BR112015019720B8 - Inibidores de (benzil-ciano-metil)-amidas de ácido 2-azabiciclo[2.2.1]heptano-3-carboxílico substituído da catepsina c e composição farmacêutica - Google Patents

Inibidores de (benzil-ciano-metil)-amidas de ácido 2-azabiciclo[2.2.1]heptano-3-carboxílico substituído da catepsina c e composição farmacêutica

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Publication number
BR112015019720B8
BR112015019720B8 BR112015019720A BR112015019720A BR112015019720B8 BR 112015019720 B8 BR112015019720 B8 BR 112015019720B8 BR 112015019720 A BR112015019720 A BR 112015019720A BR 112015019720 A BR112015019720 A BR 112015019720A BR 112015019720 B8 BR112015019720 B8 BR 112015019720B8
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BR
Brazil
Prior art keywords
heptane
cyano
benzyl
methyl
cathepsin
Prior art date
Application number
BR112015019720A
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English (en)
Other versions
BR112015019720B1 (pt
BR112015019720A2 (pt
Inventor
Alexander Pautsch
Florian Binder
Marc Grundl
Matthias Grauert
Wilhelm Haebel Peter
Ralf Anderskewitz
Stefan Peters
Thorsten Oost
Viktor Vintonyak
Original Assignee
Boehringer Ingelheim Int
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Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of BR112015019720A2 publication Critical patent/BR112015019720A2/pt
Publication of BR112015019720B1 publication Critical patent/BR112015019720B1/pt
Publication of BR112015019720B8 publication Critical patent/BR112015019720B8/pt

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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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Abstract

inibidores de (benzil-ciano-metil)-amidas de ácido 2-aza-biciclo[2.2.1]heptano-3-carboxílico substituído da catepsina c. a invenção refere-se às (benzil-ciano-metil)-amidas de ácido 2-aza-biciclo[2.2.1]heptano-3-carboxílico de fórmula (1) e seu uso como inibidores de catepsina c, composições farmacêuticas contendo-as, e métodos para o seu uso como agentes para o tratamento e/ou prevenção de doenças relacionadas com a atividade de dipeptidil peptidase i, por exemplo, doenças respiratórias.
BR112015019720A 2013-03-14 2014-03-12 Inibidores de (benzil-ciano-metil)-amidas de ácido 2-azabiciclo[2.2.1]heptano-3-carboxílico substituído da catepsina c e composição farmacêutica BR112015019720B8 (pt)

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PCT/EP2014/054794 WO2014140075A1 (en) 2013-03-14 2014-03-12 Substituted 2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides inhibitors of cathepsin c

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