IL270453B2 - Pharmacokinetic enhancements of bifunctional chelates and uses thereof - Google Patents

Pharmacokinetic enhancements of bifunctional chelates and uses thereof

Info

Publication number
IL270453B2
IL270453B2 IL270453A IL27045319A IL270453B2 IL 270453 B2 IL270453 B2 IL 270453B2 IL 270453 A IL270453 A IL 270453A IL 27045319 A IL27045319 A IL 27045319A IL 270453 B2 IL270453 B2 IL 270453B2
Authority
IL
Israel
Prior art keywords
compound
acid
alkyl
group
aryl
Prior art date
Application number
IL270453A
Other languages
English (en)
Hebrew (he)
Other versions
IL270453B1 (en
IL270453A (enExample
Inventor
Eric Steven Burak
Stuart James Mahoney
Ryan Wayne Simms
John Fitzmaurice Valliant
Darwish Alla
Original Assignee
Fusion Pharmaceuticals Inc
Eric Steven Burak
Centre For Probe Dev And Commercialization
Stuart James Mahoney
Ryan Wayne Simms
John Fitzmaurice Valliant
Darwish Alla
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fusion Pharmaceuticals Inc, Eric Steven Burak, Centre For Probe Dev And Commercialization, Stuart James Mahoney, Ryan Wayne Simms, John Fitzmaurice Valliant, Darwish Alla filed Critical Fusion Pharmaceuticals Inc
Publication of IL270453A publication Critical patent/IL270453A/en
Publication of IL270453B1 publication Critical patent/IL270453B1/en
Publication of IL270453B2 publication Critical patent/IL270453B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic Table without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Optics & Photonics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL270453A 2017-05-05 2018-05-04 Pharmacokinetic enhancements of bifunctional chelates and uses thereof IL270453B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762502260P 2017-05-05 2017-05-05
PCT/US2018/031228 WO2018204869A1 (en) 2017-05-05 2018-05-04 Pharmacokinetic enhancements of bifunctional chelates and uses thereof

Publications (3)

Publication Number Publication Date
IL270453A IL270453A (enExample) 2020-12-31
IL270453B1 IL270453B1 (en) 2025-01-01
IL270453B2 true IL270453B2 (en) 2025-05-01

Family

ID=64016761

Family Applications (1)

Application Number Title Priority Date Filing Date
IL270453A IL270453B2 (en) 2017-05-05 2018-05-04 Pharmacokinetic enhancements of bifunctional chelates and uses thereof

Country Status (15)

Country Link
US (2) US11191854B2 (enExample)
EP (1) EP3619191A4 (enExample)
JP (2) JP7693317B2 (enExample)
KR (1) KR102612882B1 (enExample)
CN (2) CN117603148A (enExample)
AU (3) AU2018261888B2 (enExample)
BR (1) BR112019023246B1 (enExample)
CA (1) CA3062553C (enExample)
CL (1) CL2019003168A1 (enExample)
EA (1) EA201992595A1 (enExample)
IL (1) IL270453B2 (enExample)
MA (1) MA48861A (enExample)
RU (1) RU2019139432A (enExample)
WO (1) WO2018204869A1 (enExample)
ZA (1) ZA201908071B (enExample)

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JP7693317B2 (ja) 2017-05-05 2025-06-17 センター・フォー・プローブ・デベロップメント・アンド・コマーシャライゼイション 二官能性キレートの薬物動態増強及びその使用
MA49398A (fr) * 2017-05-05 2020-04-22 Eric Steven Burak Anticorps monoclonaux anti-igf-1r et utilisations de ceux-ci
WO2020023092A2 (en) * 2018-04-25 2020-01-30 The Johns Hopkins University Alpha particle formulations for treatment of solid tumors
WO2019240884A2 (en) * 2018-04-27 2019-12-19 University Of Iowa Research Foundation Compositions for chelating metals at low temperatures
US20220088231A1 (en) * 2018-12-03 2022-03-24 Fusion Pharmaceuticals Inc. Radioimmunoconjugates and dna damage and repair inhibitor combination therapy
AU2019435951B2 (en) * 2019-03-20 2025-08-14 Provincial Health Services Authority Chelators and methods of making and using same
CA3167409A1 (en) * 2020-01-10 2021-07-15 Fusion Pharmaceuticals Inc. Macrocyclic chelates and uses thereof
CA3167285A1 (en) * 2020-01-10 2021-07-15 Fusion Pharmaceuticals Inc. Sustained immunotherapy
JP2023518818A (ja) * 2020-03-23 2023-05-08 フュージョン ファーマシューティカルズ インコーポレイテッド Ｆｇｆｒ３に標的化されたラジオイムノコンジュゲートおよびその使用
KR102362962B1 (ko) * 2020-06-12 2022-02-16 (주)미래바이오팜 신규한 화합물 및 이를 함유하는 신경 손상, 신경 질환, 또는 발달 장애에 대한 신경세포의 증식 촉진, 분화, 및/또는 재생을 통한 치료 또는 예방용 약제학적 조성물
CN115917313A (zh) * 2020-07-29 2023-04-04 中外制药株式会社 非放射性物质标记的药剂的药代动力学的测定方法
TW202304532A (zh) * 2021-03-23 2023-02-01 加拿大商融合製藥公司 治療癌症之方法
CA3222172A1 (en) * 2021-06-17 2022-12-22 Mayo Foundation For Medical Education And Research Methods and materials for combining biologics with multiple chelators
WO2023164777A1 (en) * 2022-03-04 2023-09-07 Fusion Pharmaceuticals Inc. Gucy2c-targeted radiopharmaceuticals and use thereof
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WO2024138060A2 (en) * 2022-12-21 2024-06-27 Mayo Foundation For Medical Education And Research Methods and materials for combining biologics with multiple chelators

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Also Published As

Publication number Publication date
EP3619191A1 (en) 2020-03-11
NZ759832A (en) 2025-05-30
CA3062553A1 (en) 2018-11-08
AU2018261888B2 (en) 2022-06-30
BR112019023246A2 (pt) 2020-05-19
RU2019139432A3 (enExample) 2021-06-16
IL270453B1 (en) 2025-01-01
CN117603148A (zh) 2024-02-27
US20190030194A1 (en) 2019-01-31
US11191854B2 (en) 2021-12-07
CA3062553C (en) 2024-02-06
AU2018261888A1 (en) 2019-11-28
KR20200006087A (ko) 2020-01-17
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CN111263747A (zh) 2020-06-09
RU2019139432A (ru) 2021-06-07
CL2019003168A1 (es) 2020-08-28
AU2024227706A1 (en) 2024-11-21
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IL270453A (enExample) 2020-12-31
JP2020518673A (ja) 2020-06-25
MA48861A (fr) 2020-04-01
EA201992595A1 (ru) 2020-04-21
BR112019023246A8 (pt) 2021-02-23
BR112019023246B1 (pt) 2023-11-14
ZA201908071B (en) 2023-04-26
EP3619191A4 (en) 2020-12-16
US20220054664A1 (en) 2022-02-24
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KR102612882B1 (ko) 2023-12-11

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