CH625557A5 - - Google Patents
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- Publication number
- CH625557A5 CH625557A5 CH1047676A CH1047676A CH625557A5 CH 625557 A5 CH625557 A5 CH 625557A5 CH 1047676 A CH1047676 A CH 1047676A CH 1047676 A CH1047676 A CH 1047676A CH 625557 A5 CH625557 A5 CH 625557A5
- Authority
- CH
- Switzerland
- Prior art keywords
- serum
- activity
- added
- mmol
- lyophilized
- Prior art date
Links
- 210000002966 serum Anatomy 0.000 claims description 46
- 230000000694 effects Effects 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 20
- 102000004190 Enzymes Human genes 0.000 claims description 16
- 108090000790 Enzymes Proteins 0.000 claims description 16
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 15
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 14
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims description 8
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 claims description 8
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
- 229940109239 creatinine Drugs 0.000 claims description 4
- 239000008103 glucose Substances 0.000 claims description 4
- 150000002500 ions Chemical class 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 3
- 241001465754 Metazoa Species 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 239000000126 substance Substances 0.000 claims description 2
- 239000000758 substrate Substances 0.000 claims description 2
- 238000002360 preparation method Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- 150000001450 anions Chemical class 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 4
- 102100031126 6-phosphogluconolactonase Human genes 0.000 description 3
- 108010029731 6-phosphogluconolactonase Proteins 0.000 description 3
- 101000950981 Bacillus subtilis (strain 168) Catabolic NAD-specific glutamate dehydrogenase RocG Proteins 0.000 description 3
- 102000001390 Fructose-Bisphosphate Aldolase Human genes 0.000 description 3
- 108010068561 Fructose-Bisphosphate Aldolase Proteins 0.000 description 3
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 description 3
- 102000016901 Glutamate dehydrogenase Human genes 0.000 description 3
- 102000003855 L-lactate dehydrogenase Human genes 0.000 description 3
- 108700023483 L-lactate dehydrogenases Proteins 0.000 description 3
- 102000002704 Leucyl aminopeptidase Human genes 0.000 description 3
- 108010004098 Leucyl aminopeptidase Proteins 0.000 description 3
- 101710098398 Probable alanine aminotransferase, mitochondrial Proteins 0.000 description 3
- 238000007792 addition Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- GZCWLCBFPRFLKL-UHFFFAOYSA-N 1-prop-2-ynoxypropan-2-ol Chemical compound CC(O)COCC#C GZCWLCBFPRFLKL-UHFFFAOYSA-N 0.000 description 2
- 102000013563 Acid Phosphatase Human genes 0.000 description 2
- 108010051457 Acid Phosphatase Proteins 0.000 description 2
- 239000004382 Amylase Substances 0.000 description 2
- 102000004420 Creatine Kinase Human genes 0.000 description 2
- 108010042126 Creatine kinase Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- AFENDNXGAFYKQO-VKHMYHEASA-N (S)-2-hydroxybutyric acid Chemical compound CC[C@H](O)C(O)=O AFENDNXGAFYKQO-VKHMYHEASA-N 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 101710088194 Dehydrogenase Proteins 0.000 description 1
- 102100024319 Intestinal-type alkaline phosphatase Human genes 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- 108090000279 Peptidyltransferases Proteins 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 102000003929 Transaminases Human genes 0.000 description 1
- 108090000340 Transaminases Proteins 0.000 description 1
- -1 a-HBDH Proteins 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- BXRRQHBNBXJZBQ-UHFFFAOYSA-L dichloromanganese;hydrate Chemical compound O.Cl[Mn]Cl BXRRQHBNBXJZBQ-UHFFFAOYSA-L 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/42—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving phosphatase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
- Y10T436/106664—Blood serum or blood plasma standard or control
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19752537127 DE2537127C3 (de) | 1975-08-20 | Kontrollserum für die klinischchemische Analyse mit einem bestimmten Gehalt an alkalischer Phosphatase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CH625557A5 true CH625557A5 (nl) | 1981-09-30 |
Family
ID=5954434
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CH1047676A CH625557A5 (nl) | 1975-08-20 | 1976-08-17 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4123384A (nl) |
| JP (2) | JPS5225087A (nl) |
| CH (1) | CH625557A5 (nl) |
| FR (1) | FR2321697A1 (nl) |
| GB (1) | GB1492530A (nl) |
| IT (1) | IT1065125B (nl) |
| NL (1) | NL167771C (nl) |
| NO (1) | NO146812C (nl) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5729691B2 (nl) * | 1975-03-15 | 1982-06-24 | ||
| US4409332A (en) * | 1982-01-12 | 1983-10-11 | Jefferies Steven R | Collagen-enzyme conjugates that exhibit no inflammatory response and method for making the same |
| EP0239363B1 (en) | 1986-03-25 | 1992-10-28 | Konica Corporation | Light-sensitive silver halide photographic material feasible for high speed processing |
| JPH0528193Y2 (nl) * | 1987-09-07 | 1993-07-20 | ||
| US5296377A (en) * | 1992-12-15 | 1994-03-22 | Boehringer Mannheim Corporation | Control reagent containing a hydroxylamine or an antioxidant |
| GB2279653B (en) | 1993-07-05 | 1998-02-11 | North Gen Hospital Nhs Trust | Stabilisation of cells with an agent comprising a heavy metal compound |
| EP0754301B1 (en) * | 1994-04-05 | 1998-09-09 | Northern General Hospital N.H.S. Trust | Preparation and stabilisation of cell suspensions |
| JP4268347B2 (ja) * | 2001-05-30 | 2009-05-27 | 富士フイルム株式会社 | 乾式分析素子用の管理血清 |
| CN102636639A (zh) * | 2012-04-19 | 2012-08-15 | 上海蓝怡科技有限公司 | 碱性磷酸酶标记物的稀释液 |
| CN112680502A (zh) * | 2020-12-07 | 2021-04-20 | 郑州标源生物科技有限公司 | 一种碱性磷酸酶质控物及其制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2999793A (en) * | 1957-07-11 | 1961-09-12 | Warner Lambert Pharmacentical | Diagnostic preparation and process for the determination of serum alkaline phosphatase |
| US3466306A (en) * | 1965-08-06 | 1969-09-09 | Warner Lambert Pharmaceutical | Process for the stabilization of organic esters of phosphoric acid |
| US3425912A (en) * | 1966-11-14 | 1969-02-04 | Smithkline Corp | Laboratory reagent for assay of alkaline phosphatase |
| US3595756A (en) * | 1968-11-26 | 1971-07-27 | Smith Kline French Lab | Laboratory reagent for assay of alkaline phosphatase |
| US3723579A (en) * | 1969-09-08 | 1973-03-27 | Searle & Co | Lyophilized aryl phosphate monoesters and process therefor |
| US3728226A (en) * | 1970-06-01 | 1973-04-17 | Baxter Laboratories Inc | Blood serum analytical control standard |
| US3926735A (en) * | 1971-10-20 | 1975-12-16 | Mallinckrodt Inc | Alkaline phosphatase assay |
| US3876375A (en) * | 1971-11-22 | 1975-04-08 | Jonas Maurukas | Biological composition for use as a reference control in diagnostic analysis |
| US3853465A (en) * | 1972-06-09 | 1974-12-10 | Technicon Instr | Turbidity reduction in serum and plasma samples using polyoxyethylated lauric acid compounds |
| US3905872A (en) * | 1973-12-14 | 1975-09-16 | American Cyanamid Co | Alkaline phosphatase test material |
-
1976
- 1976-08-04 IT IT26038/76A patent/IT1065125B/it active
- 1976-08-16 US US05/715,021 patent/US4123384A/en not_active Expired - Lifetime
- 1976-08-17 GB GB34181/76A patent/GB1492530A/en not_active Expired
- 1976-08-17 CH CH1047676A patent/CH625557A5/de not_active IP Right Cessation
- 1976-08-19 NO NO762858A patent/NO146812C/no unknown
- 1976-08-19 NL NL7609215A patent/NL167771C/nl not_active IP Right Cessation
- 1976-08-20 JP JP51099564A patent/JPS5225087A/ja active Granted
- 1976-08-20 FR FR7625423A patent/FR2321697A1/fr active Granted
-
1981
- 1981-08-04 JP JP56121495A patent/JPS5763098A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| NL167771B (nl) | 1981-08-17 |
| JPS5763098A (en) | 1982-04-16 |
| GB1492530A (en) | 1977-11-23 |
| FR2321697B1 (nl) | 1980-09-19 |
| IT1065125B (it) | 1985-02-25 |
| DE2537127B2 (de) | 1977-06-23 |
| DE2537127A1 (de) | 1977-03-03 |
| JPS5225087A (en) | 1977-02-24 |
| NO762858L (nl) | 1977-02-22 |
| US4123384A (en) | 1978-10-31 |
| NO146812B (no) | 1982-09-06 |
| JPS5718864B2 (nl) | 1982-04-19 |
| NO146812C (no) | 1982-12-15 |
| JPS615719B2 (nl) | 1986-02-20 |
| FR2321697A1 (fr) | 1977-03-18 |
| NL167771C (nl) | 1982-01-18 |
| NL7609215A (nl) | 1977-02-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PL | Patent ceased |