008-03-06 Epix Pharmaceuticals, Inc. Methods of myocardial imaging
US20090053137A1 (en) 2006-03-15 2009-02-26 Moore Dennis A Chelating Conjugates Having a Substituted Aromatic Moiety and Derivatives Thereof
US7777029B2 (en) 2006-05-02 2010-08-17 San Diego State University (Sdsu) Foundation Bifunctional chelators for sequestering lanthanides
JP2010500417A (ja) 2006-08-11 2010-01-07 ライフ テクノロジーズ コーポレーション センサータンパク質及びアッセイ方法
US8691761B2 (en) * 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
GB0624587D0 (en) 2006-12-08 2007-01-17 Univ Muenchen Tech Chelating agent
CA2676413A1 (en) * 2007-01-19 2008-07-31 Mallinckrodt Inc. Diagnostic and therapeutic cyclooxygenase-2 binding ligands
WO2008134289A2 (en) 2007-04-26 2008-11-06 Mallinckrodt Inc. High relaxivity coordinatively unsaturated lanthanide complexes
US20090053245A1 (en) * 2007-05-29 2009-02-26 Mutz Mitchell W Pharmacokinetics and Efficacy of Anti-Angiogenic Drugs and Drugs Treating Diseases of the Blood
JP2010537931A (ja) 2007-08-27 2010-12-09 マリンクロッド・インコーポレイテッド ナノ濾過および逆相クロマトグラフィーによる水溶性化合物からのシリカの除去
AU2008295506A1 (en) 2007-08-28 2009-03-12 Biogen Idec Ma Inc. Anti-IGF-1R antibodies and uses thereof
US20090208421A1 (en) 2008-02-19 2009-08-20 Dominique Meyer Process for preparing a pharmaceutical formulation of contrast agents
DE102008045937B4 (de) 2008-04-11 2017-01-26 Johannes-Gutenberg-Universität Mainz Radiopharmakon aus einem Metallion und einem Markierungsvorläufer und Verwendung des Radiopharmakons
WO2010009246A2 (en) 2008-07-16 2010-01-21 The General Hospital Corporation Methods and reagents for preparing multifunctional probes
EP2147684A1 (en) 2008-07-22 2010-01-27 Bracco Imaging S.p.A Diagnostic Agents Selective Against Metalloproteases
EP2362784A2 (en) 2008-11-06 2011-09-07 Luisa Bracci Neurotensin-derived branched peptides and uses thereof
WO2010088527A2 (en) 2009-01-30 2010-08-05 Mayo Foundation For Medical Education And Research Peptides and nanoparticles for therapeutic and diagnostic applications
CN102356087A (zh) 2009-03-19 2012-02-15 惠氏有限责任公司 [2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7)-烯-2-基)乙基]膦酸及其前体的制备方法
US20120107248A1 (en) 2009-07-08 2012-05-03 Mayo Foundation For Medical Education And Research Imaging gastrointestinal volumes and motility
US8765920B2 (en) 2009-12-23 2014-07-01 The Scripps Research Institute Tyrosine bioconjugation through aqueous Ene-like reactions
WO2011090492A1 (en) 2010-01-19 2011-07-28 Immunomedics, Inc. Novel class of monospecific and bispecific humanized antibodies that target the insulin-like growth factor type i receptor (igf-1r)
EP2397466B1 (en) 2010-06-15 2012-11-28 Centre National De La Recherche Scientifique CNRS X-ray and gamma-photon activatable organic compounds, their preparation and their uses
WO2012021796A2 (en) 2010-08-12 2012-02-16 S&T Global, Inc. Novel cyclosporin derivatives for the treatment and prevention of a viral infection
US12097269B2 (en) 2010-10-27 2024-09-24 Vikas Kundra Dual mode gadolinium nanoparticle contrast agents
FR2968999B1 (fr) 2010-12-20 2013-01-04 Guerbet Sa Nanoemulsion de chelate pour irm
CA2827170A1 (en) 2011-02-11 2012-08-16 David M. Hilbert Monovalent and multivalent multispecific complexes and uses thereof
WO2012122420A2 (en) 2011-03-09 2012-09-13 Pharmacofore, Inc. Opioid prodrugs with heterocyclic linkers
PL2721045T3 (pl) 2011-06-20 2017-11-30 Radiomedix Inc. Kompozycie, metody syntezy i zastosowanie węglowodanowych środków ukierunkowanych
FR2976825B1 (fr) 2011-06-22 2014-02-21 Total Sa Nanotraceurs pour le marquage d'eaux d'injection de champs petroliers
EP2604281B1 (en) 2011-12-14 2014-07-30 Centre National de la Recherche Scientifique (CNRS) Clicked somatostatin conjugated analogs for biological applications
KR20130083592A (ko) 2012-01-13 2013-07-23 현대약품 주식회사 치환된 피페리딘 유도체 및 이의 제조방법
WO2013148568A1 (en) 2012-03-30 2013-10-03 Merck Sharp & Dohme Corp. Igf1 biomarker for igf1r inhibitor therapy
KR20150030709A (ko) 2012-06-14 2015-03-20 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 췌장 내분비 세포로의 분화
CN102743770B (zh) 2012-06-18 2017-07-21 申宝忠 一种靶向性分子成像探针及活体分子成像方法
WO2014037498A2 (en) 2012-09-07 2014-03-13 Bracco Imaging Spa Paramagnetic solid lipid nanoparticles (pslns) containing metal amphiphilic complexes for mri.
US9931412B2 (en) 2013-02-08 2018-04-03 The Regents Of The University Of Michigan Targeted theranostics
CA2911259A1 (en) 2013-05-06 2014-11-13 Merck Patent Gmbh Macrocycles as kinase inhibitors
US10786497B2 (en) * 2013-08-16 2020-09-29 Equip, Llc Discrete PEG constructs
US10471163B2 (en) 2013-09-13 2019-11-12 The General Hospital Corporation Activatable fibrin-binding probes
EP3456700A1 (en) 2013-10-18 2019-03-20 Deutsches Krebsforschungszentrum Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
EP3068443B1 (en) * 2013-11-12 2019-04-10 Centre for Probe Development and Commercialization Residualizing linkers and uses thereof
EP3077009A4 (en) 2013-12-03 2017-06-14 The General Hospital Corporation Molecular imaging probes
FR3015547B1 (fr) 2013-12-20 2016-01-01 Total Sa Methode pour ajuster le taux d'inhibiteurs dans un puits de petrole ou de gaz
GB201403875D0 (en) 2014-03-05 2014-04-16 Cantargia Ab Novel antibodies and uses thereof
SMT201900160T1 (it) 2014-04-11 2019-05-10 Medimmune Llc Composti coniugati comprendenti anticorpi ingegnerizzati con cisteina
CN106456798B (zh) 2014-04-25 2021-02-12 瑞纳神经科学公司 具有高药物负载的抗体-药物缀合物
EP3142710A4 (en) * 2014-05-16 2018-04-25 Memorial Sloan Kettering Cancer Center One-step labeling of antibodies to high specific activity with actinium-225
US20180036442A1 (en) 2014-07-29 2018-02-08 Vrije Universiteit Brussel Radio-labelled antibody fragments for use in the prognosis, diagnosis of cancer as well as for the prediction of cancer therapy response
BE1021191B1 (fr) 2014-08-29 2015-10-27 Anmi S.A. Kit pour radiomarquage.
GB201417067D0 (en) 2014-09-26 2014-11-12 South African Nuclear Energy Radiopharmaceutical conjugate
DE102014115154A1 (de) 2014-10-17 2016-04-21 SCV-SpezialChemikalien-Vertrieb GmbH Konjugierte Bisphosphonate für die Diagnostik und Therapie von Knochenerkrankungen
WO2016086021A1 (en) 2014-11-25 2016-06-02 Bristol-Myers Squibb Company Novel pd-l1 binding polypeptides for imaging
US20190015518A1 (en) * 2016-01-04 2019-01-17 University Of Kansas Drug delivery compositions and methods
WO2017161356A1 (en) * 2016-03-18 2017-09-21 Wake Forest University Compounds, compositions and associated methods using zirconium-89 in immuno-positron emission tomography
CN108924931B (zh) * 2017-03-24 2024-05-07 中兴通讯股份有限公司 一种无线资源配置方法、装置及用户设备、网络节点
JP7693317B2 (ja) 2017-05-05 2025-06-17 センター・フォー・プローブ・デベロップメント・アンド・コマーシャライゼイション 二官能性キレートの薬物動態増強及びその使用
US10093741B1 (en) * 2017-05-05 2018-10-09 Fusion Pharmaceuticals Inc. IGF-1R monoclonal antibodies and uses thereof
MA49398A (fr) 2017-05-05 2020-04-22 Eric Steven Burak Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci

Also Published As

Publication number Publication date
EP3619191A1 (en) 2020-03-11
NZ759832A (en) 2025-05-30
CA3062553A1 (en) 2018-11-08
AU2018261888B2 (en) 2022-06-30
BR112019023246A2 (pt) 2020-05-19
RU2019139432A3 (enExample) 2021-06-16
IL270453B2 (en) 2025-05-01
IL270453B1 (en) 2025-01-01
CN117603148A (zh) 2024-02-27
US20190030194A1 (en) 2019-01-31
US11191854B2 (en) 2021-12-07
CA3062553C (en) 2024-02-06
AU2018261888A1 (en) 2019-11-28
KR20200006087A (ko) 2020-01-17
JP7693317B2 (ja) 2025-06-17
JP2023090748A (ja) 2023-06-29
CN111263747A (zh) 2020-06-09
RU2019139432A (ru) 2021-06-07
AU2024227706A1 (en) 2024-11-21
AU2022221451A1 (en) 2022-09-22
CN111263747B (zh) 2023-10-27
IL270453A (enExample) 2020-12-31
JP2020518673A (ja) 2020-06-25
MA48861A (fr) 2020-04-01
EA201992595A1 (ru) 2020-04-21
BR112019023246A8 (pt) 2021-02-23
BR112019023246B1 (pt) 2023-11-14
ZA201908071B (en) 2023-04-26
EP3619191A4 (en) 2020-12-16
US20220054664A1 (en) 2022-02-24
WO2018204869A1 (en) 2018-11-08
KR102612882B1 (ko) 2023-12-11

Similar Documents

Publication Publication Date Title
MX2024006675A (es) Anticuerpos monoclonales del receptor del factor de crecimiento 1 tipo insulina (igf-1r) y usos de los mismos.
CY1124131T1 (el) Συζευγματα αντι-ρτκ7 αντισωματος-φαρμακου
BR112019023246A8 (pt) melhorias farmacocinéticas de quelatos bifuncionais e usos dos mesmos
MX384379B (es) Ligadores que modulan la estabilidad para usar con conjugados anticuerpo-fármaco.
CL2019002824A1 (es) Anticuerpos anti-lag3.
CY1121750T1 (el) Cot διαμορφωτες και μεθοδοι χρησης αυτων
CY1123983T1 (el) Ειδικα σε axl συζευγματα αντισωματος-φαρμακου για τη θεραπεια καρκινου
MX385585B (es) Anticuerpos anti-c10orf54 y usos de los mismos.
CO2018004152A2 (es) Conjugados de anticuerpo-fármaco de pirrolobenzodiazepina y métodos de uso
MX2015013203A (es) Conjugados de anticuerpo - farmaco.
BR112018077492A2 (pt) métodos de tratamento de câncer de ovário
MX385823B (es) Conjugados de anticuerpo-farmaco hidrofilicos.
MX2018009938A (es) Profarmacos de hormona paratiroidea (pth).
MX375570B (es) Conjugados de pirrolobenzodiazepina
ECSP17011657A (es) Conjugados de fármacos con anticuerpos anti-cdh6
BR112019004785A2 (pt) variantes de alfa-glicosidase ácida e usos das mesmas
CL2016001708A1 (es) Determinantes de respuesta del cáncer a la inmunoterapia
MX370807B (es) Anticuerpos que se unen a axl.
MX377396B (es) Compuestos de azapiridona y usos de los mismos.
MX2017007169A (es) Compuestos de amina cuaternaria y conjugados de anticuerpofármaco de los mismos.
BR112019004783A2 (pt) variantes de alfa-glicosidase ácida e usos das mesmas
MX2016013857A (es) Anticuerpos anti-rnf43 novedosos y metodos de uso.
MX2024003463A (es) Anticuerpos anti-edb y conjugados anticuerpo-farmaco.
AR109376A1 (es) FORMULACIONES DE g-HIDROXIBUTIRATO DE LIBERACIÓN MODIFICADA
CL2020003414A1 (es) Tratamiento antidiabético cardiovascular seguro