CH668962A5 - Tetrahydronaphthyl-propenyl-phenole. - Google Patents
Tetrahydronaphthyl-propenyl-phenole. Download PDFInfo
- Publication number
- CH668962A5 CH668962A5 CH1938/86A CH193886A CH668962A5 CH 668962 A5 CH668962 A5 CH 668962A5 CH 1938/86 A CH1938/86 A CH 1938/86A CH 193886 A CH193886 A CH 193886A CH 668962 A5 CH668962 A5 CH 668962A5
- Authority
- CH
- Switzerland
- Prior art keywords
- compound
- propenyl
- compounds
- sep
- tetramethyl
- Prior art date
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 title claims description 6
- 125000004368 propenyl group Chemical group C(=CC)* 0.000 title description 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title description 2
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 title 2
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- CIECIINGNIMHEN-JQIJEIRASA-N 4-[(e)-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]phenol Chemical compound C=1C=C(C(CCC2(C)C)(C)C)C2=CC=1C(/C)=C/C1=CC=C(O)C=C1 CIECIINGNIMHEN-JQIJEIRASA-N 0.000 claims description 3
- DHMJOXINLWEEPL-DTQAZKPQSA-N 3-[(E)-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]phenol Chemical compound CC1(C=2C=CC(=CC=2C(CC1)(C)C)/C(=C/C=1C=C(C=CC=1)O)/C)C DHMJOXINLWEEPL-DTQAZKPQSA-N 0.000 claims description 2
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- BTYSJJCPITWDNC-JQIJEIRASA-N 2-[(e)-2-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)prop-1-enyl]phenol Chemical compound C=1C=C(C(CCC2(C)C)(C)C)C2=CC=1C(/C)=C/C1=CC=CC=C1O BTYSJJCPITWDNC-JQIJEIRASA-N 0.000 claims 1
- -1 p-hydroxyphenyl Chemical group 0.000 abstract description 12
- PTSDKUGWEFPZKO-UHFFFAOYSA-N 1-(5-methoxy-2,3,4-trimethyl-6-prop-1-enylphenyl)-1,2,3,4-tetrahydronaphthalene Chemical compound COC1=C(C(=C(C(=C1C)C)C)C1CCCC2=CC=CC=C12)C=CC PTSDKUGWEFPZKO-UHFFFAOYSA-N 0.000 abstract 1
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- 229930002330 retinoic acid Natural products 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- IPFUISOJBWATGQ-UHFFFAOYSA-M sodium;5-(2-methylsulfanylethyl)-5-pentan-2-yl-2-sulfanylidenepyrimidin-3-ide-4,6-dione Chemical compound [Na+].CCCC(C)C1(CCSC)C(=O)NC(=S)[N-]C1=O IPFUISOJBWATGQ-UHFFFAOYSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000004611 spectroscopical analysis Methods 0.000 description 1
- 238000013223 sprague-dawley female rat Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 229960001712 testosterone propionate Drugs 0.000 description 1
- 125000001712 tetrahydronaphthyl group Chemical group C1(CCCC2=CC=CC=C12)* 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 125000003944 tolyl group Chemical group 0.000 description 1
- 125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- NLIUDONFMFYFRU-UHFFFAOYSA-M triphenyl-[1-(5,5,8,8-tetramethyl-6,7-dihydronaphthalen-2-yl)ethyl]phosphanium;bromide Chemical compound [Br-].C=1C=C(C(CCC2(C)C)(C)C)C2=CC=1C(C)[P+](C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 NLIUDONFMFYFRU-UHFFFAOYSA-M 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/12—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic with no unsaturation outside the aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (26)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1938/86A CH668962A5 (de) | 1986-05-13 | 1986-05-13 | Tetrahydronaphthyl-propenyl-phenole. |
| ZW65/87A ZW6587A1 (en) | 1986-05-13 | 1987-04-10 | Tetrahydro naphthanline derivatives |
| IT20232/87A IT1203954B (it) | 1986-05-13 | 1987-04-23 | Tetraidronaftalin-derivati |
| NZ220215A NZ220215A (en) | 1986-05-13 | 1987-05-06 | Tetrahydronaphthalene derivatives and pharmaceutical compositions |
| LU86866A LU86866A1 (de) | 1986-05-13 | 1987-05-06 | Tetrahydronaphthalinderivate |
| DK232087A DK232087A (da) | 1986-05-13 | 1987-05-06 | Tetrahydronaphthalenderivater |
| ZA873244A ZA873244B (en) | 1986-05-13 | 1987-05-06 | Tetrahydro naphthaline derivatives |
| IL82448A IL82448A0 (en) | 1986-05-13 | 1987-05-07 | Tetrahydronaphthalene derivatives,their manufacture and pharmaceutical compositions containing them |
| FI872027A FI872027A7 (fi) | 1986-05-13 | 1987-05-07 | Tetrahydronaftaliinijohdannaiset. |
| CS873318A CS265240B2 (en) | 1986-05-13 | 1987-05-08 | Process for preparing tetrahydrotetramethylnaphthylpropenylphenoles |
| NL8701101A NL8701101A (nl) | 1986-05-13 | 1987-05-08 | Tetrahydronaftaleenderivaten, farmaceutische preparaten, die deze verbindingen bevatten, toepassing ervan alsmede werkwijzen ter bereiding van deze verbindingen. |
| BE8700505A BE1001668A5 (fr) | 1986-05-13 | 1987-05-11 | Derives de tetrahydronaphtalene. |
| FR878706564A FR2598706B1 (fr) | 1986-05-13 | 1987-05-11 | Derives de tetrahydronaphtalene, compositions pharmaceutiques les contenant et procede de preparation |
| SE8701933A SE8701933L (sv) | 1986-05-13 | 1987-05-11 | Tetrahydronaftalenderivat |
| HU872103A HU198002B (en) | 1986-05-13 | 1987-05-11 | Process for producing tetrahydronaphtalene derivatives and pharmaceutical compositions containing them as active components |
| GR870728A GR870728B (en) | 1986-05-13 | 1987-05-11 | Tetrahydronaphalin derivatives |
| MC871883A MC1817A1 (fr) | 1986-05-13 | 1987-05-11 | Derives de tetrahydronaphtalene |
| JP62112634A JPS62267245A (ja) | 1986-05-13 | 1987-05-11 | テトラヒドロナフタレン誘導体 |
| ES8701419A ES2005572A6 (es) | 1986-05-13 | 1987-05-12 | Un procedimiento para la preparacion de nuevos derivados del tetrahidronaftaleno |
| DE19873715809 DE3715809A1 (de) | 1986-05-13 | 1987-05-12 | Tetrahydronaphthalinderivate |
| PT84860A PT84860B (pt) | 1986-05-13 | 1987-05-12 | Processo para a preparacao de novos derivados do tetrahidronaftaleno e de composicoes farmaceuticas que os contem |
| AU72779/87A AU7277987A (en) | 1986-05-13 | 1987-05-12 | Pharmaceutically active tetrahydronaphthalene derivatives |
| GB8711205A GB2190378B (en) | 1986-05-13 | 1987-05-12 | Tetrahydronophthalene derivatives and anti-cancerous compositions containing them |
| CN198787103524A CN87103524A (zh) | 1986-05-13 | 1987-05-12 | 四氢萘衍生物 |
| NO871961A NO871961L (no) | 1986-05-13 | 1987-05-12 | Tetrahydronaftalinderivater. |
| KR870004688A KR870011073A (ko) | 1986-05-13 | 1987-05-13 | 테트라하이드로 나프탈렌유도체 및 그의 제조방법 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1938/86A CH668962A5 (de) | 1986-05-13 | 1986-05-13 | Tetrahydronaphthyl-propenyl-phenole. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH668962A5 true CH668962A5 (de) | 1989-02-15 |
Family
ID=4222110
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1938/86A CH668962A5 (de) | 1986-05-13 | 1986-05-13 | Tetrahydronaphthyl-propenyl-phenole. |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS62267245A (cs) |
| KR (1) | KR870011073A (cs) |
| CH (1) | CH668962A5 (cs) |
| CS (1) | CS265240B2 (cs) |
| GR (1) | GR870728B (cs) |
| ZA (1) | ZA873244B (cs) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5250562A (en) * | 1988-02-24 | 1993-10-05 | Hoffmann-La Roche Inc. | Stilbene derivatives |
| CA1340955C (en) * | 1988-02-24 | 2000-04-11 | Michael Klaus | Stilbene derivatives |
-
1986
- 1986-05-13 CH CH1938/86A patent/CH668962A5/de not_active IP Right Cessation
-
1987
- 1987-05-06 ZA ZA873244A patent/ZA873244B/xx unknown
- 1987-05-08 CS CS873318A patent/CS265240B2/cs unknown
- 1987-05-11 GR GR870728A patent/GR870728B/el unknown
- 1987-05-11 JP JP62112634A patent/JPS62267245A/ja active Pending
- 1987-05-13 KR KR870004688A patent/KR870011073A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| ZA873244B (en) | 1987-11-17 |
| GR870728B (en) | 1987-09-21 |
| CS265240B2 (en) | 1989-10-13 |
| CS331887A2 (en) | 1988-12-15 |
| KR870011073A (ko) | 1987-12-19 |
| JPS62267245A (ja) | 1987-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PUE | Assignment |
Owner name: F. HOFFMANN-LA ROCHE AG |
|
| PL | Patent ceased | ||
| PL | Patent ceased |