DE3872938T2 - 17-beta-(cyclopropyloxy)androst-5-en-3-beta-ol-derivate und verwandte verbindungen als c17-20 lyase-inhibitoren. - Google Patents

17-beta-(cyclopropyloxy)androst-5-en-3-beta-ol-derivate und verwandte verbindungen als c17-20 lyase-inhibitoren.

Info

Publication number
DE3872938T2
DE3872938T2 DE8888106395T DE3872938T DE3872938T2 DE 3872938 T2 DE3872938 T2 DE 3872938T2 DE 8888106395 T DE8888106395 T DE 8888106395T DE 3872938 T DE3872938 T DE 3872938T DE 3872938 T2 DE3872938 T2 DE 3872938T2
Authority
DE
Germany
Prior art keywords
beta
androst
cyclopropyloxy
related compounds
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888106395T
Other languages
English (en)
Other versions
DE3872938D1 (de
Inventor
Michael R Angelastro
Thomas R Blohm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of DE3872938D1 publication Critical patent/DE3872938D1/de
Publication of DE3872938T2 publication Critical patent/DE3872938T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J1/00Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003Androstane derivatives
    • C07J1/0018Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa
    • C07J1/0022Androstane derivatives substituted in position 17 beta, not substituted in position 17 alfa the substituent being an OH group free esterified or etherified
    • C07J1/0029Ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J31/00Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/003Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J51/00Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8888106395T 1987-04-22 1988-04-21 17-beta-(cyclopropyloxy)androst-5-en-3-beta-ol-derivate und verwandte verbindungen als c17-20 lyase-inhibitoren. Expired - Fee Related DE3872938T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/041,170 US4891367A (en) 1987-04-22 1987-04-22 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

Publications (2)

Publication Number Publication Date
DE3872938D1 DE3872938D1 (de) 1992-08-27
DE3872938T2 true DE3872938T2 (de) 1993-01-07

Family

ID=21915121

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888106395T Expired - Fee Related DE3872938T2 (de) 1987-04-22 1988-04-21 17-beta-(cyclopropyloxy)androst-5-en-3-beta-ol-derivate und verwandte verbindungen als c17-20 lyase-inhibitoren.

Country Status (20)

Country Link
US (1) US4891367A (de)
EP (1) EP0291717B1 (de)
JP (1) JP2593685B2 (de)
KR (1) KR960015036B1 (de)
CN (1) CN1024279C (de)
AT (1) ATE78487T1 (de)
AU (1) AU605575B2 (de)
CA (1) CA1309088C (de)
DE (1) DE3872938T2 (de)
DK (1) DK167766B1 (de)
ES (1) ES2051787T3 (de)
FI (1) FI87791C (de)
GR (1) GR3005370T3 (de)
HU (1) HU198508B (de)
IL (1) IL86140A (de)
NO (1) NO168892C (de)
NZ (1) NZ224287A (de)
PH (1) PH23863A (de)
PT (1) PT87293B (de)
ZA (1) ZA882715B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ224288A (en) * 1987-04-22 1989-12-21 Merrell Dow Pharma 17b-(cyclopropylamino)androst-5-en-3b-ol and related compounds and methods using these for treatment of non-humans
US4954488A (en) * 1989-06-14 1990-09-04 Merrell Dow Pharmaceuticals Inc. Method of treating hyperaldosteronism using 17β-cyclopropylaminoandrostene derivatives
US4966897A (en) * 1989-08-15 1990-10-30 Merrell Dow Pharmaceuticals Inc. 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
US5102915A (en) * 1990-03-22 1992-04-07 Merrell Dow Pharmaceuticals Inc. Cyclopropyl squalene derivatives and their use as inhibitors of cholesterol synthesis
US5051534A (en) * 1990-03-22 1991-09-24 Merrell Dow Pharmaceuticals Inc. Novel cyclopropyl squalene derivatives and their use as inhibitors of cholesterol synthesis
US5486511A (en) * 1993-05-25 1996-01-23 Merrell Dow Pharmaceuticals Inc. 4-amino-17β-(cyclopropyloxy)androst-4-en-3-one, 4-amino-17β-(cyclopropylamino)androst-4-en-3-one and related compounds as C17-20 lyase and 5α-reductase
US5661141A (en) * 1995-03-27 1997-08-26 Petrow; Vladimir 19-oxygenated steroids as therapeutic agents
US6365597B1 (en) 1996-02-14 2002-04-02 Aventis Pharmaceuticals Inc. 4-aza steroids
US6093389A (en) * 1997-12-01 2000-07-25 American Cyanamid Company Methods and compositions for attracting and controlling termites
WO2003039250A2 (en) * 2001-11-08 2003-05-15 Colorado State University Research Foundation Termite feeding stimulant and method for using same
WO2008157460A1 (en) * 2007-06-15 2008-12-24 Cook, Kevin, M. Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3135744A (en) * 1961-04-12 1964-06-02 Vismara Francesco Spa Cycloalkenyl ethers of 17 beta-hydroxy androstanes
CH471103A (de) * 1962-02-28 1969-04-15 Warner Lambert Pharmaceutical Verfahren zur Herstellung neuer (1'-Alkoxy)-alkyl- und cycloalkyläther von 17B-Hydroxysteroiden
US3475464A (en) * 1966-11-07 1969-10-28 Syntex Corp Process for the preparation of steroids and novel intermediates thereof
US3732209A (en) * 1971-03-15 1973-05-08 Hoffmann La Roche Novel 17beta-oxygenated cyclopropa(16alpha,17alpha)steroids
US3763146A (en) * 1972-02-03 1973-10-02 Syntex Corp Novel 17beta(tetrahydropyran-4-yloxy)steroids
US4139617A (en) * 1974-05-13 1979-02-13 Richardson-Merrell Inc. 19-Oxygenated-androst-5-enes for the enhancement of libido
US4361559A (en) * 1981-08-20 1982-11-30 E. R. Squibb & Sons, Inc. Antiinflammatory 17,17-bis (substituted thio) androstenes
US4420428A (en) * 1982-12-27 1983-12-13 E. R. Squibb & Sons, Inc. 16-Ketoandrostene-17-dithioketals
US4427592A (en) * 1983-01-31 1984-01-24 E. R. Squibb & Sons, Inc. Androstene-17-dithioketals
US4529548A (en) * 1984-05-07 1985-07-16 E. R. Squibb & Sons, Inc. 17β-(substituted thio)androstenes
NZ224288A (en) * 1987-04-22 1989-12-21 Merrell Dow Pharma 17b-(cyclopropylamino)androst-5-en-3b-ol and related compounds and methods using these for treatment of non-humans

Also Published As

Publication number Publication date
FI881878A (fi) 1988-10-23
AU1472088A (en) 1988-10-27
DK217488D0 (da) 1988-04-21
FI881878A0 (fi) 1988-04-21
US4891367A (en) 1990-01-02
ES2051787T3 (es) 1994-07-01
AU605575B2 (en) 1991-01-17
EP0291717B1 (de) 1992-07-22
KR960015036B1 (ko) 1996-10-24
IL86140A0 (en) 1988-11-15
NO881745L (no) 1988-10-24
NO168892C (no) 1992-04-15
KR880012634A (ko) 1988-11-28
CA1309088C (en) 1992-10-20
PH23863A (en) 1989-11-23
ZA882715B (en) 1988-10-17
CN1024279C (zh) 1994-04-20
JPS63284194A (ja) 1988-11-21
CN88102175A (zh) 1988-11-16
NZ224287A (en) 1989-11-28
GR3005370T3 (de) 1993-05-24
ATE78487T1 (de) 1992-08-15
PT87293A (pt) 1988-05-01
FI87791C (fi) 1993-02-25
HUT47305A (en) 1989-02-28
NO881745D0 (no) 1988-04-21
HU198508B (en) 1989-10-30
EP0291717A1 (de) 1988-11-23
DK217488A (da) 1988-10-23
PT87293B (pt) 1992-08-31
DK167766B1 (da) 1993-12-13
NO168892B (no) 1992-01-06
DE3872938D1 (de) 1992-08-27
FI87791B (fi) 1992-11-13
IL86140A (en) 1993-02-21
JP2593685B2 (ja) 1997-03-26

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee