DE69102651T2 - Proteaseresistenter pdgf und dessen verwendungen. - Google Patents

Proteaseresistenter pdgf und dessen verwendungen.

Info

Publication number
DE69102651T2
DE69102651T2 DE69102651T DE69102651T DE69102651T2 DE 69102651 T2 DE69102651 T2 DE 69102651T2 DE 69102651 T DE69102651 T DE 69102651T DE 69102651 T DE69102651 T DE 69102651T DE 69102651 T2 DE69102651 T2 DE 69102651T2
Authority
DE
Germany
Prior art keywords
pdgf
polypeptides
proteins
chain
proteaser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69102651T
Other languages
English (en)
Other versions
DE69102651D1 (de
Inventor
Mark Murray
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zymogenetics Inc
Original Assignee
Zymogenetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymogenetics Inc filed Critical Zymogenetics Inc
Publication of DE69102651D1 publication Critical patent/DE69102651D1/de
Application granted granted Critical
Publication of DE69102651T2 publication Critical patent/DE69102651T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/49—Platelet-derived growth factor [PDGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69102651T 1990-07-23 1991-07-22 Proteaseresistenter pdgf und dessen verwendungen. Expired - Fee Related DE69102651T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55721990A 1990-07-23 1990-07-23
PCT/US1991/005183 WO1992001716A1 (en) 1990-07-23 1991-07-22 Protease resistant pdgf and methods of use

Publications (2)

Publication Number Publication Date
DE69102651D1 DE69102651D1 (de) 1994-07-28
DE69102651T2 true DE69102651T2 (de) 1994-10-06

Family

ID=24224518

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69102651T Expired - Fee Related DE69102651T2 (de) 1990-07-23 1991-07-22 Proteaseresistenter pdgf und dessen verwendungen.

Country Status (10)

Country Link
US (2) US5895755A (de)
EP (1) EP0547064B1 (de)
JP (1) JP2823690B2 (de)
AT (1) ATE107665T1 (de)
AU (1) AU8294991A (de)
CA (1) CA2087969C (de)
DE (1) DE69102651T2 (de)
DK (1) DK0547064T3 (de)
ES (1) ES2055611T3 (de)
WO (1) WO1992001716A1 (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030105007A1 (en) * 1995-06-07 2003-06-05 Andre Beaulieu PDGF-betabeta and fibronectin combined in a solid wound dressing for the treatment of wounds
PT871730E (pt) * 1995-10-11 2004-11-30 Chiron Corp Combinacao de pdgf, kgf, igf e igfbp para cicatrizacao de ferimentos
AU5465498A (en) * 1996-12-13 1998-07-03 Michael Kunitani Analysis and separation of platelet-derived growth factor proteins
JP4768121B2 (ja) * 1998-02-05 2011-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム Ｍａｇｅファミリーからの腫瘍関連抗原及びそれらをコードする核酸配列、融合タンパク質の及びワクチン接種のための組成物の調製のための使用
US6811777B2 (en) * 2002-04-13 2004-11-02 Allan Mishra Compositions and minimally invasive methods for treating incomplete connective tissue repair
US7608258B2 (en) * 2002-04-13 2009-10-27 Allan Mishra Method for treatment of tendinosis using platelet rich plasma
WO2004070018A2 (en) * 2003-02-04 2004-08-19 Ludwig Institute For Cancer Research Vegf-b and pdgf modulation of stem cells
US7678780B2 (en) * 2003-12-29 2010-03-16 Allan Mishra Method of treating cancer using platelet releasate
US20070122906A1 (en) * 2003-12-29 2007-05-31 Allan Mishra Method of culturing cells
WO2005065269A2 (en) * 2003-12-29 2005-07-21 Am Biosolutions Compositions and method for decreasing the appearance of skin wrinkles
US7462268B2 (en) * 2004-08-20 2008-12-09 Allan Mishra Particle/cell separation device and compositions
FR2891149B1 (fr) * 2005-09-26 2007-11-30 Biodex Sarl Composition pharmaceutique a action cicatrisante comprenant un derive de dextrane soluble et un facteur de croissance derive des plaquettes.
WO2010042658A1 (en) 2008-10-07 2010-04-15 Bioparadox, Llc Use of platelet rich plasma composition in the treatment of cardiac conduction abnormalities
US20140356893A1 (en) 2013-06-04 2014-12-04 Allan Mishra Compositions and methods for using platelet-rich plasma for drug discovery, cell nuclear reprogramming, proliferation or differentiation
CN105085652B (zh) 2014-05-16 2021-06-22 中国人民解放军军事医学科学院生物工程研究所 血小板衍生生长因子b突变体、其制备方法及用途
EP3206670A4 (de) 2014-10-14 2018-06-20 Samuel Lynch Zusammensetzung zur behandlung von wunden

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4766073A (en) * 1985-02-25 1988-08-23 Zymogenetics Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US4801542A (en) * 1984-10-12 1989-01-31 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
US5045633A (en) * 1985-02-25 1991-09-03 Zymogenetics, Inc. Expression of biologically active PDGF analogs in eucaryotic cells
ATE131532T1 (de) * 1986-08-13 1995-12-15 Zymogenetics Inc Expression von biologisch-aktiven pdgf-analogen in eukaryotischen zellen
AU624789B2 (en) * 1987-02-19 1992-06-25 Amgen, Inc. Purified platelet-derived growth factor and methods for purification thereof
DE3834079A1 (de) * 1988-10-06 1990-04-12 Biotechnolog Forschung Gmbh Wachstumstimulierendes pdgf-bb und dessen verwendung sowie ein verfahren zu seiner herstellung und der des monomeren
GB9101645D0 (en) * 1991-01-25 1991-03-06 British Bio Technology Compounds

Also Published As

Publication number Publication date
DK0547064T3 (da) 1995-03-20
AU8294991A (en) 1992-02-18
CA2087969C (en) 2001-10-16
EP0547064B1 (de) 1994-06-22
JPH05508775A (ja) 1993-12-09
DE69102651D1 (de) 1994-07-28
CA2087969A1 (en) 1992-01-24
ATE107665T1 (de) 1994-07-15
JP2823690B2 (ja) 1998-11-11
US5895755A (en) 1999-04-20
ES2055611T3 (es) 1994-08-16
WO1992001716A1 (en) 1992-02-06
EP0547064A1 (de) 1993-06-23
US5905142A (en) 1999-05-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee