CA3121528A1 - Anellosomes and methods of use - Google Patents

Anellosomes and methods of use Download PDF

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Publication number
CA3121528A1
CA3121528A1 CA3121528A CA3121528A CA3121528A1 CA 3121528 A1 CA3121528 A1 CA 3121528A1 CA 3121528 A CA3121528 A CA 3121528A CA 3121528 A CA3121528 A CA 3121528A CA 3121528 A1 CA3121528 A1 CA 3121528A1
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Canada
Prior art keywords
acid sequence
orf1
nucleic acid
sequence
anellosome
Prior art date
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Pending
Application number
CA3121528A
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English (en)
French (fr)
Inventor
Erica Gabrielle Weinstein
Avak Kahvejian
Simon Delagrave
Nathan Lawrence YOZWIAK
Kevin James LEBO
Fernando Martin DIAZ
Dhananjay Maniklal NAWANDAR
Ryan D. TEDSTONE
Jared David PITTS
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Flagship Pioneering Innovations V Inc
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Flagship Pioneering Innovations V Inc
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Publication of CA3121528A1 publication Critical patent/CA3121528A1/en
Pending legal-status Critical Current

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111General methods applicable to biologically active non-coding nucleic acids
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5176Compounds of unknown constitution, e.g. material from plants or animals
    • A61K9/5184Virus capsids or envelopes enclosing drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141MicroRNAs, miRNAs
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    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/32Special delivery means, e.g. tissue-specific
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    • C12N2750/00023Virus like particles [VLP]
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    • C12N2750/00011Details
    • C12N2750/00041Use of virus, viral particle or viral elements as a vector
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    • C12N2750/00011Details
    • C12N2750/00051Methods of production or purification of viral material
    • C12N2750/00052Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
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    • C12N2750/00011Details
    • C12N2750/00071Demonstrated in vivo effect

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  • Wood Science & Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Optics & Photonics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3121528A 2018-12-12 2019-12-12 Anellosomes and methods of use Pending CA3121528A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862778841P 2018-12-12 2018-12-12
US201862778866P 2018-12-12 2018-12-12
US62/778,841 2018-12-12
US62/778,866 2018-12-12
PCT/US2019/065995 WO2020123816A2 (en) 2018-12-12 2019-12-12 Anellosomes and methods of use

Publications (1)

Publication Number Publication Date
CA3121528A1 true CA3121528A1 (en) 2020-06-18

Family

ID=69165586

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3121528A Pending CA3121528A1 (en) 2018-12-12 2019-12-12 Anellosomes and methods of use

Country Status (11)

Country Link
US (1) US20220042042A1 (enExample)
EP (1) EP3894570A2 (enExample)
JP (2) JP2022513797A (enExample)
KR (1) KR20210131310A (enExample)
CN (1) CN113631716A (enExample)
AU (1) AU2019397058A1 (enExample)
BR (1) BR112021011124A2 (enExample)
CA (1) CA3121528A1 (enExample)
IL (1) IL283782A (enExample)
MX (1) MX2021006977A (enExample)
WO (1) WO2020123816A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4337235A4 (en) * 2021-05-12 2025-07-02 Flagship Pioneering Innovations V Inc ANELLOVECTORS AND METHODS OF USE

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018201160A1 (en) 2017-04-28 2018-11-01 Agrospheres, Inc. Compositions and methods for enzyme immobilization
CA3056801A1 (en) 2017-04-28 2018-11-01 Agrospheres, Inc. Compositions and methods for the encapsulation and scalable delivery of agrochemicals
MX2020003074A (es) 2017-09-25 2020-09-14 Agrospheres Inc Composiciones y metodos para la produccion y la administracion expansible de productos biologicos.
WO2020123795A2 (en) * 2018-12-12 2020-06-18 Flagship Pioneering Innovations V, Inc. Anellosomes for delivering protein replacement therapeutic modalities
WO2021252955A1 (en) * 2020-06-12 2021-12-16 Flagship Pioneering Innovations V, Inc. Tandem anellovirus constructs
CA3206361A1 (en) * 2020-12-23 2022-06-30 Flagship Pioneering Innovations V, Inc. In vitro assembly of anellovirus capsids enclosing rna
TW202430215A (zh) 2022-12-14 2024-08-01 美商旗艦先鋒創新有限責任(Vii)公司 用於將治療劑遞送至骨之組成物和方法
WO2025080985A1 (en) 2023-10-13 2025-04-17 Flagship Pioneering Innovations V, Inc. Tissue specific anellovector delivery
WO2025160409A1 (en) 2024-01-26 2025-07-31 Flagship Pioneering Innovations V, Inc. Viral vectors for modulating vegf function

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395472B1 (en) * 1999-02-05 2002-05-28 Abbott Laboratories Methods of utilizing the TT virus
CA2932479A1 (en) * 2013-12-12 2015-06-18 The Rockefeller University Delivery, use and therapeutic applications of the crispr-cas systems and compositions for hbv and viral diseases and disorders
KR20200038236A (ko) * 2017-06-13 2020-04-10 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 큐론을 포함하는 조성물 및 그의 용도
CA3119339A1 (en) * 2018-12-12 2020-06-18 Flagship Pioneering Innovations V, Inc. Anellosomes for delivering intracellular therapeutic modalities
WO2020123795A2 (en) * 2018-12-12 2020-06-18 Flagship Pioneering Innovations V, Inc. Anellosomes for delivering protein replacement therapeutic modalities
BR112021009379A2 (pt) * 2018-12-12 2021-08-17 Flagship Pioneering Innovations V, Inc anelossomos para entrega de modalidades terapêuticas secretadas

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4337235A4 (en) * 2021-05-12 2025-07-02 Flagship Pioneering Innovations V Inc ANELLOVECTORS AND METHODS OF USE

Also Published As

Publication number Publication date
BR112021011124A2 (pt) 2022-03-15
US20220042042A1 (en) 2022-02-10
CN113631716A (zh) 2021-11-09
JP2022513797A (ja) 2022-02-09
JP2024099834A (ja) 2024-07-25
WO2020123816A2 (en) 2020-06-18
IL283782A (en) 2021-07-29
MX2021006977A (es) 2021-10-13
WO2020123816A3 (en) 2020-08-06
KR20210131310A (ko) 2021-11-02
AU2019397058A1 (en) 2021-06-10
EP3894570A2 (en) 2021-10-20

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