ES2005572A6 - Un procedimiento para la preparacion de nuevos derivados del tetrahidronaftaleno - Google Patents
Un procedimiento para la preparacion de nuevos derivados del tetrahidronaftalenoInfo
- Publication number
- ES2005572A6 ES2005572A6 ES8701419A ES8701419A ES2005572A6 ES 2005572 A6 ES2005572 A6 ES 2005572A6 ES 8701419 A ES8701419 A ES 8701419A ES 8701419 A ES8701419 A ES 8701419A ES 2005572 A6 ES2005572 A6 ES 2005572A6
- Authority
- ES
- Spain
- Prior art keywords
- pharmaceutically active
- tetrahydronaphthalene derivatives
- active tetrahydronaphthalene
- derivatives
- trihydroxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
- C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
Abstract
UN PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS DERIVADOS DEL TETRAHIDRONALTALENO, SW FORMULA GENERAL (I), EN DONDE R1 REPRESENTA O-, M- O P-HIDROXIFENILO; 2,3-, 2,4-, 2,5-, 2,6- O 3,5-DIHIDROXIFENILO; O 2,3,4-, 2,3,5-, 2,4,5-, 2,4,6-, 3,4,5- O 2,3,6-TRIHIDROXIFENILO. EL PROCEDIMIENTO CONSISTE EN PROCEDER A LA DISOSIACION DE EL(LOS) GRUPO(S) PROTECTORES DE UN COMPUESTO DE FORMULA GENERAL (II), EN DONDE R11 SIGNIFICA UN RADICAL R1 EN DONDE EL(LOS) GRUPO(S) HIDROXI ESTAÑESTAN PROTEGIDOS. LA DISOCIACION DE LOS GRUPOS PROTECTORES PUEDE LLEVARSE A CABO MEDIANTE TRATAMIENTO CON ACIDOS, BASES O AGENTES DE REDUCCION, SEGUN QUE LOS GRUPOS PROTECTORES SEAN ETERES O ESTERES.LOS COMPUESTOS DE FORMULA (I) TIENEN APLICACION EN EL TRATAMIENTO Y PROFILAXIS DE NEOPLASMAS Y DERMOTOXIS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH1938/86A CH668962A5 (de) | 1986-05-13 | 1986-05-13 | Tetrahydronaphthyl-propenyl-phenole. |
CH74287 | 1987-02-26 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2005572A6 true ES2005572A6 (es) | 1989-03-16 |
Family
ID=25685550
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8701419A Expired ES2005572A6 (es) | 1986-05-13 | 1987-05-12 | Un procedimiento para la preparacion de nuevos derivados del tetrahidronaftaleno |
Country Status (20)
Country | Link |
---|---|
CN (1) | CN87103524A (es) |
AU (1) | AU7277987A (es) |
BE (1) | BE1001668A5 (es) |
DE (1) | DE3715809A1 (es) |
DK (1) | DK232087A (es) |
ES (1) | ES2005572A6 (es) |
FI (1) | FI872027A (es) |
FR (1) | FR2598706B1 (es) |
GB (1) | GB2190378B (es) |
HU (1) | HU198002B (es) |
IL (1) | IL82448A0 (es) |
IT (1) | IT1203954B (es) |
LU (1) | LU86866A1 (es) |
MC (1) | MC1817A1 (es) |
NL (1) | NL8701101A (es) |
NO (1) | NO871961L (es) |
NZ (1) | NZ220215A (es) |
PT (1) | PT84860B (es) |
SE (1) | SE8701933L (es) |
ZW (1) | ZW6587A1 (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5264578A (en) | 1987-03-20 | 1993-11-23 | Allergan, Inc. | Disubstituted acetylenes bearing heterobicyclic groups and heteroaromatic or phenyl groups having retinoid like activity |
US5602130A (en) * | 1987-03-20 | 1997-02-11 | Allergan | Disubstituted acetylenes bearing heteroaromatic and heterobicyclic groups having retinoid like activity |
CA2017956A1 (en) * | 1989-07-06 | 1991-01-06 | Werner Bollag | Use of retinoids |
US5183827A (en) * | 1989-09-19 | 1993-02-02 | Allergan, Inc. | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity |
US5272156A (en) * | 1989-09-19 | 1993-12-21 | Allergan, Inc. | Acetylenes disubstituted with a heteroaromatic group and a 2-substituted 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity |
US5264456A (en) * | 1989-12-29 | 1993-11-23 | Allergan, Inc. | Acetylenes disubstituted with a furyl group and a substituted phenyl group having retinoid like activity |
US5324840A (en) * | 1992-06-11 | 1994-06-28 | Allergan, Inc. | Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects |
US6172115B1 (en) | 1993-02-11 | 2001-01-09 | Allergan Sales, Inc. | Method for preventing onset of restenosis after angioplasty employing an RXR-specific retinoid |
US5455265A (en) | 1993-02-11 | 1995-10-03 | Allergan, Inc. | Method of treatment with compounds having selective agonist-like activity on RXR retinoid receptors |
US5475022A (en) * | 1993-10-18 | 1995-12-12 | Allergan, Inc. | Phenyl or heteroaryl and tetrahydronaphthyl substituted diene compounds having retinoid like biological activity |
US5426118A (en) * | 1993-12-30 | 1995-06-20 | Allergan, Inc. | [4-(1,2-epoxycyclohexanyl)but-3-en-1-ynyl]aromatic and heteroaromatic acids and derivatives having retinoid-like biological activity |
US5498755A (en) * | 1994-08-23 | 1996-03-12 | Chandraratna; Roshantha A. | Disubstituted aryl and heteroaryl imines having retinoid-like biological activity |
US5543534A (en) * | 1994-12-29 | 1996-08-06 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl groups having retinoid-like biological activity |
US5599967A (en) * | 1994-12-29 | 1997-02-04 | Allergan | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl of heteroaryl group having retinoid-like biological activity |
US5514825A (en) * | 1994-12-29 | 1996-05-07 | Allergan, Inc. | Acetylenes disubstituted with a 5 substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity |
US5556996A (en) * | 1994-12-29 | 1996-09-17 | Allergan | Oxiranyls disubstituted with a phenyl group and a substituted chromanyl or tetrahydroquinolinyl group having retinoid like activity |
US5489584A (en) * | 1994-12-29 | 1996-02-06 | Allergan, Inc. | Acetylenes disubstituted with a 5-amino or substituted 5-amino substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity |
US5648514A (en) | 1994-12-29 | 1997-07-15 | Allergan | Substituted acetylenes having retinoid-like biological activity |
US5618931A (en) * | 1994-12-29 | 1997-04-08 | Allergan | Acetylenes disubstituted with a 5 substituted dihydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity |
US5534641A (en) * | 1994-12-29 | 1996-07-09 | Allergan | Acetylenes disubstituted with 2-tetrahydropyranoxyaryl and aryl or heteroaryl groups having retinoid-like biological activity |
US5618943A (en) * | 1994-12-29 | 1997-04-08 | Allergan | Acetylenes disubstituted with a 5 OXO substituted tetrahydronaphthyl group and with an aryl or heteroaryl group having retinoid-like biological activity |
US5534261A (en) * | 1995-01-17 | 1996-07-09 | University Of Southern California | Retinoid-based compositions and method for preventing adhesion formation using the same |
US6025388A (en) * | 1995-04-26 | 2000-02-15 | Allergan Sales, Inc. | Method for inhibiting gene expression promoted by AP1 protein with RARβ selective retinoids and method for treatment of diseases and conditions with such retinoids |
US5616712A (en) * | 1995-05-16 | 1997-04-01 | Allergan | Acetylenes disubstituted with a phenyl or heteroaryl group and a 2-thio-1,2,3,4-tetrahdroquinolinyl, 2-alkylthio-3,4-dihydroquinolinyl or 2-alkoxy-3,4-dihydroquinolinyl group having retinoid-like biological activity |
US5917082A (en) | 1995-06-06 | 1999-06-29 | Allergan Sales, Inc. | 2,4-pentadienoic acid derivatives having retinoid-like biological activity |
US5675033A (en) * | 1995-06-06 | 1997-10-07 | Allergan | 2,4-pentadienoic acid derivatives having retinoid-like biological activity |
US5952345A (en) | 1995-09-01 | 1999-09-14 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US5958954A (en) | 1995-09-01 | 1999-09-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US6008204A (en) | 1995-09-01 | 1999-12-28 | Allergan Sales, Inc. | Synthesis and use of retinoid compounds having negative hormone and/or antagonist activities |
US6218128B1 (en) | 1997-09-12 | 2001-04-17 | Allergan Sales, Inc. | Methods of identifying compounds having nuclear receptor negative hormone and/or antagonist activities |
AU7598596A (en) * | 1995-11-01 | 1997-05-22 | Allergan, Inc. | Sulfides, sulfoxides and sulfones disubstituted with a tetrahydronaphthalenyl, chromanyl, thiochromanyl or tetrahydroquinolinyl and substituted phenyl or heteroaryl group, having retinoid-like biological activity |
US5663357A (en) * | 1995-11-22 | 1997-09-02 | Allergan | Substituted heteroarylamides having retinoid-like biological activity |
US5675024A (en) | 1995-11-22 | 1997-10-07 | Allergan | Aryl or heteroaryl amides of tetrahydronaphthalene, chroman, thiochroman and 1,2,3,4,-tetrahydroquinoline carboxylic acids, having an electron withdrawing substituent in the aromatic or heteroaromatic moiety, having retinoid-like biological activity |
US5965606A (en) | 1995-12-29 | 1999-10-12 | Allergan Sales, Inc. | Methods of treatment with compounds having RAR.sub.α receptor specific or selective activity |
US5688957A (en) * | 1995-12-29 | 1997-11-18 | Allergan | (3"-thioxacyclohex-1"-enyl)!-but-3'-ene-1'-ynyl!aryl and (3"-thioxacyclohex-1"-enyl)!-but-3'-ene-1'-ynyl!heteroaryl carboxylic acids and esters having retinoid-like biological activity |
US5741896A (en) | 1996-06-21 | 1998-04-21 | Allergan | O- or S- substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5773594A (en) | 1996-06-21 | 1998-06-30 | Allergan | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5723666A (en) * | 1996-06-21 | 1998-03-03 | Allergan | Oxime substituted tetrahydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5747542A (en) * | 1996-06-21 | 1998-05-05 | Allergan | Oxo-substituted tetrahydronaphthalene derivatives having retinold and/or retinoid antagonist-like biological activity |
US6555690B2 (en) | 1996-06-21 | 2003-04-29 | Allergan, Inc. | Alkyl or aryl substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5808124A (en) * | 1996-06-21 | 1998-09-15 | Allergan | O- or S-substituted dihydronaphthalene derivatives having retinoid and/or retinoid antagonist-like biological activity |
US5763635A (en) | 1996-06-21 | 1998-06-09 | Allergan | Tetrahydronaphthalene derivatives substituted in the 8 position with alkyhidene groups having retinoid and/or retinoid antagonist-like biological activity |
US5739338A (en) * | 1996-11-05 | 1998-04-14 | Allergan | N-aryl substituted tetrahydroquinolines having retinoid agonist, retinoid antagonist or retinoid inverse agonist type biological activity |
US5728846A (en) | 1996-12-12 | 1998-03-17 | Allergan | Benzo 1,2-g!-chrom-3-ene and benzo 1,2-g!-thiochrom-3-ene derivatives |
US5760276A (en) | 1997-03-06 | 1998-06-02 | Allergan | Aryl-and heteroarylcyclohexenyl substituted alkenes having retinoid agonist, antagonist or inverse agonist type biological activity |
US6037488A (en) | 1997-04-19 | 2000-03-14 | Allergan Sales, Inc. | Trisubstituted phenyl derivatives having retinoid agonist, antagonist or inverse agonist type biological activity |
US5919970A (en) | 1997-04-24 | 1999-07-06 | Allergan Sales, Inc. | Substituted diaryl or diheteroaryl methanes, ethers and amines having retinoid agonist, antagonist or inverse agonist type biological activity |
US6313107B1 (en) | 2000-08-29 | 2001-11-06 | Allergan Sales, Inc. | Methods of providing and using compounds having activity as inhibitors of cytochrome P450RAI |
US6380256B1 (en) | 2000-08-29 | 2002-04-30 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
US6369225B1 (en) | 2000-08-29 | 2002-04-09 | Allergan Sales, Inc. | Compounds having activity as inhibitors of cytochrome P450RAI |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4326055A (en) * | 1977-12-22 | 1982-04-20 | Hoffmann-La Roche Inc. | Stilbene derivatives |
CA1162200A (en) * | 1981-02-13 | 1984-02-14 | Michael Klaus | Process for the manufacture of indanyl (or tetrahydronaphthyl)propenyl phenyl derivatives |
EP0084667B1 (de) * | 1982-01-23 | 1985-09-18 | BASF Aktiengesellschaft | Phenylethylen-Derivate, ihre Herstellung und Verwendung als Arzneimittel |
DE3202100A1 (de) * | 1982-01-23 | 1983-08-04 | Basf Ag, 6700 Ludwigshafen | Substituierte benzoesaeure-4-hydroxyanilide, ihre herstellung und diese enthaltende pharmazeutische zubereitungen |
DE3602473A1 (de) * | 1986-01-28 | 1987-07-30 | Basf Ag | Vinylphenolderivate, ihre herstellung und verwendung |
-
1987
- 1987-04-10 ZW ZW65/87A patent/ZW6587A1/xx unknown
- 1987-04-23 IT IT20232/87A patent/IT1203954B/it active
- 1987-05-06 DK DK232087A patent/DK232087A/da not_active Application Discontinuation
- 1987-05-06 NZ NZ220215A patent/NZ220215A/xx unknown
- 1987-05-06 LU LU86866A patent/LU86866A1/de unknown
- 1987-05-07 IL IL82448A patent/IL82448A0/xx unknown
- 1987-05-07 FI FI872027A patent/FI872027A/fi not_active Application Discontinuation
- 1987-05-08 NL NL8701101A patent/NL8701101A/nl not_active Application Discontinuation
- 1987-05-11 FR FR878706564A patent/FR2598706B1/fr not_active Expired - Fee Related
- 1987-05-11 MC MC871883A patent/MC1817A1/xx unknown
- 1987-05-11 HU HU872103A patent/HU198002B/hu not_active IP Right Cessation
- 1987-05-11 SE SE8701933A patent/SE8701933L/ not_active Application Discontinuation
- 1987-05-11 BE BE8700505A patent/BE1001668A5/fr not_active IP Right Cessation
- 1987-05-12 GB GB8711205A patent/GB2190378B/en not_active Expired - Fee Related
- 1987-05-12 DE DE19873715809 patent/DE3715809A1/de not_active Withdrawn
- 1987-05-12 PT PT84860A patent/PT84860B/pt not_active IP Right Cessation
- 1987-05-12 CN CN198787103524A patent/CN87103524A/zh active Pending
- 1987-05-12 NO NO871961A patent/NO871961L/no unknown
- 1987-05-12 ES ES8701419A patent/ES2005572A6/es not_active Expired
- 1987-05-12 AU AU72779/87A patent/AU7277987A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
GB2190378A (en) | 1987-11-18 |
DE3715809A1 (de) | 1987-11-19 |
IL82448A0 (en) | 1987-11-30 |
NO871961D0 (no) | 1987-05-12 |
SE8701933D0 (sv) | 1987-05-11 |
MC1817A1 (fr) | 1988-03-18 |
FI872027A0 (fi) | 1987-05-07 |
HU198002B (en) | 1989-07-28 |
PT84860B (pt) | 1990-02-08 |
AU7277987A (en) | 1987-11-19 |
NL8701101A (nl) | 1987-12-01 |
IT1203954B (it) | 1989-02-23 |
DK232087A (da) | 1987-11-14 |
FR2598706A1 (fr) | 1987-11-20 |
BE1001668A5 (fr) | 1990-02-06 |
SE8701933L (sv) | 1987-11-14 |
FI872027A (fi) | 1987-11-14 |
DK232087D0 (da) | 1987-05-06 |
NO871961L (no) | 1987-11-16 |
FR2598706B1 (fr) | 1990-07-06 |
CN87103524A (zh) | 1987-12-02 |
ZW6587A1 (en) | 1987-12-02 |
GB2190378B (en) | 1990-11-14 |
NZ220215A (en) | 1990-06-26 |
PT84860A (en) | 1987-06-01 |
LU86866A1 (de) | 1988-06-13 |
GB8711205D0 (en) | 1987-06-17 |
IT8720232A0 (it) | 1987-04-23 |
HUT43806A (en) | 1987-12-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 20000301 |