CH621560A5 - Process for the preparation of 3-ketosteroids disubstituted in position 16 - Google Patents

Process for the preparation of 3-ketosteroids disubstituted in position 16 Download PDF

Info

Publication number
CH621560A5
CH621560A5 CH354376A CH354376A CH621560A5 CH 621560 A5 CH621560 A5 CH 621560A5 CH 354376 A CH354376 A CH 354376A CH 354376 A CH354376 A CH 354376A CH 621560 A5 CH621560 A5 CH 621560A5
Authority
CH
Switzerland
Prior art keywords
carbon atoms
group
compound
radicals
formula
Prior art date
Application number
CH354376A
Other languages
German (de)
English (en)
Inventor
Frederick Cassidy
Original Assignee
Beecham Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group Ltd filed Critical Beecham Group Ltd
Publication of CH621560A5 publication Critical patent/CH621560A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0033—Androstane derivatives substituted in position 17 alfa and 17 beta
    • C07J1/0037—Androstane derivatives substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being a saturated hydrocarbon group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0018—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022—Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
CH354376A 1975-03-21 1976-03-22 Process for the preparation of 3-ketosteroids disubstituted in position 16 CH621560A5 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB11819/75A GB1538227A (en) 1975-03-21 1975-03-21 16,16-disubstituted steroids of the androstene series

Publications (1)

Publication Number Publication Date
CH621560A5 true CH621560A5 (en) 1981-02-13

Family

ID=9993275

Family Applications (2)

Application Number Title Priority Date Filing Date
CH354376A CH621560A5 (en) 1975-03-21 1976-03-22 Process for the preparation of 3-ketosteroids disubstituted in position 16
CH228479A CH631996A5 (en) 1975-03-21 1979-03-09 Process for the preparation of 16-disubstituted steroids

Family Applications After (1)

Application Number Title Priority Date Filing Date
CH228479A CH631996A5 (en) 1975-03-21 1979-03-09 Process for the preparation of 16-disubstituted steroids

Country Status (15)

Country Link
JP (2) JPS51118756A (nl)
AT (1) AT357700B (nl)
AU (1) AU501246B2 (nl)
BE (1) BE839751A (nl)
CA (1) CA1069498A (nl)
CH (2) CH621560A5 (nl)
DE (1) DE2610497C2 (nl)
DK (1) DK143757C (nl)
FR (2) FR2304345A1 (nl)
GB (1) GB1538227A (nl)
IE (1) IE42308B1 (nl)
IL (2) IL49132A (nl)
NL (1) NL184111C (nl)
SE (2) SE7603410L (nl)
ZA (1) ZA761324B (nl)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1602960A (en) * 1977-05-25 1981-11-18 Beecham Group Ltd Process for preparing 16,16-disubstituted steroids of the androstene series
DE2943778A1 (de) * 1979-10-26 1981-05-07 Schering Ag Berlin Und Bergkamen, 1000 Berlin 17 (alpha) -alkylsteroide, diese enthaltende praeparate sowie verfahren zu ihrer herstellung
DE3514272A1 (de) * 1985-04-17 1986-10-23 Schering AG, 1000 Berlin und 4709 Bergkamen Dermatica
JPS63300153A (ja) * 1987-05-29 1988-12-07 日本碍子株式会社 建築用ほうろうパネル
GB9021546D0 (en) * 1990-10-04 1990-11-21 Beecham Group Plc Novel composition
JPH06502161A (ja) * 1990-10-31 1994-03-10 ビーチャム・グループ・パブリック・リミテッド・カンパニー レチノイド浸透作用エンハンサーを含む局所用組成物
GB9205194D0 (en) * 1992-03-10 1992-04-22 Smithkline Beecham Plc Novel composition
US20050009797A1 (en) * 2001-12-19 2005-01-13 Mitsuaki Nakamura Androstane derivative having substituent in 7- abd 17--positions
CN108558975B (zh) * 2018-04-26 2021-03-02 昆明理工大学 12β-羟基-雄甾4,14-二烯-16-酮类化合物及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3853926A (en) * 1973-05-29 1974-12-10 Searle & Co 17{62 -hydroxy-16,16-dimethylester-4-en-3-one

Also Published As

Publication number Publication date
IL58505A0 (en) 1980-01-31
ATA191376A (de) 1979-12-15
DK143757B (da) 1981-10-05
IE42308L (en) 1976-09-21
NL184111C (nl) 1989-04-17
AU1220776A (en) 1977-09-22
FR2445340B1 (nl) 1983-02-11
IL49132A (en) 1980-05-30
IE42308B1 (en) 1980-07-16
JPS61178920A (ja) 1986-08-11
CH631996A5 (en) 1982-09-15
CA1069498A (en) 1980-01-08
ZA761324B (en) 1977-02-23
GB1538227A (en) 1979-01-10
FR2304345B1 (nl) 1980-11-07
AT357700B (de) 1980-07-25
FR2304345A1 (fr) 1976-10-15
NL184111B (nl) 1988-11-16
JPS51118756A (en) 1976-10-18
DK143757C (da) 1982-03-22
JPS6355488B2 (nl) 1988-11-02
DE2610497A1 (de) 1976-10-07
DK123476A (da) 1976-09-22
SE7902256L (sv) 1979-03-13
SE7603410L (sv) 1976-09-22
DE2610497C2 (de) 1986-10-16
JPS625920B2 (nl) 1987-02-07
IL49132A0 (en) 1976-05-31
BE839751A (fr) 1976-09-20
AU501246B2 (en) 1979-06-14
NL7602949A (nl) 1976-09-23
FR2445340A1 (fr) 1980-07-25

Similar Documents

Publication Publication Date Title
EP0027961B1 (de) 17-alpha-Substituierte Steroide, diese enthaltende Präparate sowie Verfahren zu ihrer Herstellung
DE69027262T2 (de) 4-Substitutiertes 17-beta-(Cyclopropyloxy)androst-5-en-3-beta-ol und seine Derivate, verwendbar als Inhibitoren der C17-20-Lyase
DE3124780C2 (nl)
DE2633925A1 (de) Topisch anwendbare steroidzusammensetzung
CH647532A5 (de) 10-(1,2-propadienyl)-steroide und pharmazeutische zubereitungen, die diese verbindungen enthalten.
DE2643936A1 (de) Arzneimittel mit erythropoietischer wirksamkeit
CH621560A5 (en) Process for the preparation of 3-ketosteroids disubstituted in position 16
DE3872938T2 (de) 17-beta-(cyclopropyloxy)androst-5-en-3-beta-ol-derivate und verwandte verbindungen als c17-20 lyase-inhibitoren.
DE68918219T2 (de) 3-Beta, 17-beta Hydroxy-Steroide und ähnliche Steroid-Verbindungen.
DE2707121A1 (de) Steroid-enolester, verfahren zu ihrer herstellung und arzneimittel, die diese enthalten
DE3402330A1 (de) 1(alpha),2(alpha)-methylen-6-methylen- und 6(alpha)-methyl-pregnene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
EP0062903B1 (de) 17-Alpha-Alkyl-17-beta-hydroxy-1-alpha-methyl-4-androsten-3-one, Verfahren zu ihrer Herstellung und pharmazeutische Präparate, die diese Verbindungen enthalten
DE2413559A1 (de) Neue steroide, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
EP0031591A1 (de) 2,2-Dimethyl-3-oxoandrosta-4,6-dien-17S-spiro-5'-(2'-oxo-3'-methyloxazolidin), Verfahren zu seiner Herstellung und dieses enthaltende Arzneimittel
CH643863A5 (de) Steroid-5-alpha-reduktase-inhibitoren, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate.
EP0780397B1 (de) Neue 17alpha-Cyanomethylestra-4,9-dien-derivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende pharmazeutische Zusammensetzungen
DE2100319C3 (de) Neue Östranverbindungen, ihre Herstellung und sie enthaltende Arzneimittel
DE2441647A1 (de) 17beta-aethinyl-3,17alpha-oestradiolverbindungen, verfahren zu ihrer herstellung, arzneimittel und 17beta-aethinyl-16alpha, 17alpha-epoxyoestran-3-olverbindungen
DE3514272A1 (de) Dermatica
DE2246462B2 (de) ihrer Herstellung sowie diese enthaltende Arzneimittel
DE1808425C (de) 3 Oxo 17beta hydroxy 17 alpha (but 2 myl> 13 beta C tief 1 bis C tief 3 alkyl gona 4,9,11 tnene
DE1793608B1 (de) 17alpha-Alkyl-,-Alkenyl- oder -Alkinyl-13ss-alkylgon-4-oder-5(10)-en-17ss-ol-3-one
DE1593448C (de) 13beta-Äthyl-gon-4-en-3-on-thioketale, deren Herstellung und diese enthaltendes Mittel
DE2527311A1 (de) 7a-hydroxy-19-norpregn-4-en-3,20- dion-derivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische mittel
DE1593515B2 (de) 6-Chlor-21 -f luor-1,2alpha-methylen-Delta hoch 4,6 -pregnadiene, Verfahren zu deren Herstellung sowie diese enthaltende Mittel

Legal Events

Date Code Title Description
PL Patent ceased