CH681081A5 - - Google Patents

Download PDF

Info

Publication number
CH681081A5
CH681081A5 CH1114/89A CH111489A CH681081A5 CH 681081 A5 CH681081 A5 CH 681081A5 CH 1114/89 A CH1114/89 A CH 1114/89A CH 111489 A CH111489 A CH 111489A CH 681081 A5 CH681081 A5 CH 681081A5
Authority
CH
Switzerland
Prior art keywords
sequence
polypeptide
amino acid
egf
amino acids
Prior art date
Application number
CH1114/89A
Other languages
German (de)
English (en)
Inventor
Joseph Brown
Daniel R Twardzik
Hans Marquardt
George J Todaro
A Gregory Bruce
Timothy M Rose
Anthony F Purchio
Shiu-Lok Hu
Wen Chang
Suo Win Liu
Thomas J Franceschini
Mohammed Shoyab
Greg Plowman
Original Assignee
Oncogen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen filed Critical Oncogen
Publication of CH681081A5 publication Critical patent/CH681081A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
CH1114/89A 1988-03-24 1989-03-28 CH681081A5 (enExample)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17265388A 1988-03-24 1988-03-24

Publications (1)

Publication Number Publication Date
CH681081A5 true CH681081A5 (enExample) 1993-01-15

Family

ID=22628611

Family Applications (1)

Application Number Title Priority Date Filing Date
CH1114/89A CH681081A5 (enExample) 1988-03-24 1989-03-28

Country Status (22)

Country Link
JP (1) JPH0279981A (enExample)
KR (1) KR890014743A (enExample)
AU (2) AU3169589A (enExample)
BE (1) BE1004202A5 (enExample)
CH (1) CH681081A5 (enExample)
DE (1) DE3910084A1 (enExample)
DK (1) DK146789A (enExample)
ES (1) ES2013408A6 (enExample)
FI (1) FI891308A7 (enExample)
FR (1) FR2632321A1 (enExample)
GB (1) GB2219799B (enExample)
GR (1) GR1000876B (enExample)
HU (1) HUT50501A (enExample)
IE (1) IE890950L (enExample)
IL (1) IL89673A0 (enExample)
IT (1) IT1234961B (enExample)
LU (1) LU87489A1 (enExample)
NL (1) NL8900724A (enExample)
NO (1) NO891273D0 (enExample)
NZ (1) NZ228427A (enExample)
PT (1) PT90118B (enExample)
SE (1) SE8901031L (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU626524B2 (en) * 1987-05-29 1992-08-06 Bristol-Myers Squibb Company Cloning and expression of simian transforming growth factor- beta 1
CA2037440A1 (en) * 1990-03-02 1991-09-03 Gregory D. Plowman Her3: a novel egf receptor homolog
EP0739984A1 (en) * 1995-04-26 1996-10-30 San Tumorforschungs-Gmbh Bivalent polypeptides containing at least two domains
US6852506B1 (en) 1996-04-10 2005-02-08 Human Genome Sciences, Inc. Extracellular/epidermal growth factor-like protein
CA2249213A1 (en) * 1996-04-10 1997-10-16 Human Genome Sciences, Inc. Extracellular/epidermal growth factor-like protein

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0108132A1 (en) * 1982-05-06 1984-05-16 Applied Molecular Genetics Inc. The manufacture and expression of genes for urogastrone and polypeptide analogs thereof
JPS6028994A (ja) * 1983-07-08 1985-02-14 Wakunaga Seiyaku Kk 〔２１―ロイシン〕ヒトウロガストロン
WO1985002198A1 (en) * 1983-11-01 1985-05-23 Amgen Microbial expression of type i transforming growth factor, polypeptide analogs thereof and hybrid egf/tgf polypeptides
JP2554459B2 (ja) * 1984-07-02 1996-11-13 アース製薬 株式会社 β−ウロガストロン遺伝子、対応プラスミド組換体及び対応形質転換体
FI862734A7 (fi) * 1984-10-30 1986-06-26 Oncogen Uudet polypeptidit, joilla on kasvutekijäaktiivisuutta ja nukleiinihap posekvenssit, jotka koodaavat polypeptidejä.
GB8507666D0 (en) * 1985-03-25 1985-05-01 Wellcome Found Epidermal growth factor production
US4743679A (en) * 1986-02-24 1988-05-10 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
GB2210618B (en) * 1987-10-08 1991-10-16 British Bio Technology Synthetic egf gene
ES2081801T3 (es) * 1987-10-30 1996-03-16 Bristol Myers Squibb Co Plasmidos de expresion.
EP0372005A4 (en) * 1987-10-30 1990-06-26 Oncogen EXPRESSION SYSTEMS FOR THE PREPARATION OF POLYPEPTIDES IN PROKARYOTIC CELLS.

Also Published As

Publication number Publication date
IL89673A0 (en) 1989-09-28
PT90118B (pt) 1994-07-29
AU2990492A (en) 1993-03-04
AU3169589A (en) 1989-09-28
FI891308A0 (fi) 1989-03-20
LU87489A1 (fr) 1989-10-26
PT90118A (pt) 1989-11-10
KR890014743A (ko) 1989-10-25
SE8901031D0 (sv) 1989-03-22
SE8901031L (sv) 1989-09-25
FI891308L (fi) 1989-09-25
GB8906758D0 (en) 1989-05-10
IT1234961B (it) 1992-06-09
GR1000876B (el) 1993-03-16
IE890950L (en) 1989-09-24
BE1004202A5 (fr) 1992-10-13
NO891273D0 (no) 1989-03-22
GR890100185A (en) 1990-01-19
DK146789D0 (da) 1989-03-22
ES2013408A6 (es) 1990-05-01
NZ228427A (en) 1993-03-26
FR2632321A1 (fr) 1989-12-08
HUT50501A (en) 1990-02-28
GB2219799B (en) 1992-10-14
DK146789A (da) 1989-09-25
FI891308A7 (fi) 1989-09-25
JPH0279981A (ja) 1990-03-20
GB2219799A (en) 1989-12-20
NL8900724A (nl) 1989-10-16
IT8919917A0 (it) 1989-03-24
DE3910084A1 (de) 1989-11-16

Similar Documents

Publication Publication Date Title
EP0658199B1 (de) Herstellung von heterodimerem pdgf-ab mit hilfe eines bicistronischen vektorsystems in säugerzellen
DE69007975T2 (de) Fusionsprotein bestehend aus gm-csf und il-3.
DE3785864T2 (de) Verfahren zur Herstellung von menschlichem Epidermalwachstumsfaktor und dessen Analogen.
DE68916537T2 (de) Herstellung eines insulinähnlichen, wachstümsfaktor bindenden proteins.
DE3689845T2 (de) Rekombinanter fibroblast-wachstumsfaktor.
DE3880739T2 (de) Expression von menschlichem proapolipoprotein a-1.
DE69033668T2 (de) Dns kodierend für einen für epithelzellen spezifischen wachstumsfaktor
CH681080A5 (enExample)
DE69020335T2 (de) B-ketten-analoge des von blutplättchen abstammenden wachstumsfaktors und verfahren zu deren homogener herstellung.
DE3689495T2 (de) TGF-beta codierende Nucleinsäure und deren Verwendungen.
JPH07505039A (ja) 骨形成因子
DE69314574T2 (de) Megakaryozyten-Differenzierungsfaktor
DE3851035T2 (de) Interleukin-7.
DD283418A5 (de) Verfahren zur herstellung des bifunktionellen wachstumsregulationsfaktors amphiregulin
DE3853842T2 (de) Wachstumsregler zusammenhängend mit Blutplättchen.
DE69102651T2 (de) Proteaseresistenter pdgf und dessen verwendungen.
DE69924009T2 (de) Methode zur verstärkung der biologischen aktivität von liganden
CH681081A5 (enExample)
DE69324345T2 (de) Expression von osteogenem faktor op-1 in mit rekombinantem baculovirus infizierten spodoptera frugiperda-zellen
EP0453456B1 (de) Pdgf-a, pdgf-aa, pdgf-ab, herstellungsverfahren und sie enthaltende arzneimittel
AU600433B2 (en) Novel polypeptides having growth factor activity and nucleic acid sequences encoding the polypeptides
AT398433B (de) Transforming growth faktor beta1/transforming growth faktor beta2-hybrid-prekursor und dafür codierende nucleotidsequenz
DE69104048T2 (de) Beseitigung interner initiation des löslichen cd4-gens.
DE68912248T2 (de) Diuretischer Faktor.
DE3853112T2 (de) DNA Moleküle, welche plazentales Rinder-Lactogen-Peptid und das Pre-Peptid kodieren und genetisch transformierte Zellen, die diese Moleküle enthalten.

Legal Events

Date Code Title Description
PL Patent ceased
PL Patent ceased