CA3121528A1 - Anellosomes and methods of use - Google Patents

Anellosomes and methods of use Download PDF

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Publication number
CA3121528A1
CA3121528A1 CA3121528A CA3121528A CA3121528A1 CA 3121528 A1 CA3121528 A1 CA 3121528A1 CA 3121528 A CA3121528 A CA 3121528A CA 3121528 A CA3121528 A CA 3121528A CA 3121528 A1 CA3121528 A1 CA 3121528A1
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Canada
Prior art keywords
acid sequence
orf1
nucleic acid
sequence
anellosome
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Pending
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CA3121528A
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English (en)
French (fr)
Inventor
Erica Gabrielle Weinstein
Avak Kahvejian
Simon Delagrave
Nathan Lawrence YOZWIAK
Kevin James LEBO
Fernando Martin DIAZ
Dhananjay Maniklal NAWANDAR
Ryan D. TEDSTONE
Jared David PITTS
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Flagship Pioneering Innovations V Inc
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Flagship Pioneering Innovations V Inc
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Publication of CA3121528A1 publication Critical patent/CA3121528A1/en
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A—HUMAN NECESSITIES
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5176—Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5184—Virus capsids or envelopes enclosing drugs
    • A—HUMAN NECESSITIES
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
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    • C12N2750/00023—Virus like particles [VLP]
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    • C12N2750/00011—Details
    • C12N2750/00041—Use of virus, viral particle or viral elements as a vector
    • C12N2750/00043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2750/00011—Details
    • C12N2750/00051—Methods of production or purification of viral material
    • C12N2750/00052—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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    • C12N2750/00011—Details
    • C12N2750/00071—Demonstrated in vivo effect

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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA3121528A 2018-12-12 2019-12-12 Anellosomes and methods of use Pending CA3121528A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862778841P 2018-12-12 2018-12-12
US201862778866P 2018-12-12 2018-12-12
US62/778,866 2018-12-12
US62/778,841 2018-12-12
PCT/US2019/065995 WO2020123816A2 (en) 2018-12-12 2019-12-12 Anellosomes and methods of use

Publications (1)

Publication Number Publication Date
CA3121528A1 true CA3121528A1 (en) 2020-06-18

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ID=69165586

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Application Number Title Priority Date Filing Date
CA3121528A Pending CA3121528A1 (en) 2018-12-12 2019-12-12 Anellosomes and methods of use

Country Status (11)

Country Link
US (1) US12637693B2 (enExample)
EP (1) EP3894570A2 (enExample)
JP (2) JP2022513797A (enExample)
KR (1) KR20210131310A (enExample)
CN (1) CN113631716A (enExample)
AU (1) AU2019397058A1 (enExample)
BR (1) BR112021011124A2 (enExample)
CA (1) CA3121528A1 (enExample)
IL (1) IL283782A (enExample)
MX (1) MX2021006977A (enExample)
WO (1) WO2020123816A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4337235A4 (en) * 2021-05-12 2025-07-02 Flagship Pioneering Innovations V Inc ANELLOVECTORS AND METHODS OF USE

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BR112020005803A2 (pt) 2017-09-25 2020-12-01 Agrospheres, Inc. composições e métodos para produção e administração moduláveis de produtos biológicos
CA3121528A1 (en) 2018-12-12 2020-06-18 Flagship Pioneering Innovations V, Inc. Anellosomes and methods of use
JP2022513459A (ja) * 2018-12-12 2022-02-08 フラッグシップ パイオニアリング イノベーションズ ブイ， インコーポレイテッド タンパク質代替治療モダリティを送達するためのアネロソーム
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TW202430215A (zh) 2022-12-14 2024-08-01 美商旗艦先鋒創新有限責任（Ｖｉｉ）公司 用於將治療劑遞送至骨之組成物和方法
TW202529819A (zh) 2023-10-13 2025-08-01 美商旗艦先鋒創新公司 組織特異性指環載體(anellovector)遞送
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