ES2845473T3 - (Bencil-ciano-metil)-amidas sustituidas de ácido 2-aza-biciclo[2.2.1]heptano-3-carboxílico inhibidores de la catepsina- C - Google Patents
(Bencil-ciano-metil)-amidas sustituidas de ácido 2-aza-biciclo[2.2.1]heptano-3-carboxílico inhibidores de la catepsina- C Download PDFInfo
- Publication number
- ES2845473T3 ES2845473T3 ES14709652T ES14709652T ES2845473T3 ES 2845473 T3 ES2845473 T3 ES 2845473T3 ES 14709652 T ES14709652 T ES 14709652T ES 14709652 T ES14709652 T ES 14709652T ES 2845473 T3 ES2845473 T3 ES 2845473T3
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- Prior art keywords
- alkylene
- alkyl
- independently
- independently selected
- cycloalkyl
- Prior art date
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- 0 *N([C@]1[C@]2CC1)[C@@]2C(N[C@@](Cc(c(F)c1)ccc1N=[N+]=[N-])C#N)=O Chemical compound *N([C@]1[C@]2CC1)[C@@]2C(N[C@@](Cc(c(F)c1)ccc1N=[N+]=[N-])C#N)=O 0.000 description 3
- WNLXAUXQXSIXJZ-UHFFFAOYSA-N C(C(C1)NCC11C2C(C3NC4)C5CNC2CC5)C1c1c3c4ccc1 Chemical compound C(C(C1)NCC11C2C(C3NC4)C5CNC2CC5)C1c1c3c4ccc1 WNLXAUXQXSIXJZ-UHFFFAOYSA-N 0.000 description 1
- LKDJYZBKCVSODK-UHFFFAOYSA-N C(C1)C2NC1CNC2 Chemical compound C(C1)C2NC1CNC2 LKDJYZBKCVSODK-UHFFFAOYSA-N 0.000 description 1
- DJWDAKFSDBOQJK-UHFFFAOYSA-N C(C1)C2NCC1NC2 Chemical compound C(C1)C2NCC1NC2 DJWDAKFSDBOQJK-UHFFFAOYSA-N 0.000 description 1
- ATNXGUBNSJAEQE-UHFFFAOYSA-N C(C1C2)C3C11C45C67C89C%10%11C2C8C6C4C1CC%10CC%11C9C7C35 Chemical compound C(C1C2)C3C11C45C67C89C%10%11C2C8C6C4C1CC%10CC%11C9C7C35 ATNXGUBNSJAEQE-UHFFFAOYSA-N 0.000 description 1
- UKHJNJFJCGBKSF-UHFFFAOYSA-N C1C2NCC1NC2 Chemical compound C1C2NCC1NC2 UKHJNJFJCGBKSF-UHFFFAOYSA-N 0.000 description 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N C1NCCNC1 Chemical compound C1NCCNC1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 1
- DCTDBKRLYIDBRN-UHFFFAOYSA-N C1OCC2=CC=CCC12 Chemical compound C1OCC2=CC=CCC12 DCTDBKRLYIDBRN-UHFFFAOYSA-N 0.000 description 1
- LPAGFVYQRIESJQ-UHFFFAOYSA-N C1c(cccc2)c2NC1 Chemical compound C1c(cccc2)c2NC1 LPAGFVYQRIESJQ-UHFFFAOYSA-N 0.000 description 1
- QXQQOFWCYXYFAE-ZUIVOOLFSA-N CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(NC(Cc(c(OCc1ccccc1)c1)ccc1-c1cc(N(C)C(C2)=O)c2cc1)C#N)=O)O Chemical compound CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(NC(Cc(c(OCc1ccccc1)c1)ccc1-c1cc(N(C)C(C2)=O)c2cc1)C#N)=O)O QXQQOFWCYXYFAE-ZUIVOOLFSA-N 0.000 description 1
- MEYCZYQDAXBIMG-ADHYTWILSA-N CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(NC(Cc1ccc(-c(ccc(Cl)c2)c2N(C)C2=O)c2c1)C#N)=O)=O Chemical compound CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(NC(Cc1ccc(-c(ccc(Cl)c2)c2N(C)C2=O)c2c1)C#N)=O)=O MEYCZYQDAXBIMG-ADHYTWILSA-N 0.000 description 1
- AXMMETSGAWZDMI-UUSDYUTISA-N CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(NC(Cc1ccc(B2OC(C)(C)C(C)(C)O2)c(C(OC)=O)c1)C#N)=O)=O Chemical compound CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(NC(Cc1ccc(B2OC(C)(C)C(C)(C)O2)c(C(OC)=O)c1)C#N)=O)=O AXMMETSGAWZDMI-UUSDYUTISA-N 0.000 description 1
- WMBWBPLILFWHMI-YVVXQTMVSA-N CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(N[C@@H](Cc(ccc(Br)c1)c1F)C(N)=O)=O)=O Chemical compound CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(N[C@@H](Cc(ccc(Br)c1)c1F)C(N)=O)=O)=O WMBWBPLILFWHMI-YVVXQTMVSA-N 0.000 description 1
- IXOGUGASMMKTED-YVVXQTMVSA-N CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(N[C@@H](Cc(ccc(N=[N+]=[N-])c1)c1F)C(N)=O)=O)=O Chemical compound CC(C)(C)OC(N([C@H]1C[C@@H]2CC1)[C@@H]2C(N[C@@H](Cc(ccc(N=[N+]=[N-])c1)c1F)C(N)=O)=O)=O IXOGUGASMMKTED-YVVXQTMVSA-N 0.000 description 1
- WIISZLORDJSPAF-UHFFFAOYSA-N CC(C)c(cc(C(F)(F)F)cc1)c1[NH+](C)[O-] Chemical compound CC(C)c(cc(C(F)(F)F)cc1)c1[NH+](C)[O-] WIISZLORDJSPAF-UHFFFAOYSA-N 0.000 description 1
- YSHOWEKUVWPFNR-UHFFFAOYSA-O CC[N+](CC)(CC)S(NC(OC)=O)(=O)=O Chemical compound CC[N+](CC)(CC)S(NC(OC)=O)(=O)=O YSHOWEKUVWPFNR-UHFFFAOYSA-O 0.000 description 1
- OMDHOEFLZYLHJH-BLDHOGSXSA-N CN(C(CC1)=O)c2c1ccc(-c1cc(O)c(CC(C#N)NC([C@H]3N[C@H]4C[C@@H]3CC4)=O)cc1)c2 Chemical compound CN(C(CC1)=O)c2c1ccc(-c1cc(O)c(CC(C#N)NC([C@H]3N[C@H]4C[C@@H]3CC4)=O)cc1)c2 OMDHOEFLZYLHJH-BLDHOGSXSA-N 0.000 description 1
- SVARUVQPDCVUTH-UHDBIXDDSA-N CN(c1cc(Cl)ccc1-c1ccc(CC(C#N)NC([C@H]2N[C@H]3C[C@@H]2CC3)=O)cc11)C1=O Chemical compound CN(c1cc(Cl)ccc1-c1ccc(CC(C#N)NC([C@H]2N[C@H]3C[C@@H]2CC3)=O)cc11)C1=O SVARUVQPDCVUTH-UHDBIXDDSA-N 0.000 description 1
- XRTGYBDFAGUWTC-UHFFFAOYSA-N CNC(Nc1cc(Br)ccc1N)=S Chemical compound CNC(Nc1cc(Br)ccc1N)=S XRTGYBDFAGUWTC-UHFFFAOYSA-N 0.000 description 1
- DFRSYVJABDOPAN-UHFFFAOYSA-N CNc([nH]c1c2)nc1ccc2Br Chemical compound CNc([nH]c1c2)nc1ccc2Br DFRSYVJABDOPAN-UHFFFAOYSA-N 0.000 description 1
- UCHNRCLIUNTABE-UHFFFAOYSA-N CNc(cc(cc1)Cl)c1I Chemical compound CNc(cc(cc1)Cl)c1I UCHNRCLIUNTABE-UHFFFAOYSA-N 0.000 description 1
- WIHHVKUARKTSBU-UHFFFAOYSA-N Nc(c(N)c1)ccc1Br Chemical compound Nc(c(N)c1)ccc1Br WIHHVKUARKTSBU-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
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- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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| KR20190092374A (ko) * | 2016-10-03 | 2019-08-07 | 시질론 테라퓨틱스, 인크. | 화합물, 장치, 및 이의 용도 |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
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| KR20210069079A (ko) | 2018-09-28 | 2021-06-10 | 얀센 파마슈티카 엔.브이. | 모노아실글리세롤 리파아제 조절제 |
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| CA3199568A1 (en) * | 2020-12-04 | 2022-06-09 | Reistone Biopharma Company Limited | Small molecule inhibitor of cathepsin c and medicinal use thereof |
| JP7693817B2 (ja) * | 2021-02-05 | 2025-06-17 | エス-インフィニティ ファーマシューティカルズ カンパニー リミテッド | 1,4-オキサゼパンを含む縮合環誘導体 |
| CA3215375A1 (en) * | 2021-04-29 | 2022-11-03 | Insmed Incorporated | Certain n-(1-cyano-2-phenylethyl)-1,4-oxazepane-2-carboxamides for treating cystic fibrosis |
| CN113831360A (zh) * | 2021-09-10 | 2021-12-24 | 中钢集团南京新材料研究院有限公司 | 酰胺邻位导向硼化合成1-咔唑-硼酸频哪醇酯的方法 |
| CN116462677A (zh) * | 2022-01-20 | 2023-07-21 | 上海和誉生物医药科技有限公司 | 一种多稠环prmt5抑制剂及其制备方法和应用 |
| US20230234973A1 (en) * | 2022-01-27 | 2023-07-27 | Heron Neutron Medical Corp. | Intermediate, preparing method thereof, and method of preparing drug |
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| WO2023208081A1 (en) * | 2022-04-28 | 2023-11-02 | Shenzhen Bay Laboratory | Substituted fluorosulfate and use thereof |
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| KR20250120411A (ko) | 2022-12-16 | 2025-08-08 | 신젠타 크롭 프로텍션 아게 | 벤즈이미다졸 유도체 |
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Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4125727A (en) | 1976-10-18 | 1978-11-14 | American Cyanamid Company | Method of preparing imidazoisoindolediones |
| GB8922355D0 (en) | 1989-10-04 | 1989-11-22 | British Telecomm | Sealing gland |
| US6960597B2 (en) | 2000-06-30 | 2005-11-01 | Orth-Mcneil Pharmaceutical, Inc. | Aza-bridged-bicyclic amino acid derivatives as α4 integrin antagonists |
| DE20012487U1 (de) | 2000-07-19 | 2001-04-05 | Wenger, Lukas, 85521 Ottobrunn | Beheizbare Scheibenwischer an Kraftfahrzeugen |
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| US6982263B2 (en) | 2001-06-08 | 2006-01-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Nitriles useful as reversible inhibitors of cysteine proteases |
| TW200306189A (en) | 2002-03-21 | 2003-11-16 | Merz Pharma Gmbh & Co Kgaa | Azabicyclic, azatricyclic and azaspirocyclic derivatives of aminocyclohexane NMDA, 5HT3, and neuronal nicotinic receptor antagonists |
| WO2004110988A1 (en) | 2003-06-18 | 2004-12-23 | Prozymex A/S | Protease inhibitors |
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| WO2005065778A1 (en) * | 2004-01-08 | 2005-07-21 | Merck Frosst Canada Ltd. | Cathepsin cysteine protease inhibitors |
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| EP2072519A4 (en) | 2006-09-28 | 2009-10-21 | Banyu Pharma Co Ltd | DIARYLKETIMINDERIVAT |
| JP5240201B2 (ja) * | 2007-10-12 | 2013-07-17 | 富士通株式会社 | Ip電話自動試験システム及び方法 |
| WO2009074829A1 (en) | 2007-12-12 | 2009-06-18 | Astrazeneca Ab | Peptidyl nitriles and use thereof as dipeptidyl peptidase i inhibitors |
| WO2010128324A1 (en) | 2009-05-07 | 2010-11-11 | Astrazeneca Ab | Substituted 1-cyanoethylheterocyclylcarboxamide compounds 750 |
| WO2010142985A1 (en) | 2009-06-10 | 2010-12-16 | Astrazeneca Ab | Substituted n-[1-cyano-2-(phenyl)ethyl]piperidin-2-ylcarboxmide compounds 761 |
| US8383639B2 (en) | 2009-10-15 | 2013-02-26 | Bristol-Myers Squibb Company | HIV integrase inhibitors |
| WO2012119941A1 (en) * | 2011-03-04 | 2012-09-13 | Prozymex A/S | Peptidyl nitrilcompounds as peptidase inhibitors |
| US8999975B2 (en) * | 2011-09-19 | 2015-04-07 | Boehringer Ingelheim International Gmbh | Substituted N- [1-cyano-2- (phenyl) ethyl] -2-azabicyclo [2.2.1] heptane-3-carboxamide inhibitors of cathepsin C |
| US9428452B2 (en) | 2012-04-27 | 2016-08-30 | Glaxo Group Limited | Compounds |
| US9056874B2 (en) | 2012-05-04 | 2015-06-16 | Novartis Ag | Complement pathway modulators and uses thereof |
| HK1209100A1 (en) | 2012-05-22 | 2016-03-24 | 基因泰克有限公司 | N-substituted benzamides and their use in the treatment of pain |
| US8859774B2 (en) | 2012-05-25 | 2014-10-14 | Corcept Therapeutics, Inc. | Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators |
| JO3459B1 (ar) | 2012-09-09 | 2020-07-05 | H Lundbeck As | تركيبات صيدلانية لعلاج مرض الزهايمر |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| CA2886495C (en) | 2012-09-28 | 2023-09-19 | Ignyta, Inc. | Azaquinazoline inhibitors of atypical protein kinase c |
| JP2015533134A (ja) | 2012-10-09 | 2015-11-19 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 錠剤の機械的安定性に適切な少なくとも1種の水和物形成活性物質及び/又はアジュバントを含有する機械的に安定な錠剤、特にアルギニン含有錠剤の製造における選択的に水分調整された打錠材料の使用 |
| JP6461802B2 (ja) | 2012-10-15 | 2019-01-30 | エピザイム,インコーポレイティド | 置換ベンゼン化合物 |
| SG11201502369XA (en) | 2012-10-16 | 2015-05-28 | Janssen Pharmaceutica Nv | Methylene linked quinolinyl modulators of ror-gamma-t |
| NZ707495A (en) | 2012-11-01 | 2019-01-25 | Incyte Holdings Corp | Tricyclic fused thiophene derivatives as jak inhibitors |
| DK2935248T3 (en) | 2012-12-21 | 2018-04-23 | Plexxikon Inc | RELATIONS AND PROCEDURE FOR CHINESE MODULATION AND INDICATIONS THEREOF |
| US9233974B2 (en) | 2012-12-21 | 2016-01-12 | Gilead Sciences, Inc. | Antiviral compounds |
| SG11201504946VA (en) | 2012-12-21 | 2015-07-30 | Quanticel Pharmaceuticals Inc | Histone demethylase inhibitors |
| EP2953457B1 (en) | 2013-02-08 | 2020-04-08 | Celgene CAR LLC | Erk inhibitors and uses thereof |
| TWI599567B (zh) | 2013-03-14 | 2017-09-21 | 健生藥品公司 | P2x7調節劑 |
| MX355945B (es) | 2013-03-14 | 2018-05-07 | Novartis Ag | 3-pirimidin-4-il-oxazolidin-2-onas como inhibidoras de idh mutante. |
| AR095426A1 (es) | 2013-03-14 | 2015-10-14 | Onyx Therapeutics Inc | Inhibidores tripeptídicos de la epoxicetona proteasa |
| JO3383B1 (ar) | 2013-03-14 | 2019-03-13 | Lilly Co Eli | مثبطات cdc7 |
| JP6218860B2 (ja) * | 2013-03-14 | 2017-10-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | カテプシンcの置換2−アザ−ビシクロ[2.2.1]ヘプタン−3−カルボン酸(ベンジル−シアノ−メチル)−アミド阻害剤 |
| US20140275082A1 (en) | 2013-03-14 | 2014-09-18 | Abbvie Inc. | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases |
| US9242969B2 (en) | 2013-03-14 | 2016-01-26 | Novartis Ag | Biaryl amide compounds as kinase inhibitors |
| EP3366678A1 (en) | 2013-03-14 | 2018-08-29 | Newlink Genetics Corporation | Tricyclic compounds as inhibitors of immunosuppression mediated by tryptophan metabolization |
| US20160001608A1 (en) | 2014-07-03 | 2016-01-07 | Bridgestone Americas Tire Operations, Llc | Sidewall decoration on rim guard |
| BR112017004580A2 (pt) | 2014-09-12 | 2018-01-23 | GlaxoSmithKline Intellectual Property | composto, composição farmacêutica, produto de combinação, uso de um composto ou sal farmaceuticamente aceitável, e, método de tratamento. |
| UY36294A (es) | 2014-09-12 | 2016-04-29 | Novartis Ag | Compuestos y composiciones como inhibidores de quinasa |
| AR101696A1 (es) | 2014-09-12 | 2017-01-04 | Lilly Co Eli | Compuestos de azetidiniloxifenilpirrolidina |
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