ES8401488A1 - Procedimiento de preparacion de derivados de diaza-3,7a-cicloherta-(j,k)-fluorenos. - Google Patents
Procedimiento de preparacion de derivados de diaza-3,7a-cicloherta-(j,k)-fluorenos.Info
- Publication number
- ES8401488A1 ES8401488A1 ES517874A ES517874A ES8401488A1 ES 8401488 A1 ES8401488 A1 ES 8401488A1 ES 517874 A ES517874 A ES 517874A ES 517874 A ES517874 A ES 517874A ES 8401488 A1 ES8401488 A1 ES 8401488A1
- Authority
- ES
- Spain
- Prior art keywords
- diazacyclohepta
- preparation
- fluorene derivatives
- therapeutical use
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Revetment (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Non-Reversible Transmitting Devices (AREA)
- Glass Compositions (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE DIAZA-3,7A-CICLOHEPTA-J,K-FLUORENOS.CONSISTE EN LA REDUCCION DE UN COMPUESTO DE FORMULA (II) MEDIANTE UNA MEZCLA DE HIDRURO DE ALUMINIO Y LITIO Y CLORURO DE ALUMINIO PARA OBTENER UN COMPUESTO DE FORMULA (I). SI SE DESEA OBTENER UN COMPUESTO (I) EN EL QUE R2 ES UN ATOMO DE HIDROGENE, LA REDUCCION DEL COMPPUESTO DE FORMULA (II), EN LA QUE R2 ES UN GRUPO BENCILO, VA SEGUIDA DE LA DESBENCILACION DEL COMPUESTO (I) OBTENIDO, EN EL QUE R2 ES UN GRUPO BENCILO, POR UNA HIDROGENACION CATALITICA. LOS RADICALES DE LAS FORMULAS ANTERIORESTIENEN EL SIGUIENTE SIGNIFICADO: R1, ES UN ATOMO DE HIDROGENO O DE CLORO O UN RADICAL METOXI; R2 ES UN ATOMO DE HIDROGENO, EL RADICAL METILO O BENCILO; Y R3 Y R4 O SON ATOMOS DE HIDROGENO, O R3 ES CH3 Y R4 ES H, O R3 ES H Y R4 ES CH3.ESTOS COMPUESTOS PUEDEN UTILIZARSE, POR SU ACTIVIDAD ANTIANOXICA, PARA EL TRATAMIENTO DE TRASTORNOS DE LA VIGILIA, DE PERDIDAS DE MEMORIA DEBIDAS A TRAUMATISMOS CRANEANOS, DE ENCEFALOPATIAS METABOLICAS Y DE ESTADOS DEPRESIVOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8122643A FR2517679A1 (fr) | 1981-12-03 | 1981-12-03 | Derives de diaza-3,7a cyclohepta (j,k) fluorenes, leur preparation et leur application en therapeutique |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES517874A0 ES517874A0 (es) | 1983-12-01 |
| ES8401488A1 true ES8401488A1 (es) | 1983-12-01 |
Family
ID=9264634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES517874A Expired ES8401488A1 (es) | 1981-12-03 | 1982-12-02 | Procedimiento de preparacion de derivados de diaza-3,7a-cicloherta-(j,k)-fluorenos. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4503058A (es) |
| EP (1) | EP0082040B1 (es) |
| JP (1) | JPS58109487A (es) |
| AT (1) | ATE17485T1 (es) |
| AU (1) | AU553493B2 (es) |
| CA (1) | CA1196329A (es) |
| DE (1) | DE3268605D1 (es) |
| DK (1) | DK535082A (es) |
| ES (1) | ES8401488A1 (es) |
| FI (1) | FI71321C (es) |
| FR (1) | FR2517679A1 (es) |
| GR (1) | GR77848B (es) |
| HU (1) | HU186180B (es) |
| IL (1) | IL67400A (es) |
| NO (1) | NO824040L (es) |
| NZ (1) | NZ202688A (es) |
| PT (1) | PT75925B (es) |
| ZA (1) | ZA828877B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4624954A (en) * | 1985-12-20 | 1986-11-25 | American Home Products Corporation | 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof, useful for the treatment of cognitive impairments |
| US4665183A (en) * | 1985-12-20 | 1987-05-12 | American Home Products Corp. | Process for preparing 6,7,8,9-tetrahydro-10-methylpyrido[1,2-a]indol-9-amines and derivatives thereof useful for the treatment of cognitive impairments |
| CA2027814C (en) * | 1989-10-20 | 1996-07-30 | Ryuji Ueno | Treatment of hepatobiliary disease with 15-keto-prostaglandin compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD129791A5 (de) * | 1976-04-13 | 1978-02-08 | Synthelabo | Verfahren zur herstellung von naphtyridinderivaten |
| US4228168A (en) * | 1978-11-22 | 1980-10-14 | Tanabe Seiyaku Co., Ltd. | Azepino [1,2,3-lm]-β-carboline compounds and pharmaceutical composition thereof |
| JPS55161389A (en) * | 1979-06-01 | 1980-12-15 | Ngk Spark Plug Co | Method of connecting porcelain insulator to fitting |
-
1981
- 1981-12-03 FR FR8122643A patent/FR2517679A1/fr active Granted
-
1982
- 1982-11-29 DE DE8282402172T patent/DE3268605D1/de not_active Expired
- 1982-11-29 EP EP82402172A patent/EP0082040B1/fr not_active Expired
- 1982-11-29 AT AT82402172T patent/ATE17485T1/de active
- 1982-12-02 IL IL67400A patent/IL67400A/xx unknown
- 1982-12-02 DK DK535082A patent/DK535082A/da not_active Application Discontinuation
- 1982-12-02 ES ES517874A patent/ES8401488A1/es not_active Expired
- 1982-12-02 ZA ZA828877A patent/ZA828877B/xx unknown
- 1982-12-02 NZ NZ202688A patent/NZ202688A/en unknown
- 1982-12-02 GR GR69964A patent/GR77848B/el unknown
- 1982-12-02 CA CA000416847A patent/CA1196329A/en not_active Expired
- 1982-12-02 PT PT75925A patent/PT75925B/pt unknown
- 1982-12-02 HU HU828374A patent/HU186180B/hu unknown
- 1982-12-02 NO NO824040A patent/NO824040L/no unknown
- 1982-12-02 FI FI824155A patent/FI71321C/fi not_active IP Right Cessation
- 1982-12-02 AU AU91076/82A patent/AU553493B2/en not_active Ceased
- 1982-12-02 US US06/446,368 patent/US4503058A/en not_active Expired - Fee Related
- 1982-12-03 JP JP57213239A patent/JPS58109487A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA1196329A (en) | 1985-11-05 |
| FI824155A0 (fi) | 1982-12-02 |
| ES517874A0 (es) | 1983-12-01 |
| GR77848B (es) | 1984-09-25 |
| EP0082040A1 (fr) | 1983-06-22 |
| FR2517679B1 (es) | 1984-01-27 |
| HU186180B (en) | 1985-06-28 |
| EP0082040B1 (fr) | 1986-01-15 |
| FI824155L (fi) | 1983-06-04 |
| AU9107682A (en) | 1983-06-09 |
| FI71321B (fi) | 1986-09-09 |
| DK535082A (da) | 1983-06-04 |
| JPS58109487A (ja) | 1983-06-29 |
| FI71321C (fi) | 1986-12-19 |
| IL67400A0 (en) | 1983-05-15 |
| NO824040L (no) | 1983-06-06 |
| ATE17485T1 (de) | 1986-02-15 |
| IL67400A (en) | 1985-07-31 |
| ZA828877B (en) | 1983-09-28 |
| NZ202688A (en) | 1985-01-31 |
| AU553493B2 (en) | 1986-07-17 |
| PT75925B (fr) | 1985-12-20 |
| DE3268605D1 (en) | 1986-02-27 |
| FR2517679A1 (fr) | 1983-06-10 |
| US4503058A (en) | 1985-03-05 |
| PT75925A (fr) | 1983-01-01 |
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