CL2014003078A1 - Homodimero de una proteínas del factor 21 de crecimiento del fibroblasto (fgf21); molecula de adn que la codifica; proceso para producirla y sus uso. - Google Patents

Homodimero de una proteínas del factor 21 de crecimiento del fibroblasto (fgf21); molecula de adn que la codifica; proceso para producirla y sus uso.

Info

Publication number
CL2014003078A1
CL2014003078A1 CL2014003078A CL2014003078A CL2014003078A1 CL 2014003078 A1 CL2014003078 A1 CL 2014003078A1 CL 2014003078 A CL2014003078 A CL 2014003078A CL 2014003078 A CL2014003078 A CL 2014003078A CL 2014003078 A1 CL2014003078 A1 CL 2014003078A1
Authority
CL
Chile
Prior art keywords
fgf21
homodimer
encodes
protein
produce
Prior art date
Application number
CL2014003078A
Other languages
English (en)
Spanish (es)
Inventor
Craig Duane Dickinson
David Albert Driver
Malgorzata Donata Gonciarz
Ryan James Darling
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48670814&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2014003078(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of CL2014003078A1 publication Critical patent/CL2014003078A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/81—Carrier - bound or immobilized peptides or proteins and the preparation thereof, e.g. biological cell or cell fragment as carrier
    • Y10S530/812—Peptides or proteins is immobilized on, or in, an organic carrier
    • Y10S530/813—Carrier is a saccharide
    • Y10S530/814—Cellulose or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CL2014003078A 2012-06-11 2014-11-13 Homodimero de una proteínas del factor 21 de crecimiento del fibroblasto (fgf21); molecula de adn que la codifica; proceso para producirla y sus uso. CL2014003078A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261658104P 2012-06-11 2012-06-11
US201361777386P 2013-03-12 2013-03-12

Publications (1)

Publication Number Publication Date
CL2014003078A1 true CL2014003078A1 (es) 2015-02-27

Family

ID=48670814

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2014003078A CL2014003078A1 (es) 2012-06-11 2014-11-13 Homodimero de una proteínas del factor 21 de crecimiento del fibroblasto (fgf21); molecula de adn que la codifica; proceso para producirla y sus uso.

Country Status (24)

Country Link
US (2) US8741841B2 (h)
EP (1) EP2858662B1 (h)
JP (1) JP6182600B2 (h)
KR (1) KR20150006060A (h)
CN (1) CN104394882B (h)
AR (1) AR091216A1 (h)
AU (1) AU2013274638A1 (h)
BR (1) BR112014029966A2 (h)
CA (1) CA2871145A1 (h)
CL (1) CL2014003078A1 (h)
CO (1) CO7151525A2 (h)
EA (1) EA201492053A1 (h)
EC (1) ECSP14030742A (h)
ES (1) ES2644787T3 (h)
HK (1) HK1203357A1 (h)
IL (1) IL235832A0 (h)
IN (1) IN2014MN02132A (h)
MX (1) MX2014015257A (h)
PE (1) PE20150201A1 (h)
PH (1) PH12014502766A1 (h)
SG (1) SG11201408095XA (h)
TN (1) TN2014000439A1 (h)
TW (1) TWI513705B (h)
WO (1) WO2013188181A1 (h)

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US9290557B2 (en) 2012-11-28 2016-03-22 Ngm Biopharmaceuticals, Inc. Compositions comprising variants and fusions of FGF19 polypeptides
US9273107B2 (en) 2012-12-27 2016-03-01 Ngm Biopharmaceuticals, Inc. Uses and methods for modulating bile acid homeostasis and treatment of bile acid disorders and diseases
PL2938740T3 (pl) 2012-12-27 2022-07-11 Ngm Biopharmaceuticals, Inc. Chimeryczne peptydy fgf19 do zastosowania w leczeniu zaburzeń gospodarki kwasami żółciowymi
SG11201602870YA (en) 2013-10-28 2016-05-30 Ngm Biopharmaceuticals Inc Cancer models and associated methods
US9738716B2 (en) 2014-01-24 2017-08-22 Ngm Biopharmaceuticals, Inc. Beta klotho binding proteins and methods of use thereof
RU2016137264A (ru) * 2014-02-21 2018-03-26 МЕДИММЬЮН, ЭлЭлСи Слияния антитела к pcsk9~glp-1 и способы применения
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WO2016187558A2 (en) 2015-05-20 2016-11-24 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Method to improve neurologic outcomes in temperature managed patients
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KR102668200B1 (ko) 2015-10-28 2024-05-23 주식회사유한양행 지속형 fgf21 융합 단백질 및 이를 포함하는 약학적 조성물
KR102670157B1 (ko) 2015-10-28 2024-05-29 주식회사유한양행 이중 작용 단백질 및 이를 포함하는 약학적 조성물
EP3888672A1 (en) 2015-11-09 2021-10-06 NGM Biopharmaceuticals, Inc. Methods for treatment of bile acid-related disorders
CN105348380B (zh) * 2015-12-28 2019-03-01 江苏康缘瑞翱生物医药科技有限公司 犬成纤维细胞生长因子21及其在治疗犬内分泌疾病中的用途
WO2018032638A1 (zh) 2016-08-19 2018-02-22 安源医药科技（上海）有限公司 用于构建融合蛋白的连接肽
CN106279437B (zh) 2016-08-19 2017-10-31 安源医药科技（上海）有限公司 高糖基化人凝血因子viii融合蛋白及其制备方法与用途
CN107759697B (zh) 2016-08-19 2023-03-24 安源医药科技（上海）有限公司 制备融合蛋白的方法
EP3503882A4 (en) 2016-08-26 2020-07-29 NGM Biopharmaceuticals, Inc. METHOD FOR TREATING FIBROBLAST GROWTH FACTOR-19-MEDIATED CARCINOMAS AND TUMORS
JP7328891B2 (ja) 2016-11-10 2023-08-17 ユーハン・コーポレイション 融合タンパク質を含む、肝炎、肝線維症、および肝硬変を予防または処置するための医薬組成物
JP7181886B2 (ja) 2017-03-14 2022-12-01 サンシャイン・レイク・ファーマ・カンパニー・リミテッド 免疫グロブリンのＦｃ部分を含む二重標的融合タンパク質
BR112019021923A2 (pt) 2017-04-21 2020-06-02 Yuhan Corporation Método para produzir proteínas de função dupla e suas derivadas
CN107385020A (zh) * 2017-06-23 2017-11-24 西安医学院 瘦素在人重组fgf21蛋白活性检测中的应用
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JP7664168B2 (ja) * 2019-03-05 2025-04-17 サンシャイン・レイク・ファーマ・カンパニー・リミテッド ポリペプチド分子及びその適用
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Also Published As

Publication number Publication date
CA2871145A1 (en) 2013-12-19
US20140228282A1 (en) 2014-08-14
IN2014MN02132A (h) 2015-09-11
EA201492053A1 (ru) 2015-02-27
SG11201408095XA (en) 2015-01-29
IL235832A0 (en) 2015-01-29
EP2858662B1 (en) 2017-08-09
US20130330336A1 (en) 2013-12-12
HK1203357A1 (en) 2015-10-30
PH12014502766A1 (en) 2015-02-09
PE20150201A1 (es) 2015-02-19
JP2015527974A (ja) 2015-09-24
TW201408693A (zh) 2014-03-01
BR112014029966A2 (pt) 2017-09-12
JP6182600B2 (ja) 2017-08-16
EP2858662A1 (en) 2015-04-15
ECSP14030742A (es) 2015-09-30
CO7151525A2 (es) 2014-12-29
US8741841B2 (en) 2014-06-03
US8927492B2 (en) 2015-01-06
CN104394882B (zh) 2016-06-22
TWI513705B (zh) 2015-12-21
CN104394882A (zh) 2015-03-04
AR091216A1 (es) 2015-01-21
MX2014015257A (es) 2015-03-05
AU2013274638A1 (en) 2014-11-06
WO2013188181A1 (en) 2013-12-19
KR20150006060A (ko) 2015-01-15
TN2014000439A1 (en) 2016-03-30
ES2644787T3 (es) 2017-11-30

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