CH631015A5 - Verfahren zur herstellung eines reagenzes zum nachweis oder zur bestimmung von antikoerpern, antigenen und antikoerper/antigen-komplexen in einer fluessigkeit. - Google Patents
Verfahren zur herstellung eines reagenzes zum nachweis oder zur bestimmung von antikoerpern, antigenen und antikoerper/antigen-komplexen in einer fluessigkeit. Download PDFInfo
- Publication number
- CH631015A5 CH631015A5 CH645875A CH645875A CH631015A5 CH 631015 A5 CH631015 A5 CH 631015A5 CH 645875 A CH645875 A CH 645875A CH 645875 A CH645875 A CH 645875A CH 631015 A5 CH631015 A5 CH 631015A5
- Authority
- CH
- Switzerland
- Prior art keywords
- antibody
- antigen
- reagent
- clq
- sample
- Prior art date
Links
- 239000003153 chemical reaction reagent Substances 0.000 title claims description 36
- 239000000427 antigen Substances 0.000 title claims description 29
- 102000036639 antigens Human genes 0.000 title claims description 29
- 108091007433 antigens Proteins 0.000 title claims description 29
- 239000007788 liquid Substances 0.000 title claims description 16
- 238000004519 manufacturing process Methods 0.000 title description 3
- 238000000034 method Methods 0.000 claims description 34
- 239000000203 mixture Substances 0.000 claims description 15
- 239000007790 solid phase Substances 0.000 claims description 14
- 108060003951 Immunoglobulin Proteins 0.000 claims description 11
- 102000018358 immunoglobulin Human genes 0.000 claims description 11
- 229920000936 Agarose Polymers 0.000 claims description 9
- 239000000758 substrate Substances 0.000 claims description 9
- 239000002245 particle Substances 0.000 claims description 7
- 238000001514 detection method Methods 0.000 claims description 6
- 238000003018 immunoassay Methods 0.000 claims description 5
- 239000011248 coating agent Substances 0.000 claims description 4
- 238000000576 coating method Methods 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 3
- 230000001900 immune effect Effects 0.000 claims 2
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- 239000004816 latex Substances 0.000 claims 1
- 229920000126 latex Polymers 0.000 claims 1
- 210000002966 serum Anatomy 0.000 description 29
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 22
- 239000000243 solution Substances 0.000 description 19
- 229960005181 morphine Drugs 0.000 description 12
- 238000000926 separation method Methods 0.000 description 9
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- 239000011324 bead Substances 0.000 description 4
- 239000000872 buffer Substances 0.000 description 4
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- 229960000587 glutaral Drugs 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 230000000717 retained effect Effects 0.000 description 4
- 239000000126 substance Substances 0.000 description 4
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 3
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 3
- 208000025747 Rheumatic disease Diseases 0.000 description 3
- 206010043376 Tetanus Diseases 0.000 description 3
- 241000700605 Viruses Species 0.000 description 3
- 230000004520 agglutination Effects 0.000 description 3
- 239000013060 biological fluid Substances 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 230000002255 enzymatic effect Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000000552 rheumatic effect Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 210000002700 urine Anatomy 0.000 description 3
- 102000004641 Fetal Proteins Human genes 0.000 description 2
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- 241000282414 Homo sapiens Species 0.000 description 2
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- 102000003992 Peroxidases Human genes 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 238000005206 flow analysis Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 229940072221 immunoglobulins Drugs 0.000 description 2
- 108040007629 peroxidase activity proteins Proteins 0.000 description 2
- 239000008363 phosphate buffer Substances 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 229920002684 Sepharose Polymers 0.000 description 1
- 102000005686 Serum Globulins Human genes 0.000 description 1
- 108010045362 Serum Globulins Proteins 0.000 description 1
- 244000247617 Teramnus labialis var. labialis Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- SOIFLUNRINLCBN-UHFFFAOYSA-N ammonium thiocyanate Chemical compound [NH4+].[S-]C#N SOIFLUNRINLCBN-UHFFFAOYSA-N 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 238000011088 calibration curve Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000002843 carboxylic acid group Chemical group 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- VDQQXEISLMTGAB-UHFFFAOYSA-N chloramine T Chemical compound [Na+].CC1=CC=C(S(=O)(=O)[N-]Cl)C=C1 VDQQXEISLMTGAB-UHFFFAOYSA-N 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000000536 complexating effect Effects 0.000 description 1
- BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical compound O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 1
- 238000001493 electron microscopy Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000010166 immunofluorescence Methods 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 210000004324 lymphatic system Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- 239000004570 mortar (masonry) Substances 0.000 description 1
- 238000004848 nephelometry Methods 0.000 description 1
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000058 polyacrylate Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000002798 spectrophotometry method Methods 0.000 description 1
- 229920002994 synthetic fiber Polymers 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229960001479 tosylchloramide sodium Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
- G01N33/545—Synthetic resin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54306—Solid-phase reaction mechanisms
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/966—Chemistry: molecular biology and microbiology involving an enzyme system with high turnover rate or complement magnified assay, e.g. multi-enzyme systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/811—Test for named disease, body condition or organ function
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/819—Multifunctional antigen or antibody
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/821—Chemistry: analytical and immunological testing involving complement factors or complement systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/823—Immunogenic carrier or carrier per se
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/826—Additives, e.g. buffers, diluents, preservatives
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB22377/74A GB1508132A (en) | 1974-05-20 | 1974-05-20 | Analysis of biological fluids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH631015A5 true CH631015A5 (de) | 1982-07-15 |
Family
ID=10178404
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH645875A CH631015A5 (de) | 1974-05-20 | 1975-05-20 | Verfahren zur herstellung eines reagenzes zum nachweis oder zur bestimmung von antikoerpern, antigenen und antikoerper/antigen-komplexen in einer fluessigkeit. |
| CH645975A CH627281A5 (Direct) | 1974-05-20 | 1975-05-20 | |
| CH878779A CH637770A5 (de) | 1974-05-20 | 1979-09-28 | Zur durchfuehrung von immunoassays sowie zur abtrennung eines antikoerper/antigen-komplexes aus einer fluessigkeitsprobe geeignetes reagenz sowie verwendung dieses reagenzes. |
| CH918880A CH630465A5 (de) | 1974-05-20 | 1980-12-12 | Verfahren zum nachweis oder zur bestimmung eines antikoerper/antigen-komplexes in einer fluidprobe. |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH645975A CH627281A5 (Direct) | 1974-05-20 | 1975-05-20 | |
| CH878779A CH637770A5 (de) | 1974-05-20 | 1979-09-28 | Zur durchfuehrung von immunoassays sowie zur abtrennung eines antikoerper/antigen-komplexes aus einer fluessigkeitsprobe geeignetes reagenz sowie verwendung dieses reagenzes. |
| CH918880A CH630465A5 (de) | 1974-05-20 | 1980-12-12 | Verfahren zum nachweis oder zur bestimmung eines antikoerper/antigen-komplexes in einer fluidprobe. |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US4062935A (Direct) |
| JP (4) | JPS5949545B2 (Direct) |
| AU (2) | AU498364B2 (Direct) |
| BE (2) | BE829278A (Direct) |
| CH (4) | CH631015A5 (Direct) |
| DE (3) | DE2560554C2 (Direct) |
| FR (2) | FR2272398B1 (Direct) |
| GB (1) | GB1508132A (Direct) |
| IT (1) | IT1038305B (Direct) |
| NL (2) | NL182175C (Direct) |
| SE (4) | SE435425B (Direct) |
Families Citing this family (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1508132A (en) * | 1974-05-20 | 1978-04-19 | Technicon Instr | Analysis of biological fluids |
| US4283383A (en) * | 1974-05-20 | 1981-08-11 | Technicon Instruments Corporation | Analysis of biological fluids |
| SE441042B (sv) * | 1976-09-08 | 1985-09-02 | Pharmacia Diagnostics Ab | Sett att pavisa rheumatoida faktorer |
| SE441041B (sv) * | 1976-09-08 | 1985-09-02 | Pharmacia Diagnostics Ab | Sett vid pavisning av rheumatoida faktorer |
| JPS5339265U (Direct) * | 1976-09-09 | 1978-04-05 | ||
| GB1603406A (en) * | 1977-08-31 | 1981-11-25 | Nat Res Dev | Assay of immune complexes |
| GB1590524A (en) * | 1976-11-24 | 1981-06-03 | Nat Res Dev | Assay of immune complexes |
| GB1592450A (en) * | 1976-12-10 | 1981-07-08 | Technicon Instr | Biological analysis |
| JPS5387877U (Direct) * | 1976-12-21 | 1978-07-19 | ||
| JPS5387876U (Direct) * | 1976-12-21 | 1978-07-19 | ||
| JPS53115946A (en) * | 1977-03-18 | 1978-10-09 | Matsushita Electric Ind Co Ltd | High frequency heating apparatus |
| JPS53119441A (en) * | 1977-03-28 | 1978-10-18 | Matsushita Electric Ind Co Ltd | High-frequency heater |
| JPS53128781A (en) * | 1977-04-15 | 1978-11-10 | Matsushita Electric Industrial Co Ltd | Touch switch and method of producing same |
| DE2731992A1 (de) * | 1977-07-15 | 1979-02-01 | Behringwerke Ag | Verfahren zur bestimmung von immunologisch veraendertem immunglobulin |
| ES471585A1 (es) * | 1977-07-15 | 1979-01-16 | Behringwerke Ag | Procedimiento para la determinacion de reactivos fc |
| JPS5423977A (en) * | 1977-07-22 | 1979-02-22 | Sato Shinichi | Contacttswitch circuit |
| US4210622A (en) * | 1977-09-07 | 1980-07-01 | National Research Development Corporation | Kit for assay of immune complexes |
| US4231750A (en) * | 1977-12-13 | 1980-11-04 | Diagnostic Reagents, Inc. | Methods for performing chemical assays using fluorescence and photon counting |
| JPS54113064U (Direct) * | 1978-01-30 | 1979-08-08 | ||
| DE2836046A1 (de) * | 1978-08-17 | 1980-02-28 | Behringwerke Ag | Immunologisches bestimmungsverfahren |
| US4307190A (en) * | 1978-10-30 | 1981-12-22 | Technicon Instruments Corporation | Immunoassay using ascitic fluid |
| DE2853453A1 (de) * | 1978-12-11 | 1980-06-19 | Behringwerke Ag | Mittel zur therapie von immunkomplexerkrankungen |
| FI58566C (fi) * | 1979-02-22 | 1981-02-10 | Orion Yhtymae Oy | Foerbaettrat foerfarande att framstaella indikatorsystem foer bestaemning av antigen-antikroppsreaktioner med hjaelp av hemolys i gel |
| GB2045431B (en) * | 1979-02-26 | 1983-04-20 | Technicon Instr | Immunoassay utilising two particulate reagents |
| US4282002A (en) * | 1979-09-06 | 1981-08-04 | Akzona Incorporated | Sensitized sheep stroma immunoassay for rheumatoid factor |
| US4399229A (en) * | 1980-04-14 | 1983-08-16 | Immutron, Inc. | Rapid radioimmunoassay product and method of making and using same |
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| NL125235C (Direct) * | 1965-04-15 | |||
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| US3639558A (en) * | 1968-02-19 | 1972-02-01 | Louis Csizmas | Immunological reagent particles having proteinaceous materials covalently bonded thereto |
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| NL154599B (nl) * | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
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1974
- 1974-05-20 GB GB22377/74A patent/GB1508132A/en not_active Expired
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1975
- 1975-05-17 DE DE2560554A patent/DE2560554C2/de not_active Expired
- 1975-05-17 DE DE2522086A patent/DE2522086C2/de not_active Expired
- 1975-05-17 DE DE2522087A patent/DE2522087C2/de not_active Expired
- 1975-05-19 US US05/578,698 patent/US4062935A/en not_active Expired - Lifetime
- 1975-05-19 US US05/578,699 patent/US4143124A/en not_active Expired - Lifetime
- 1975-05-20 BE BE156526A patent/BE829278A/xx not_active IP Right Cessation
- 1975-05-20 IT IT23549/75A patent/IT1038305B/it active
- 1975-05-20 FR FR7515589A patent/FR2272398B1/fr not_active Expired
- 1975-05-20 JP JP50060115A patent/JPS5949545B2/ja not_active Expired
- 1975-05-20 JP JP50060114A patent/JPS598779B2/ja not_active Expired
- 1975-05-20 NL NLAANVRAGE7505868,A patent/NL182175C/xx not_active IP Right Cessation
- 1975-05-20 BE BE156525A patent/BE829277A/xx not_active IP Right Cessation
- 1975-05-20 AU AU81332/75A patent/AU498364B2/en not_active Expired
- 1975-05-20 FR FR7515590A patent/FR2272102B1/fr not_active Expired
- 1975-05-20 CH CH645875A patent/CH631015A5/de not_active IP Right Cessation
- 1975-05-20 SE SE7505734A patent/SE435425B/xx not_active IP Right Cessation
- 1975-05-20 NL NL7505867A patent/NL7505867A/xx active Search and Examination
- 1975-05-20 CH CH645975A patent/CH627281A5/de not_active IP Right Cessation
- 1975-05-20 AU AU81333/75A patent/AU496821B2/en not_active Expired
- 1975-05-20 SE SE7505735A patent/SE435325B/xx not_active IP Right Cessation
-
1978
- 1978-06-27 SE SE7807275A patent/SE443660B/sv not_active IP Right Cessation
- 1978-08-01 SE SE7808314A patent/SE447606B/sv not_active IP Right Cessation
-
1979
- 1979-09-28 CH CH878779A patent/CH637770A5/de not_active IP Right Cessation
-
1980
- 1980-12-12 CH CH918880A patent/CH630465A5/de not_active IP Right Cessation
-
1983
- 1983-06-15 JP JP58105968A patent/JPS5915860A/ja active Granted
-
1984
- 1984-06-13 JP JP59120050A patent/JPS6022662A/ja active Granted
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Owner name: TECHNICON INSTRUMENTS CORPORATION TRANSFER- TECHNI |
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