CH647234A5 - Pyrrolidine derivatives - Google Patents
Pyrrolidine derivatives Download PDFInfo
- Publication number
- CH647234A5 CH647234A5 CH4849/81A CH484981A CH647234A5 CH 647234 A5 CH647234 A5 CH 647234A5 CH 4849/81 A CH4849/81 A CH 4849/81A CH 484981 A CH484981 A CH 484981A CH 647234 A5 CH647234 A5 CH 647234A5
- Authority
- CH
- Switzerland
- Prior art keywords
- compounds
- general formula
- oxo
- hydrogen
- pyrrolidinyl
- Prior art date
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- 150000003235 pyrrolidines Chemical class 0.000 title claims abstract description 8
- 150000001875 compounds Chemical class 0.000 claims abstract description 107
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 31
- 239000001257 hydrogen Substances 0.000 claims abstract description 31
- 150000003839 salts Chemical class 0.000 claims abstract description 21
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 20
- 239000002253 acid Substances 0.000 claims abstract description 17
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 13
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims abstract description 12
- 125000001589 carboacyl group Chemical group 0.000 claims abstract description 12
- 230000002490 cerebral effect Effects 0.000 claims abstract description 9
- 150000002431 hydrogen Chemical class 0.000 claims abstract description 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 8
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims abstract description 8
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims abstract description 8
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 5
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- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000008012 organic excipient Substances 0.000 description 1
- 125000002524 organometallic group Chemical group 0.000 description 1
- 125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
- 230000003204 osmotic effect Effects 0.000 description 1
- 150000003901 oxalic acid esters Chemical class 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 229910003446 platinum oxide Inorganic materials 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- LVTJOONKWUXEFR-FZRMHRINSA-N protoneodioscin Natural products O(C[C@@H](CC[C@]1(O)[C@H](C)[C@@H]2[C@]3(C)[C@H]([C@H]4[C@@H]([C@]5(C)C(=CC4)C[C@@H](O[C@@H]4[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@@H](O)[C@H](O[C@H]6[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O6)[C@H](CO)O4)CC5)CC3)C[C@@H]2O1)C)[C@H]1[C@H](O)[C@H](O)[C@H](O)[C@@H](CO)O1 LVTJOONKWUXEFR-FZRMHRINSA-N 0.000 description 1
- ZDYVRSLAEXCVBX-UHFFFAOYSA-N pyridinium p-toluenesulfonate Chemical compound C1=CC=[NH+]C=C1.CC1=CC=C(S([O-])(=O)=O)C=C1 ZDYVRSLAEXCVBX-UHFFFAOYSA-N 0.000 description 1
- 150000004040 pyrrolidinones Chemical class 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 229960001367 tartaric acid Drugs 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 150000003899 tartaric acid esters Chemical class 0.000 description 1
- 239000012485 toluene extract Substances 0.000 description 1
- 238000003420 transacetalization reaction Methods 0.000 description 1
- 125000004665 trialkylsilyl group Chemical group 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Priority Applications (50)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH4849/81A CH647234A5 (en) | 1981-07-24 | 1981-07-24 | Pyrrolidine derivatives |
| IS2742A IS2742A7 (is) | 1981-07-24 | 1982-06-22 | Efni afleidd af Pyrrolidin og aðferð til framleiðslu þeirra |
| FR8210861A FR2515179A1 (fr) | 1981-07-24 | 1982-06-22 | Derives de pyrrolidine, leur procede de preparation, les intermediaires pour leur synthese et leur application therapeutique |
| NO822222A NO159592C (no) | 1981-07-24 | 1982-06-29 | Analogifremgangsmaate for fremstilling av terapeutisk aktive pyrrolidinderivater. |
| IT22335/82A IT1152287B (it) | 1981-07-24 | 1982-07-09 | Pirrolidin-derivati |
| CA000407012A CA1176251A (en) | 1981-07-24 | 1982-07-09 | Pyrrolidine derivatives |
| MW26/82A MW2682A1 (en) | 1981-07-24 | 1982-07-12 | Pyrrolidine derivatives |
| DK317382A DK157848C (da) | 1981-07-24 | 1982-07-14 | Analogifremgangsmaade til fremstilling af 2-(3-hydroxy-2-oxo-1-pyrrolidinyl)carboxylsyreamidderivater samt et udgangsmateriale til anvendelse ved denne fremgangsmaade |
| NZ201297A NZ201297A (en) | 1981-07-24 | 1982-07-16 | Pyrrolidine derivatives and pharmaceutical compositions |
| ZW144/82A ZW14482A1 (en) | 1981-07-24 | 1982-07-16 | Pyrrolidine derivates |
| ZA825104A ZA825104B (en) | 1981-07-24 | 1982-07-16 | Pyrrolidine derivatives |
| IL66341A IL66341A (en) | 1981-07-24 | 1982-07-16 | Pyrrolidin-2-oxo-1-acetamides,their manufacture and pharmaceutical compositions containing them |
| EG430/82A EG15921A (en) | 1981-07-24 | 1982-07-17 | Method of preparation pyrrolidine derivatives |
| AU86158/82A AU557651B2 (en) | 1981-07-24 | 1982-07-19 | Pyrrolidine derivatives |
| OA57742A OA07151A (fr) | 1981-07-24 | 1982-07-19 | Dérivés de la pyrrolidine . |
| FI822543A FI75158C (fi) | 1981-07-24 | 1982-07-19 | Foerfarande foer framstaellning av pyrrolidinderivat samt i foerfarande anvaendbara mellanprodukter. |
| RO108194A RO84097B (ro) | 1981-07-24 | 1982-07-19 | Procedeu pentru prepararea unor derivati de pirolidina |
| MT915A MTP915B (en) | 1981-07-24 | 1982-07-20 | Pyrralidine derivatives |
| NL8202922A NL8202922A (nl) | 1981-07-24 | 1982-07-20 | Pyrrolidinederivaten. |
| DD82241833A DD202540A5 (de) | 1981-07-24 | 1982-07-21 | Verfahren zur herstellung von pyrrolidinderivaten |
| CS825575A CS226746B2 (en) | 1981-07-24 | 1982-07-21 | Method of preparing pyrrolidine derivatives |
| HU822357A HU187777B (en) | 1981-07-24 | 1982-07-21 | Process for preparing pyrrolidine derivatives |
| MC821598A MC1476A1 (fr) | 1981-07-24 | 1982-07-22 | Derives de la pyrrolidine |
| SU823466582A SU1281172A3 (ru) | 1981-07-24 | 1982-07-22 | Способ получени производных пирролидина в виде смеси диастереоизомеров или их оптически активных антиподов или их кислотно-аддитивных солей |
| GR68825A GR76177B (is) | 1981-07-24 | 1982-07-22 | |
| EP82106690A EP0071216B1 (de) | 1981-07-24 | 1982-07-23 | 3-Hydroxypyrrolidin-2-on-Derivate, Verfahren und Zwischenprodukte zu deren Herstellung und diese enthaltende Arzneimittel |
| SE8204445A SE8204445L (sv) | 1981-07-24 | 1982-07-23 | Pyrrolidinderivat |
| KR8203307A KR890000768B1 (ko) | 1981-07-24 | 1982-07-23 | 피롤리딘 유도체 및 이의 제조방법 |
| PH27623A PH19149A (en) | 1981-07-24 | 1982-07-23 | Pyrrolidine derivatives |
| BG8257520A BG38334A3 (en) | 1981-07-24 | 1982-07-23 | Method for preparing pyrolidinic derivatives |
| DE19823227649 DE3227649A1 (de) | 1981-07-24 | 1982-07-23 | Pyrrolidinderivate |
| PT75314A PT75314B (en) | 1981-07-24 | 1982-07-23 | Pyrrolidine derivatives |
| GB08221446A GB2110207B (en) | 1981-07-24 | 1982-07-23 | Pyrrolidine derivatives |
| ES514267A ES514267A0 (es) | 1981-07-24 | 1982-07-23 | "un procedimiento para la preparacion de derivados de pirrolidina". |
| AT0286382A AT384424B (de) | 1981-07-24 | 1982-07-23 | Verfahren zur herstellung von neuen 3-hydroxy-2-oxo-pyrrolidinderivaten und ihren salzen |
| BR8204328A BR8204328A (pt) | 1981-07-24 | 1982-07-23 | Compostos processo para sua fabricacao medicamento uso de tais compostos e compostos intermediarios para os mesmos |
| PL1982237634A PL138918B1 (en) | 1981-07-24 | 1982-07-23 | Method of obtaining novel pyrolidine derivatives |
| AT82106690T ATE24488T1 (de) | 1981-07-24 | 1982-07-23 | 3-hydroxypyrrolidin-2-on-derivate, verfahren und zwischenprodukte zu deren herstellung und diese enthaltende arzneimittel. |
| LU84294A LU84294A1 (de) | 1981-07-24 | 1982-07-23 | Pyrrolidinderivate |
| IE1768/82A IE53428B1 (en) | 1981-07-24 | 1982-07-23 | Pyrrolidine derivatives |
| DE8282106690T DE3274851D1 (en) | 1981-07-24 | 1982-07-23 | 3-hydroxypyrrolidin-2-one derivatives, process and intermediates for their preparation and pharmaceutical preparations containing them |
| JP57127795A JPS5824558A (ja) | 1981-07-24 | 1982-07-23 | ピロリジン誘導体 |
| ES520820A ES8404678A1 (es) | 1981-07-24 | 1983-03-22 | Un procedimiento para la preparacion de derivados de pirrolidina. |
| US06/506,147 US4476308A (en) | 1981-07-24 | 1983-06-20 | 1-Pyrrolidine acetamides |
| US06/624,303 US4650878A (en) | 1981-07-24 | 1984-06-25 | 2-(2-oxo-1-pyrrolidinyl) acetic acids |
| GB08426076A GB2152038B (en) | 1981-07-24 | 1984-10-16 | Pyrrolidine derivatives |
| SG227/88A SG22788G (en) | 1981-07-24 | 1988-04-05 | Pyrrolidine derivatives |
| HK537/88A HK53788A (en) | 1981-07-24 | 1988-07-14 | Pyrrolidine derivatives |
| KR1019890000280A KR890000767B1 (ko) | 1981-07-24 | 1989-01-12 | 피롤리딘 유도체의 제조방법 |
| US07/508,675 US5034402A (en) | 1981-07-24 | 1990-04-12 | Methods and pharmaceutical compositions using pyrrolidine derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH4849/81A CH647234A5 (en) | 1981-07-24 | 1981-07-24 | Pyrrolidine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH647234A5 true CH647234A5 (en) | 1985-01-15 |
Family
ID=4283624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH4849/81A CH647234A5 (en) | 1981-07-24 | 1981-07-24 | Pyrrolidine derivatives |
Country Status (10)
| Country | Link |
|---|---|
| JP (1) | JPS5824558A (is) |
| KR (1) | KR890000768B1 (is) |
| BR (1) | BR8204328A (is) |
| CH (1) | CH647234A5 (is) |
| ES (1) | ES8404678A1 (is) |
| GR (1) | GR76177B (is) |
| IS (1) | IS2742A7 (is) |
| MW (1) | MW2682A1 (is) |
| PL (1) | PL138918B1 (is) |
| ZA (1) | ZA825104B (is) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0224256A1 (de) * | 1985-11-26 | 1987-06-03 | Lonza Ag | 4-Alkoxy-2-oxo-pyrrolidin-1-yl-essigsäurealkylester |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100498268B1 (ko) * | 1997-12-09 | 2005-11-01 | 주식회사 엘지생활건강 | 피롤리돈계 양쪽성 계면활성제 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2923975A1 (de) * | 1979-06-13 | 1980-12-18 | Nattermann A & Cie | Pyrrolidinone, verfahren zu deren herstellung und diese enthaltende arzneimittel |
-
1981
- 1981-07-24 CH CH4849/81A patent/CH647234A5/de not_active IP Right Cessation
-
1982
- 1982-06-22 IS IS2742A patent/IS2742A7/is unknown
- 1982-07-12 MW MW26/82A patent/MW2682A1/xx unknown
- 1982-07-16 ZA ZA825104A patent/ZA825104B/xx unknown
- 1982-07-22 GR GR68825A patent/GR76177B/el unknown
- 1982-07-23 KR KR8203307A patent/KR890000768B1/ko not_active IP Right Cessation
- 1982-07-23 BR BR8204328A patent/BR8204328A/pt unknown
- 1982-07-23 PL PL1982237634A patent/PL138918B1/pl unknown
- 1982-07-23 JP JP57127795A patent/JPS5824558A/ja active Granted
-
1983
- 1983-03-22 ES ES520820A patent/ES8404678A1/es not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0224256A1 (de) * | 1985-11-26 | 1987-06-03 | Lonza Ag | 4-Alkoxy-2-oxo-pyrrolidin-1-yl-essigsäurealkylester |
Also Published As
| Publication number | Publication date |
|---|---|
| ES520820A0 (es) | 1984-05-16 |
| KR840000489A (ko) | 1984-02-22 |
| ZA825104B (en) | 1983-04-27 |
| IS2742A7 (is) | 1983-01-25 |
| BR8204328A (pt) | 1983-07-19 |
| ES8404678A1 (es) | 1984-05-16 |
| JPH0345064B2 (is) | 1991-07-09 |
| PL138918B1 (en) | 1986-11-29 |
| JPS5824558A (ja) | 1983-02-14 |
| MW2682A1 (en) | 1984-03-14 |
| PL237634A1 (en) | 1984-01-30 |
| KR890000768B1 (ko) | 1989-04-05 |
| GR76177B (is) | 1984-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |