CL2008002861A1 - Polipeptido aislado de m. ruminantium; vector, molecula conjugada y celula huesped que comprenden dicho polipeptido; anticuerpo o fragmento que se une al polipeptido; composicion farmaceutica que comprende la molecula conjugada; metodo para dirigir una celula metanogena para identificacion, aislamiento o inhibicion. - Google Patents
Polipeptido aislado de m. ruminantium; vector, molecula conjugada y celula huesped que comprenden dicho polipeptido; anticuerpo o fragmento que se une al polipeptido; composicion farmaceutica que comprende la molecula conjugada; metodo para dirigir una celula metanogena para identificacion, aislamiento o inhibicion.Info
- Publication number
- CL2008002861A1 CL2008002861A1 CL2008002861A CL2008002861A CL2008002861A1 CL 2008002861 A1 CL2008002861 A1 CL 2008002861A1 CL 2008002861 A CL2008002861 A CL 2008002861A CL 2008002861 A CL2008002861 A CL 2008002861A CL 2008002861 A1 CL2008002861 A1 CL 2008002861A1
- Authority
- CL
- Chile
- Prior art keywords
- polypeptide
- conjugated molecule
- cell
- polypeptides
- peptides
- Prior art date
Links
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 14
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 14
- 229920001184 polypeptide Polymers 0.000 title abstract 9
- 238000000034 method Methods 0.000 title abstract 2
- 239000013598 vector Substances 0.000 title abstract 2
- 241001109650 Micromonospora ruminantium Species 0.000 title 1
- 239000012634 fragment Substances 0.000 title 1
- 230000005764 inhibitory process Effects 0.000 title 1
- 238000002955 isolation Methods 0.000 title 1
- 230000000696 methanogenic effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000008685 targeting Effects 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 4
- 230000000813 microbial effect Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- -1 POLIPEPTIDES Proteins 0.000 abstract 1
- 210000003850 cellular structure Anatomy 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6402—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals
- C12N9/6405—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from non-mammals not being snakes
- C12N9/641—Cysteine endopeptidases (3.4.22)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56911—Bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/10—Detection of antigens from microorganism in sample from host
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/20—Reduction of greenhouse gas [GHG] emissions in agriculture, e.g. CO2
- Y02P60/22—Methane [CH4], e.g. from rice paddies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Virology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Hematology (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97510407P | 2007-09-25 | 2007-09-25 | |
| US98984007P | 2007-11-22 | 2007-11-22 | |
| US98984107P | 2007-11-22 | 2007-11-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2008002861A1 true CL2008002861A1 (es) | 2009-03-06 |
Family
ID=40511642
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2008002859A CL2008002859A1 (es) | 2007-09-25 | 2008-09-25 | Péptido señal con actividad de permeabilización de células microbianas; vector; célula huésped; molécula conjugada que lo comprende; y método para permeabilizar una célula microbiana. |
| CL2008002861A CL2008002861A1 (es) | 2007-09-25 | 2008-09-25 | Polipeptido aislado de m. ruminantium; vector, molecula conjugada y celula huesped que comprenden dicho polipeptido; anticuerpo o fragmento que se une al polipeptido; composicion farmaceutica que comprende la molecula conjugada; metodo para dirigir una celula metanogena para identificacion, aislamiento o inhibicion. |
| CL2008002860A CL2008002860A1 (es) | 2007-09-25 | 2008-09-25 | Polipeptido; polinucleotido que lo codifica; vector y fago aislado que comprenda este polinucleotido; anticuerpo que se une a este polipeptido; molecula de fusion que comprende este polipeptido; celula huesped metanogena que comprende el vector; composicion farmaceutica que comprende el polinucleotido. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2008002859A CL2008002859A1 (es) | 2007-09-25 | 2008-09-25 | Péptido señal con actividad de permeabilización de células microbianas; vector; célula huésped; molécula conjugada que lo comprende; y método para permeabilizar una célula microbiana. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2008002860A CL2008002860A1 (es) | 2007-09-25 | 2008-09-25 | Polipeptido; polinucleotido que lo codifica; vector y fago aislado que comprenda este polinucleotido; anticuerpo que se une a este polipeptido; molecula de fusion que comprende este polipeptido; celula huesped metanogena que comprende el vector; composicion farmaceutica que comprende el polinucleotido. |
Country Status (17)
| Country | Link |
|---|---|
| US (7) | US8592556B2 (OSRAM) |
| EP (5) | EP3327030B1 (OSRAM) |
| JP (5) | JP5558356B2 (OSRAM) |
| CN (4) | CN102015755A (OSRAM) |
| AR (3) | AR068553A1 (OSRAM) |
| AU (4) | AU2008304018A1 (OSRAM) |
| BR (5) | BRPI0817299A8 (OSRAM) |
| CA (3) | CA2700129C (OSRAM) |
| CL (3) | CL2008002859A1 (OSRAM) |
| DK (3) | DK2203466T3 (OSRAM) |
| ES (3) | ES2587595T3 (OSRAM) |
| MX (3) | MX2010003328A (OSRAM) |
| NZ (1) | NZ745324A (OSRAM) |
| RU (1) | RU2528854C2 (OSRAM) |
| UY (3) | UY31361A1 (OSRAM) |
| WO (3) | WO2009041830A2 (OSRAM) |
| ZA (1) | ZA201001933B (OSRAM) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0817299A8 (pt) * | 2007-09-25 | 2019-01-29 | Pastoral Greenhouse Gas Res Limited | vacinas e componentes de vacina para inibição de células microbianas |
| GB0815484D0 (en) | 2008-08-26 | 2008-10-01 | Univ Leuven Kath | Antibacterial agents |
| KR101701890B1 (ko) * | 2009-06-26 | 2017-02-02 | 뤼산도 아게 | 항균제 |
| EP3058950B1 (en) * | 2009-06-26 | 2020-03-04 | Lysando AG | Antimicrobial agents |
| AR077992A1 (es) | 2009-08-27 | 2011-10-05 | Pastoral Greenhouse Gas Res Ltd | Secuencia del genoma completo del metanogeno methanobrevibacter ruminantium |
| SG184836A1 (en) * | 2010-04-27 | 2012-11-29 | Lysando Ag | Method of reducing biofilms |
| EP2899200B1 (en) * | 2012-09-19 | 2020-05-06 | Gemvax & Kael Co., Ltd. | Cell penetrating peptide, conjugate comprising same, and composition comprising conjugate |
| CN105658796B (zh) * | 2012-12-12 | 2021-10-26 | 布罗德研究所有限公司 | 用于序列操纵的crispr-cas组分系统、方法以及组合物 |
| US10760064B2 (en) | 2013-03-15 | 2020-09-01 | The General Hospital Corporation | RNA-guided targeting of genetic and epigenomic regulatory proteins to specific genomic loci |
| US9885033B2 (en) | 2013-03-15 | 2018-02-06 | The General Hospital Corporation | Increasing specificity for RNA-guided genome editing |
| US10011850B2 (en) | 2013-06-21 | 2018-07-03 | The General Hospital Corporation | Using RNA-guided FokI Nucleases (RFNs) to increase specificity for RNA-Guided Genome Editing |
| CA2930015A1 (en) | 2013-11-07 | 2015-05-14 | Editas Medicine, Inc. | Crispr-related methods and compositions with governing grnas |
| WO2016073433A1 (en) * | 2014-11-06 | 2016-05-12 | E. I. Du Pont De Nemours And Company | Peptide-mediated delivery of rna-guided endonuclease into cells |
| CN104789675A (zh) * | 2015-04-15 | 2015-07-22 | 江苏师范大学 | 一种检测荷斯坦奶牛瘤胃微生物的方法 |
| WO2016178207A1 (en) * | 2015-05-04 | 2016-11-10 | Ramot At Tel-Aviv University Ltd. | Methods and kits for fragmenting dna |
| US9512446B1 (en) | 2015-08-28 | 2016-12-06 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
| US9926546B2 (en) | 2015-08-28 | 2018-03-27 | The General Hospital Corporation | Engineered CRISPR-Cas9 nucleases |
| DK3484996T3 (da) * | 2016-07-14 | 2020-12-07 | Basf Se | Fermenteringsmedium, der omfatter et chelateringsmiddel |
| KR102747205B1 (ko) * | 2016-12-29 | 2024-12-31 | 일루미나, 인코포레이티드 | 세포 구획 내의 생체분자에 대한 직교 접근 및 그의 태그부착을 위한 분석 시스템 |
| WO2018126499A1 (zh) | 2017-01-05 | 2018-07-12 | 深圳迈瑞生物医疗电子股份有限公司 | 网织红细胞模拟粒子、血小板模拟粒子制备方法及质控物 |
| US10745439B2 (en) * | 2017-03-20 | 2020-08-18 | Regents Of The University Of Minnesota | Kinase substrates and methods of use thereof |
| WO2019147743A1 (en) | 2018-01-26 | 2019-08-01 | Massachusetts Institute Of Technology | Structure-guided chemical modification of guide rna and its applications |
| CN116349651A (zh) * | 2018-03-19 | 2023-06-30 | 瑞泽恩制药公司 | 使用crispr/cas系统对动物进行转录调制 |
| CN113646330A (zh) | 2018-11-14 | 2021-11-12 | 鲁比克治疗股份有限公司 | 工程化cd25多肽及其用途 |
| JP7619941B2 (ja) | 2018-11-14 | 2025-01-22 | アイバイオ, インク. | Cd25抗体 |
| CN109627301B (zh) * | 2019-02-18 | 2022-08-05 | 浙江新银象生物工程有限公司 | Nisin固体稳定剂开发及应用 |
| WO2021185948A1 (en) * | 2020-03-19 | 2021-09-23 | Micreos Human Health B.V. | A stabilized protein of interest |
| US20230072496A1 (en) * | 2020-04-10 | 2023-03-09 | Liberty Biosecurity, Llc | Polypeptide compositions and uses thereof |
| CN112143747B (zh) * | 2020-09-09 | 2022-09-13 | 昆明理工大学 | 一种噬菌体裂解酶及其基因、基因重组表达载体与应用 |
| PT4037666T (pt) | 2020-12-08 | 2024-06-25 | Ruminant Biotech Corp Ltd | Aperfeiçoamentos de dispositivos e métodos para administração de substâncias a animais |
| CN112961217B (zh) * | 2021-03-19 | 2022-11-08 | 江苏元本生物科技有限公司 | 一种靶向Siglec-15的噬菌体多肽 |
| CN113121705B (zh) * | 2021-04-19 | 2023-03-24 | 成都英普博集生物科技有限公司 | 用于制备短肽混合物的融合蛋白、目的多肽、短肽混合物的制备方法及应用 |
| EP4554616A1 (en) * | 2022-07-11 | 2025-05-21 | Arkea Bio Corp. | Compositions and methods for reducing methane emissions in ruminant populations |
| CN115417927A (zh) * | 2022-09-08 | 2022-12-02 | 南京松天盛科生物科技有限公司 | 小鼠腹水致敏物及其应用 |
| AR130970A1 (es) * | 2022-11-03 | 2025-02-05 | Helix Nanotechnologies Inc | Vacunas ruminales y metanógenas y usos de estas |
| CN115938486B (zh) * | 2022-12-06 | 2023-11-10 | 内蒙古农业大学 | 基于图神经网络的抗菌性乳酸菌株筛选方法 |
| WO2025219570A1 (en) | 2024-04-17 | 2025-10-23 | Johannes Kepler Universität Linz | Composition for inhibiting protein translocation and methods using the same |
| WO2025233675A1 (en) * | 2024-05-10 | 2025-11-13 | Institut Pasteur | Use of talosaminidase to regulate populations of archaeal methanogens in industrial, agricultural and medical settings |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US159861A (en) * | 1875-02-16 | Improvement in brooms | ||
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| JPH01500746A (ja) * | 1983-05-03 | 1989-03-16 | エス.エス.エム.インターナショナル ケミカル カンパニー リミテッド | 改善された医薬活性を有する組成物および獣医用の目的にそれを使用すること |
| GB8815968D0 (en) * | 1988-07-05 | 1988-08-10 | Pfizer Ltd | Veterinary devices |
| JPH05219927A (ja) * | 1992-02-14 | 1993-08-31 | Gumma Pref Gov | 飼料の混合装置及び混合飼料の製造方法 |
| JP3651915B2 (ja) * | 1993-06-30 | 2005-05-25 | 財団法人神奈川科学技術アカデミー | シグナル配列ペプチドをコードするdna断片の探索法及びそのためのベクター |
| DK0724454T3 (da) * | 1993-10-19 | 2004-07-12 | Commw Scient Ind Res Org | Fremgangsmåde til forbedring af drövtyggerdyrs eller drövtyggerlignende dyrs udnyttelse af næringsstoffer |
| JPH09507121A (ja) | 1993-10-26 | 1997-07-22 | アフィマックス テクノロジーズ ナームロゼ ベノートスハップ | 生物学的チップ上の核酸プローブアレー |
| NZ278977A (en) | 1994-01-20 | 1997-03-24 | Pastoral Agric Res Inst Nz Ltd | Sustained release bolus for ruminants |
| ES2207644T3 (es) | 1994-01-20 | 2004-06-01 | Agresearch Limited | Dispositivo de administracion a los rumiantes de sustancias utiles. |
| US6015880A (en) | 1994-03-16 | 2000-01-18 | California Institute Of Technology | Method and substrate for performing multiple sequential reactions on a matrix |
| AUPN353695A0 (en) | 1995-06-14 | 1995-07-06 | Commonwealth Scientific And Industrial Research Organisation | Immunogenic preparation and method for improving the productivity of ruminant animals |
| WO1998007830A2 (en) * | 1996-08-22 | 1998-02-26 | The Institute For Genomic Research | COMPLETE GENOME SEQUENCE OF THE METHANOGENIC ARCHAEON, $i(METHANOCOCCUS JANNASCHII) |
| US5985907A (en) * | 1998-08-12 | 1999-11-16 | Health Research, Inc. | Method for inhibiting growth of methanogens |
| WO2002077183A2 (en) | 2001-03-21 | 2002-10-03 | Elitra Pharmaceuticals, Inc. | Identification of essential genes in microorganisms |
| AU2002326949A1 (en) | 2001-09-18 | 2003-05-12 | The Board Of Regents Of The University Of Nebraska | Method for the inhibition of methanogenesis |
| US7314974B2 (en) * | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| US20060068386A1 (en) * | 2002-03-04 | 2006-03-30 | Alexei Slesarev | Complete genome and protein sequence of the hyperthermophile methanopyrus kandleri av19 and monophyly of archael methanogens and methods of use thereof |
| SE523209C2 (sv) * | 2002-05-14 | 2004-04-06 | Akzo Nobel Nv | Förfarande för att reducera metanbildningen från matspjälkningsaktiviteter hos djur |
| US20100048595A1 (en) | 2005-03-23 | 2010-02-25 | Washington University In St. Louis | Use of archaea to modulate the nutrient harvesting functions of the gastrointestinal microbiota |
| BRPI0817299A8 (pt) * | 2007-09-25 | 2019-01-29 | Pastoral Greenhouse Gas Res Limited | vacinas e componentes de vacina para inibição de células microbianas |
| CN101434924A (zh) * | 2008-12-17 | 2009-05-20 | 中南大学 | 一种分离严格厌氧产甲烷古菌的方法 |
| AR077992A1 (es) * | 2009-08-27 | 2011-10-05 | Pastoral Greenhouse Gas Res Ltd | Secuencia del genoma completo del metanogeno methanobrevibacter ruminantium |
| CN101864362B (zh) * | 2010-05-19 | 2012-05-09 | 江苏加德绿色能源有限公司 | 一种复合微生物菌剂及其应用 |
| DE102011119230B4 (de) * | 2011-11-23 | 2013-07-11 | Audi Ag | Kraftwagen-Blinkleuchte und Verfahren zum Betreiben einer Blinkleuchte |
| JP2016511630A (ja) * | 2012-12-21 | 2016-04-21 | ダニスコ・ユーエス・インク | 代案の下流メバロン酸経路を使用するイソプレン、イソプレノイド、およびイソプレノイド前駆体の生成 |
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