CH629385A5 - Arzneimitteltraeger zum aufbringen einer kompatiblen, pharmakologisch aktiven, chemischen substanz auf eine schleimhaut. - Google Patents
Arzneimitteltraeger zum aufbringen einer kompatiblen, pharmakologisch aktiven, chemischen substanz auf eine schleimhaut. Download PDFInfo
- Publication number
- CH629385A5 CH629385A5 CH86877A CH86877A CH629385A5 CH 629385 A5 CH629385 A5 CH 629385A5 CH 86877 A CH86877 A CH 86877A CH 86877 A CH86877 A CH 86877A CH 629385 A5 CH629385 A5 CH 629385A5
- Authority
- CH
- Switzerland
- Prior art keywords
- carrier
- water
- sodium
- aqueous solution
- carrier according
- Prior art date
Links
- 239000000126 substance Substances 0.000 title claims description 24
- 239000003937 drug carrier Substances 0.000 claims description 59
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 36
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 36
- 239000007864 aqueous solution Substances 0.000 claims description 25
- 210000004400 mucous membrane Anatomy 0.000 claims description 25
- 239000000203 mixture Substances 0.000 claims description 24
- 150000003839 salts Chemical class 0.000 claims description 21
- 230000007704 transition Effects 0.000 claims description 21
- 239000011780 sodium chloride Substances 0.000 claims description 19
- 229920001400 block copolymer Polymers 0.000 claims description 17
- 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 claims description 15
- 239000000243 solution Substances 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 14
- -1 polyoxyethylene units Polymers 0.000 claims description 14
- 229920001577 copolymer Polymers 0.000 claims description 11
- 230000001681 protective effect Effects 0.000 claims description 10
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
- 230000036760 body temperature Effects 0.000 claims description 6
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 6
- 239000004334 sorbic acid Substances 0.000 claims description 6
- 235000010199 sorbic acid Nutrition 0.000 claims description 6
- 229940075582 sorbic acid Drugs 0.000 claims description 6
- 239000003223 protective agent Substances 0.000 claims description 5
- 229910052708 sodium Inorganic materials 0.000 claims description 5
- 239000011734 sodium Substances 0.000 claims description 5
- 239000001488 sodium phosphate Substances 0.000 claims description 5
- 230000001580 bacterial effect Effects 0.000 claims description 4
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 4
- 239000004327 boric acid Substances 0.000 claims description 4
- 235000010338 boric acid Nutrition 0.000 claims description 4
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 claims description 4
- VWDWKYIASSYTQR-UHFFFAOYSA-N sodium nitrate Chemical compound [Na+].[O-][N+]([O-])=O VWDWKYIASSYTQR-UHFFFAOYSA-N 0.000 claims description 4
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 claims description 4
- 229910052783 alkali metal Inorganic materials 0.000 claims description 3
- 238000011109 contamination Methods 0.000 claims description 3
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims description 3
- 229940033663 thimerosal Drugs 0.000 claims description 3
- JCIIKRHCWVHVFF-UHFFFAOYSA-N 1,2,4-thiadiazol-5-amine;hydrochloride Chemical compound Cl.NC1=NC=NS1 JCIIKRHCWVHVFF-UHFFFAOYSA-N 0.000 claims description 2
- PMZURENOXWZQFD-UHFFFAOYSA-L Sodium Sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O PMZURENOXWZQFD-UHFFFAOYSA-L 0.000 claims description 2
- 239000000853 adhesive Substances 0.000 claims description 2
- 230000001070 adhesive effect Effects 0.000 claims description 2
- 230000008859 change Effects 0.000 claims description 2
- 230000009969 flowable effect Effects 0.000 claims description 2
- 229940096826 phenylmercuric acetate Drugs 0.000 claims description 2
- 239000004323 potassium nitrate Substances 0.000 claims description 2
- 235000010333 potassium nitrate Nutrition 0.000 claims description 2
- 229910000160 potassium phosphate Inorganic materials 0.000 claims description 2
- 235000011009 potassium phosphates Nutrition 0.000 claims description 2
- OTYBMLCTZGSZBG-UHFFFAOYSA-L potassium sulfate Chemical compound [K+].[K+].[O-]S([O-])(=O)=O OTYBMLCTZGSZBG-UHFFFAOYSA-L 0.000 claims description 2
- 229910052939 potassium sulfate Inorganic materials 0.000 claims description 2
- 235000011151 potassium sulphates Nutrition 0.000 claims description 2
- 239000004317 sodium nitrate Substances 0.000 claims description 2
- 235000010344 sodium nitrate Nutrition 0.000 claims description 2
- 229910000162 sodium phosphate Inorganic materials 0.000 claims description 2
- 235000011008 sodium phosphates Nutrition 0.000 claims description 2
- 229910052938 sodium sulfate Inorganic materials 0.000 claims description 2
- 235000011152 sodium sulphate Nutrition 0.000 claims description 2
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 2
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims 2
- PPBRXRYQALVLMV-UHFFFAOYSA-N Styrene Chemical compound C=CC1=CC=CC=C1 PPBRXRYQALVLMV-UHFFFAOYSA-N 0.000 claims 2
- 150000004820 halides Chemical class 0.000 claims 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 235000007686 potassium Nutrition 0.000 claims 1
- 235000015424 sodium Nutrition 0.000 claims 1
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims 1
- 239000003814 drug Substances 0.000 description 36
- 235000002639 sodium chloride Nutrition 0.000 description 33
- 239000000499 gel Substances 0.000 description 28
- 229940079593 drug Drugs 0.000 description 20
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 12
- 239000013543 active substance Substances 0.000 description 12
- 239000004480 active ingredient Substances 0.000 description 10
- 239000000546 pharmaceutical excipient Substances 0.000 description 10
- 229920001992 poloxamer 407 Polymers 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 9
- 229940126601 medicinal product Drugs 0.000 description 9
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- 230000001225 therapeutic effect Effects 0.000 description 8
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical class OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000002585 base Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 239000012530 fluid Substances 0.000 description 6
- 239000006260 foam Substances 0.000 description 6
- 230000002070 germicidal effect Effects 0.000 description 6
- 239000000825 pharmaceutical preparation Substances 0.000 description 6
- 239000001103 potassium chloride Substances 0.000 description 6
- 235000011164 potassium chloride Nutrition 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- 239000008194 pharmaceutical composition Substances 0.000 description 5
- 229940127557 pharmaceutical product Drugs 0.000 description 5
- 238000007792 addition Methods 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
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- 230000003204 osmotic effect Effects 0.000 description 4
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- 238000003756 stirring Methods 0.000 description 4
- 208000010412 Glaucoma Diseases 0.000 description 3
- NCXMLFZGDNKEPB-UHFFFAOYSA-N Pimaricin Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCC(C)OC(=O)C=CC2OC2CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 NCXMLFZGDNKEPB-UHFFFAOYSA-N 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- WDQPAMHFFCXSNU-BGABXYSRSA-N clofazimine Chemical compound C12=CC=CC=C2N=C2C=C(NC=3C=CC(Cl)=CC=3)C(=N/C(C)C)/C=C2N1C1=CC=C(Cl)C=C1 WDQPAMHFFCXSNU-BGABXYSRSA-N 0.000 description 3
- 229960004287 clofazimine Drugs 0.000 description 3
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 3
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- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 3
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- QCHFTSOMWOSFHM-WPRPVWTQSA-N (+)-Pilocarpine Chemical compound C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C QCHFTSOMWOSFHM-WPRPVWTQSA-N 0.000 description 2
- 206010010996 Corneal degeneration Diseases 0.000 description 2
- QZKRHPLGUJDVAR-UHFFFAOYSA-K EDTA trisodium salt Chemical compound [Na+].[Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O QZKRHPLGUJDVAR-UHFFFAOYSA-K 0.000 description 2
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- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
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- IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 description 2
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- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 description 2
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 2
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- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 2
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- 238000001914 filtration Methods 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- PGBHMTALBVVCIT-VCIWKGPPSA-N framycetin Chemical compound N[C@@H]1[C@@H](O)[C@H](O)[C@H](CN)O[C@@H]1O[C@H]1[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](N)C[C@@H](N)[C@@H]2O)O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CN)O2)N)O[C@@H]1CO PGBHMTALBVVCIT-VCIWKGPPSA-N 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000000762 glandular Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 208000018931 inflamed eyes Diseases 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
- 238000005342 ion exchange Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000000644 isotonic solution Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910000403 monosodium phosphate Inorganic materials 0.000 description 1
- 235000019799 monosodium phosphate Nutrition 0.000 description 1
- 229940053050 neomycin sulfate Drugs 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 201000005111 ocular hyperemia Diseases 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 229940021222 peritoneal dialysis isotonic solution Drugs 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 229960001416 pilocarpine Drugs 0.000 description 1
- RNAICSBVACLLGM-GNAZCLTHSA-N pilocarpine hydrochloride Chemical compound Cl.C1OC(=O)[C@@H](CC)[C@H]1CC1=CN=CN1C RNAICSBVACLLGM-GNAZCLTHSA-N 0.000 description 1
- 229940099429 polyoxyl 40 stearate Drugs 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 239000011698 potassium fluoride Substances 0.000 description 1
- 235000003270 potassium fluoride Nutrition 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000009993 protective function Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000012266 salt solution Substances 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- SKIVFJLNDNKQPD-UHFFFAOYSA-N sulfacetamide Chemical compound CC(=O)NS(=O)(=O)C1=CC=C(N)C=C1 SKIVFJLNDNKQPD-UHFFFAOYSA-N 0.000 description 1
- 229960002673 sulfacetamide Drugs 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US05/661,612 US4100271A (en) | 1976-02-26 | 1976-02-26 | Clear, water-miscible, liquid pharmaceutical vehicles and compositions which gel at body temperature for drug delivery to mucous membranes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH629385A5 true CH629385A5 (de) | 1982-04-30 |
Family
ID=24654353
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH86877A CH629385A5 (de) | 1976-02-26 | 1977-01-25 | Arzneimitteltraeger zum aufbringen einer kompatiblen, pharmakologisch aktiven, chemischen substanz auf eine schleimhaut. |
Country Status (9)
Families Citing this family (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4511554A (en) * | 1980-06-02 | 1985-04-16 | Bristol-Myers Company | Non-staining antiperspirant stick composition |
| US4287176A (en) * | 1980-10-09 | 1981-09-01 | American Cyanamid Co. | Anthelmintic levamisole and tetramisole gel compositions |
| US4368186A (en) * | 1981-05-07 | 1983-01-11 | Syntex (U.S.A.) Inc. | Methods and compositions for intravaginal contraception |
| US4609546A (en) * | 1982-06-24 | 1986-09-02 | Japan Chemical Research Co., Ltd. | Long-acting composition |
| EP0263533A3 (en) * | 1983-03-01 | 1990-05-30 | C.R.C. Compagnia di Ricerca Chimica S.p.A. | A method for preparing the cytidine monophosphate of 5-acetamido-3,5-dideoxy-d-glycero-d-galactononulosaminic acid |
| US4511563A (en) * | 1983-07-15 | 1985-04-16 | Basf Wyandotte Corporation | Clear analgesic gels with reduced tackiness |
| DE3428264A1 (de) * | 1984-07-27 | 1986-03-06 | Schering Ag | Gelhaltige pharmazeutische zubereitungen |
| US4707470A (en) * | 1985-05-17 | 1987-11-17 | Smithkline Beckman Corporation | Polyene antibiotic emulsion formulation |
| DE3532562A1 (de) * | 1985-09-12 | 1987-03-12 | Dolorgiet Gmbh & Co Kg | Transdermal resorbierbare, wasserhaltige zubereitungen von arylpropionsaeurederivaten und verfahren zur herstellung derselben |
| US4931274A (en) * | 1986-02-27 | 1990-06-05 | Physiological Research Associates | Composition for the effective treatment of scalp diseases that delivers magnesium adsorbed in alumina silicate clays to affected sites |
| US5047236A (en) * | 1986-05-15 | 1991-09-10 | Emory University | Method of treating stroke |
| US5028599A (en) * | 1986-05-15 | 1991-07-02 | Emory University | Method of treating mycardial damage |
| US5182106A (en) * | 1986-05-15 | 1993-01-26 | Emory University | Method for treating hypothermia |
| US5240701A (en) * | 1986-05-15 | 1993-08-31 | Emory University | Method of performing angioplasty procedures |
| US5041288A (en) * | 1986-05-15 | 1991-08-20 | Emory University | Method of treating tissue damaged by reperfusion injury |
| US4997644A (en) * | 1986-05-15 | 1991-03-05 | Emory University | Method of treating adult respiratory distress syndrome |
| US5648071A (en) * | 1986-05-15 | 1997-07-15 | Emory University | Method of treating tumors |
| US5250294A (en) * | 1986-05-15 | 1993-10-05 | Emory University | Improved perfusion medium for transplantation of organs |
| US4937070A (en) * | 1986-05-15 | 1990-06-26 | Emory University | Methods and compositions for treatment of pathological hydrophobic interactions in biological fluids |
| US5017370A (en) * | 1986-05-15 | 1991-05-21 | Emory University | Improved method of performing angioplasty procedures |
| US5080894A (en) * | 1986-05-15 | 1992-01-14 | Emory University | Method and composition for reducing tissue damage |
| US5089260A (en) * | 1986-05-15 | 1992-02-18 | Emory University | Method of treating ischemic tissue |
| US5071649A (en) * | 1986-05-15 | 1991-12-10 | Emory University | Method of preventing blockage in catheters |
| US5030448A (en) * | 1986-05-15 | 1991-07-09 | Emory University | Method of delivering drugs to damaged or diseased tissue |
| US5039520A (en) * | 1986-05-15 | 1991-08-13 | Emory University | Plasma extender |
| US5032394A (en) * | 1986-05-15 | 1991-07-16 | Emory University | Method of treating burns |
| US5078995A (en) * | 1986-05-15 | 1992-01-07 | Emory University | Fibrionolytic composition |
| US5674911A (en) * | 1987-02-20 | 1997-10-07 | Cytrx Corporation | Antiinfective polyoxypropylene/polyoxyethylene copolymers and methods of use |
| US5811088A (en) * | 1987-02-20 | 1998-09-22 | Emory University | Antiinfective compounds and methods of use |
| GB2203039B (en) * | 1987-03-02 | 1990-10-24 | American Cyanamid Co | Stable ophthalmic preparations containing acetazolamide |
| NZ226171A (en) * | 1987-09-18 | 1990-06-26 | Ethicon Inc | Gel formulation containing polypeptide growth factor |
| US5457093A (en) * | 1987-09-18 | 1995-10-10 | Ethicon, Inc. | Gel formulations containing growth factors |
| US5981485A (en) * | 1997-07-14 | 1999-11-09 | Genentech, Inc. | Human growth hormone aqueous formulation |
| US5135751A (en) * | 1988-11-16 | 1992-08-04 | Mediventures Incorporated | Composition for reducing postsurgical adhesions |
| US6436425B1 (en) | 1988-11-16 | 2002-08-20 | Mdv Technologies, Inc. | Method and non-gelling composition for inhibiting post-surgical adhesions |
| US5681576A (en) * | 1988-11-16 | 1997-10-28 | Mdv Technologies, Inc. | Method and composition for post surgical adhesion reduction |
| EP0386960A3 (en) * | 1989-03-07 | 1991-10-23 | American Cyanamid Company | Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings |
| US5593683A (en) * | 1990-05-01 | 1997-01-14 | Mdv Technologies, Inc. | Method of making thermoreversible polyoxyalkylene gels |
| CA2040460C (en) * | 1990-05-01 | 1997-06-10 | Tacey X. Viegas | Drug delivery with thermoreversible gels |
| GB2248842A (en) * | 1990-10-16 | 1992-04-22 | American Cyanamid Co | Film-forming polymer compositions |
| US5847023A (en) * | 1990-10-26 | 1998-12-08 | Mdv Technologies, Inc. | Thermal irreversible gel corneal contact lens formed in situ |
| US6933286B2 (en) | 1991-03-19 | 2005-08-23 | R. Martin Emanuele | Therapeutic delivery compositions and methods of use thereof |
| SK100893A3 (en) | 1991-03-19 | 1994-04-06 | Cytrx Corp | Polyoxypropylene-polyoxyethylene copolymers with improved biological activity |
| USRE38558E1 (en) | 1991-03-19 | 2004-07-20 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| US5696298A (en) * | 1991-03-19 | 1997-12-09 | Cytrx Corporation | Polyoxypropylene/polyoxyethylene copolymers with improved biological activity |
| US20020123476A1 (en) * | 1991-03-19 | 2002-09-05 | Emanuele R. Martin | Therapeutic delivery compositions and methods of use thereof |
| US7202225B1 (en) | 1993-10-15 | 2007-04-10 | Emanuele R Martin | Therapeutic delivery compositions and methods of use thereof |
| US5595732A (en) * | 1991-03-25 | 1997-01-21 | Hoffmann-La Roche Inc. | Polyethylene-protein conjugates |
| US5622649A (en) * | 1991-06-27 | 1997-04-22 | Emory University | Multiple emulsions and methods of preparation |
| US5318780A (en) * | 1991-10-30 | 1994-06-07 | Mediventures Inc. | Medical uses of in situ formed gels |
| US5470568A (en) * | 1992-02-13 | 1995-11-28 | Arch Development Corporation | Methods and compositions of a polymer (poloxamer) for cell repair |
| US5605687A (en) * | 1992-05-15 | 1997-02-25 | Arch Development Corporation | Methods and compositions of a polymer (poloxamer) for repair of electrical injury |
| JP2683783B2 (ja) * | 1992-07-10 | 1997-12-03 | 雪印乳業株式会社 | シェーグレン症候群治療剤 |
| US5382657A (en) * | 1992-08-26 | 1995-01-17 | Hoffmann-La Roche Inc. | Peg-interferon conjugates |
| ES2063662B1 (es) * | 1992-10-13 | 1995-06-16 | Inverni Della Beffa Spa | Preparaciones oftalmicas de liberacion extendida. |
| US5292525A (en) * | 1992-10-14 | 1994-03-08 | Merck & Co., Inc. | Method and composition for removing an alginate from a cutaneous substrate |
| ATE189772T1 (de) * | 1993-04-16 | 2000-03-15 | Wakamoto Pharma Co Ltd | Unter wärmeeinwirkung reversibel gelierende medizinische zusammensetzung auf wasserbasis |
| AU1119895A (en) * | 1993-11-30 | 1995-06-19 | Zenichi Ogita | External preparation |
| US5658560A (en) * | 1994-01-18 | 1997-08-19 | Serikov; Vladimir B. | Method of treating endotoxemia by administering tyloxapol |
| ATE206441T1 (de) | 1994-03-04 | 2001-10-15 | Univ Washington | Block- und pfropfcopolymere und dazu gehöriges verfahren |
| KR100215739B1 (ko) * | 1994-10-13 | 1999-08-16 | 오쿠다 기요아키 | 가역성열겔화 수용성 의약 조성물을 함유하는 동결건조 제제 |
| WO1997021441A1 (en) * | 1995-12-11 | 1997-06-19 | Mdv Technologies, Inc. | Ophthalmic composition comprising polyoxyethylene-polyoxypropylene polymers |
| US5861174A (en) * | 1996-07-12 | 1999-01-19 | University Technology Corporation | Temperature sensitive gel for sustained delivery of protein drugs |
| AU758178B2 (en) | 1998-09-04 | 2003-03-20 | Scios Inc. | Hydrogel compositions for the controlled release administration of growth factors |
| US6669927B2 (en) | 1998-11-12 | 2003-12-30 | 3M Innovative Properties Company | Dental compositions |
| US6312666B1 (en) * | 1998-11-12 | 2001-11-06 | 3M Innovative Properties Company | Methods of whitening teeth |
| US6312667B1 (en) * | 1998-11-12 | 2001-11-06 | 3M Innovative Properties Company | Methods of etching hard tissue in the oral environment |
| CA2383570C (en) | 1999-09-11 | 2008-08-12 | The Procter & Gamble Company | Pourable liquid vehicles |
| US7776803B2 (en) * | 2001-06-05 | 2010-08-17 | Steven B Leeb | Working materials with smart cutting fluids |
| US7060663B1 (en) | 2001-06-05 | 2006-06-13 | Steven B Leeb | Smart cutting fluids |
| US7138133B2 (en) * | 2001-10-10 | 2006-11-21 | The Procter & Gamble Company | Orally administered liquid compositions |
| US6620405B2 (en) | 2001-11-01 | 2003-09-16 | 3M Innovative Properties Company | Delivery of hydrogel compositions as a fine mist |
| WO2009040072A2 (en) | 2007-09-11 | 2009-04-02 | Mondobiotech Laboratories Ag | Use of a peptide as a therapeutic agent |
| RU2010113987A (ru) | 2007-09-11 | 2011-10-20 | Мондобайотек Лабораториз Аг (Li) | ПРИМЕНЕНИЕ BFGF 1-24 И НЕОБЯЗАТЕЛЬНО (Arg 8) ВАЗОПРЕССИНА ДЛЯ ЛЕЧЕНИЯ, НАПРИМЕР, ИНФЕКЦИИ S. PNEUMONIAE |
| AU2008303851A1 (en) | 2007-09-11 | 2009-04-02 | Mondobiotech Laboratories Ag | Use of the peptides MAIPPKKNQDK (cow kappa casein 106-116) and/or YGFQNA (serorphin) as therapeutic agents |
| KR20100059865A (ko) | 2007-09-11 | 2010-06-04 | 몬도바이오테크 래보래토리즈 아게 | Ａｉｄｓ 또는 알츠하이머 병의 치료를 위한 치료제로서의 베타－멜라노트로핀의 용도 |
| AU2008297896A1 (en) | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of a octreotide as a therapeutic agent |
| KR20100059856A (ko) | 2007-09-11 | 2010-06-04 | 몬도바이오테크 래보래토리즈 아게 | 치료제로서의 항염증성 펩티드―１의 용도 |
| CA2698759A1 (en) | 2007-09-11 | 2009-03-19 | Dorian Bevec | Use of a peptide as a therapeutic agent |
| JP2010539037A (ja) | 2007-09-11 | 2010-12-16 | モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト | 治療剤としてのペプチドの使用 |
| WO2009033776A1 (en) | 2007-09-11 | 2009-03-19 | Mondobiotech Laboratories Ag | Use of a defensin peptide as a therapeutic agent |
| JP2010539013A (ja) | 2007-09-11 | 2010-12-16 | モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト | 治療剤としてのペプチドの使用 |
| WO2011113507A2 (en) | 2010-03-15 | 2011-09-22 | Ulrich Dietz | Use of nitrocarboxylic acids for the treatment, diagnosis and prophylaxis of aggressive healing patterns |
| EP3453722A1 (en) | 2017-09-06 | 2019-03-13 | Julius-Maximilians-Universität Würzburg | Pharmaceuticals and devices for the covalent immobilization to the extracellular matrix by transglutaminase |
| WO2019106193A1 (en) | 2017-12-01 | 2019-06-06 | University Of Copenhagen | Peptide hormone with one or more o-glycans |
| EP3569614A1 (en) | 2018-05-18 | 2019-11-20 | Julius-Maximilians-Universität Würzburg | Compounds and methods for the immobilization of myostatin-inhibitors on the extracellular matrix by transglutaminase |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2921885A (en) * | 1955-11-25 | 1960-01-19 | Colgate Palmolive Co | Antibacterial composition |
| US3240709A (en) * | 1962-05-16 | 1966-03-15 | Burton Parsons Chemicals Inc | Method of cleansing contact lenses |
| US3740421A (en) * | 1966-09-19 | 1973-06-19 | Basf Wyandotte Corp | Polyoxyethylene-polyoxypropylene aqueous gels |
| US3639574A (en) * | 1967-10-25 | 1972-02-01 | Basf Wyandotte Corp | Stable hydrogen peroxide gels |
| USB724600I5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1968-04-26 | |||
| US3867533A (en) * | 1968-12-20 | 1975-02-18 | Basf Wyandotte Corp | Preparation of aqueous gel compositions containing a water-insoluble organic ingredient |
| US3947573A (en) * | 1969-12-01 | 1976-03-30 | Burton, Parsons And Company, Inc. | Opthalmic solution |
| US3767788A (en) * | 1970-06-08 | 1973-10-23 | Burton Parsons Chemicals Inc | Ophthalmic solution |
| US3884826A (en) * | 1973-07-20 | 1975-05-20 | Barnes Hind Pharm Inc | Thixotropic cleaning agent for hard contact lenses |
-
1976
- 1976-02-26 US US05/661,612 patent/US4100271A/en not_active Expired - Lifetime
- 1976-12-31 CA CA268,988A patent/CA1090252A/en not_active Expired
-
1977
- 1977-01-05 GB GB253/77A patent/GB1571832A/en not_active Expired
- 1977-01-25 CH CH86877A patent/CH629385A5/de not_active IP Right Cessation
- 1977-02-25 DE DE2708152A patent/DE2708152B2/de not_active Withdrawn
- 1977-02-26 JP JP2076377A patent/JPS52125619A/ja active Granted
- 1977-08-16 AU AU27949/77A patent/AU515420B2/en not_active Ceased
- 1977-08-23 NL NL7709273A patent/NL7709273A/xx not_active Application Discontinuation
- 1977-08-25 FR FR7725923A patent/FR2400903A1/fr active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| JPS52125619A (en) | 1977-10-21 |
| JPS5748049B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1982-10-14 |
| AU2794977A (en) | 1979-02-22 |
| NL7709273A (nl) | 1979-02-27 |
| US4100271A (en) | 1978-07-11 |
| CA1090252A (en) | 1980-11-25 |
| DE2708152A1 (de) | 1977-09-08 |
| GB1571832A (en) | 1980-07-23 |
| AU515420B2 (en) | 1981-04-02 |
| DE2708152B2 (de) | 1981-02-19 |
| FR2400903B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1983-10-28 |
| FR2400903A1 (fr) | 1979-03-23 |
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