CL2015002301A1 - Acido 2-aza-biciclo[2.2.1]heptano-3-carboxílico (bencil-ciano-metil)-amidas sustituidas inhibidores de catepsina c. - Google Patents
Acido 2-aza-biciclo[2.2.1]heptano-3-carboxílico (bencil-ciano-metil)-amidas sustituidas inhibidores de catepsina c.Info
- Publication number
- CL2015002301A1 CL2015002301A1 CL2015002301A CL2015002301A CL2015002301A1 CL 2015002301 A1 CL2015002301 A1 CL 2015002301A1 CL 2015002301 A CL2015002301 A CL 2015002301A CL 2015002301 A CL2015002301 A CL 2015002301A CL 2015002301 A1 CL2015002301 A1 CL 2015002301A1
- Authority
- CL
- Chile
- Prior art keywords
- aza
- bicyclo
- heptane
- cyano
- benzyl
- Prior art date
Links
- 102000005600 Cathepsins Human genes 0.000 title 1
- 108010084457 Cathepsins Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- JEJUQZPFSCGQQY-UHFFFAOYSA-N n-(1-cyano-2-phenylethyl)-3-azabicyclo[2.2.1]heptane-2-carboxamide Chemical group N1C(C2)CCC2C1C(=O)NC(C#N)CC1=CC=CC=C1 JEJUQZPFSCGQQY-UHFFFAOYSA-N 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 230000000172 allergic effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 208000010668 atopic eczema Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000002327 eosinophilic effect Effects 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000000813 microbial effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
Classifications
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- C—CHEMISTRY; METALLURGY
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
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- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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2015
- 2015-07-20 IL IL240030A patent/IL240030B/en active IP Right Grant
- 2015-08-17 CL CL2015002301A patent/CL2015002301A1/es unknown
- 2015-08-31 TN TN2015000381A patent/TN2015000381A1/en unknown
- 2015-09-04 PH PH12015501964A patent/PH12015501964B1/en unknown
- 2015-12-01 US US14/955,379 patent/US9713606B2/en active Active
-
2017
- 2017-06-06 US US15/614,996 patent/US10238633B2/en active Active
- 2017-09-26 JP JP2017184322A patent/JP6689805B2/ja active Active
-
2019
- 2019-02-08 US US16/271,068 patent/US20190167636A1/en not_active Abandoned
- 2019-12-19 US US16/720,347 patent/US20200138780A1/en not_active Abandoned
-
2021
- 2021-04-19 US US17/234,004 patent/US20210260027A1/en not_active Abandoned
-
2023
- 2023-06-08 US US18/331,492 patent/US20230310373A1/en not_active Abandoned
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