CL2019002735A1 - Anticuerpos que se unen a steap-1. - Google Patents

Anticuerpos que se unen a steap-1.

Info

Publication number
CL2019002735A1
CL2019002735A1 CL2019002735A CL2019002735A CL2019002735A1 CL 2019002735 A1 CL2019002735 A1 CL 2019002735A1 CL 2019002735 A CL2019002735 A CL 2019002735A CL 2019002735 A CL2019002735 A CL 2019002735A CL 2019002735 A1 CL2019002735 A1 CL 2019002735A1
Authority
CL
Chile
Prior art keywords
antibodies
steap
bind
polynucleotic
methods
Prior art date
Application number
CL2019002735A
Other languages
English (en)
Inventor
Ekkehard Moessner
Laurent Lariviere
Thomas Hofer
Maximiliane Koenig
Jens Niewoehner
Tina Weinzierl
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CL2019002735A1 publication Critical patent/CL2019002735A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE EN GENERAL A ANTICUERPOS QUE SE UNEN A STEAP-1, INCLUYENDO MOLÉCULAS DE UNIÓN A ANTÍGENO BIESPECÍFICAS, POR EJEMPLO, PARA ACTIVAR LINFOCITOS T. ADEMÁS, LA PRESENTE INVENCIÓN SE REFIERE A POLINUCLEÓTIDOS QUE CODIFICAN DICHOS ANTICUERPOS Y A VECTORES Y CÉLULAS HOSPEDADORAS QUE COMPRENDEN DICHOS POLINUCLEÓTIDOS. LA INVENCIÓN SE REFIERE ADEMÁS A MÉTODOS PARA PRODUCIR LOS ANTICUERPOS Y A MÉTODOS PARA USARLOS EN EL TRATAMIENTO DE ENFERMEDADES.
CL2019002735A 2017-04-03 2019-09-25 Anticuerpos que se unen a steap-1. CL2019002735A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17164466 2017-04-03

Publications (1)

Publication Number Publication Date
CL2019002735A1 true CL2019002735A1 (es) 2020-01-17

Family

ID=58489188

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019002735A CL2019002735A1 (es) 2017-04-03 2019-09-25 Anticuerpos que se unen a steap-1.

Country Status (19)

Country Link
US (2) US11180571B2 (es)
EP (1) EP3606963B1 (es)
JP (1) JP7247101B2 (es)
CN (1) CN110494452B (es)
AU (1) AU2018247767A1 (es)
BR (1) BR112019018767A2 (es)
CA (1) CA3055132A1 (es)
CL (1) CL2019002735A1 (es)
CO (1) CO2019010164A2 (es)
CR (1) CR20190430A (es)
ES (1) ES2955852T3 (es)
IL (1) IL269394A (es)
MA (1) MA49289A (es)
MX (1) MX2019011769A (es)
PE (1) PE20200010A1 (es)
PH (1) PH12019502274A1 (es)
RU (1) RU2019134462A (es)
SG (1) SG11201909218RA (es)
WO (1) WO2018184966A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020010079A2 (en) 2018-07-02 2020-01-09 Amgen Inc. Anti-steap1 antigen-binding protein
WO2020084032A1 (en) 2018-10-25 2020-04-30 F. Hoffmann-La Roche Ag Modification of antibody fcrn binding
US20240117030A1 (en) * 2022-03-03 2024-04-11 Pfizer Inc. Multispecific antibodies and uses thereof
GB202208119D0 (en) 2022-06-01 2022-07-13 Univ Oslo Hf Anti-steap1 car

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