DE69130981D1 - Expression von makrophagen-induzierbaren proteinen (mips) in hefezellen - Google Patents

Expression von makrophagen-induzierbaren proteinen (mips) in hefezellen

Info

Publication number
DE69130981D1
DE69130981D1 DE69130981T DE69130981T DE69130981D1 DE 69130981 D1 DE69130981 D1 DE 69130981D1 DE 69130981 T DE69130981 T DE 69130981T DE 69130981 T DE69130981 T DE 69130981T DE 69130981 D1 DE69130981 D1 DE 69130981D1
Authority
DE
Germany
Prior art keywords
mip
expression
mips
macrophage
year
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69130981T
Other languages
English (en)
Inventor
Patricia Tekamp-Olson
Carol Gallegos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis Vaccines and Diagnostics Inc
Original Assignee
Chiron Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiron Corp filed Critical Chiron Corp
Application granted granted Critical
Publication of DE69130981D1 publication Critical patent/DE69130981D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C07K14/523—Beta-chemokines, e.g. RANTES, I-309/TCA-3, MIP-1alpha, MIP-1beta/ACT-2/LD78/SCIF, MCP-1/MCAF, MCP-2, MCP-3, LDCF-1, LDCF-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69130981T 1990-09-14 1991-09-13 Expression von makrophagen-induzierbaren proteinen (mips) in hefezellen Expired - Lifetime DE69130981D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58263690A 1990-09-14 1990-09-14
PCT/US1991/006489 WO1992005198A1 (en) 1990-09-14 1991-09-13 EXPRESSION OF MACROPHAGE INDUCIBLE PROTEINS (MIPs) IN YEAST CELLS

Publications (1)

Publication Number Publication Date
DE69130981D1 true DE69130981D1 (de) 1999-04-15

Family

ID=24329903

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69130981T Expired - Lifetime DE69130981D1 (de) 1990-09-14 1991-09-13 Expression von makrophagen-induzierbaren proteinen (mips) in hefezellen

Country Status (7)

Country Link
US (1) US5814484A (de)
EP (1) EP0548214B1 (de)
JP (1) JPH06503710A (de)
AT (1) ATE177472T1 (de)
CA (1) CA2091266A1 (de)
DE (1) DE69130981D1 (de)
WO (1) WO1992005198A1 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057123A (en) * 1991-12-23 2000-05-02 British Biotech Pharmaceuticals Limited Stem cell inhibiting proteins
GB9308060D0 (en) * 1993-04-19 1993-06-02 Cancer Res Campaign Tech Stem cell inhibitor
US6451562B1 (en) 1993-12-22 2002-09-17 Human Genome Sciences, Inc. Polypeptides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) polynucleotides
DK0735818T3 (da) * 1993-12-22 2004-07-26 Human Genome Sciences Inc Makrofag-inflammatoriske proteiner MIP-3, Mip-4 og Mip-1gamma
US6811773B1 (en) 1993-12-22 2004-11-02 Human Genome Sciences, Inc. Human monocyte colony inhibitory factor (M-CIF) polypeptides
US5504003A (en) * 1994-03-08 1996-04-02 Human Genome Sciences, Inc. Macrophage inflammatory protein-3 and -4
US6001606A (en) * 1994-03-08 1999-12-14 Human Genome Sciences, Inc. Polynucleotides encoding myeloid progenitor inhibitory factor-1 (MPIF-1) and polypeptides encoded thereby
US5556767A (en) * 1993-12-22 1996-09-17 Human Genome Sciences, Inc. Polynucleotide encoding macrophage inflammatory protein γ
US6488925B2 (en) 1993-12-22 2002-12-03 Human Genome Sciences, Inc. Macrophage inflammatory protein-4 (MIP-4) polypeptides
US6495129B1 (en) 1994-03-08 2002-12-17 Human Genome Sciences, Inc. Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3)
MX9701330A (es) 1994-08-23 1998-02-28 Human Genome Sciences Inc Quimiocina beta-9 humana.
US6458349B1 (en) 1995-06-02 2002-10-01 Human Genome Sciences, Inc. Chemokine β-4 polypeptides
US6391589B1 (en) 1994-08-23 2002-05-21 Human Genome Sciences, Inc. Human chemokine beta-10 mutant polypeptides
US6174995B1 (en) 1994-08-23 2001-01-16 Haodong Li Human chemokines, CKβ4 and CKβ10/MCP-4
US5981230A (en) * 1994-08-23 1999-11-09 Human Genome Sciences, Inc. Polynucleotide encoding chemokine β-4
KR19990008335A (ko) * 1995-05-05 1999-01-25 로버트 에리치. 벤슨 인체 케모킨 베타-8, 케모킨 베타-1 및 대식세포 염증 단백질-4
GB9600559D0 (en) * 1996-01-11 1996-03-13 British Biotech Pharm Use of chemokines
ZA97990B (en) * 1996-02-09 1997-08-06 Schering Corp Mammalian dendritic cell chemokine reagents.
US6290948B1 (en) * 1996-05-14 2001-09-18 Smithkline Beecham Corporation Method of treating sepsis and ARDS using chamohine beta-10
US5981231A (en) 1996-06-17 1999-11-09 Human Genome Sciences, Inc. Polynucleotides encoding chemokine β-15
US6121023A (en) * 1998-01-22 2000-09-19 Akzo Nobel N.V. Isothermal transcription based assay for the detection and quantification of the chemokine rantes
CA2484121A1 (en) 2002-05-01 2003-11-13 Human Genome Sciences, Inc. Antibodies that specifically bind to chemokine beta-4
EP2640744A4 (de) 2010-11-19 2014-05-28 Eisai R&D Man Co Ltd Neutralisierung von antikörpern gegen ccl20

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL86693A (en) * 1987-06-12 1994-06-24 Stichting Centraal Lab Proteins that have the activity IIIV of the blood, a process for their preparation that uses cells are produced through genetic engineering and pharmaceutical preparations that contain them
EP0310136B1 (de) * 1987-10-02 1997-02-26 The Rockefeller University Von Makrophagen abstammender Entzündungsvermittler(MIP-1-alpha et MIP-1-beta)
CA1340772C (en) * 1987-12-30 1999-09-28 Patricia Tekamp-Olson Expression and secretion of heterologous protiens in yeast employing truncated alpha-factor leader sequences
IL92685A0 (en) * 1988-12-16 1990-09-17 Us Commerce Dna encoding lymphokine/cytokine like proteins,cells transformed thereby and production of said proteins and antibodies against them
EP0494268B2 (de) * 1989-09-25 1999-04-28 Genetics Institute, Inc. Verfahren zur wachstumshemmung von stammzellen

Also Published As

Publication number Publication date
WO1992005198A1 (en) 1992-04-02
EP0548214A1 (de) 1993-06-30
EP0548214B1 (de) 1999-03-10
CA2091266A1 (en) 1992-03-15
JPH06503710A (ja) 1994-04-28
ATE177472T1 (de) 1999-03-15
US5814484A (en) 1998-09-29

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