CH661930A5 - Process for the preparation of 17-esters of clobetasol - Google Patents

Process for the preparation of 17-esters of clobetasol Download PDF

Info

Publication number
CH661930A5
CH661930A5 CH113/84A CH11384A CH661930A5 CH 661930 A5 CH661930 A5 CH 661930A5 CH 113/84 A CH113/84 A CH 113/84A CH 11384 A CH11384 A CH 11384A CH 661930 A5 CH661930 A5 CH 661930A5
Authority
CH
Switzerland
Prior art keywords
epoxy
diene
dione
methylpregna
llß
Prior art date
Application number
CH113/84A
Other languages
English (en)
Italian (it)
Inventor
Peter Macdonald
Original Assignee
Sicor Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sicor Spa filed Critical Sicor Spa
Publication of CH661930A5 publication Critical patent/CH661930A5/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CH113/84A 1983-03-29 1984-01-10 Process for the preparation of 17-esters of clobetasol CH661930A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT20334/83A IT1194178B (it) 1983-03-29 1983-03-29 Processo per la preparazione di 17-esteri di clobetasolo e composti ottenuti

Publications (1)

Publication Number Publication Date
CH661930A5 true CH661930A5 (en) 1987-08-31

Family

ID=11165811

Family Applications (1)

Application Number Title Priority Date Filing Date
CH113/84A CH661930A5 (en) 1983-03-29 1984-01-10 Process for the preparation of 17-esters of clobetasol

Country Status (10)

Country Link
JP (2) JPS59205397A (no)
CA (1) CA1220468A (no)
CH (1) CH661930A5 (no)
DK (1) DK42884A (no)
FI (1) FI840344A (no)
IT (1) IT1194178B (no)
NL (1) NL8400910A (no)
NO (1) NO840065L (no)
SE (1) SE8400145L (no)
YU (1) YU54684A (no)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108727458A (zh) * 2018-05-10 2018-11-02 浙江仙居仙乐药业有限公司 一种17-丙酸酯的合成方法
CN111944002A (zh) * 2020-07-29 2020-11-17 河南利华制药有限公司 一种倍氯米松二丙酸酯中间体及制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1253831A (en) * 1968-01-19 1971-11-17 Glaxo Lab Ltd 9alpha,21-DIHALOPREGNANE COMPOUNDS
JPS51125372A (en) * 1975-03-31 1976-11-01 Taisho Pharmaceut Co Ltd Aprocess for preparing pregnane steroid-17-ester-21-halides

Also Published As

Publication number Publication date
NO840065L (no) 1984-10-01
IT1194178B (it) 1988-09-14
YU54684A (en) 1986-10-31
JPS59205399A (ja) 1984-11-20
JPS59205397A (ja) 1984-11-20
FI840344A (fi) 1984-09-30
SE8400145D0 (sv) 1984-01-12
DK42884A (da) 1984-09-30
FI840344A0 (fi) 1984-01-27
DK42884D0 (da) 1984-01-31
IT8320334A0 (it) 1983-03-29
JPS6228160B2 (no) 1987-06-18
CA1220468A (en) 1987-04-14
SE8400145L (sv) 1984-09-30
NL8400910A (nl) 1984-10-16

Similar Documents

Publication Publication Date Title
US4041055A (en) Process for the preparation of 17α-hydroxyprogesterones and corticoids from androstenes
FI78111C (fi) Foerfarande foer framstaellning av terapeutiskt aktiva 3,20-dioxo-1,4-pregnadien-17 -ol 17-aromatisk- heterocykliska karboxylater.
FI117600B (fi) Menetelmä valmistaa 21-kloorikortikosteroideja
DK154145B (da) Fremgangsmaade til fremstilling af corticoid-17-alkylcarbonater
US7718793B2 (en) Method for the preparation of 6-α fluoro corticosteroids
DE2649097A1 (de) Verfahren zur herstellung von corticoidderivaten und corticoidderivate
JP3734090B2 (ja) 新規シリル化合物およびその使用
US4255331A (en) 3-Acetoxy-9β-11β-epoxy-dienes and the preparation of the corresponding 6α-halogen-4-ene-3-ones
EP1395603B1 (en) Preparation of flumethasone and its 17-carboxyl androsten analogue
CH661930A5 (en) Process for the preparation of 17-esters of clobetasol
AT363202B (de) Verfahren zur herstellung von neuen mehrfach halogenierten steroiden
JP2004534795A5 (no)
JPH0257559B2 (no)
US4207235A (en) Selective epoxidation of steroidal bromohydrins
JP2004538294A (ja) ６α−フルオロプレグナンの立体選択的製造方法および中間体
EP0001737A1 (de) 17-Alpha-(3-Jodbenzoyloxy)-9-Alpha-chlor-4-pregnen-3.20-dione, deren D-Homo-analoga und Verfahren zu ihrer Herstellung
CA1144538A (en) Steroids of the pregnane series substituted in the 17-position, and their manufacture and use
KR820001643B1 (ko) 6-할로-프레그난류의 개량된 제조방법
SU862829A3 (ru) Способ получени производных 9-фторпреднизолона
SK403491A3 (en) Androstane carbothionates and pharmaceutical agents containing thereof
HU200610B (en) New process for producing 21-halogen pregnane derivatives
PL140353B1 (en) Method of purifying beta-methazon acetate

Legal Events

Date Code Title Description
PL Patent ceased