CL2013003123A1 - Molécula de nucleasa híbrida; composición que comprende dicha molécula; método para preparar dicha molécula; método para tratar lupus eritematoso sistémico. - Google Patents

Molécula de nucleasa híbrida; composición que comprende dicha molécula; método para preparar dicha molécula; método para tratar lupus eritematoso sistémico.

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Publication number
CL2013003123A1
CL2013003123A1 CL2013003123A CL2013003123A CL2013003123A1 CL 2013003123 A1 CL2013003123 A1 CL 2013003123A1 CL 2013003123 A CL2013003123 A CL 2013003123A CL 2013003123 A CL2013003123 A CL 2013003123A CL 2013003123 A1 CL2013003123 A1 CL 2013003123A1
Authority
CL
Chile
Prior art keywords
molecule
preparing
composition
lupus erythematosus
systemic lupus
Prior art date
Application number
CL2013003123A
Other languages
English (en)
Spanish (es)
Inventor
Martha Hayden-Ledbetter
Keith Elkon
Xizhang Sun
Jeffrey A Ledbetter
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of CL2013003123A1 publication Critical patent/CL2013003123A1/es

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C12Y—ENZYMES
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    • C12Y301/27—Endoribonucleases producing 3'-phosphomonoesters (3.1.27)
    • C12Y301/27005—Pancreatic ribonuclease (3.1.27.5)

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  • Biotechnology (AREA)
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  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Microbiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
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  • Gynecology & Obstetrics (AREA)
  • Urology & Nephrology (AREA)
CL2013003123A 2011-04-29 2013-10-28 Molécula de nucleasa híbrida; composición que comprende dicha molécula; método para preparar dicha molécula; método para tratar lupus eritematoso sistémico. CL2013003123A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161480961P 2011-04-29 2011-04-29
US201261617241P 2012-03-29 2012-03-29

Publications (1)

Publication Number Publication Date
CL2013003123A1 true CL2013003123A1 (es) 2014-08-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CL2013003123A CL2013003123A1 (es) 2011-04-29 2013-10-28 Molécula de nucleasa híbrida; composición que comprende dicha molécula; método para preparar dicha molécula; método para tratar lupus eritematoso sistémico.

Country Status (28)

Country Link
US (6) US10202588B2 (https=)
EP (2) EP3449933A1 (https=)
JP (7) JP6063450B2 (https=)
KR (6) KR102161657B1 (https=)
CN (2) CN103930127B (https=)
AU (5) AU2012249360B2 (https=)
BR (1) BR112013027547B1 (https=)
CA (1) CA2834626A1 (https=)
CL (1) CL2013003123A1 (https=)
CO (1) CO6811815A2 (https=)
CR (1) CR20130598A (https=)
DK (1) DK2704737T3 (https=)
DO (1) DOP2013000250A (https=)
EA (1) EA201391585A1 (https=)
EC (1) ECSP13013060A (https=)
ES (1) ES2666303T3 (https=)
HR (1) HRP20180564T1 (https=)
HU (1) HUE038759T2 (https=)
IL (5) IL300276B2 (https=)
LT (1) LT2704737T (https=)
MX (3) MX351953B (https=)
NZ (1) NZ616989A (https=)
PE (1) PE20141172A1 (https=)
PH (1) PH12013502441B1 (https=)
PL (1) PL2704737T3 (https=)
SG (2) SG194680A1 (https=)
SI (1) SI2704737T1 (https=)
WO (1) WO2012149440A2 (https=)

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BR112020003670A2 (pt) 2017-08-22 2020-09-01 Sanabio, Llc receptores de interferon solúveis e usos dos mesmos
US10988746B2 (en) * 2018-10-08 2021-04-27 Neutrolis, Inc. Manufacturing and engineering of DNASE enzymes for therapy
AU2019358915B2 (en) * 2018-10-08 2025-09-18 Neutrolis, Inc. Engineering of DNASE enzymes for manufacturing and therapy
US20220089786A1 (en) * 2019-01-04 2022-03-24 Resolve Therapeutics, Llc Treatment of sjogren's disease with nuclease fusion proteins
JP2020136505A (ja) 2019-02-20 2020-08-31 株式会社Ｊｏｌｅｄ 半導体装置および表示装置
US20230062096A1 (en) * 2020-01-11 2023-03-02 Yale University Compositions and methods for treating, ameliorating, and/or preventing diseases or disorders caused by or associated with dnase1 and/or dnase1l3 deficiency
CA3181572A1 (en) * 2020-06-08 2021-12-16 Paul STABACH Compositions and methods for treating and/or preventing coagulopathy and/or sepsis in patients suffering from bacterial and/or viral infections
CN112088903A (zh) * 2020-09-28 2020-12-18 武汉愔紫生物科技有限公司 一种大分子蛋白在抗菌抗病毒消毒剂中的应用
US12180521B2 (en) 2021-02-19 2024-12-31 Theripion, Inc. Paraoxonase fusion polypeptides and related compositions and methods
CN115595315B (zh) * 2021-06-28 2024-08-16 四川大学华西医院 核糖核酸酶i在抑制疼痛的药物中的新用途
CN121518579A (zh) * 2024-08-12 2026-02-13 上海交通大学医学院 一种减少线粒体dna泄露的方法

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