GB2219799B - Hybrid epidermal growth factor receptor binding polypeptides - Google Patents

Hybrid epidermal growth factor receptor binding polypeptides

Info

Publication number
GB2219799B
GB2219799B GB8906758A GB8906758A GB2219799B GB 2219799 B GB2219799 B GB 2219799B GB 8906758 A GB8906758 A GB 8906758A GB 8906758 A GB8906758 A GB 8906758A GB 2219799 B GB2219799 B GB 2219799B
Authority
GB
United Kingdom
Prior art keywords
hybrid
growth factor
receptor binding
factor receptor
epidermal growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
GB8906758A
Other languages
English (en)
Other versions
GB8906758D0 (en
GB2219799A (en
Inventor
Joseph P Brown
Daniel R Twardzik
Hans Marquardt
George J Todaro
A Gregory Bruce
Timothy M Rose
Anthony F Purchio
Shiu-Lok Hu
Wen Chang
Suo Win Liu
Thomas J Franceschini
Mohammed Shoyab
Greg Plowman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Oncogen LP
Original Assignee
Oncogen LP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncogen LP filed Critical Oncogen LP
Publication of GB8906758D0 publication Critical patent/GB8906758D0/en
Publication of GB2219799A publication Critical patent/GB2219799A/en
Application granted granted Critical
Publication of GB2219799B publication Critical patent/GB2219799B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF], i.e. urogastrone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/495—Transforming growth factor [TGF]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C12N15/625—DNA sequences coding for fusion proteins containing a sequence coding for a signal sequence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
    • C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/24011—Poxviridae
    • C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
    • C12N2710/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
GB8906758A 1988-03-24 1989-03-23 Hybrid epidermal growth factor receptor binding polypeptides Expired - Fee Related GB2219799B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US17265388A 1988-03-24 1988-03-24

Publications (3)

Publication Number Publication Date
GB8906758D0 GB8906758D0 (en) 1989-05-10
GB2219799A GB2219799A (en) 1989-12-20
GB2219799B true GB2219799B (en) 1992-10-14

Family

ID=22628611

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8906758A Expired - Fee Related GB2219799B (en) 1988-03-24 1989-03-23 Hybrid epidermal growth factor receptor binding polypeptides

Country Status (22)

Country Link
JP (1) JPH0279981A (enExample)
KR (1) KR890014743A (enExample)
AU (2) AU3169589A (enExample)
BE (1) BE1004202A5 (enExample)
CH (1) CH681081A5 (enExample)
DE (1) DE3910084A1 (enExample)
DK (1) DK146789A (enExample)
ES (1) ES2013408A6 (enExample)
FI (1) FI891308A7 (enExample)
FR (1) FR2632321A1 (enExample)
GB (1) GB2219799B (enExample)
GR (1) GR1000876B (enExample)
HU (1) HUT50501A (enExample)
IE (1) IE890950L (enExample)
IL (1) IL89673A0 (enExample)
IT (1) IT1234961B (enExample)
LU (1) LU87489A1 (enExample)
NL (1) NL8900724A (enExample)
NO (1) NO891273D0 (enExample)
NZ (1) NZ228427A (enExample)
PT (1) PT90118B (enExample)
SE (1) SE8901031L (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU626524B2 (en) * 1987-05-29 1992-08-06 Bristol-Myers Squibb Company Cloning and expression of simian transforming growth factor- beta 1
CA2037440A1 (en) * 1990-03-02 1991-09-03 Gregory D. Plowman Her3: a novel egf receptor homolog
EP0739984A1 (en) * 1995-04-26 1996-10-30 San Tumorforschungs-Gmbh Bivalent polypeptides containing at least two domains
US6852506B1 (en) 1996-04-10 2005-02-08 Human Genome Sciences, Inc. Extracellular/epidermal growth factor-like protein
CA2249213A1 (en) * 1996-04-10 1997-10-16 Human Genome Sciences, Inc. Extracellular/epidermal growth factor-like protein

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983004030A1 (en) * 1982-05-06 1983-11-24 Applied Molecular Genetics, Inc. The manufacture and expression of genes for urogastrone and polypeptide analogs thereof
EP0131868A1 (en) * 1983-07-08 1985-01-23 Wakunaga Seiyaku Kabushiki Kaisha (21-Leucine) human urogastrone, corresponding gene, corresponding recombinant plasmid, transformed cell and process for production thereof
EP0150572A1 (en) * 1983-11-01 1985-08-07 Amgen Microbial expression of type 1 transforming growth factor, polypeptide analogs thereof and hybrid EGF/TGF polypeptides
GB2162851A (en) * 1984-07-02 1986-02-12 Earth Chemical Co beta -urogastrone gene
GB2172890A (en) * 1985-03-25 1986-10-01 Wellcome Found Epidermal growth factor production
EP0234888A2 (en) * 1986-02-24 1987-09-02 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
GB2210618A (en) * 1987-10-08 1989-06-14 British Bio Technology Synthetic gene

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI862734A7 (fi) * 1984-10-30 1986-06-26 Oncogen Uudet polypeptidit, joilla on kasvutekijäaktiivisuutta ja nukleiinihap posekvenssit, jotka koodaavat polypeptidejä.
ES2081801T3 (es) * 1987-10-30 1996-03-16 Bristol Myers Squibb Co Plasmidos de expresion.
EP0372005A4 (en) * 1987-10-30 1990-06-26 Oncogen EXPRESSION SYSTEMS FOR THE PREPARATION OF POLYPEPTIDES IN PROKARYOTIC CELLS.

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1983004030A1 (en) * 1982-05-06 1983-11-24 Applied Molecular Genetics, Inc. The manufacture and expression of genes for urogastrone and polypeptide analogs thereof
EP0131868A1 (en) * 1983-07-08 1985-01-23 Wakunaga Seiyaku Kabushiki Kaisha (21-Leucine) human urogastrone, corresponding gene, corresponding recombinant plasmid, transformed cell and process for production thereof
EP0150572A1 (en) * 1983-11-01 1985-08-07 Amgen Microbial expression of type 1 transforming growth factor, polypeptide analogs thereof and hybrid EGF/TGF polypeptides
GB2162851A (en) * 1984-07-02 1986-02-12 Earth Chemical Co beta -urogastrone gene
GB2172890A (en) * 1985-03-25 1986-10-01 Wellcome Found Epidermal growth factor production
EP0234888A2 (en) * 1986-02-24 1987-09-02 Creative Biomolecules, Inc. Process for producing human epidermal growth factor and analogs thereof
GB2210618A (en) * 1987-10-08 1989-06-14 British Bio Technology Synthetic gene

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Nature Vol.313,1985 pages 491-492 *

Also Published As

Publication number Publication date
IL89673A0 (en) 1989-09-28
PT90118B (pt) 1994-07-29
AU2990492A (en) 1993-03-04
AU3169589A (en) 1989-09-28
FI891308A0 (fi) 1989-03-20
LU87489A1 (fr) 1989-10-26
PT90118A (pt) 1989-11-10
KR890014743A (ko) 1989-10-25
SE8901031D0 (sv) 1989-03-22
SE8901031L (sv) 1989-09-25
FI891308L (fi) 1989-09-25
GB8906758D0 (en) 1989-05-10
IT1234961B (it) 1992-06-09
CH681081A5 (enExample) 1993-01-15
GR1000876B (el) 1993-03-16
IE890950L (en) 1989-09-24
BE1004202A5 (fr) 1992-10-13
NO891273D0 (no) 1989-03-22
GR890100185A (en) 1990-01-19
DK146789D0 (da) 1989-03-22
ES2013408A6 (es) 1990-05-01
NZ228427A (en) 1993-03-26
FR2632321A1 (fr) 1989-12-08
HUT50501A (en) 1990-02-28
DK146789A (da) 1989-09-25
FI891308A7 (fi) 1989-09-25
JPH0279981A (ja) 1990-03-20
GB2219799A (en) 1989-12-20
NL8900724A (nl) 1989-10-16
IT8919917A0 (it) 1989-03-24
DE3910084A1 (de) 1989-11-16

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 19940323