CL2004001126A1 - Complejos de polimeros en cascada y sus composiciones farmaceuticas, utiles para la preparacion de agentes de diagnostico por nmr. - Google Patents

Complejos de polimeros en cascada y sus composiciones farmaceuticas, utiles para la preparacion de agentes de diagnostico por nmr.

Info

Publication number
CL2004001126A1
CL2004001126A1 CL200401126A CL2004001126A CL2004001126A1 CL 2004001126 A1 CL2004001126 A1 CL 2004001126A1 CL 200401126 A CL200401126 A CL 200401126A CL 2004001126 A CL2004001126 A CL 2004001126A CL 2004001126 A1 CL2004001126 A1 CL 2004001126A1
Authority
CL
Chile
Prior art keywords
cascada
nmr
useful
preparation
pharmaceutical compositions
Prior art date
Application number
CL200401126A
Other languages
English (en)
Inventor
Heribert Schmitt-Willich
Johannes Platzek
Bernd Raduchel
Andreas Muehler
Thomas Frenzel
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of CL2004001126A1 publication Critical patent/CL2004001126A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/124—Macromolecular compounds dendrimers, dendrons, hyperbranched compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/06—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules
    • A61K51/065—Macromolecular compounds, carriers being organic macromolecular compounds, i.e. organic oligomeric, polymeric, dendrimeric molecules conjugates with carriers being macromolecules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/76—Metal complexes of amino carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
    • C07C237/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/54—Three nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/16—Dendrimers and dendritic polymers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
CL200401126A 1995-07-04 2004-05-19 Complejos de polimeros en cascada y sus composiciones farmaceuticas, utiles para la preparacion de agentes de diagnostico por nmr. CL2004001126A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19525924A DE19525924A1 (de) 1995-07-04 1995-07-04 Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
PCT/EP1996/002671 WO1997002051A2 (de) 1995-07-04 1996-06-20 Kaskaden-polymer-komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (1)

Publication Number Publication Date
CL2004001126A1 true CL2004001126A1 (es) 2005-03-28

Family

ID=7766984

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200401126A CL2004001126A1 (es) 1995-07-04 2004-05-19 Complejos de polimeros en cascada y sus composiciones farmaceuticas, utiles para la preparacion de agentes de diagnostico por nmr.

Country Status (27)

Country Link
US (6) US5820849A (es)
EP (1) EP0836485B1 (es)
JP (1) JP3723219B2 (es)
KR (1) KR100428272B1 (es)
CN (2) CN1079679C (es)
AT (1) ATE220924T1 (es)
BG (1) BG62600B1 (es)
BR (1) BR9609478A (es)
CA (1) CA2225959A1 (es)
CL (1) CL2004001126A1 (es)
CZ (1) CZ294951B6 (es)
DE (2) DE19525924A1 (es)
DK (1) DK0836485T3 (es)
ES (1) ES2177792T3 (es)
HK (2) HK1013915A1 (es)
IL (2) IL122554A (es)
MX (1) MX9800023A (es)
NO (1) NO324560B1 (es)
NZ (1) NZ312127A (es)
PL (1) PL187712B1 (es)
PT (1) PT836485E (es)
RU (1) RU2166501C2 (es)
SK (1) SK283838B6 (es)
TW (2) TW200306999A (es)
UA (1) UA61890C2 (es)
WO (1) WO1997002051A2 (es)
ZA (1) ZA965686B (es)

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DE4425857A1 (de) * 1994-07-07 1996-01-11 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE19525924A1 (de) * 1995-07-04 1997-01-09 Schering Ag Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
DE19652387A1 (de) * 1996-12-04 1998-06-10 Schering Ag Macrocyclische Metallkomplexcarbonsäuren, ihre Verwendung sowie Verfahren zu ihrer Herstellung
DE19728954C1 (de) * 1997-06-30 1999-04-22 Schering Ag Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung
DE19729013A1 (de) * 1997-07-03 1999-02-04 Schering Ag Oligomere, perfluoralkylhaltige Verbindungen, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
US6019959A (en) * 1997-07-31 2000-02-01 Schering Aktiengesellschaft Oligomeric compounds that contain perfluoroalkyl, process for their production, and their use in NMR diagnosis
US7745142B2 (en) 1997-09-15 2010-06-29 Molecular Devices Corporation Molecular modification assays
US6297018B1 (en) 1998-04-17 2001-10-02 Ljl Biosystems, Inc. Methods and apparatus for detecting nucleic acid polymorphisms
DE19758105A1 (de) * 1997-12-18 1999-06-24 Schering Ag Dendritische Polymer-Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung
US7405320B2 (en) 1998-06-22 2008-07-29 Immunomedics, Inc. Therapeutic and diagnostic conjugates for use with multispecific antibodies
US6406297B1 (en) 1999-02-18 2002-06-18 The Regents Of The University Of California Salicylamide-lanthanide complexes for use as luminescent markers
US6515113B2 (en) 1999-02-18 2003-02-04 The Regents Of The University Of California Phthalamide lanthanide complexes for use as luminescent markers
NZ517017A (en) 1999-07-29 2004-05-28 Epix Medical Inc Targeting multimeric imaging agents through multiocus binding and improving the efficacy of in vivo contrast agents
US6549798B2 (en) 2001-02-07 2003-04-15 Epix Medical, Inc. Magnetic resonance angiography data
US20050019267A1 (en) * 2001-06-25 2005-01-27 Brechbiel Martin W Macromolecular imaging agents for liver imaging
DE10135356C1 (de) 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
TWI221406B (en) 2001-07-30 2004-10-01 Epix Medical Inc Systems and methods for targeted magnetic resonance imaging of the vascular system
GB0122049D0 (en) * 2001-09-12 2001-10-31 Nycomed Imaging As Method
US7648678B2 (en) 2002-12-20 2010-01-19 Dako Denmark A/S Method and system for pretreatment of tissue slides
AR047692A1 (es) * 2003-07-10 2006-02-08 Epix Medical Inc Imagenes de blancos estacionarios
EP1541568A1 (de) * 2003-12-09 2005-06-15 Deutsches Wollforschungsinstitut an der Rheinisch-Westfälischen Technischen Hochschule Aachen e.V. Reaktive cyclische Carbonate und Harnstoffe zur Modifizierung von Biomolekülen, Polymeren und Oberflächen
DE10361140B4 (de) * 2003-12-16 2006-11-09 Schering Ag Verfahren zur Herstellung von dendritischen Trimesinsäuretriamiden, dabei verwendete Diethylentriaminderivate und Verwendung der Diethylentriaminderivate
US7199268B2 (en) 2003-12-16 2007-04-03 Schering Aktiengesellschaft Process for the production of dendritic trimesic acid triamides
CA2552537A1 (en) * 2003-12-30 2006-01-05 The Regents Of The University Of California Aromatic triamide-lanthanide complexes
US20050171424A1 (en) * 2004-01-13 2005-08-04 The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services Methods for imaging the lymphatic system using dendrimer-based contrast agents
DE102004062258B3 (de) * 2004-12-23 2006-01-05 Schering Ag Hydroxypyridinon-Derivate, deren Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
US20060204443A1 (en) * 2005-03-11 2006-09-14 The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services Methods for tumor treatment using dendrimer conjugates
US8557601B2 (en) 2006-07-10 2013-10-15 The Regents Of The University Of California Luminescent 1-hydroxy-2-pyridinone chelates of lanthanides
WO2008063721A2 (en) 2006-08-15 2008-05-29 The Regents Of The University Of California Luminescent macrocyclic lanthanide complexes
JP5563299B2 (ja) * 2006-08-17 2014-07-30 エピックス ファーマシューティカルズ，インコーポレイテッド リンパ系撮像方法
DE102007002726A1 (de) * 2007-01-18 2008-07-31 Bayer Schering Pharma Aktiengesellschaft Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
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US20100008864A1 (en) * 2008-07-10 2010-01-14 Andreas Meijer Aromatic multimers
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EP3263562A1 (en) * 2009-12-24 2018-01-03 Lumiphore, Inc. Radiopharmaceutical complexes
KR101334780B1 (ko) 2010-08-13 2013-12-02 한국생명공학연구원 요오드를 함유한 방사형상의 고분자 화합물, 이의 제조방법 및 이를 포함하는 ｃｔ용 조영제 조성물
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US11453652B2 (en) 2013-03-15 2022-09-27 Lumiphore, Inc. Di-macrocycles
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CA3044877A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
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JOP20210114A1 (ar) 2018-11-23 2023-01-30 Bayer Ag تركيبة وسط تباين وعملية لتحضيرها

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Also Published As

Publication number Publication date
US6177060B1 (en) 2001-01-23
NZ312127A (en) 2000-01-28
US6861043B2 (en) 2005-03-01
IL150258A (en) 2004-06-20
DE59609487D1 (de) 2002-08-29
PL187712B1 (pl) 2004-09-30
KR100428272B1 (ko) 2004-06-16
CN1079679C (zh) 2002-02-27
EP0836485B1 (de) 2002-07-24
JP3723219B2 (ja) 2005-12-07
BG102111A (en) 1998-08-31
AU6358696A (en) 1997-02-05
CN1189779A (zh) 1998-08-05
IL150258A0 (en) 2002-12-01
IL122554A0 (en) 1998-06-15
US6426059B1 (en) 2002-07-30
ES2177792T3 (es) 2002-12-16
US20040091426A1 (en) 2004-05-13
CZ398A3 (cs) 1998-04-15
BR9609478A (pt) 1999-05-25
TW200306999A (en) 2003-12-01
NO324560B1 (no) 2007-11-19
KR19990028708A (ko) 1999-04-15
CN1148360C (zh) 2004-05-05
JPH11510834A (ja) 1999-09-21
US6063361A (en) 2000-05-16
US7211241B2 (en) 2007-05-01
US5820849A (en) 1998-10-13
PT836485E (pt) 2002-12-31
ZA965686B (en) 1997-01-24
CN1377881A (zh) 2002-11-06
WO1997002051A2 (de) 1997-01-23
WO1997002051A3 (de) 1997-03-27
IL122554A (en) 2004-06-20
US20020187101A1 (en) 2002-12-12
TW579380B (en) 2004-03-11
UA61890C2 (en) 2003-12-15
HK1050898A1 (en) 2003-07-11
DK0836485T3 (da) 2002-09-30
SK283838B6 (sk) 2004-03-02
NO980002L (no) 1998-03-04
DE19525924A1 (de) 1997-01-09
AU713470B2 (en) 1999-12-02
CZ294951B6 (cs) 2005-04-13
EP0836485A2 (de) 1998-04-22
HK1013915A1 (en) 1999-09-17
SK177997A3 (en) 1998-07-08
BG62600B1 (bg) 2000-03-31
MX9800023A (es) 1998-07-31
NO980002D0 (no) 1998-01-02
ATE220924T1 (de) 2002-08-15
PL324342A1 (en) 1998-05-25
RU2166501C2 (ru) 2001-05-10
CA2225959A1 (en) 1997-01-23

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