CH648556A5 - Fluorprostacycline. - Google Patents

Fluorprostacycline. Download PDF

Info

Publication number
CH648556A5
CH648556A5 CH816/82A CH81682A CH648556A5 CH 648556 A5 CH648556 A5 CH 648556A5 CH 816/82 A CH816/82 A CH 816/82A CH 81682 A CH81682 A CH 81682A CH 648556 A5 CH648556 A5 CH 648556A5
Authority
CH
Switzerland
Prior art keywords
formula
fluoro
compound
ether
hydroxy
Prior art date
Application number
CH816/82A
Other languages
German (de)
English (en)
Inventor
George William Holland
Perry Rosen
Hans Maag
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CH648556A5 publication Critical patent/CH648556A5/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • C07D307/935Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
    • C07D307/937Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans with hydrocarbon or substituted hydrocarbon radicals directly attached in position 2, e.g. prostacyclins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
CH816/82A 1981-03-11 1982-02-10 Fluorprostacycline. CH648556A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24281881A 1981-03-11 1981-03-11
US33779182A 1982-01-07 1982-01-07

Publications (1)

Publication Number Publication Date
CH648556A5 true CH648556A5 (de) 1985-03-29

Family

ID=26935366

Family Applications (2)

Application Number Title Priority Date Filing Date
CH4762/84A CH651033A5 (de) 1981-03-11 1982-02-10 Fluorprostacycline.
CH816/82A CH648556A5 (de) 1981-03-11 1982-02-10 Fluorprostacycline.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CH4762/84A CH651033A5 (de) 1981-03-11 1982-02-10 Fluorprostacycline.

Country Status (19)

Country Link
AT (1) AT381308B (es)
AU (2) AU558000B2 (es)
CA (1) CA1208634A (es)
CH (2) CH651033A5 (es)
DE (1) DE3208880A1 (es)
DK (1) DK104882A (es)
ES (1) ES510286A0 (es)
FR (3) FR2503161B1 (es)
GB (2) GB2094310B (es)
HU (1) HU190684B (es)
IE (1) IE52388B1 (es)
IL (1) IL65177A (es)
IT (1) IT1195917B (es)
LU (1) LU83992A1 (es)
NL (1) NL8200992A (es)
NO (1) NO154494C (es)
NZ (1) NZ199912A (es)
PH (2) PH17410A (es)
SE (2) SE453294B (es)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0209694A1 (en) * 1985-06-24 1987-01-28 F. Hoffmann-La Roche Ag Novel prostacyclins

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU190007B (en) * 1982-05-06 1986-08-28 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt,Hu Process for producing new aromatic prostacylin analogues
DK40485A (da) * 1984-03-02 1985-09-03 Hoffmann La Roche Prostaglandin-mellemprodukter
US4680415A (en) * 1985-06-24 1987-07-14 Hoffmann-La Roche Inc. Intermediates for 7-fluoro dihydro PGI compounds
US4808734A (en) * 1986-12-01 1989-02-28 Hoffmann-La Roche Inc. 16-cycloalkyl-7-fluoro-prostacyclins
CH674363A5 (es) * 1986-12-01 1990-05-31 Hoffmann La Roche
RU2239925C1 (ru) * 2003-09-03 2004-11-10 Анисимова Ирина Александровна Свеча зажигания для двигателя внутреннего сгорания

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL51189A (en) * 1976-02-04 1985-08-30 Upjohn Co Prostaglandin analogs
GB1583961A (en) * 1976-05-11 1981-02-04 Wellcome Found Prostacyclin and derivatives thereof
US4178367A (en) * 1977-02-21 1979-12-11 Ono Pharmaceutical Co. Ltd. Prostaglandin I2 analogues
DE2811950A1 (de) * 1978-03-18 1979-12-13 Hoechst Ag Neue analoga von prostacyclin
US4254042A (en) * 1979-07-05 1981-03-03 The Upjohn Company 19-Hydroxy-19-methyl-4,5-didehydro-PGI1 compounds
WO1981001002A1 (en) * 1979-10-10 1981-04-16 Univ Chicago Fluoro-substituted prostaglandins and prostacyclins
GB2084991B (en) * 1980-09-22 1984-06-20 Hoffmann La Roche Prostacyclins
GB2088856B (en) * 1980-10-27 1984-06-27 Chinoin Gyogyszer Es Vegyeszet 7-substituted pg12-derivatives their preparation and pharmaceutical compositions containing them
DE3176313D1 (en) * 1980-12-09 1987-08-20 Teijin Ltd Novel halogenated prostacyclins, process for the production thereof, and pharmaceutical use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0209694A1 (en) * 1985-06-24 1987-01-28 F. Hoffmann-La Roche Ag Novel prostacyclins

Also Published As

Publication number Publication date
FR2515644A1 (fr) 1983-05-06
DE3208880A1 (de) 1982-09-23
ES8304934A1 (es) 1983-04-01
PH17410A (en) 1984-08-08
NO154494B (no) 1986-06-23
SE8703023D0 (sv) 1987-07-31
AU6855587A (en) 1987-05-07
AU576441B2 (en) 1988-08-25
AU558000B2 (en) 1987-01-15
NZ199912A (en) 1985-08-30
FR2515650A1 (fr) 1983-05-06
IE52388B1 (en) 1987-10-14
PH18584A (en) 1985-08-12
GB2158822A (en) 1985-11-20
GB2094310A (en) 1982-09-15
HU190684B (en) 1986-10-28
NO820779L (no) 1982-09-13
ATA94982A (de) 1986-02-15
LU83992A1 (de) 1983-11-17
DK104882A (da) 1982-09-12
SE453294B (sv) 1988-01-25
IL65177A (en) 1985-10-31
IT1195917B (it) 1988-11-03
SE8703023L (sv) 1987-07-31
GB2158822B (en) 1986-06-18
ES510286A0 (es) 1983-04-01
FR2515644B1 (es) 1984-05-25
AT381308B (de) 1986-09-25
FR2503161A1 (fr) 1982-10-08
CA1208634A (en) 1986-07-29
GB8426077D0 (en) 1984-11-21
IL65177A0 (en) 1982-05-31
NL8200992A (nl) 1982-10-01
GB2094310B (en) 1985-07-03
FR2503161B1 (fr) 1986-04-18
NO154494C (no) 1986-10-01
IE820547L (en) 1982-09-11
AU8115682A (en) 1982-09-16
SE8201506L (sv) 1982-09-12
IT8219966A0 (it) 1982-03-04
FR2515650B1 (fr) 1985-08-09
CH651033A5 (de) 1985-08-30

Similar Documents

Publication Publication Date Title
US4558142A (en) 7-Fluoro-prostacyclin analogs
DE2704933A1 (de) Prostaglandin-analoga mit dreifachbindung zwischen c-13 und c-14 und verfahren zu ihrer herstellung
EP0119949B1 (de) Neue Carbacycline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CH639062A5 (de) Prostacyclinanaloga.
EP0099538B1 (de) Neue Carbacycline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
CH648556A5 (de) Fluorprostacycline.
EP0130142B1 (de) Neue Prostacyclinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE2610503C2 (de) Optisch aktive 13,14-Dehydro-11- desoxy-prostaglandine, Verfahren zu ihrer Herstellung und sie enthaltendes pharmazeutisches Mittel
WO1981001002A1 (en) Fluoro-substituted prostaglandins and prostacyclins
CA1301179C (en) 7-oxabicyclo(2.2.1)heptane hydroxamic acid derivatives useful as "dual inhibitors"
DE2611788C2 (de) Fluorprostaglandine, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Mittel
US4650883A (en) Hexahydro-3-fluoro-4-octenyl-2H-cyclopenta[β]furan-2-ones
DE69531110T2 (de) Difluoroprostacycline, Zwischenprodukte zu deren Herstellung und Herstellungsverfahren
US4665198A (en) Tetrahydro-cyclopenta[β]furanes
US4612380A (en) 7-fluoro-prostacyclin analogs
DE2704932A1 (de) Prostaglandin-analoga mit dreifachbindung zwischen c-13 und c-14 und verfahren zu ihrer herstellung
DE2654668A1 (de) Verfahren zur herstellung von verbindungen des prostaglandintyps und nach diesem verfahren erhaltene produkte
EP0284547A1 (de) 6-Oxoprostaglandin-E-Derivate, Verfahren zu ihrer Herstellung und Arzneimittel
EP0086404A1 (de) Neue Carbacycline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AT392071B (de) Neue prostacycline
EP0261185B1 (de) 7-oxoprostacyclinderivate und verfahren zu ihrer herstellung
DE2537406A1 (de) Verfahren zur herstellung von 9,11,15-trihydroxy-13,14-dehydro-prostaglandinen, die dabei erhaltenen produkte und deren pharmazeutische verwendung
DE3024723A1 (de) Prostacyclin-derivate, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
DE4010355A1 (de) Bicyclo(3.3.0)octan-derivate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
DE3830878A1 (de) 2-oxa-bicyclo(2.2.1)heptanderivate und diese verbindungen enthaltende arzneimittel

Legal Events

Date Code Title Description
PUE Assignment

Owner name: F. HOFFMANN-LA ROCHE AG

PL Patent ceased