CH650679A5 - Gegen diabetes mellitus wirksames pharmazeutisches mittel. - Google Patents
Gegen diabetes mellitus wirksames pharmazeutisches mittel. Download PDFInfo
- Publication number
- CH650679A5 CH650679A5 CH5010/82A CH501082A CH650679A5 CH 650679 A5 CH650679 A5 CH 650679A5 CH 5010/82 A CH5010/82 A CH 5010/82A CH 501082 A CH501082 A CH 501082A CH 650679 A5 CH650679 A5 CH 650679A5
- Authority
- CH
- Switzerland
- Prior art keywords
- insulin
- human
- peptide
- diabetes
- molar ratio
- Prior art date
Links
- 206010012601 diabetes mellitus Diseases 0.000 title claims description 14
- 239000008186 active pharmaceutical agent Substances 0.000 title 1
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims description 54
- 239000000203 mixture Substances 0.000 claims description 44
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 claims description 39
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- 101000976075 Homo sapiens Insulin Proteins 0.000 claims description 35
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29671581A | 1981-08-27 | 1981-08-27 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH650679A5 true CH650679A5 (de) | 1985-08-15 |
Family
ID=23143238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH5010/82A CH650679A5 (de) | 1981-08-27 | 1982-08-23 | Gegen diabetes mellitus wirksames pharmazeutisches mittel. |
Country Status (20)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3326473A1 (de) * | 1983-07-22 | 1985-01-31 | Hoechst Ag, 6230 Frankfurt | Pharmazeutisches mittel zur behandlung des diabetes mellitus |
| CA1296253C (en) * | 1986-10-20 | 1992-02-25 | Praveen Tyle | Stabilized growth hormone compositions |
| JPH01501389A (ja) * | 1986-10-20 | 1989-05-18 | ノボ インダストリ アクティーゼルスカブ | ポリペプチド製剤 |
| AU612141B2 (en) * | 1987-02-25 | 1991-07-04 | Novo Nordisk A/S | Novel insulin derivatives |
| US5212154A (en) * | 1987-08-14 | 1993-05-18 | Akzo N.V. | Preparation for treating complications in diabetes |
| EP0303308B1 (en) * | 1987-08-14 | 1991-05-29 | Akzo N.V. | Preparation for preventing or combating complications in diabetes |
| SE520392C2 (sv) | 1996-09-27 | 2003-07-01 | Creative Peptides Sweden Ab C | Specifika peptider för behandling av diabetes mellitus |
| GB0323979D0 (en) | 2003-10-13 | 2003-11-19 | Creative Peptides Sweden Ab | Therapeutic applications for c-peptide |
| WO2006053906A1 (en) * | 2004-11-22 | 2006-05-26 | Novo Nordisk A/S | Soluble, stable insulin-containing formulations with a protamine salt |
| GB0511269D0 (en) | 2005-06-02 | 2005-07-13 | Creative Peptides Sweden Ab | Sustained release preparation of pro-insulin C-peptide |
| GB0601950D0 (en) * | 2006-01-31 | 2006-03-15 | Creative Peptides Sweden Ab | Compositions and methods of treating diabetes |
| EP2341942A1 (en) | 2008-09-19 | 2011-07-13 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
| WO2011146518A2 (en) * | 2010-05-17 | 2011-11-24 | Cebix Inc. | Pegylated c-peptide |
| WO2013075117A2 (en) | 2011-11-17 | 2013-05-23 | John Wahren | Pegylated c-peptide |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2789080A (en) * | 1952-08-14 | 1957-04-16 | Christensen Henry Marinus | Insulin-albumin compositions |
| CH330318A (de) * | 1953-09-08 | 1958-05-31 | British Drug Houses Ltd | Verfahren zur Herstellung eines Insulinpräparates mit verlängerter Wirkungszeit |
-
1982
- 1982-08-23 ZW ZW174/82A patent/ZW17482A1/xx unknown
- 1982-08-23 CA CA000409900A patent/CA1176158A/en not_active Expired
- 1982-08-23 IL IL66611A patent/IL66611A0/xx unknown
- 1982-08-23 CH CH5010/82A patent/CH650679A5/de not_active IP Right Cessation
- 1982-08-24 PH PH27772A patent/PH19361A/en unknown
- 1982-08-24 MW MW38/82A patent/MW3882A1/xx unknown
- 1982-08-24 BE BE6/47701A patent/BE894185A/fr not_active IP Right Cessation
- 1982-08-24 NL NL8203315A patent/NL192192C/nl not_active IP Right Cessation
- 1982-08-24 ZA ZA826159A patent/ZA826159B/xx unknown
- 1982-08-24 DZ DZ826637A patent/DZ452A1/fr active
- 1982-08-24 NZ NZ201682A patent/NZ201682A/en unknown
- 1982-08-25 SE SE8204873A patent/SE460334B/sv not_active IP Right Cessation
- 1982-08-25 FR FR8214595A patent/FR2513126B1/fr not_active Expired
- 1982-08-25 JP JP57148494A patent/JPS5846024A/ja active Pending
- 1982-08-25 AU AU87594/82A patent/AU551879B2/en not_active Expired
- 1982-08-26 GB GB08224484A patent/GB2104382B/en not_active Expired
- 1982-08-26 IE IE2064/82A patent/IE54119B1/en not_active IP Right Cessation
- 1982-08-26 LU LU84359A patent/LU84359A1/fr unknown
- 1982-08-27 IT IT8223017A patent/IT1153182B/it active
- 1982-08-27 DE DE19823232034 patent/DE3232034A1/de active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| LU84359A1 (fr) | 1983-02-28 |
| AU551879B2 (en) | 1986-05-15 |
| NL192192C (nl) | 1997-03-04 |
| GB2104382A (en) | 1983-03-09 |
| IL66611A0 (en) | 1982-12-31 |
| JPS5846024A (ja) | 1983-03-17 |
| IT8223017A0 (it) | 1982-08-27 |
| MW3882A1 (en) | 1984-07-11 |
| FR2513126A1 (fr) | 1983-03-25 |
| SE460334B (sv) | 1989-10-02 |
| NZ201682A (en) | 1985-08-16 |
| NL8203315A (nl) | 1983-03-16 |
| PH19361A (en) | 1986-04-02 |
| AU8759482A (en) | 1983-03-03 |
| IE54119B1 (en) | 1989-06-21 |
| CA1176158A (en) | 1984-10-16 |
| ZA826159B (en) | 1984-04-25 |
| DZ452A1 (fr) | 2004-09-13 |
| DE3232034A1 (de) | 1983-03-10 |
| FR2513126B1 (fr) | 1986-04-18 |
| BE894185A (fr) | 1983-02-24 |
| SE8204873L (sv) | 1983-02-28 |
| IT1153182B (it) | 1987-01-14 |
| DE3232034C2 (enrdf_load_stackoverflow) | 1991-04-11 |
| SE8204873D0 (sv) | 1982-08-25 |
| NL192192B (nl) | 1996-11-01 |
| ZW17482A1 (en) | 1982-11-17 |
| IE822064L (en) | 1983-02-27 |
| GB2104382B (en) | 1984-12-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |